TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 420.316 | Formula: C18H15Cl2N5OS
H donors: 1 H acceptors: 4 LogP: 5.14 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccccc1Cl)CSc1nnnn1c1ccc(cc1Cl)C1CC1
InChi: 1S/C18H15Cl2N5OS/c19-13-3-1-2-4-15(13)21-17(26)10-27-18-22-23-24-25(18)16-8-7-12(9-14(16)20)11-5-6-11/h1-4,7-9,11H,5-6,10H2,(H,21,26)
InChiKey: VSDLKKKMFXZPMP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0025	0.0364	0.0364
Echinococcus multilocularis	expressed conserved protein	0.0017	0.0184	0.0184
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0008	0.0002	0.0002
Echinococcus multilocularis	transient receptor potential gamma protein	0.0008	0.0002	0.0002
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0025	0.0364	0.0364
Echinococcus multilocularis	voltage gated potassium channel	0.0037	0.0615	0.0615
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0174	0.0442
Schistosoma mansoni	notch	0.0016	0.0174	0.0174
Echinococcus multilocularis	potassium voltage gated channel protein	0.0008	0.0002	0.0002
Schistosoma mansoni	slit	0.0016	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0174	0.0442
Schistosoma mansoni	two-pore calcium channel	0.0008	0.0002	0.0002
Echinococcus multilocularis	neurogenic locus notch protein	0.0016	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0615	0.1576
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0128	0.2558	0.2558
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0074	0.0074
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0128	0.2558	0.6574
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0017	0.0184	0.5
Onchocerca volvulus		0.0012	0.0074	0.0184
Schistosoma mansoni	serine/threonine protein kinase	0.0017	0.0184	0.0184
Brugia malayi	N-terminal motif family protein	0.0017	0.0184	0.0466
Brugia malayi	EGF-like domain containing protein	0.0016	0.0174	0.0442
Echinococcus granulosus	transient receptor potential cation channel	0.0008	0.0002	0.0002
Echinococcus granulosus	transient receptor potential cation channel	0.0008	0.0002	0.0002
Trypanosoma brucei	STE group serine/threonine-protein kinase, putative	0.0012	0.0074	0.3934
Echinococcus granulosus	transient receptor potential cation channel	0.0008	0.0002	0.0002
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.0002	0.0002
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.0074	0.0074
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0017	0.0184	0.5
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0074	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0174	0.0442
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0074	0.0184
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0017	0.0184	0.1544
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0017	0.0184	0.0184
Echinococcus multilocularis	potassium voltage gated channel protein	0.0008	0.0002	0.0002
Mycobacterium ulcerans	hypothetical protein	0.0017	0.0184	0.5
Brugia malayi	EGF-like domain containing protein	0.0016	0.0174	0.0442
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0017	0.0184	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0017	0.0184	0.0477
Brugia malayi	Cadherin domain containing protein	0.0016	0.0174	0.0442
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0074	0.0074
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0017	0.0184	0.0466
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0008	0.0002	0.0002
Echinococcus multilocularis	notch	0.0016	0.0174	0.0174
Schistosoma mansoni	transient receptor potential channel 4	0.0008	0.0002	0.0002
Brugia malayi	EGF-like domain containing protein	0.0016	0.0174	0.0442
Echinococcus multilocularis	transient receptor potential cation channel	0.0008	0.0002	0.0002
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0017	0.0184	0.5
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0008	0.0002	0.0002
Echinococcus granulosus	cAMP dependent protein kinase regulatory	0.0017	0.0184	0.0184
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0008	0.0002	0.0002
Schistosoma mansoni	60S ribosomal protein L21	0.002	0.0254	0.0254
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.0074	0.0184
Schistosoma mansoni	cpg binding protein	0.0033	0.0537	0.0537
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0017	0.0184	0.0184
Schistosoma mansoni	vesicular amine transporter	0.0008	0.0002	0.0002
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0025	0.0364	0.0364
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0008	0.0002	0.0002
Echinococcus multilocularis	calcium activated potassium channel	0.0008	0.0002	0.0002
Echinococcus granulosus	sodium leak channel non selective protein	0.0008	0.0002	0.0002
Echinococcus granulosus	short transient receptor potential channel 6	0.0008	0.0002	0.0002
