Detailed information for compound 429541

Basic information

Technical information
  • TDR Targets ID: 429541
  • Name: N-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]naph thalene-1-sulfonamide
  • MW: 409.501 | Formula: C22H23N3O3S
  • H donors: 1 H acceptors: 3 LogP: 3.26 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCN(CC1)c1ccccc1)CNS(=O)(=O)c1cccc2c1cccc2
  • InChi: 1S/C22H23N3O3S/c26-22(25-15-13-24(14-16-25)19-9-2-1-3-10-19)17-23-29(27,28)21-12-6-8-18-7-4-5-11-20(18)21/h1-12,23H,13-17H2
  • InChiKey: QICBVNVCIQTAGV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-oxo-2-(4-phenyl-1-piperazinyl)ethyl]-1-naphthalenesulfonamide
  • N-[2-keto-2-(4-phenylpiperazino)ethyl]naphthalene-1-sulfonamide
  • N-[2-keto-2-(4-phenylpiperazin-1-yl)ethyl]naphthalene-1-sulfonamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens purinergic receptor P2X, ligand-gated ion channel, 7 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tubulin subunit alpha 0.0067 0.1178 0.186
Loa Loa (eye worm) hypothetical protein 0.004 0.0561 0.0886
Echinococcus multilocularis Tubulin alpha 1 chain 0.0211 0.4518 0.7135
Echinococcus granulosus geminin 0.0169 0.3543 0.5596
Entamoeba histolytica tubulin family protein 0.0289 0.6332 1
Echinococcus multilocularis tubulin alpha chain 0.0211 0.4518 0.7135
Echinococcus multilocularis Tubulin alpha 1 chain 0.0211 0.4518 0.7135
Echinococcus multilocularis geminin 0.0169 0.3543 0.5596
Echinococcus multilocularis tubulin alpha chain 0.0211 0.4518 0.7135
Echinococcus granulosus tubulin epsilon chain 0.0153 0.3188 0.5034
Leishmania major alpha tubulin 0.0211 0.4518 0.7135
Echinococcus multilocularis Tubulin beta 2C chain 0.0289 0.6332 1
Leishmania major beta tubulin 0.0289 0.6332 1
Trypanosoma cruzi tubulin gamma chain 0.0153 0.3188 0.5034
Trichomonas vaginalis tubulin alpha chain, putative 0.0087 0.1645 0.0907
Schistosoma mansoni P2X receptor subunit 0.0082 0.1534 0.2423
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0785 0.124
Trichomonas vaginalis tubulin alpha chain, putative 0.0087 0.1645 0.0907
Echinococcus granulosus tubulin beta 4A class IVa 0.0289 0.6332 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.2389 0.3772
Echinococcus multilocularis tubulin gamma 1 chain 0.0153 0.3188 0.5034
Leishmania major alpha tubulin 0.0211 0.4518 0.7135
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0153 0.3188 0.5034
Echinococcus multilocularis Tubulin beta 2C chain 0.0289 0.6332 1
Loa Loa (eye worm) blistered cuticle protein 3 0.004 0.0561 0.0886
Echinococcus multilocularis Tubulin beta 2C chain 0.0289 0.6332 1
Brugia malayi Tubulin alpha chain 0.0067 0.1178 0.186
Trichomonas vaginalis tubulin beta chain, putative 0.0211 0.4518 0.648
Brugia malayi Tubulin beta chain 0.0067 0.1178 0.186
Trypanosoma brucei tubulin delta chain 0.0067 0.1178 0.186
Loa Loa (eye worm) animal heme peroxidase 0.004 0.0561 0.0886
Plasmodium vivax tubulin epsilon chain, putative 0.0153 0.3188 0.5034
Trichomonas vaginalis tubulin beta chain, putative 0.0211 0.4518 0.648
Echinococcus multilocularis tubulin delta chain 0.0067 0.1178 0.186
Loa Loa (eye worm) hypothetical protein 0.004 0.0561 0.0886
