TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 324.413 | Formula: C21H24O3
H donors: 1 H acceptors: 3 LogP: 4.37 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: OC/C(=C/CC/C(=C/CC1=C(C)C(=O)c2c(C1=O)cccc2)/C)/C
InChi: 1S/C21H24O3/c1-14(7-6-8-15(2)13-22)11-12-17-16(3)20(23)18-9-4-5-10-19(18)21(17)24/h4-5,8-11,22H,6-7,12-13H2,1-3H3/b14-11+,15-8+
InChiKey: XEBFMYJUEVJEKQ-GGQZXFEVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.004	0.0487	0.0487
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0043	0.0539	0.0603
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.004	0.0487	0.5
Echinococcus granulosus	GPCR family 2	0.0033	0.0326	0.0364
Brugia malayi	latrophilin 2 splice variant baaae	0.0072	0.1189	0.1329
Onchocerca volvulus		0.0238	0.4916	0.9774
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0079	0.1359	0.1519
Onchocerca volvulus		0.0079	0.1359	0.2703
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.0744	0.0744
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0243	0.503	0.562
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0037	0.0402	0.0449
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0037	0.0402	0.0449
Loa Loa (eye worm)	ICD-1 protein	0.004	0.047	0.0525
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0079	0.1359	0.1519
Echinococcus granulosus	acetylcholinesterase	0.0418	0.8949	1
Onchocerca volvulus		0.004	0.0487	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0539	0.0603
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0402	0.0449
Toxoplasma gondii	NAC domain-containing protein	0.004	0.047	0.9648
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0243	0.503	0.562
Schistosoma mansoni	hypothetical protein	0.0072	0.1189	0.1189
Echinococcus granulosus	sodium and chloride dependent glycine	0.004	0.0487	0.0544
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0079	0.1359	0.1519
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0402	0.0449
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0961	0.1073
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0037	0.0402	0.0449
Trypanosoma brucei	transcription factor BTF3, putative	0.004	0.047	0.5
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1164	0.1301
Brugia malayi	Cation transporter family protein	0.0079	0.1359	0.1519
Loa Loa (eye worm)	hypothetical protein	0.0238	0.4916	0.5493
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0961	0.0961
Schistosoma mansoni	transcription factor LCR-F1	0.0041	0.0496	0.0496
Onchocerca volvulus		0.004	0.0487	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0402	0.0449
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.004	0.0487	1
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0961	0.1073
Echinococcus granulosus	serotonin transporter	0.0238	0.4916	0.5493
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0961	0.0961
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0071	0.1164	0.5
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0079	0.1359	0.1519
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0037	0.0402	0.0449
Schistosoma mansoni	nAChR subunit	0.0079	0.1359	0.1359
Onchocerca volvulus		0.004	0.0487	0.0969
Echinococcus multilocularis	glycine receptor subunit beta	0.0079	0.1359	0.1519
Schistosoma mansoni	BC026374 protein (S09 family)	0.0071	0.1164	0.1164
Brugia malayi	hypothetical protein	0.0037	0.0402	0.0449
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0079	0.1359	0.1519
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1359	0.1519
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.004	0.0487	0.0487
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0079	0.1359	0.1519
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.004	0.0487	0.0544
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0079	0.1359	0.1359
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0079	0.1359	0.1519
Brugia malayi	excitatory GABA receptor EXP-1A	0.0079	0.1359	0.1519
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0326	0.0364
Loa Loa (eye worm)	serotonin transporter b	0.0238	0.4916	0.5493
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0402	0.0449
Entamoeba histolytica	hypothetical protein	0.0041	0.0496	0.3714
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0079	0.1359	0.1519
Schistosoma mansoni	transcription factor btf3	0.004	0.047	0.047
Treponema pallidum	sodium- and chloride- dependent transporter	0.0238	0.4916	0.5
Loa Loa (eye worm)	norepinephrine transporter	0.0238	0.4916	0.5493
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0079	0.1359	0.1519
Loa Loa (eye worm)	hypothetical protein	0.004	0.0487	0.0544
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0326	0.0364
Schistosoma mansoni	hypothetical protein	0.0033	0.0326	0.0326
Loa Loa (eye worm)	ACC-1 protein	0.0079	0.1359	0.1519