Echinococcus multilocularis	voltage dependent calcium channel	0.0008	0.0002	0.0002
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.0002	0.0002
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0008	0.0002	0.0002
Echinococcus granulosus	protein jagged 2	0.0016	0.0174	0.0174
Echinococcus multilocularis	dnaJ subfamily B	0.0477	1	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0025	0.0364	0.1258
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0017	0.0184	0.0184
Brugia malayi	Calcium binding EGF domain containing protein	0.0016	0.0174	0.0442
Echinococcus multilocularis	short transient receptor potential channel 6	0.0008	0.0002	0.0002
Echinococcus granulosus	hyperpolarization activated cyclic	0.0025	0.0364	0.0364
Schistosoma mansoni	cpg binding protein	0.0035	0.0578	0.0578
Schistosoma mansoni	hypothetical protein	0.0008	0.0002	0.0002
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0017	0.0184	0.0184
Brugia malayi	EGF-like domain containing protein	0.0016	0.0174	0.0442
Echinococcus granulosus	neurogenic locus notch protein 4	0.0016	0.0174	0.0174
Schistosoma mansoni	notch	0.0016	0.0174	0.0174
Echinococcus multilocularis	short transient receptor potential channel 6	0.0008	0.0002	0.0002
Brugia malayi	Fibulin-1 precursor	0.0043	0.0744	0.1908
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0074	0.0184
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0017	0.0184	0.0477
Brugia malayi	steroid hormone receptor	0.0012	0.0074	0.0184
Echinococcus multilocularis	voltage gated hydrogen channel 1	0.0008	0.0002	0.0002
Echinococcus granulosus	single minded 2	0.0012	0.0074	0.0074
Schistosoma mansoni	notch	0.0016	0.0174	0.0174
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.0074	0.0184
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.0002	0.0002
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0043	0.0744	0.1908
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.0074	0.0074
Schistosoma mansoni	notch	0.0016	0.0174	0.0174
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0008	0.0002	0.0002
Trypanosoma brucei	cAMP binding protein, putative	0.0017	0.0184	1
Brugia malayi	GCC2 and GCC3 family protein	0.0016	0.0174	0.0442
Schistosoma mansoni	hypothetical protein	0.0016	0.0174	0.0174
Echinococcus granulosus	voltage dependent calcium channel	0.0008	0.0002	0.0002
Brugia malayi	Calcium binding EGF domain containing protein	0.0016	0.0174	0.0442
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0074	0.0184
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.0074	0.0184
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0017	0.0184	0.0184
Schistosoma mansoni	voltage-gated cation channel	0.0008	0.0002	0.0002
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0043	0.0744	0.1908
Mycobacterium ulcerans	transcriptional regulatory protein	0.0017	0.0184	0.5
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.0002	0.0002
Leishmania major	hypothetical protein, unknown function	0.0017	0.0184	1
Brugia malayi	EGF-like domain containing protein	0.0016	0.0174	0.0442
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.012	0.2378	1
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.0008	0.0002	0.0002
Schistosoma mansoni	voltage-gated potassium channel	0.0037	0.0615	0.0615
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0074	0.0074
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0025	0.0364	0.0929
Brugia malayi	nuclear receptor NHR-88	0.0012	0.0074	0.0184
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0008	0.0002	0.0002
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.0074	0.0074
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.0074	0.0074
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0017	0.0184	0.0466
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0025	0.0364	0.0364
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.0074	0.0074
Echinococcus multilocularis	neural cadherin	0.0016	0.0174	0.0174
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0184	0.0477
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0074	0.0184
Brugia malayi	aryl hydrocarbon receptor nuclear translocator protein, putative	0.0012	0.0074	0.0183
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0012	0.0074	0.0184
Echinococcus granulosus	potassium voltage gated channel protein	0.0008	0.0002	0.0002
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0074	0.0074
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.0074	0.0074
Onchocerca volvulus	Neurogenic locus notch homolog	0.0016	0.0174	0.0442
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.0008	0.0002	0.0002
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0044	0.0044
Echinococcus granulosus	neurogenic locus protein delta	0.0016	0.0174	0.0174
Leishmania major	hypothetical protein, conserved	0.0017	0.0184	1
