TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 758.57 | Formula: C28H39O22P
H donors: 1 H acceptors: 10 LogP: -1.79 Rotable bonds: 22
Rule of 5 violations (Lipinski): 2
SMILES: CC(=O)OC[C@@H]1O[C@@H](OP(=O)(O[C@@H]2O[C@@H](COC(=O)C)[C@H]([C@@H]([C@@H]2OC(=O)C)OC(=O)C)OC(=O)C)O)[C@H]([C@@H]([C@@H]1OC(=O)C)OC(=O)C)OC(=O)C
InChi: 1S/C28H39O22P/c1-11(29)39-9-19-21(41-13(3)31)23(43-15(5)33)25(45-17(7)35)27(47-19)49-51(37,38)50-28-26(46-18(8)36)24(44-16(6)34)22(42-14(4)32)20(48-28)10-40-12(2)30/h19-28H,9-10H2,1-8H3,(H,37,38)/t19-,20-,21-,22-,23+,24+,25+,26+,27-,28-/m1/s1
InChiKey: XMAOERHIRJOHQN-DOVVIOQKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	cAMP-dependent protein kinase regulatory subunit	0.0076	0.0478	0.114
Toxoplasma gondii	cAMP-dependent protein kinase regulatory subunit	0.0076	0.0478	0.114
Schistosoma mansoni	voltage-gated potassium channel	0.0076	0.0478	0.0478
Schistosoma mansoni	protein kinase	0.0011	0.0005	0.0005
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0012	0.001	0.0023
Brugia malayi	Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog	0.0076	0.0478	0.0478
Echinococcus multilocularis	voltage gated potassium channel	0.0076	0.0478	0.0923
Echinococcus granulosus	hyperpolarization activated cyclic	0.0076	0.0478	0.0923
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0141	0.0948	0.0948
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.001	0.0203
Entamoeba histolytica	protein kinase, putative	0.0012	0.001	0.5451
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0948	0.0948
Entamoeba histolytica	protein kinase, putative	0.0012	0.001	0.5451
Trypanosoma cruzi	cyclic nucleotide-binding domain containing protein, putative	0.0076	0.0478	1
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0724	0.5182	1
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.001	0.0203
Echinococcus granulosus	patatin phospholipase domain containing protein	0.0076	0.0478	0.0923
Trypanosoma cruzi	NIMA-related kinase, putative	0.0012	0.001	0.0203
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0141	0.0948	0.0948
Trypanosoma brucei	cAMP binding protein, putative	0.0076	0.0478	1
Schistosoma mansoni	sodium/chloride dependent transporter	0.0734	0.5257	0.5257
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0076	0.0478	1
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0141	0.0948	0.0948
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0012	0.001	0.001
Schistosoma mansoni	voltage-gated potassium channel	0.0076	0.0478	0.0478
Plasmodium vivax	CAMP-dependent protein kinase regulatory subunit, putative	0.0076	0.0478	0.5042
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0076	0.0478	0.0478
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0011	0.0005	0.001
Echinococcus granulosus	hyperpolarization activated cyclic	0.0076	0.0478	0.0923
Trypanosoma cruzi	hypothetical protein, conserved	0.0076	0.0478	1
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0012	0.001	0.0203
Plasmodium falciparum	transporter, putative	0.0141	0.0948	0.2262
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0141	0.0948	0.0948
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0948	0.0948
Trypanosoma cruzi	Flagellar Member 6	0.0076	0.0478	1
Echinococcus granulosus	cAMP dependent protein kinase type I beta	0.0076	0.0478	0.0923
Echinococcus granulosus	activin receptor type	0.0011	0.0005	0.001
Echinococcus granulosus	serine/threonine protein kinase	0.0012	0.001	0.0019
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0141	0.0948	0.0948
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0016	0.004	0.0077
Toxoplasma gondii	hypothetical protein	0.0141	0.0948	0.2262
Schistosoma mansoni	serine/threonine-protein kinase	0.0012	0.001	0.001
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0076	0.0478	0.0923
Leishmania major	hypothetical protein, conserved	0.0076	0.0478	0.8646
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0012	0.001	0.0203
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0141	0.0948	0.183
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0011	0.0005	0.001
Schistosoma mansoni	serine/threonine protein kinase	0.1387	1	1
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0948	0.0948
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0012	0.001	0.5451
