Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | formyl peptide receptor 1 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Inhibition of fMLP-OMe-induced superoxide anion production in human neutrophils | ChEMBL. | 17475488 |
Activity (functional) | 0 | Inhibition of fMLP-OMe-induced granule enzyme release in human neutrophils assesed by lysozyme activity | ChEMBL. | 17475488 |
IC50 (functional) | = 1.48 nM | Inhibition of fMLP-OMe-induced chemotaxis in human neutrophils | ChEMBL. | 17475488 |
Ki (binding) | > 10000 nM | Displacement of [3H]-fMLP from FPR in human neutrophils | ChEMBL. | 17475488 |
Ki (binding) | > 10000 nM | Displacement of [3H]-fMLP from FPR in human neutrophils | ChEMBL. | 17475488 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.