Echinococcus multilocularis	patatin phospholipase domain containing protein	0.0017	0.0184	0.0184
Schistosoma mansoni	hypothetical protein	0.0016	0.0174	0.0174
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0017	0.0184	1
Echinococcus granulosus	hypothetical protein	0.0008	0.0002	0.0002
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0008	0.0002	0.0002
Toxoplasma gondii	cAMP-dependent protein kinase regulatory subunit	0.0017	0.0184	0.1544
Echinococcus granulosus	two pore calcium channel protein 1	0.0008	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0174	0.0442
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0025	0.0364	0.0364
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0174	0.0442
Schistosoma mansoni	voltage-gated potassium channel	0.0037	0.0615	0.0615
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0017	0.0184	0.0184
Trypanosoma cruzi	cAMP response protein 1	0.0017	0.0184	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.0074	0.0074
Echinococcus granulosus	slit 2 protein	0.0016	0.0174	0.0174
Schistosoma mansoni	hypothetical protein	0.0016	0.0174	0.0174
Schistosoma mansoni	cpg binding protein	0.0035	0.0578	0.0578
Trichomonas vaginalis	cAMP-dependent protein kinase regulatory subunit, putative	0.0017	0.0184	0.0477
Schistosoma mansoni	voltage-dependent calcium channel	0.0008	0.0002	0.0002
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0184	0.0466
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0008	0.0002	0.0002
Echinococcus granulosus	cAMP dependent protein kinase type II regulatory	0.0017	0.0184	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0074	0.0184
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0074	0.0184
Echinococcus multilocularis	potassium large conductance calcium activated	0.0008	0.0002	0.0002
Toxoplasma gondii	EGF family domain-containing protein	0.0016	0.0174	0.1463
Echinococcus granulosus	Tolloid protein 1	0.0043	0.0744	0.0744
Echinococcus multilocularis	potassium voltage gated channel protein	0.0008	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0174	0.0442
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0744	0.1908
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.0074	0.0074
Mycobacterium ulcerans	hypothetical protein	0.0017	0.0184	0.5
Schistosoma mansoni	hypothetical protein	0.0016	0.0174	0.0174
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0044	0.0106
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0074	0.0184
Leishmania major	protein kinase, putative	0.0017	0.0184	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.0074	0.0184
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0044	0.0044
Echinococcus granulosus	voltage dependent calcium channel	0.0008	0.0002	0.0002
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0017	0.0184	0.0184
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0016	0.0174	0.0174
Echinococcus granulosus	hyperpolarization activated cyclic	0.0025	0.0364	0.0364
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0016	0.0174	0.0174
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.0074	0.0184
Schistosoma mansoni	cell polarity protein	0.0016	0.0174	0.0174
Echinococcus granulosus	transient receptor potential cation channel	0.0008	0.0002	0.0002
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0017	0.0184	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0174	0.0442
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0174	0.0442
Echinococcus multilocularis	neurogenic locus notch protein	0.0016	0.0174	0.0174
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0041	0.0098
Echinococcus granulosus	notch	0.0016	0.0174	0.0174
Echinococcus multilocularis	laminin	0.0043	0.0744	0.0744
Leishmania major	protein kinase A regulatory subunit, putative	0.0017	0.0184	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.012	0.2378	1
Echinococcus multilocularis	neurogenic locus protein delta	0.0016	0.0174	0.0174
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0037	0.0615	0.0615
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0744	0.1908
Loa Loa (eye worm)	hypothetical protein	0.0191	0.389	1
Echinococcus granulosus	neurogenic locus notch protein	0.0016	0.0174	0.0174
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.0074	0.0184
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0074	0.0184
Echinococcus granulosus	TRP transient receptor potential channel	0.0008	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0174	0.0442
Echinococcus multilocularis	two pore calcium channel protein 1	0.0008	0.0002	0.0002
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0025	0.0364	0.0364
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0174	0.0442
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0008	0.0002	0.0002