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1359	0.1519
Schistosoma mansoni	nAChR subunit	0.0037	0.0402	0.0402
Loa Loa (eye worm)	acetylcholinesterase 1	0.0418	0.8949	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1189	0.1329
Brugia malayi	Carboxylesterase family protein	0.0071	0.1164	0.1301
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1359	0.1519
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0961	0.1073
Schistosoma mansoni	gliotactin	0.0071	0.1164	0.1164
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.0744	0.0744
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0961	0.1073
Echinococcus granulosus	tar DNA binding protein	0.0062	0.0961	0.1073
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0071	0.1164	0.1164
Loa Loa (eye worm)	hypothetical protein	0.004	0.0487	0.0544
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0052	0.0744	0.0831
Onchocerca volvulus		0.0037	0.0402	0.0799
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0243	0.503	0.562
Schistosoma mansoni	neurotransmitter gated ion channel	0.0037	0.0402	0.0402
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0105	0.1934	0.2161
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0539	0.0603
Echinococcus granulosus	nAChR subunit	0.0079	0.1359	0.1519
Entamoeba histolytica	hypothetical protein	0.0041	0.0496	0.3714
Echinococcus granulosus	carboxylesterase 5A	0.0418	0.8949	1
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0071	0.1164	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.0744	0.0744
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0243	0.503	0.562
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0071	0.1164	0.1301
Plasmodium vivax	hypothetical protein, conserved	0.004	0.0487	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0238	0.4916	0.5493
Brugia malayi	Carboxylesterase family protein	0.0418	0.8949	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1164	0.1301
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0079	0.1359	0.1519
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.0744	0.0831
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0071	0.1164	0.1164
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1164	0.1301
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.004	0.0487	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0402	0.0449
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0079	0.1359	0.1519
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0079	0.1359	0.1519
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0079	0.1359	0.1519
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.004	0.0487	0.0544
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.004	0.0487	0.0544
Echinococcus granulosus	para nitrobenzyl esterase	0.0071	0.1164	0.1301
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.004	0.0487	0.0544
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0071	0.1164	0.1164
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0037	0.0402	0.0449
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0079	0.1359	0.1519
Brugia malayi	RNA binding protein	0.0062	0.0961	0.1073
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0079	0.1359	0.1519
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0071	0.1164	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0402	0.0449
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0079	0.1359	0.1359
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0079	0.1359	0.1519
Brugia malayi	Carboxylesterase family protein	0.0071	0.1164	0.1301
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0539	0.0603
Plasmodium falciparum	basic transcription factor 3b, putative	0.004	0.047	0.9648
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0161	0.3195	0.3195
Trypanosoma cruzi	transcription factor btf3, putative	0.004	0.047	0.5
Brugia malayi	Carboxylesterase family protein	0.0071	0.1164	0.1301
Loa Loa (eye worm)	hypothetical protein	0.0238	0.4916	0.5493
Entamoeba histolytica	hypothetical protein	0.0041	0.0496	0.3714
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0079	0.1359	0.1519
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0037	0.0402	0.0449
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.004	0.0487	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1359	0.1519
Brugia malayi	hypothetical protein	0.0037	0.0402	0.0449
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0043	0.0539	0.0603
Loa Loa (eye worm)	hypothetical protein	0.0418	0.8949	1
Echinococcus multilocularis	sodium and chloride dependent glycine	0.004	0.0487	0.0544
Schistosoma mansoni	nAChR subunit	0.0079	0.1359	0.1359
Loa Loa (eye worm)	hypothetical protein	0.0161	0.3195	0.357
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1359	0.1519
Schistosoma mansoni	nAChR subunit	0.0079	0.1359	0.1359