Loa Loa (eye worm) tubulin alpha-3 chain 0.0124 0.2508 0.3961
Plasmodium vivax tubulin alpha chain, putative 0.0211 0.4518 0.7135
Echinococcus granulosus Tubulin alpha 1 chain 0.0211 0.4518 0.7135
Schistosoma mansoni tubulin subunit beta 0.0289 0.6332 1
Trypanosoma cruzi epsilon tubulin, putative 0.0153 0.3188 0.5034
Echinococcus granulosus tubulin alpha chain 0.0211 0.4518 0.7135
Echinococcus multilocularis hypothetical protein 0.0211 0.4518 0.7135
Echinococcus granulosus beta tubulin 0.0289 0.6332 1
Echinococcus granulosus tubulin alpha chain 0.0211 0.4518 0.7135
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0144 0.2976 0.3488
Trypanosoma brucei alpha tubulin 0.0211 0.4518 0.7135
Echinococcus multilocularis Tubulin alpha 1 chain 0.0211 0.4518 0.7135
Echinococcus granulosus Tubulin beta 2C chain 0.0289 0.6332 1
Schistosoma mansoni alpha tubulin 0.0211 0.4518 0.7135
Loa Loa (eye worm) hypothetical protein 0.004 0.0561 0.0886
Loa Loa (eye worm) BEN-1 protein 0.0289 0.6332 1
Leishmania major beta tubulin 0.0289 0.6332 1
Leishmania major alpha tubulin 0.0211 0.4518 0.7135
Entamoeba histolytica tubulin family protein 0.0289 0.6332 1
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.2389 0.3772
Trypanosoma brucei alpha tubulin, putative 0.0087 0.1645 0.2599
Trichomonas vaginalis tubulin alpha chain, putative 0.0087 0.1645 0.0907
Plasmodium vivax tubulin alpha chain, putative 0.0211 0.4518 0.7135
Schistosoma mansoni tubulin subunit beta 0.0289 0.6332 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0124 0.2508 0.2581
Trypanosoma cruzi beta tubulin, putative 0.0289 0.6332 1
Leishmania major gamma-tubulin 0.0153 0.3188 0.5034
Echinococcus multilocularis peroxidasin 0.004 0.0561 0.0886
Loa Loa (eye worm) tubulin beta-1 chain 0.0289 0.6332 1
Echinococcus granulosus tubulin subunit TubB 0.0211 0.4518 0.7135
Schistosoma mansoni tubulin subunit alpha 0.0211 0.4518 0.7135
Trichomonas vaginalis tubulin alpha chain, putative 0.0289 0.6332 1
Echinococcus granulosus alpha tubulin 0.0211 0.4518 0.7135
Trypanosoma cruzi alpha tubulin, putative 0.0211 0.4518 0.7135
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0087 0.1645 0.0907
Echinococcus multilocularis p2X purinoceptor 4 0.0082 0.1534 0.2423
Loa Loa (eye worm) tubulin alpha chain 0.0211 0.4518 0.7135
Trichomonas vaginalis tubulin, putative 0.0087 0.1645 0.0907
Echinococcus granulosus tubulin delta chain 0.0067 0.1178 0.186
Echinococcus granulosus tubulin alpha 0.0153 0.3188 0.5034
Brugia malayi tubulin alpha chain - mouse 0.0211 0.4518 0.7135
Plasmodium falciparum tubulin epsilon chain, putative 0.0153 0.3188 0.5034
Loa Loa (eye worm) alpha-tubulin 0.0211 0.4518 0.7135
Leishmania major beta tubulin 0.0289 0.6332 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0289 0.6332 1
Trypanosoma brucei alpha tubulin 0.0211 0.4518 0.7135
Brugia malayi beta-tubulin, identical 0.0289 0.6332 1
Leishmania major beta tubulin 0.0289 0.6332 1
Loa Loa (eye worm) hypothetical protein 0.0211 0.4518 0.7135
Echinococcus granulosus tubulin subunit beta 0.0289 0.6332 1
Loa Loa (eye worm) hypothetical protein 0.015 0.312 0.4928
Brugia malayi tubulin alpha-2 chain 0.0211 0.4518 0.7135
