Detailed information for compound 430038

Basic information

Technical information
  • TDR Targets ID: 430038
  • Name: 3,9-dihydroxy-11H-chromeno[4,3-b]indol-6-one
  • MW: 267.236 | Formula: C15H9NO4
  • H donors: 3 H acceptors: 3 LogP: 2.49 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc2c(c1)oc(=O)c1c2[nH]c2c1ccc(c2)O
  • InChi: 1S/C15H9NO4/c17-7-1-3-9-11(5-7)16-14-10-4-2-8(18)6-12(10)20-15(19)13(9)14/h1-6,16-18H
  • InChiKey: BUSSJLNPECLYJI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3,9-dihydroxy-11H-[1]benzopyrano[4,3-b]indol-6-one
  • AIDS-140989
  • AIDS140989
  • NSC655185
  • NCI60_019101
  • 3,9-Dihydroxychromeno[4,3-b]indol-6(11H)-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0102 0.0102
Brugia malayi putative neuropeptide receptor NPR1 0.0035 0.0102 0.0322
Echinococcus multilocularis g-protein coupled receptor 0.0035 0.0102 0.0102
Echinococcus granulosus g protein coupled receptor 0.0035 0.0102 0.0102
Schistosoma mansoni amine GPCR 0.0035 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0035 0.0102 0.0102
Onchocerca volvulus Bile acid receptor homolog 0.0375 0.3167 1
Brugia malayi putative neuropeptide receptor 0.0035 0.0102 0.0322
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0101 0.0696 0.5
Treponema pallidum ATP-dependent RNA helicase 0.0101 0.0696 0.5
Schistosoma mansoni biogenic amine receptor 0.0035 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Brugia malayi follicle stimulating hormone receptor 0.0035 0.0102 0.0322
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0035 0.0102 0.0102
Echinococcus granulosus neuropeptide Y receptor 0.0035 0.0102 0.0102
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0102 0.0102
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0035 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0102 0.0102
Onchocerca volvulus 0.0035 0.0102 0.0322
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0101 0.0696 0.0696
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0102 0.0102
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0035 0.0102 0.0102
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0101 0.0696 0.5
Echinococcus multilocularis neuropeptide receptor A26 0.0035 0.0102 0.0102
Loa Loa (eye worm) neuropeptide F receptor 0.0035 0.0102 0.0102
Echinococcus granulosus tm gpcr rhodopsin 0.0035 0.0102 0.0102
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0035 0.0102 0.0102
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0102 0.0102
Schistosoma mansoni myosin xvIII 0.0035 0.0102 0.0102
Schistosoma mansoni hypothetical protein 0.0035 0.0102 0.0102
Brugia malayi AKH receptor 0.0035 0.0102 0.0322
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0102 0.0102
Onchocerca volvulus 0.0035 0.0102 0.0322
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0102 0.0102
Echinococcus multilocularis G-protein coupled receptor, putative 0.0035 0.0102 0.0102
Brugia malayi Tachykinin-like peptides receptor 99D 0.0035 0.0102 0.0322
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Echinococcus multilocularis somatostatin receptor 0.0035 0.0102 0.0102
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0102 0.0102
Echinococcus multilocularis neuropeptide s receptor 0.0035 0.0102 0.0102
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0035 0.0102 0.0102
Brugia malayi larval opioid receptor 0.0035 0.0102 0.0322
Brugia malayi ecdysteroid receptor 0.0375 0.3167 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0035 0.0102 0.0102
Echinococcus granulosus neuropeptides capa receptor 0.0035 0.0102 0.0102
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0102 0.0102
Schistosoma mansoni adenoreceptor 0.0035 0.0102 0.0102
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0035 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0375 0.3167 0.3167
Echinococcus multilocularis neuropeptide receptor 0.0035 0.0102 0.0102
Brugia malayi hypothetical protein 0.0035 0.0102 0.0322
Plasmodium falciparum eukaryotic initiation factor 4A 0.0101 0.0696 0.5
Onchocerca volvulus 0.0035 0.0102 0.0322
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Echinococcus granulosus g protein coupled receptor 0.0035 0.0102 0.0102
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0102 0.0102