Brugia malayi	hypothetical protein	0.004	0.0487	0.0544
Plasmodium falciparum	amino acid transporter, putative	0.004	0.0487	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1359	0.1519
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0238	0.4916	0.5493
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0037	0.0402	0.0449
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0105	0.1934	0.2161
Schistosoma mansoni	nAChR subunit	0.0037	0.0402	0.0402
Schistosoma mansoni	sodium/chloride dependent transporter	0.004	0.0487	0.0487
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0041	0.0496	0.0554
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0105	0.1934	0.2161
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0043	0.0539	0.0539
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0326	0.0364
Echinococcus multilocularis	sodium and chloride dependent glycine	0.004	0.0487	0.0544
Brugia malayi	hypothetical protein	0.0147	0.2871	0.3208
Brugia malayi	Cation transporter family protein	0.0079	0.1359	0.1519
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0071	0.1164	0.1301
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0326	0.0364
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0238	0.4916	0.4916
Loa Loa (eye worm)	hypothetical protein	0.004	0.0487	0.0544
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0043	0.0539	0.0539
Schistosoma mansoni	nAChR subunit	0.0079	0.1359	0.1359
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1359	0.1519
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0418	0.8949	0.8949
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.0961	0.1073
Schistosoma mansoni	hypothetical protein	0.0033	0.0326	0.0326
Trypanosoma cruzi	transcription factor btf3, putative	0.004	0.047	0.5
Echinococcus granulosus	glycine receptor subunit beta	0.0079	0.1359	0.1519
Echinococcus multilocularis	neuroligin	0.0071	0.1164	0.1301
Entamoeba histolytica	hypothetical protein	0.0043	0.0539	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0402	0.0449
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0071	0.1164	0.1164
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.004	0.0487	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0105	0.1934	0.2161
Onchocerca volvulus		0.0071	0.1164	0.2315
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1359	0.1519
Loa Loa (eye worm)	hypothetical protein	0.004	0.0487	0.0544
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0243	0.503	0.562
Loa Loa (eye worm)	carboxylesterase	0.0418	0.8949	1
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0043	0.0539	0.0603
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1164	0.1301
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1359	0.1519
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.004	0.0487	0.0544
Schistosoma mansoni	sodium/chloride dependent transporter	0.004	0.0487	0.0487
Loa Loa (eye worm)	carboxylesterase	0.0071	0.1164	0.1301
Onchocerca volvulus		0.0071	0.1164	0.2315
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0961	0.0961
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0243	0.503	0.562
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0079	0.1359	0.1519
Echinococcus granulosus	transcription factor btf3	0.004	0.047	0.0525
Schistosoma mansoni	neurotransmitter gated ion channel	0.0037	0.0402	0.0402
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0071	0.1164	0.1301
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0961	0.0961
Loa Loa (eye worm)	hypothetical protein	0.0161	0.3195	0.357
Plasmodium vivax	basic transcription factor 3b, putative	0.004	0.047	0.9648
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0402	0.0449
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0037	0.0402	0.0449
Schistosoma mansoni	nAChR subunit	0.0079	0.1359	0.1359
Brugia malayi	Cation transporter family protein	0.0161	0.3195	0.357
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.004	0.0487	1
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0326	0.0364
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0079	0.1359	0.1519
Loa Loa (eye worm)	hypothetical protein	0.0125	0.2375	0.2653
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.004	0.0487	0.0544
Echinococcus multilocularis	glycine receptor subunit beta	0.0079	0.1359	0.1519
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0037	0.0402	0.0449
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0326	0.0364
Loa Loa (eye worm)	acetylcholine receptor protein	0.0037	0.0402	0.0449
Brugia malayi	hypothetical protein	0.0037	0.0402	0.0449
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0079	0.1359	0.1519
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1359	0.1519
Schistosoma mansoni	hypothetical protein	0.0033	0.0326	0.0326
