Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0.2805 | 0.5 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0042 | 0.2805 | 0.5 |
Mycobacterium ulcerans | oxidoreductase | 0.0042 | 0.2805 | 0.5 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0045 | 0.3038 | 0.8794 |
Mycobacterium ulcerans | dehydrogenase | 0.0042 | 0.2805 | 0.5 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0042 | 0.2805 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0.2805 | 0.5 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0009 | 0.0113 | 0.0327 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0009 | 0.0113 | 0.026 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0042 | 0.2805 | 1 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0042 | 0.2805 | 0.6461 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0018 | 0.0774 | 0.1782 |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0.0113 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0009 | 0.0113 | 0.026 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.2908 | 0.8417 |
Echinococcus granulosus | NDR protein kinase | 0.0009 | 0.0113 | 0.026 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.2805 | 0.812 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0009 | 0.0113 | 0.026 |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0.0113 | 1 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0009 | 0.0113 | 0.026 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0042 | 0.2805 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0018 | 0.0774 | 0.1782 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.2805 | 0.812 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0009 | 0.0113 | 0.026 |
Schistosoma mansoni | amine oxidase | 0.0042 | 0.2805 | 0.6461 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.2805 | 0.812 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0018 | 0.0774 | 0.1782 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0042 | 0.2805 | 0.5 |
Mycobacterium ulcerans | monoamine oxidase | 0.0042 | 0.2805 | 0.5 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0009 | 0.0113 | 0.026 |
Brugia malayi | protein kinase C II. | 0.0018 | 0.0774 | 0.1903 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0042 | 0.2805 | 0.6461 |
Brugia malayi | SWIRM domain containing protein | 0.0042 | 0.2805 | 0.7754 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0009 | 0.0113 | 0.026 |
Leishmania major | tubulin-tyrosine ligase-like protein | 0.013 | 1 | 1 |
Echinococcus multilocularis | 0.0042 | 0.2805 | 0.6461 | |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0009 | 0.0113 | 0.026 |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0.0113 | 1 |
Echinococcus granulosus | protein kinase C gamma type | 0.0055 | 0.3795 | 0.874 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0042 | 0.2805 | 0.5 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0044 | 0.2908 | 0.6697 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0009 | 0.0113 | 0.0327 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.3455 | 1 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0044 | 0.2908 | 0.6697 |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0.0113 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0113 | 0.0327 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0042 | 0.2805 | 1 |
Schistosoma mansoni | atypical protein kinase C | 0.0016 | 0.066 | 0.152 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0042 | 0.2805 | 0.6461 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0009 | 0.0113 | 0.026 |
Trypanosoma brucei | tubulin-tyrosine ligase, putative | 0.013 | 1 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0042 | 0.2805 | 0.5 |
Brugia malayi | hypothetical protein | 0.0042 | 0.2805 | 0.7754 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0042 | 0.2805 | 0.7754 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0042 | 0.2805 | 0.6461 |
Schistosoma mansoni | serine/threonine kinase | 0.0009 | 0.0113 | 0.026 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0061 | 0.4342 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0009 | 0.0113 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0009 | 0.0113 | 0.026 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0009 | 0.0113 | 0.0327 |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0.0113 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0009 | 0.0113 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0.0113 | 1 |
Onchocerca volvulus | 0.0042 | 0.2805 | 1 | |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0042 | 0.2805 | 0.5 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0009 | 0.0113 | 0.0327 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.2805 | 0.812 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0042 | 0.2805 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0042 | 0.2805 | 0.5 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0042 | 0.2805 | 0.5 |
Trypanosoma cruzi | tubulin-tyrosine ligase, putative | 0.013 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0009 | 0.0113 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0009 | 0.0113 | 0.5 |
Echinococcus granulosus | protein kinase c iota type | 0.0016 | 0.066 | 0.152 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0044 | 0.2908 | 0.6697 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0009 | 0.0113 | 0.026 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0042 | 0.2805 | 0.6461 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.2805 | 0.812 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0009 | 0.0113 | 0.0327 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0042 | 0.2805 | 0.5 |
Echinococcus multilocularis | protein kinase c iota type | 0.0016 | 0.066 | 0.152 |
Schistosoma mansoni | amine oxidase | 0.0042 | 0.2805 | 0.6461 |
Brugia malayi | Protein kinase c protein 2 | 0.0052 | 0.3585 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0.0113 | 1 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0009 | 0.0113 | 0.026 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0009 | 0.0113 | 0.026 |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0.0113 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0.0113 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0.0113 | 1 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0009 | 0.0113 | 0.0327 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0042 | 0.2805 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0.0113 | 1 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0018 | 0.0774 | 0.2239 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0055 | 0.3795 | 0.874 |
Trypanosoma cruzi | tubulin-tyrosine ligase, putative | 0.013 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0061 | 0.4342 | 1 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0061 | 0.4342 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0061 | 0.4342 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.2805 | 0.812 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0042 | 0.2805 | 0.6461 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0009 | 0.0113 | 0.026 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0009 | 0.0113 | 0.0327 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ratio (functional) | = 1.7 | Pgp antagonism was determined percentage of NCI/ADR cells surviving in the absence of vinblastine/percentage of NCI/ADR cells surviving in the presence of vinblastine | ChEMBL. | 14998330 |
Ratio (functional) | 1.2 | Ratio of the Pgp to that of MRP1 was determined | ChEMBL. | 14998330 |
Ratio (functional) | 1.4 | MRP1 antagonism was determined percentage of MCF-7/VP cells surviving in the absence of vincristine/percentage of MCF-7/VP cells survivingin the presence of vincristine | ChEMBL. | 14998330 |
Ratio (functional) | = 1.7 | Pgp antagonism was determined percentage of NCI/ADR cells surviving in the absence of vinblastine/percentage of NCI/ADR cells surviving in the presence of vinblastine | ChEMBL. | 14998330 |
Toxicity (ADMET) | = 21 % | Toxicity was determined against of MCF-7 cells at a dose of 10 ug/mL | ChEMBL. | 14998330 |
Toxicity (ADMET) | = 21 % | Toxicity was determined against of MCF-7 cells at a dose of 10 ug/mL | ChEMBL. | 14998330 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.