Loa Loa (eye worm) neuropeptide F receptor 0.0035 0.0102 0.0102
Echinococcus granulosus g-protein coupled receptor 0.0035 0.0102 0.0102
Schistosoma mansoni hypothetical protein 0.0035 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Schistosoma mansoni opsin-like receptor 0.0035 0.0102 0.0102
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Echinococcus granulosus eukaryotic initiation factor 4A 0.0101 0.0696 0.0696
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0035 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0035 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Echinococcus granulosus 7TM GPCR rhodopsin 0.0035 0.0102 0.0102
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0035 0.0102 0.0102
Brugia malayi G-protein coupled receptor 0.0035 0.0102 0.0322
Echinococcus multilocularis dro:myosuppressin receptor 0.0035 0.0102 0.0102
Schistosoma mansoni hypothetical protein 0.0035 0.0102 0.0102
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0101 0.0696 0.0696
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Echinococcus granulosus neuropeptide receptor 0.0035 0.0102 0.0102
Echinococcus granulosus 7tm_1 domain containing protein 0.0035 0.0102 0.0102
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0035 0.0102 0.0102
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0035 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Echinococcus granulosus somatostatin receptor 0.0035 0.0102 0.0102
Schistosoma mansoni alpha-1 adrenergic receptor 0.0035 0.0102 0.0102
Schistosoma mansoni opsin-like receptor 0.0035 0.0102 0.0102
Echinococcus granulosus G protein coupled receptor 139 0.0035 0.0102 0.0102
Echinococcus granulosus hypothetical protein 0.0035 0.0102 0.0102
Onchocerca volvulus 0.0035 0.0102 0.0322
Echinococcus granulosus peptide allatostatin:somatostatin 0.0035 0.0102 0.0102
Echinococcus multilocularis neuropeptide Y receptor 0.0035 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0101 0.0696 0.2196
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0035 0.0102 0.0322
Echinococcus granulosus serotonin receptor 0.0035 0.0102 0.0102
Onchocerca volvulus Neuropeptide F receptor homolog 0.0035 0.0102 0.0322
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Schistosoma mansoni biogenic amine receptor 0.0035 0.0102 0.0102
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0101 0.0696 0.0696
Brugia malayi GnHR receptor homolog 0.0035 0.0102 0.0322
Brugia malayi ORL1-like opioid receptor 0.0035 0.0102 0.0322
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0035 0.0102 0.0102
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0035 0.0102 0.0102
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.1135 1 1
Echinococcus granulosus g protein coupled receptor 0.0035 0.0102 0.0102
Schistosoma mansoni neuropeptide receptor 0.0035 0.0102 0.0102
Echinococcus granulosus alpha 1A adrenergic receptor 0.0035 0.0102 0.0102
Echinococcus multilocularis neuropeptides capa receptor 0.0035 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Echinococcus granulosus tm gpcr rhodopsin 0.0035 0.0102 0.0102
Echinococcus multilocularis g protein coupled receptor 0.0035 0.0102 0.0102
Echinococcus granulosus neuropeptides capa receptor 0.0035 0.0102 0.0102
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0035 0.0102 0.0102
Echinococcus multilocularis g protein coupled receptor 0.0035 0.0102 0.0102
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0035 0.0102 0.0322
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Echinococcus granulosus neuropeptide FF receptor 2 0.0035 0.0102 0.0102
Schistosoma mansoni neuropeptide f receptor 76f 0.0035 0.0102 0.0102
Echinococcus granulosus neuropeptide Y receptor 0.0035 0.0102 0.0102
Schistosoma mansoni amine GPCR 0.0035 0.0102 0.0102
Leishmania major eukaryotic initiation factor 4a, putative 0.0101 0.0696 0.5
Onchocerca volvulus 0.0035 0.0102 0.0322
Echinococcus granulosus tachykinin peptides receptor 99D 0.0035 0.0102 0.0102
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0035 0.0102 0.0102
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0101 0.0696 0.5
Brugia malayi hypothetical protein 0.0035 0.0102 0.0322
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Loa Loa (eye worm) G-protein coupled receptor 0.0035 0.0102 0.0102