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0017	0.0184	0.1544
Treponema pallidum	cyclic nucleotide binding protein	0.0017	0.0184	0.5
Echinococcus granulosus	transient receptor potential cation channel	0.0008	0.0002	0.0002
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0037	0.0615	0.1576
Echinococcus granulosus	protein jagged 2	0.0016	0.0174	0.0174
Echinococcus granulosus	protein jagged 1	0.0016	0.0174	0.0174
Trypanosoma cruzi	cAMP binding protein, putative	0.0017	0.0184	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0063	0.1176	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0025	0.0364	0.1258
Schistosoma mansoni	transient receptor potential channel	0.0008	0.0002	0.0002
Echinococcus multilocularis	voltage gated potassium channel	0.0008	0.0002	0.0002
Chlamydia trachomatis	cAMP-dependent protein kinase regulatory subunit	0.0017	0.0184	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.0074	0.0184
Schistosoma mansoni	notch	0.0016	0.0174	0.0174
Trypanosoma cruzi	cAMP response protein 1, putative	0.0017	0.0184	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0025	0.0364	0.0364
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0017	0.0184	0.1544
Schistosoma mansoni	hypothetical protein	0.0016	0.0174	0.0174
Brugia malayi	Calcium binding EGF domain containing protein	0.0016	0.0174	0.0442
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0017	0.0184	0.0184
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0025	0.0364	0.0364
Echinococcus multilocularis	transient receptor potential cation channel	0.0008	0.0002	0.0002
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0037	0.0615	0.0615
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.0002	0.0002
Schistosoma mansoni	transient receptor potential channel	0.0008	0.0002	0.0002
Onchocerca volvulus	Bile acid receptor homolog	0.0191	0.389	1
Loa Loa (eye worm)	Notch2	0.0016	0.0174	0.0442
Echinococcus multilocularis	sodium leak channel non selective protein	0.0008	0.0002	0.0002
Schistosoma mansoni	cyclic nucleotide-gated ion channel	0.0017	0.0184	0.0184
Schistosoma mansoni	coup transcription factor	0.0012	0.0074	0.0074
Echinococcus multilocularis	protein jagged 1	0.0016	0.0174	0.0174
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0074	0.0074
Echinococcus multilocularis	ryanodine receptor 44f	0.0008	0.0002	0.0002
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0043	0.0744	0.632
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0017	0.0184	0.0184
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.0008	0.0002	0.0002
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.0074	0.0184
Echinococcus granulosus	ryanodine receptor 44f	0.0008	0.0002	0.0002
Onchocerca volvulus		0.0033	0.0537	0.1375
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.0074	0.0074
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0008	0.0002	0.0002
Schistosoma mansoni	laminin gamma-3 chain	0.0016	0.0174	0.0174
Echinococcus granulosus	voltage gated hydrogen channel 1	0.0008	0.0002	0.0002
Schistosoma mansoni	camp-dependent protein kinase type II regulatory subunit	0.0017	0.0184	0.0184
Echinococcus multilocularis	conserved hypothetical protein	0.0008	0.0002	0.0002
Brugia malayi	Egg laying defective protein 4	0.0017	0.0184	0.0466
Schistosoma mansoni	voltage-gated potassium channel	0.002	0.0254	0.0254
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.0074	0.0074
Echinococcus multilocularis	transient receptor potential cation channel	0.0008	0.0002	0.0002
Trypanosoma cruzi	cyclic nucleotide-binding domain containing protein, putative	0.0017	0.0184	1
Schistosoma mansoni	septate junction protein	0.0016	0.0174	0.0174
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0025	0.0364	0.0364
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.0074	0.0074
Plasmodium falciparum	cAMP-dependent protein kinase regulatory subunit	0.0017	0.0184	0.5
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.0008	0.0002	0.0002
Echinococcus granulosus	sodium channel protein	0.0008	0.0002	0.0002
Echinococcus granulosus	voltage gated potassium channel	0.0037	0.0615	0.0615
Schistosoma mansoni	similar to Protein C20orf152 homolog	0.0017	0.0184	0.0184
Onchocerca volvulus	Slit protein homolog	0.0016	0.0174	0.0442
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0008	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0074	0.0184
Mycobacterium leprae	Conserved hypothetical protein	0.0017	0.0184	1
Schistosoma mansoni	ryanodine receptor related	0.0008	0.0002	0.0002
Echinococcus multilocularis	protein jagged 1	0.0016	0.0174	0.0174
Echinococcus multilocularis	fibrillin 1	0.0043	0.0744	0.0744
Brugia malayi	Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative	0.0017	0.0184	0.0466
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.0002	0.0002