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.047	0.4036
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0079	0.1359	0.1519
Echinococcus multilocularis	transcription factor btf3	0.004	0.047	0.0525
Brugia malayi	hypothetical protein	0.0071	0.1164	0.1301
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.004	0.0487	0.0487
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0071	0.1164	0.5
Loa Loa (eye worm)	ACC-1 protein	0.0079	0.1359	0.1519
Schistosoma mansoni	neurotransmitter gated ion channel	0.0043	0.0539	0.0539
Plasmodium vivax	amine transporter, putative	0.004	0.0487	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0402	0.0449
Onchocerca volvulus		0.0079	0.1359	0.2703
Brugia malayi	Carboxylesterase family protein	0.0071	0.1164	0.1301
Onchocerca volvulus		0.0043	0.0539	0.1072
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0079	0.1359	0.1519
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.004	0.0487	0.0544
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0079	0.1359	0.1519
Echinococcus multilocularis	para nitrobenzyl esterase	0.0071	0.1164	0.1301
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0539	0.0603
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0243	0.503	0.562
Echinococcus multilocularis	acetylcholinesterase	0.0418	0.8949	1
Brugia malayi	Carboxylesterase family protein	0.0418	0.8949	1
Onchocerca volvulus		0.0161	0.3195	0.6351
Loa Loa (eye worm)	GABA receptor subunit	0.0043	0.0539	0.0603
Loa Loa (eye worm)	carboxylesterase	0.0071	0.1164	0.1301
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0041	0.0496	0.0554
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0402	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0326	0.0364
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0079	0.1359	0.1519
Loa Loa (eye worm)	LGC-31 protein	0.0079	0.1359	0.1519
Schistosoma mansoni	nAChR subunit	0.0079	0.1359	0.1359
Schistosoma mansoni	acetylcholinesterase	0.0071	0.1164	0.1164
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0402	0.0449
Toxoplasma gondii	hypothetical protein	0.004	0.0487	1
Onchocerca volvulus		0.0161	0.3195	0.6351
Onchocerca volvulus	Putative nachr subunit	0.0243	0.503	1
Mycobacterium ulcerans	carboxylesterase, LipT	0.0071	0.1164	0.5
Loa Loa (eye worm)	hypothetical protein	0.004	0.0487	0.0544
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.004	0.0487	0.0487
Onchocerca volvulus		0.0037	0.0402	0.0799
Onchocerca volvulus		0.0071	0.1164	0.2315
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0043	0.0539	0.0603
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0079	0.1359	0.1359
Leishmania major	basic transcription factor 3a, putative	0.004	0.047	0.5
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1359	0.1519
Schistosoma mansoni	sodium/chloride dependent transporter	0.0238	0.4916	0.4916
Echinococcus multilocularis	nAChR subunit	0.0043	0.0539	0.0603
Schistosoma mansoni	sodium-dependent amino acid transporter	0.004	0.0487	0.0487
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0079	0.1359	0.1519
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0037	0.0402	0.0449
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0052	0.0744	0.0831
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.0744	0.0831
Loa Loa (eye worm)	hypothetical protein	0.0238	0.4916	0.5493
Brugia malayi	beta-NAC-like protein	0.004	0.047	0.0525
Schistosoma mansoni	hypothetical protein	0.0033	0.0326	0.0326
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.004	0.0487	0.0544
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.004	0.0487	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1164	0.1301
Plasmodium falciparum	transporter, putative	0.004	0.0487	1
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0079	0.1359	0.1519
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1359	0.1519
Echinococcus granulosus	sodium and chloride dependent glycine	0.004	0.0487	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0539	0.0603
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0079	0.1359	0.1519
Echinococcus multilocularis	nAChR subunit	0.0079	0.1359	0.1519
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0402	0.0449
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0079	0.1359	0.1519
Brugia malayi	hypothetical protein	0.0041	0.0496	0.0554
Echinococcus granulosus	neuroligin	0.0071	0.1164	0.1301
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1359	0.1519
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0961	0.0961
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0079	0.1359	0.1519
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.047	0.4036
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0079	0.1359	0.1519
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0079	0.1359	0.1519
