Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0409997 | 0.0834839 | 0.0779101 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0922994 | 0.668812 | 0.708336 |
Loa Loa (eye worm) | thymidylate synthase | 0.086183 | 0.599024 | 0.630211 |
Echinococcus granulosus | Tolloid protein 1 | 0.0746678 | 0.467635 | 0.694285 |
Onchocerca volvulus | 0.068963 | 0.402544 | 0.419721 | |
Giardia lamblia | High cysteine protein | 0.0346259 | 0.0107594 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0746678 | 0.467635 | 0.489453 |
Schistosoma mansoni | hypothetical protein | 0.068963 | 0.402544 | 0.426333 |
Echinococcus multilocularis | laminin | 0.0746678 | 0.467635 | 0.694285 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0922994 | 0.668812 | 1 |
Schistosoma mansoni | notch | 0.0346259 | 0.0107594 | 0.0113952 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.086183 | 0.599024 | 1 |
Toxoplasma gondii | kringle domain-containing protein | 0.068963 | 0.402544 | 0.396046 |
Schistosoma mansoni | slit | 0.0346259 | 0.0107594 | 0.0113952 |
Echinococcus granulosus | thymidylate synthase | 0.086183 | 0.599024 | 0.893948 |
Echinococcus granulosus | dihydrofolate reductase | 0.0351426 | 0.0166546 | 0.00895858 |
Schistosoma mansoni | dihydrofolate reductase | 0.0351426 | 0.0166546 | 0.0176388 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0746678 | 0.467635 | 0.495271 |
Echinococcus multilocularis | thymidylate synthase | 0.086183 | 0.599024 | 0.893948 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0746678 | 0.467635 | 0.489453 |
Echinococcus granulosus | laminin | 0.0746678 | 0.467635 | 0.694285 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0746678 | 0.467635 | 0.489453 |
Schistosoma mansoni | notch | 0.0346259 | 0.0107594 | 0.0113952 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0746678 | 0.467635 | 0.489453 |
Toxoplasma gondii | PAN domain-containing protein | 0.104586 | 0.809001 | 0.806924 |
Onchocerca volvulus | 0.0850955 | 0.586615 | 0.616917 | |
Brugia malayi | Protein kinase domain containing protein | 0.068963 | 0.402544 | 0.419721 |
Loa Loa (eye worm) | hypothetical protein | 0.0746678 | 0.467635 | 0.489453 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0746678 | 0.467635 | 0.461845 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.068963 | 0.402544 | 0.59537 |
Brugia malayi | Kringle domain containing protein | 0.068963 | 0.402544 | 0.419721 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.121326 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.121326 | 1 | 1 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0346259 | 0.0107594 | 0.0113952 |
Brugia malayi | dihydrofolate reductase family protein | 0.0351426 | 0.0166546 | 0.00631557 |
Loa Loa (eye worm) | hypothetical protein | 0.0746678 | 0.467635 | 0.489453 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0746678 | 0.467635 | 0.694285 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.121326 | 1 | 1 |
Schistosoma mansoni | notch | 0.0346259 | 0.0107594 | 0.0113952 |
Brugia malayi | thymidylate synthase | 0.086183 | 0.599024 | 0.630211 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.116435 | 0.944201 | 1 |
Echinococcus multilocularis | fibrillin 1 | 0.0746678 | 0.467635 | 0.694285 |
Schistosoma mansoni | egf-like domain protein | 0.0746678 | 0.467635 | 0.495271 |
Echinococcus granulosus | tissue type plasminogen activator | 0.068963 | 0.402544 | 0.59537 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0746678 | 0.467635 | 0.461845 |
Schistosoma mansoni | hypothetical protein | 0.0346259 | 0.0107594 | 0.0113952 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0922994 | 0.668812 | 1 |
Schistosoma mansoni | notch | 0.0346259 | 0.0107594 | 0.0113952 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0351426 | 0.0166546 | 0.00895858 |
Onchocerca volvulus | 0.086183 | 0.599024 | 0.630211 | |
Toxoplasma gondii | PAN domain-containing protein | 0.104586 | 0.809001 | 0.806924 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0346259 | 0.0107594 | 0.0113952 |
Brugia malayi | Trypsin family protein | 0.116435 | 0.944201 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.121326 | 1 | 1 |