Trichomonas vaginalis tubulin, putative 0.0289 0.6332 1
Leishmania major alpha tubulin 0.0211 0.4518 0.7135
Brugia malayi Animal haem peroxidase family protein 0.004 0.0561 0.0886
Giardia lamblia Gamma tubulin 0.0153 0.3188 0.3899
Leishmania major beta tubulin 0.0289 0.6332 1
Loa Loa (eye worm) tubulin alpha 2 0.0144 0.2976 0.4699
Leishmania major beta tubulin 0.0289 0.6332 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0211 0.4518 0.7135
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0211 0.4518 0.648
Giardia lamblia Alpha-tubulin 0.0211 0.4518 0.648
Trypanosoma brucei alpha tubulin 0.0211 0.4518 0.7135
Trichomonas vaginalis tubulin beta chain, putative 0.0289 0.6332 1
Leishmania major beta tubulin 0.0289 0.6332 1
Trypanosoma brucei beta tubulin 0.0289 0.6332 1
Toxoplasma gondii beta tubulin 0.0289 0.6332 1
Loa Loa (eye worm) alpha-tubulin 0.0211 0.4518 0.7135
Loa Loa (eye worm) hypothetical protein 0.0144 0.2976 0.4699
Brugia malayi Animal haem peroxidase family protein 0.004 0.0561 0.0886
Schistosoma mansoni hypothetical protein 0.0034 0.0422 0.0666
Trypanosoma cruzi tubulin delta chain 0.0067 0.1178 0.186
Loa Loa (eye worm) hypothetical protein 0.004 0.0561 0.0886
Loa Loa (eye worm) hypothetical protein 0.004 0.0561 0.0886
Echinococcus multilocularis p2X purinoceptor 4 0.0082 0.1534 0.2423
Echinococcus granulosus p2X purinoceptor 4 0.0082 0.1534 0.2423
Echinococcus granulosus Tubulin alpha 1 chain 0.0211 0.4518 0.7135
Leishmania major alpha tubulin 0.0211 0.4518 0.7135
Leishmania major alpha tubulin 0.0211 0.4518 0.7135
Leishmania major alpha tubulin 0.0211 0.4518 0.7135
Trichomonas vaginalis tubulin beta chain, putative 0.0087 0.1645 0.0907
Echinococcus granulosus p2X purinoceptor 4 0.0082 0.1534 0.2423
Schistosoma mansoni alpha tubulin 0.0211 0.4518 0.7135
Leishmania major beta tubulin 0.0289 0.6332 1
Loa Loa (eye worm) tubulin beta chain 0.0067 0.1178 0.186
Trichomonas vaginalis tubulin gamma chain, putative 0.0153 0.3188 0.3899
Schistosoma mansoni tubulin subunit epsilon 0.0153 0.3188 0.5034
Echinococcus granulosus tubulin alpha 3 chain 0.0211 0.4518 0.7135
Brugia malayi alpha-tubulin 0.0211 0.4518 0.7135
Giardia lamblia Alpha-tubulin 0.0211 0.4518 0.648
Echinococcus multilocularis beta tubulin 0.0289 0.6332 1
Brugia malayi Animal haem peroxidase family protein 0.004 0.0561 0.0886
Loa Loa (eye worm) tubulin alpha-2 chain 0.0211 0.4518 0.7135
Echinococcus multilocularis tubulin epsilon chain 0.0153 0.3188 0.5034
Echinococcus multilocularis tubulin alpha chain 0.0211 0.4518 0.7135
Plasmodium falciparum tubulin gamma chain 0.0153 0.3188 0.5034
Leishmania major alpha tubulin 0.0211 0.4518 0.7135
Schistosoma mansoni tubulin subunit beta 0.0289 0.6332 1
Echinococcus granulosus Tubulin beta 2C chain 0.0289 0.6332 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0289 0.6332 1
Echinococcus granulosus beta tubulin 0.0289 0.6332 1
Leishmania major alpha tubulin 0.0211 0.4518 0.7135
Trichomonas vaginalis tubulin gamma chain, putative 0.0153 0.3188 0.3899
Loa Loa (eye worm) tubulin alpha 2 0.0057 0.0966 0.1525
Schistosoma mansoni tubulin subunit beta 0.0289 0.6332 1