Onchocerca volvulus 0.0035 0.0102 0.0322
Brugia malayi G protein-coupled receptor 0.0035 0.0102 0.0322
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0035 0.0102 0.0102
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0101 0.0696 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0035 0.0102 0.0102
Brugia malayi hypothetical protein 0.0035 0.0102 0.0322
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0035 0.0102 0.0102
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0102 0.0102
Brugia malayi Serotonin receptor 0.0035 0.0102 0.0322
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Brugia malayi G-protein coupled receptor 0.0035 0.0102 0.0322
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.0102 0.0102
Brugia malayi hypothetical protein 0.0035 0.0102 0.0322
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0035 0.0102 0.0102
Brugia malayi hypothetical protein 0.0035 0.0102 0.0322
Schistosoma mansoni neuropeptide F-like receptor 0.0035 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Echinococcus multilocularis serotonin receptor 0.1135 1 1
Echinococcus multilocularis fmrfamide receptor 0.0035 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0035 0.0102 0.0102
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0035 0.0102 0.0322
Schistosoma mansoni histamine h1 receptor 0.0035 0.0102 0.0102
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0035 0.0102 0.0102
Echinococcus granulosus neuropeptide receptor 0.0035 0.0102 0.0102
Schistosoma mansoni amine GPCR 0.0035 0.0102 0.0102
Onchocerca volvulus 0.0035 0.0102 0.0322
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0035 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0035 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Loa Loa (eye worm) TYRA-2 protein 0.0035 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0101 0.0696 0.5
Onchocerca volvulus 0.0035 0.0102 0.0322
Echinococcus multilocularis fmrfamide receptor 0.0035 0.0102 0.0102
Onchocerca volvulus 0.0035 0.0102 0.0322
Echinococcus granulosus allatostatin A receptor 0.0035 0.0102 0.0102
Brugia malayi hypothetical protein 0.0035 0.0102 0.0322
Echinococcus multilocularis neuropeptide Y receptor 0.0035 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0035 0.0102 0.0102
Echinococcus granulosus tm gpcr rhodopsin 0.0035 0.0102 0.0102
Brugia malayi Melatonin receptor type 1A 0.0035 0.0102 0.0322
Echinococcus granulosus orexin receptor type 2 0.0035 0.0102 0.0102
Echinococcus granulosus dro:myosuppressin receptor 0.0035 0.0102 0.0102
Onchocerca volvulus 0.0035 0.0102 0.0322
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0035 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Leishmania major eukaryotic initiation factor 4a, putative 0.0101 0.0696 0.5
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0035 0.0102 0.0102
Schistosoma mansoni neuropeptide receptor 0.0035 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.0102 0.0102
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0101 0.0696 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0035 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0035 0.0102 0.0102
Onchocerca volvulus 0.0035 0.0102 0.0322
Loa Loa (eye worm) hypothetical protein 0.0101 0.0696 0.0696
Schistosoma mansoni hypothetical protein 0.0035 0.0102 0.0102
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0102 0.0102
Brugia malayi Serotonin receptor 0.0035 0.0102 0.0322
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0035 0.0102 0.0102
Brugia malayi hypothetical protein 0.0035 0.0102 0.0322
Schistosoma mansoni opsin-like receptor 0.0035 0.0102 0.0102
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0035 0.0102 0.0102
Brugia malayi neuropeptide F receptor 0.0035 0.0102 0.0322
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0035 0.0102 0.0322
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0101 0.0696 0.0696
Brugia malayi RE15519p 0.0035 0.0102 0.0322
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Brugia malayi Dopamine receptor protein 2 0.0035 0.0102 0.0322
Echinococcus granulosus biogenic amine 5HT receptor 0.0035 0.0102 0.0102
Brugia malayi sulfakinin receptor protein 0.0035 0.0102 0.0322
Schistosoma mansoni amine GPCR 0.0035 0.0102 0.0102