Schistosoma mansoni | cell polarity protein | 0.0346259 | 0.0107594 | 0.0113952 |
Schistosoma mansoni | notch | 0.0346259 | 0.0107594 | 0.0113952 |
Loa Loa (eye worm) | hypothetical protein | 0.0746678 | 0.467635 | 0.489453 |
Echinococcus granulosus | enteropeptidase | 0.0922994 | 0.668812 | 1 |
Onchocerca volvulus | Arrow homolog | 0.0746678 | 0.467635 | 0.489453 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0746678 | 0.467635 | 0.489453 |
Mycobacterium ulcerans | thymidylate synthase | 0.086183 | 0.599024 | 1 |
Echinococcus multilocularis | Mastin | 0.0922994 | 0.668812 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0409997 | 0.0834839 | 0.5 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0409997 | 0.0834839 | 0.114754 |
Echinococcus multilocularis | enteropeptidase | 0.0922994 | 0.668812 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0351426 | 0.0166546 | 0.00631557 |
Schistosoma mansoni | hypothetical protein | 0.0346259 | 0.0107594 | 0.0113952 |
Schistosoma mansoni | hypothetical protein | 0.0346259 | 0.0107594 | 0.0113952 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0351426 | 0.0166546 | 0.00631557 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.086183 | 0.599024 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.086183 | 0.599024 | 0.634425 |
Loa Loa (eye worm) | hypothetical protein | 0.116435 | 0.944201 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.121326 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.116435 | 0.944201 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.121326 | 1 | 0.5 |
Onchocerca volvulus | 0.116435 | 0.944201 | 1 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.068963 | 0.402544 | 0.348123 |
Schistosoma mansoni | hypothetical protein | 0.0346259 | 0.0107594 | 0.0113952 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0746678 | 0.467635 | 0.489453 |
Echinococcus granulosus | Mastin | 0.0922994 | 0.668812 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0346259 | 0.0107594 | 0.0113952 |
Schistosoma mansoni | septate junction protein | 0.0346259 | 0.0107594 | 0.0113952 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0351426 | 0.0166546 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.068963 | 0.402544 | 0.419721 |
Loa Loa (eye worm) | hypothetical protein | 0.068963 | 0.402544 | 0.419721 |
Brugia malayi | Fibulin-1 precursor | 0.0746678 | 0.467635 | 0.489453 |
Loa Loa (eye worm) | hypothetical protein | 0.116435 | 0.944201 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0746678 | 0.467635 | 0.489453 |
Schistosoma mansoni | notch | 0.0346259 | 0.0107594 | 0.0113952 |
Schistosoma mansoni | hypothetical protein | 0.0346259 | 0.0107594 | 0.0113952 |
Schistosoma mansoni | hypothetical protein | 0.0346259 | 0.0107594 | 0.0113952 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 8.95 nM | Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by lactate dehydrogenase assay | ChEMBL. | 17482816 |
IC50 (functional) | = 8.95 nM | Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by lactate dehydrogenase assay | ChEMBL. | 17482816 |
IC50 (functional) | = 9.59 nM | Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1 after 48 hrs by lactate dehydrogenase assay | ChEMBL. | 17482816 |
IC50 (functional) | = 9.59 nM | Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1 after 48 hrs by lactate dehydrogenase assay | ChEMBL. | 17482816 |
IC50 (functional) | = 10.2 nM | Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1 after 72 hrs by lactate dehydrogenase assay | ChEMBL. | 17482816 |
IC50 (functional) | = 10.2 nM | Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1 after 72 hrs by lactate dehydrogenase assay | ChEMBL. | 17482816 |
IC50 (functional) | = 10.4 nM | Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by lactate dehydrogenase assay | ChEMBL. | 17482816 |
IC50 (functional) | = 10.4 nM | Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by lactate dehydrogenase assay | ChEMBL. | 17482816 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 17482816 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.