Plasmodium falciparum tubulin delta chain, putative 0.0067 0.1178 0.186
Loa Loa (eye worm) tubulin alpha 2 0.0144 0.2976 0.4699
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0422 0.0666
Schistosoma mansoni tubulin subunit alpha 0.0211 0.4518 0.7135
Echinococcus granulosus Tubulin beta 2C chain 0.0289 0.6332 1
Trypanosoma brucei epsilon tubulin 0.0153 0.3188 0.5034
Trichomonas vaginalis tubulin epsilon chain, putative 0.0211 0.4518 0.648
Echinococcus granulosus tubulin alpha 1C chain 0.0211 0.4518 0.7135
Echinococcus granulosus peroxidasin 0.004 0.0561 0.0886
Echinococcus granulosus tubulin alpha chain 0.0211 0.4518 0.7135
Echinococcus multilocularis Tubulin beta 2C chain 0.0289 0.6332 1
Giardia lamblia Beta tubulin 0.0289 0.6332 1
Leishmania major beta tubulin 0.0289 0.6332 1
Trichomonas vaginalis tubulin beta chain, putative 0.0211 0.4518 0.648
Toxoplasma gondii beta-1 tubulin, putative 0.0289 0.6332 1
Trypanosoma cruzi tubulin delta chain 0.0067 0.1178 0.186
Schistosoma mansoni peroxidasin 0.004 0.0561 0.0886
Loa Loa (eye worm) hypothetical protein 0.005 0.0785 0.124
Brugia malayi Cell division protein ftsZ 0.0067 0.1178 0.186
Schistosoma mansoni tubulin subunit beta 0.0067 0.1178 0.186
Echinococcus multilocularis peroxisome assembly protein 26 0.0211 0.4518 0.7135
Schistosoma mansoni P2X receptor subunit 0.0082 0.1534 0.2423
Leishmania major alpha tubulin 0.0211 0.4518 0.7135
Leishmania major beta tubulin 0.0289 0.6332 1
Leishmania major beta tubulin 0.0289 0.6332 1
Trypanosoma brucei beta tubulin 0.0153 0.3188 0.5034
Entamoeba histolytica tubulin alpha-1 chain 0.0211 0.4518 0.423
Echinococcus multilocularis tubulin alpha chain 0.0211 0.4518 0.7135
Giardia lamblia Beta tubulin 0.0289 0.6332 1
Brugia malayi Tubulin beta-1 chain 0.0289 0.6332 1
Trypanosoma cruzi zeta tubulin, putative 0.0067 0.1178 0.186
Plasmodium vivax tubulin gamma chain, putative 0.0153 0.3188 0.5034
Leishmania major beta tubulin 0.0289 0.6332 1
Schistosoma mansoni peroxidasin 0.004 0.0561 0.0886
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0785 0.124
Schistosoma mansoni tubulin subunit delta 0.0067 0.1178 0.186
Echinococcus multilocularis tubulin alpha 3 chain 0.0211 0.4518 0.7135
Trypanosoma brucei beta tubulin 0.0289 0.6332 1
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0067 0.1178 0.5
Echinococcus multilocularis tubulin alpha 3 chain 0.0211 0.4518 0.7135
Trypanosoma cruzi zeta tubulin, putative 0.0067 0.1178 0.186
Onchocerca volvulus 0.015 0.312 1
Schistosoma mansoni tubulin subunit alpha 0.0211 0.4518 0.7135
Schistosoma mansoni hypothetical protein 0.0169 0.3543 0.5596
Loa Loa (eye worm) tubulin beta-4 chain 0.0289 0.6332 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0561 0.0886
Brugia malayi Animal haem peroxidase family protein 0.004 0.0561 0.0886
Echinococcus multilocularis Tubulin beta 2C chain 0.0289 0.6332 1
Brugia malayi MH2 domain containing protein 0.0119 0.2389 0.3772
Trypanosoma brucei alpha tubulin 0.0211 0.4518 0.7135
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0144 0.2976 0.4699
Toxoplasma gondii alpha tubulin TUBA1 0.0211 0.4518 0.7135