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.004	0.0487	0.0544
Loa Loa (eye worm)	hypothetical protein	0.004	0.0487	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0418	0.8949	1
Loa Loa (eye worm)	hypothetical protein	0.0147	0.2871	0.3208
Schistosoma mansoni	hypothetical protein	0.0041	0.0496	0.0496
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0079	0.1359	0.1359
Onchocerca volvulus		0.0161	0.3195	0.6351
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0079	0.1359	0.1519
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0079	0.1359	0.1519
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.004	0.0487	0.0487
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.004	0.0487	0.0544
Brugia malayi	hypothetical protein	0.0037	0.0402	0.0449
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0037	0.0402	0.0449
Brugia malayi	TAR-binding protein	0.0062	0.0961	0.1073
Trichomonas vaginalis	spcc417.12 protein, putative	0.0071	0.1164	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.0744	0.0831
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.047	0.4036
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1164	0.1301
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1164	0.1301
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0402	0.0449
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0079	0.1359	0.1519
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0326	0.0364
Echinococcus multilocularis	carboxylesterase 5A	0.0418	0.8949	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0402	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0539	0.0603
Toxoplasma gondii	hypothetical protein	0.004	0.0487	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0487	0.0544
Onchocerca volvulus		0.0071	0.1164	0.2315
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0037	0.0402	0.0402
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.004	0.0487	1
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0037	0.0402	0.0449
Echinococcus granulosus	nAChR subunit	0.0043	0.0539	0.0603
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0326	0.0364
Echinococcus multilocularis	serotonin transporter	0.0238	0.4916	0.5493
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.004	0.0487	0.0544
Schistosoma mansoni	nAChR subunit	0.0079	0.1359	0.1359
Schistosoma mansoni	acetylcholine receptor-related	0.0037	0.0402	0.0402
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0161	0.3195	0.3195
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0037	0.0402	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0402	0.0449
Onchocerca volvulus		0.0079	0.1359	0.2703
Loa Loa (eye worm)	hypothetical protein	0.0243	0.503	0.562
Brugia malayi	hypothetical protein	0.0037	0.0402	0.0449
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0079	0.1359	0.1519
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0539	0.0603
Echinococcus multilocularis	acetylcholinesterase	0.0418	0.8949	1
Echinococcus granulosus	BC026374 protein S09 family	0.0071	0.1164	0.1301
Echinococcus granulosus	acetylcholinesterase	0.0418	0.8949	1
Entamoeba histolytica	hypothetical protein	0.0041	0.0496	0.3714
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1359	0.1519
Echinococcus granulosus	glycine receptor subunit beta	0.0079	0.1359	0.1519
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0539	0.0603
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0243	0.503	0.562
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.004	0.0487	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1359	0.1519
Onchocerca volvulus		0.0037	0.0402	0.0799
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.0744	0.0831
Onchocerca volvulus		0.0071	0.1164	0.2315
Onchocerca volvulus		0.0043	0.0539	0.1072
Onchocerca volvulus		0.0147	0.2871	0.5709
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1359	0.1519

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)		Agonist activity at human SXR transfected in human HepG2 cells coexpressing GAL4 assessed as activation of receptor-mediated CYP3A4 gene transcription at 1 X 10'-6 M after 48 hrs by luciferase reporter gene assay	ChEMBL.	21561094
Activity (binding)		Binding affinity to human SXR transfected in human HepG2 cells coexpressing GAL4 assessed as transcriptional activation at 5 X 10'-6 M after 48 hrs by luciferase reporter gene assay	ChEMBL.	21561094
Activity (functional)	0	Apoptosis inducing activity in human HL60 cells at 10 uM after 74 hrs	ChEMBL.	17239598
Activity (functional)	0	Induction of apoptosis against human MG63 cells after 72 hrs	ChEMBL.	18171617

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL230390

Bibliographic References

3 literature references were collected for this gene.

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Detailed information for compound 429294