Schistosoma mansoni	serine/threonine protein kinase	0.0017	0.0184	0.0184
Echinococcus multilocularis	cAMP dependent protein kinase type I beta	0.0017	0.0184	0.0184
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.0074	0.0184
Echinococcus multilocularis	protein jagged 2	0.0016	0.0174	0.0174
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0008	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0174	0.0442
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0174	0.0442
Echinococcus granulosus	transient receptor potential cation channel	0.0008	0.0002	0.0002
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0025	0.0364	0.0364
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0008	0.0002	0.0002
Schistosoma mansoni	voltage-gated potassium channel	0.014	0.2809	0.2809
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.0043	0.0744	0.1908
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0008	0.0002	0.0002
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.0074	0.0074
Brugia malayi	EGF-like domain containing protein	0.0016	0.0174	0.0442
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0017	0.0184	0.1544
Echinococcus multilocularis	cpg binding protein	0.0035	0.0578	0.0578
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.0074	0.0184
Brugia malayi	cAMP-dependent protein kinase regulatory chain, putative	0.0017	0.0184	0.0466
Leishmania major	hypothetical protein, conserved	0.0017	0.0184	1
Echinococcus multilocularis	potassium voltage gated channel protein	0.0008	0.0002	0.0002
Echinococcus multilocularis	transient receptor potential cation channel	0.0008	0.0002	0.0002
Onchocerca volvulus		0.0016	0.0174	0.0442
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0017	0.0184	0.0184
Leishmania major	protein kinase, putative	0.0017	0.0184	1
Echinococcus granulosus	potassium voltage gated channel protein	0.0008	0.0002	0.0002
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0071	0.1338	0.1338
Trypanosoma brucei	cAMP response protein 1, putative	0.0017	0.0184	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0174	0.0442
Schistosoma mansoni	hypothetical protein	0.0017	0.0184	0.0184
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.0008	0.0002	0.0002
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0008	0.0002	0.0002
Echinococcus granulosus	protein jagged 1	0.0016	0.0174	0.0174
Schistosoma mansoni	serine/threonine protein kinase	0.0017	0.0184	0.0184
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.0002	0.0002
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.0074	0.0074
Plasmodium vivax	rap guanine nucleotide exchange factor, putative	0.0017	0.0184	0.5
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0074	0.0184
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0043	0.0744	0.1908
Echinococcus granulosus	neurogenic locus notch protein	0.0016	0.0174	0.0174
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0033	0.0537	0.1375
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0016	0.0174	0.0442
Echinococcus multilocularis	two pore calcium channel protein 2	0.0008	0.0002	0.0002
Echinococcus granulosus	patatin phospholipase domain containing protein	0.0017	0.0184	0.0184
Echinococcus granulosus	cpg binding protein	0.0035	0.0578	0.0578
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.0074	0.0184
Brugia malayi	Muscle positioning protein 4	0.0016	0.0174	0.0442
Echinococcus granulosus	potassium voltage gated channel protein	0.0008	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0174	0.0442
Onchocerca volvulus		0.0017	0.0184	0.0466
Onchocerca volvulus		0.0016	0.0174	0.0442
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.0074	0.0074
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.0002	0.0002
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0017	0.0184	0.1544
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0025	0.0364	0.0364
Echinococcus granulosus	shaker cognate	0.0008	0.0002	0.0002
Brugia malayi	notch-like transmembrane receptor	0.0016	0.0174	0.0442
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.0002	0.0002
Plasmodium falciparum	cGMP-dependent protein kinase	0.0017	0.0184	0.5
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0128	0.2558	0.6574
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0364	0.0929
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0174	0.0442
Echinococcus granulosus	neural cadherin	0.0016	0.0174	0.0174
Brugia malayi	Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog	0.0017	0.0184	0.0466
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0008	0.0002	0.0002
Echinococcus multilocularis	transient receptor potential cation channel	0.0008	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0174	0.0442
Onchocerca volvulus		0.0016	0.0174	0.0442