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0067 0.1178 0.186
Mycobacterium ulcerans cell division protein FtsZ 0.0067 0.1178 0.5
Schistosoma mansoni P2X receptor subunit 0.0082 0.1534 0.2423
Loa Loa (eye worm) tubulin gamma chain 0.0153 0.3188 0.5034
Plasmodium falciparum tubulin beta chain 0.0289 0.6332 1
Schistosoma mansoni tubulin subunit beta 0.0289 0.6332 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0422 0.0666
Leishmania major epsilon tubulin, putative 0.0153 0.3188 0.5034
Loa Loa (eye worm) BEN-1 protein 0.0289 0.6332 1
Echinococcus multilocularis tubulin subunit TubB 0.0211 0.4518 0.7135
Plasmodium falciparum alpha tubulin 1 0.0211 0.4518 0.7135
Loa Loa (eye worm) hypothetical protein 0.0124 0.2508 0.3961
Loa Loa (eye worm) hypothetical protein 0.004 0.0561 0.0886
Echinococcus granulosus Tubulin alpha 1 chain 0.0211 0.4518 0.7135
Brugia malayi Tubulin alpha chain 0.0211 0.4518 0.7135
Brugia malayi hypothetical protein 0.015 0.312 0.4928
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0289 0.6332 1
Plasmodium vivax delta tubulin, putative 0.0067 0.1178 0.186
Trypanosoma brucei epsilon tubulin 0.0153 0.3188 0.5034
Schistosoma mansoni hypothetical protein 0.0169 0.3543 0.5596
Mycobacterium tuberculosis Cell division protein FtsZ 0.0067 0.1178 1
Loa Loa (eye worm) beta-tubulin 0.0289 0.6332 1
Echinococcus granulosus peroxisome assembly protein 26 0.0211 0.4518 0.7135
Echinococcus multilocularis tubulin alpha chain 0.0211 0.4518 0.7135
Echinococcus multilocularis tubulin subunit beta 0.0289 0.6332 1
Echinococcus granulosus tubulin gamma 1 chain 0.0153 0.3188 0.5034
Trichomonas vaginalis tubulin beta chain, putative 0.0211 0.4518 0.648
Schistosoma mansoni tubulin subunit beta 0.0289 0.6332 1
Loa Loa (eye worm) tubulin beta-2A chain 0.0289 0.6332 1
Brugia malayi Tubulin gamma chain 0.0153 0.3188 0.5034
Leishmania major beta tubulin 0.0289 0.6332 1
Trypanosoma brucei epsilon tubulin 0.0153 0.3188 0.5034
Leishmania major beta tubulin 0.0289 0.6332 1
Echinococcus granulosus p2X purinoceptor 4 0.0082 0.1534 0.2423
Echinococcus multilocularis tubulin beta 1 chain 0.0289 0.6332 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0561 0.0886
Echinococcus multilocularis tubulin alpha 0.0153 0.3188 0.5034
Echinococcus granulosus tubulin alpha 3 chain 0.0211 0.4518 0.7135
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0067 0.1178 0.186
Loa Loa (eye worm) hypothetical protein 0.004 0.0561 0.0886
Trypanosoma brucei beta tubulin 0.0289 0.6332 1
Trichomonas vaginalis tubulin beta chain, putative 0.0211 0.4518 0.648
Loa Loa (eye worm) hypothetical protein 0.004 0.0561 0.0886
Echinococcus multilocularis tubulin alpha 1C chain 0.0211 0.4518 0.7135
Leishmania major beta tubulin 0.0289 0.6332 1
Toxoplasma gondii beta-tubulin, putative 0.0289 0.6332 1
Brugia malayi Peroxidasin 0.004 0.0561 0.0886
Echinococcus granulosus tubulin alpha chain 0.0211 0.4518 0.7135
Plasmodium falciparum alpha tubulin 2 0.0211 0.4518 0.7135
Schistosoma mansoni P2X receptor subunit 0.0082 0.1534 0.2423
Giardia lamblia Beta tubulin 0.0289 0.6332 1
Echinococcus granulosus tubulin alpha chain 0.0211 0.4518 0.7135