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0101 0.0696 0.0696
Echinococcus granulosus neuropeptide receptor A26 0.0035 0.0102 0.0102
Schistosoma mansoni neuropeptide receptor 0.0035 0.0102 0.0102
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Onchocerca volvulus 0.0035 0.0102 0.0322
Onchocerca volvulus 0.0035 0.0102 0.0322
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0102 0.0102
Schistosoma mansoni amine GPCR 0.0035 0.0102 0.0102
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0035 0.0102 0.0102
Schistosoma mansoni neuropeptide receptor 0.0035 0.0102 0.0102
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0102 0.0102
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0035 0.0102 0.0322
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0101 0.0696 0.5
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0035 0.0102 0.0102
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0102 0.0102
Brugia malayi Dopamine receptor 0.0035 0.0102 0.0322
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0035 0.0102 0.0102
Onchocerca volvulus 0.0035 0.0102 0.0322
Schistosoma mansoni biogenic amine receptor 0.0035 0.0102 0.0102
Echinococcus multilocularis serotonin receptor 0.1135 1 1
Echinococcus granulosus sex peptide receptor 0.0035 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0102 0.0102
Loa Loa (eye worm) G-protein coupled receptor 0.0035 0.0102 0.0102
Echinococcus granulosus fmrfamide receptor 0.0035 0.0102 0.0102
Echinococcus multilocularis allatostatin A receptor 0.0035 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0102
Onchocerca volvulus 0.0035 0.0102 0.0322
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0035 0.0102 0.0102
Brugia malayi eukaryotic initiation factor 4A 0.0101 0.0696 0.2196
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0101 0.0696 0.5
Onchocerca volvulus 0.0035 0.0102 0.0322
Loa Loa (eye worm) melatonin receptor type 1A 0.0035 0.0102 0.0102
Schistosoma mansoni neuropeptide F-like receptor 0.0035 0.0102 0.0102
Echinococcus multilocularis sex peptide receptor 0.0035 0.0102 0.0102
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0102 0.0102
Schistosoma mansoni biogenic amine (5HT) receptor 0.1135 1 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0035 0.0102 0.0322
Echinococcus multilocularis orexin receptor type 2 0.0035 0.0102 0.0102
Echinococcus multilocularis G protein coupled receptor 139 0.0035 0.0102 0.0102
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0035 0.0102 0.0102
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0101 0.0696 0.5
Echinococcus granulosus neuropeptide s receptor 0.0035 0.0102 0.0102
Echinococcus multilocularis neuropeptide FF receptor 2 0.0035 0.0102 0.0102
Onchocerca volvulus 0.0035 0.0102 0.0322
Loa Loa (eye worm) hypothetical protein 0.1135 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0102 0.0102
Brugia malayi neuropeptide F receptor 0.0035 0.0102 0.0322
Echinococcus multilocularis neuropeptide receptor 0.0035 0.0102 0.0102
Brugia malayi hypothetical protein 0.0035 0.0102 0.0322
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0102 0.0102
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0035 0.0102 0.0102
Brugia malayi Dopamine receptor protein 1 0.0035 0.0102 0.0322
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0035 0.0102 0.0322
Brugia malayi hypothetical protein 0.0035 0.0102 0.0322
Echinococcus multilocularis g protein coupled receptor 0.0035 0.0102 0.0102
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0101 0.0696 0.5
Plasmodium vivax RNA helicase-1, putative 0.0101 0.0696 0.5
Brugia malayi hypothetical protein 0.0035 0.0102 0.0322

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.723 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.662 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.644 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.61 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.582 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.494 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.487 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.477 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (ADMET) 0 Cytotoxicity against HUVEC after 24 hrs by MTT assay ChEMBL. 17591441

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.