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0744	0.1908
Echinococcus multilocularis	cAMP dependent protein kinase type II regulatory	0.0017	0.0184	0.0184
Trypanosoma cruzi	Flagellar Member 6	0.0017	0.0184	1
Echinococcus granulosus	two pore calcium channel protein 2	0.0008	0.0002	0.0002
Onchocerca volvulus	Arrow homolog	0.0043	0.0744	0.1908
Mycobacterium ulcerans	transmembrane transport protein	0.0017	0.0184	0.5
Echinococcus multilocularis	voltage dependent calcium channel	0.0008	0.0002	0.0002
Schistosoma mansoni	hypothetical protein	0.0016	0.0174	0.0174
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0008	0.0002	0.0002
Echinococcus multilocularis	sodium channel protein	0.0008	0.0002	0.0002
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.0074	0.0184
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0017	0.0184	1
Leishmania major	hypothetical protein, conserved	0.0017	0.0184	1
Echinococcus multilocularis	transfer RNA-Gly	0.0008	0.0002	0.0002
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0025	0.0364	0.0364
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.0074	0.0184
Schistosoma mansoni	voltage-gated potassium channel	0.0025	0.0364	0.0364
Schistosoma mansoni	voltage-gated ion channel	0.0008	0.0002	0.0002
Mycobacterium ulcerans	hypothetical protein	0.0017	0.0184	0.5
Echinococcus multilocularis	cAMP dependent protein kinase regulatory	0.0017	0.0184	0.0184
Echinococcus granulosus	potassium large conductance calcium activated	0.0008	0.0002	0.0002
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0008	0.0002	0.0002
Echinococcus granulosus	laminin	0.0043	0.0744	0.0744
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0184	0.0466
Brugia malayi	nuclear hormone receptor	0.0012	0.0074	0.0184
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0008	0.0002	0.0002
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0008	0.0002	0.0002
Schistosoma mansoni	calcium channel voltage-dependent p/q type alpha 1a-related	0.0008	0.0002	0.0002
Echinococcus granulosus	potassium voltage gated channel protein	0.0008	0.0002	0.0002
Echinococcus granulosus	delta-like protein 1	0.0016	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0744	0.1908
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0174	0.0442
Echinococcus multilocularis	fibropellin Ia	0.0016	0.0174	0.0174
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.0074	0.0184
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.0074	0.0184
Onchocerca volvulus	Putative cubilin	0.0016	0.0174	0.0442
Mycobacterium ulcerans	regulatory protein	0.0017	0.0184	0.5
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.0074	0.0074
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.0002	0.0002
Leishmania major	regulatory subunit of protein kinase a-like protein	0.0017	0.0184	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.0074	0.0184
Mycobacterium tuberculosis	Probable conserved transmembrane transport protein	0.0017	0.0184	0.5
Onchocerca volvulus		0.0016	0.0174	0.0442
Echinococcus granulosus	transient receptor potential gamma protein	0.0008	0.0002	0.0002
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0074	0.0184
Echinococcus multilocularis	neurogenic locus protein delta	0.0016	0.0174	0.0174
Schistosoma mansoni	hypothetical protein	0.0477	1	1
Trichomonas vaginalis	cAMP-dependent protein kinase type I-beta regulatory subunit, putative	0.0017	0.0184	0.0477
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0174	0.0442
Echinococcus multilocularis	slit 2 protein	0.0016	0.0174	0.0174
Schistosoma mansoni	hypothetical protein	0.0012	0.0074	0.0074
Echinococcus multilocularis	transient receptor potential cation channel	0.0008	0.0002	0.0002
Echinococcus granulosus	potassium voltage gated channel protein	0.0008	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0744	0.1908
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.0074	0.0074
Onchocerca volvulus		0.0016	0.0174	0.0442
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0008	0.0002	0.0002
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.0017	0.0184	0.0184
Brugia malayi	Delta serrate ligand family protein	0.0016	0.0174	0.0442
Brugia malayi	Calcium binding EGF domain containing protein	0.0043	0.0744	0.1908
Schistosoma mansoni	calcium-activated potassium channel	0.0008	0.0002	0.0002
Schistosoma mansoni	hypothetical protein	0.0016	0.0174	0.0174
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0025	0.0364	0.0929
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0017	0.0184	1
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0008	0.0002	0.0002
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0128	0.2558	0.2558
Schistosoma mansoni	egf-like domain protein	0.0043	0.0744	0.0744
Loa Loa (eye worm)	hypothetical protein	0.0111	0.2197	0.5644