Trypanosoma brucei tubulin gamma chain 0.0153 0.3188 0.5034
Brugia malayi Animal haem peroxidase family protein 0.004 0.0561 0.0886
Trypanosoma cruzi epsilon tubulin, putative 0.0153 0.3188 0.5034
Trichomonas vaginalis tubulin beta chain, putative 0.0211 0.4518 0.648
Loa Loa (eye worm) animal heme peroxidase 0.004 0.0561 0.0886
Loa Loa (eye worm) hypothetical protein 0.004 0.0561 0.0886
Echinococcus multilocularis p2X purinoceptor 4 0.0082 0.1534 0.2423
Toxoplasma gondii alpha-tubulin I, putative 0.0211 0.4518 0.7135
Leishmania major beta tubulin 0.0289 0.6332 1
Leishmania major alpha tubulin 0.0211 0.4518 0.7135
Loa Loa (eye worm) hypothetical protein 0.004 0.0561 0.0886
Echinococcus granulosus Tubulin beta 2C chain 0.0289 0.6332 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0561 0.0886
Brugia malayi Tubulin alpha-2 chain 0.0211 0.4518 0.7135
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0785 0.124
Trichomonas vaginalis tubulin, putative 0.0087 0.1645 0.0907
Echinococcus multilocularis beta tubulin 0.0289 0.6332 1
Loa Loa (eye worm) tubulin alpha chain 0.0211 0.4518 0.7135
Leishmania major zeta tubulin, putative 0.0067 0.1178 0.186
Loa Loa (eye worm) animal heme peroxidase 0.004 0.0561 0.0886
Loa Loa (eye worm) animal heme peroxidase 0.004 0.0561 0.0886
Leishmania major delta tubulin, putative 0.0067 0.1178 0.186
Plasmodium vivax tubulin beta chain, putative 0.0289 0.6332 1
Brugia malayi hypothetical protein 0.004 0.0561 0.0886
Brugia malayi Tubulin alpha-2 chain 0.0211 0.4518 0.7135
Trichomonas vaginalis tubulin epsilon chain, putative 0.0211 0.4518 0.648
Onchocerca volvulus 0.0087 0.1645 0.4237
Trichomonas vaginalis tubulin epsilon chain, putative 0.0289 0.6332 1
Leishmania major alpha tubulin 0.0211 0.4518 0.7135
Mycobacterium leprae cell division protein FtsZ 0.0067 0.1178 0.5
Schistosoma mansoni tubulin subunit gamma 0.0153 0.3188 0.5034
Trypanosoma brucei beta tubulin 0.0289 0.6332 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0561 0.0886
Entamoeba histolytica tubulin alpha chain, putative 0.0211 0.4518 0.423
Trichomonas vaginalis tubulin alpha chain, putative 0.0153 0.3188 0.3899
Brugia malayi Blistered cuticle protein 3 0.004 0.0561 0.0886
Trypanosoma brucei zeta tubulin, putative 0.0067 0.1178 0.186
Loa Loa (eye worm) tubulin beta chain 0.0289 0.6332 1
Leishmania major beta tubulin 0.0289 0.6332 1
Trypanosoma brucei zeta tubulin 0.0067 0.1178 0.186
Echinococcus granulosus tubulin alpha 1C chain 0.0211 0.4518 0.7135
Echinococcus granulosus tubulin beta 1 chain 0.0289 0.6332 1
Brugia malayi Tubulin beta chain 0.0087 0.1645 0.2599
Echinococcus granulosus Tubulin beta 2C chain 0.0289 0.6332 1
Schistosoma mansoni alpha tubulin 0.0211 0.4518 0.7135
Leishmania major beta tubulin 0.0289 0.6332 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 1000 nM Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as effect on intracellular calcium influx ChEMBL. 17585854
IC50 (functional) > 1000 nM Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as effect on intracellular calcium influx ChEMBL. 17585854

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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