Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adrenoceptor alpha 1D | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor alpha 1A | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor alpha 1B | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | Alpha-1D adrenergic receptor, putative | Get druggable targets OG5_128924 | All targets in OG5_128924 |
Schistosoma mansoni | amine GPCR | Get druggable targets OG5_128924 | All targets in OG5_128924 |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Get druggable targets OG5_128924 | All targets in OG5_128924 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0069 | 0.0244 | 0.5 |
Echinococcus granulosus | cGMP dependent protein kinase 1 | 0.0435 | 1 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0199 | 0.3705 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0069 | 0.0244 | 0.5 |
Toxoplasma gondii | protein kinase G AGC kinase family member PKG | 0.0435 | 1 | 1 |
Echinococcus granulosus | cGMP dependent protein kinase 1 | 0.0435 | 1 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0199 | 0.3705 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0435 | 1 | 1 |
Plasmodium falciparum | cGMP-dependent protein kinase | 0.0435 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0069 | 0.0244 | 0.5 |
Echinococcus multilocularis | expressed conserved protein | 0.0435 | 1 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0199 | 0.3705 | 0.3548 |
Leishmania major | trypanothione reductase | 0.0199 | 0.3705 | 1 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0069 | 0.0244 | 0.0244 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0069 | 0.0244 | 0.5 |
Echinococcus multilocularis | cGMP dependent protein kinase 1 | 0.0435 | 1 | 1 |
Treponema pallidum | NADH oxidase | 0.0069 | 0.0244 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0199 | 0.3705 | 0.3548 |
Echinococcus multilocularis | cGMP dependent protein kinase 1 | 0.0435 | 1 | 1 |
Schistosoma mansoni | amine GPCR | 0.0411 | 0.9383 | 0.9383 |
Plasmodium falciparum | thioredoxin reductase | 0.0199 | 0.3705 | 0.3548 |
Mycobacterium ulcerans | hypothetical protein | 0.0432 | 0.9928 | 1 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0069 | 0.0244 | 0.066 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0069 | 0.0244 | 0.5 |
Brugia malayi | glutathione reductase | 0.0199 | 0.3705 | 0.3548 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0199 | 0.3705 | 1 |
Echinococcus granulosus | cGMP dependent protein kinase | 0.0435 | 1 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0199 | 0.3705 | 0.3548 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0069 | 0.0244 | 0.066 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0199 | 0.3705 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0069 | 0.0244 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0199 | 0.3705 | 0.3548 |
Brugia malayi | Thioredoxin reductase | 0.0199 | 0.3705 | 0.3548 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0435 | 1 | 1 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0069 | 0.0244 | 0.066 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0069 | 0.0244 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0199 | 0.3705 | 1 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0069 | 0.0244 | 0.066 |
Loa Loa (eye worm) | AGC/PKG protein kinase | 0.0435 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 3.8 nM | Binding affinity to human cloned adrenergic alpha1a receptor | ChEMBL. | 17517507 |
Ki (binding) | = 3.8 nM | Binding affinity to human cloned adrenergic alpha1a receptor | ChEMBL. | 17517507 |
Ki (binding) | = 32 nM | Binding affinity to human cloned adrenergic alpha1d receptor | ChEMBL. | 17517507 |
Ki (binding) | = 32 nM | Binding affinity to human cloned adrenergic alpha1d receptor | ChEMBL. | 17517507 |
Ki (binding) | = 159 nM | Binding affinity for dopamine D2 receptor | ChEMBL. | 17517507 |
Ki (binding) | = 159 nM | Binding affinity for dopamine D2 receptor | ChEMBL. | 17517507 |
Ki (binding) | = 337 nM | Binding affinity to human cloned adrenergic alpha1b receptor | ChEMBL. | 17517507 |
Ki (binding) | = 337 nM | Binding affinity to human cloned adrenergic alpha1b receptor | ChEMBL. | 17517507 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.