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0074	0.0074
Schistosoma mansoni	transient receptor potential channel	0.0008	0.0002	0.0002
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.0074	0.0074
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0016	0.0174	0.0174
Echinococcus granulosus	fibropellin Ia	0.0016	0.0174	0.0174
Mycobacterium tuberculosis	Conserved protein	0.0017	0.0184	0.5
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0025	0.0364	0.0929
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0174	0.0442
Schistosoma mansoni	voltage-gated potassium channel	0.014	0.2809	0.2809
Brugia malayi	Cadherin domain containing protein	0.0016	0.0174	0.0442
Brugia malayi	CXXC zinc finger family protein	0.0033	0.0537	0.1375
Mycobacterium ulcerans	hypothetical protein	0.0017	0.0184	0.5
Schistosoma mansoni	camp-dependent protein kinase type II-alpha regulatory subunit	0.0017	0.0184	0.0184
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0017	0.0184	0.0184
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.0074	0.0074
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0008	0.0002	0.0002
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.0008	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0074	0.0184
Echinococcus granulosus	voltage gated potassium channel	0.0008	0.0002	0.0002
Brugia malayi	EGF-like domain containing protein	0.0016	0.0174	0.0442
Trypanosoma brucei	protein kinase A regulatory subunit	0.0017	0.0184	1
Trypanosoma brucei	Flagellar Member 6	0.0017	0.0184	1
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0008	0.0002	0.0002
Echinococcus granulosus	cAMP dependent protein kinase type I beta	0.0017	0.0184	0.0184
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0043	0.0744	0.632
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0043	0.0744	0.0744
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0016	0.0174	0.0442
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0008	0.0002	0.0002
Loa Loa (eye worm)	cAMP-dependent protein kinase regulatory subunit	0.0017	0.0184	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0174	0.0442
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.0074	0.0074
Treponema pallidum	cyclic nucleotide binding protein	0.0017	0.0184	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0174	0.0442
Schistosoma mansoni	notch	0.0016	0.0174	0.0174
Treponema pallidum	catabolite gene activator	0.0017	0.0184	0.5
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0017	0.0184	0.0184
Onchocerca volvulus		0.0017	0.0184	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0174	0.0442
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0025	0.0364	0.0364
Echinococcus multilocularis	Tolloid protein 1	0.0043	0.0744	0.0744
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0074	0.0184
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.0074	0.0074
Echinococcus granulosus	cGMP dependent protein kinase	0.0017	0.0184	0.0184
Treponema pallidum	catabolite gene activator (Crp)	0.0017	0.0184	0.5
Loa Loa (eye worm)	notch protein	0.0016	0.0174	0.0442
Plasmodium vivax	CAMP-dependent protein kinase regulatory subunit, putative	0.0017	0.0184	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.0074	0.0184
Trypanosoma cruzi	protein kinase A regulatory subunit	0.0017	0.0184	1
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.0002	0.0002
Trypanosoma cruzi	hypothetical protein, conserved	0.0017	0.0184	1
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.0002	0.0002
Echinococcus granulosus	calcium activated potassium channel	0.0008	0.0002	0.0002
Schistosoma mansoni	camp-dependent protein kinase regulatory chain	0.0017	0.0184	0.0184
Echinococcus granulosus	short transient receptor potential channel 6	0.0008	0.0002	0.0002
Mycobacterium tuberculosis	Probable glutamine-transport ATP-binding protein ABC transporter GlnQ	0.0017	0.0184	0.5
Echinococcus multilocularis	shaker cognate	0.0008	0.0002	0.0002
Mycobacterium tuberculosis	Probable transcriptional regulatory protein Cmr	0.0017	0.0184	0.5
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0025	0.0364	0.0364
Giardia lamblia	CAMP-dependent protein kinase regulatory chain	0.0017	0.0184	1
Leishmania major	cyclic nucleotide-binding protein-like protein	0.0017	0.0184	1
Brugia malayi	ecdysteroid receptor	0.0191	0.389	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0012	0.0074	0.0184

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 13 nM	Inhibition of wild type HIV1 reverse transcriptase	ChEMBL.	17451954
IC50 (binding)	= 103 nM	Inhibition of HIV1 reverse transcriptase K103N/Y181C mutant	ChEMBL.	17451954
t1/2 (ADMET)	0	Half life in human liver microsomes	ChEMBL.	17451954

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 429515