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0012	0.001	0.0203
Trypanosoma cruzi	cAMP binding protein, putative	0.0076	0.0478	1
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0141	0.0948	0.0948
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.001	0.0203
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0012	0.001	0.0203
Schistosoma mansoni	protein kinase	0.0011	0.0005	0.0005
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0012	0.001	0.0203
Leishmania major	hypothetical protein, conserved	0.0076	0.0478	0.8646
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0012	0.001	0.0203
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.001	0.0203
Mycobacterium ulcerans	regulatory protein	0.0076	0.0478	0.1161
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0076	0.0478	0.0478
Trypanosoma brucei	protein kinase, putative	0.0011	0.0005	0.0104
Trypanosoma brucei	Flagellar Member 6	0.0076	0.0478	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0478	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0478	0.0478
Schistosoma mansoni	hypothetical protein	0.0076	0.0478	0.0478
Echinococcus granulosus	voltage gated potassium channel	0.0076	0.0478	0.0923
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.001	0.0203
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.001	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0724	0.5182	0.5182
Entamoeba histolytica	protein kinase, putative	0.0013	0.0018	1
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0076	0.0478	1
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0076	0.0478	0.0478
Mycobacterium ulcerans	hypothetical protein	0.0076	0.0478	0.1161
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0076	0.0478	0.0923
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.001	0.0203
Entamoeba histolytica	hypothetical protein	0.0012	0.001	0.5451
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0076	0.0478	0.0923
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0076	0.0478	0.114
Leishmania major	hypothetical protein, unknown function	0.0076	0.0478	0.8646
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.001	0.0203
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0076	0.0478	0.0478
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0012	0.001	0.5451
Entamoeba histolytica	protein kinase, putative	0.0012	0.001	0.5451
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0948	0.0948
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0141	0.0948	0.183
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0076	0.0478	0.114
Trypanosoma cruzi	cAMP response protein 1, putative	0.0076	0.0478	1
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0141	0.0948	0.183
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0076	0.0478	0.0478
Echinococcus multilocularis	activin receptor type	0.0011	0.0005	0.001
Loa Loa (eye worm)	cAMP-dependent protein kinase regulatory subunit	0.0076	0.0478	0.0478
Trichomonas vaginalis	cAMP-dependent protein kinase regulatory subunit, putative	0.0076	0.0478	1
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.001	0.0203
Loa Loa (eye worm)	CMGC/CDK/CDK7 protein kinase	0.0491	0.3494	0.3494
Toxoplasma gondii	protein kinase domain-containing protein	0.0012	0.001	0.0023
Brugia malayi	Egg laying defective protein 4	0.0588	0.4193	0.4193
Onchocerca volvulus		0.0141	0.0948	1
Mycobacterium ulcerans	transmembrane transport protein	0.0076	0.0478	0.1161
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0076	0.0478	0.0478
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0076	0.0478	0.0478
Echinococcus granulosus	serotonin transporter	0.0141	0.0948	0.183
Mycobacterium ulcerans	hypothetical protein	0.0076	0.0478	0.1161
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0012	0.001	0.0203
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0141	0.0948	0.2262
Plasmodium vivax	rap guanine nucleotide exchange factor, putative	0.0076	0.0478	0.5042
Schistosoma mansoni	serine/threonine-protein kinase	0.0012	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0478	0.0478
Echinococcus multilocularis	cAMP dependent protein kinase type I beta	0.0076	0.0478	0.0923
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0076	0.0478	0.0923
Trichomonas vaginalis	cAMP-dependent protein kinase type I-beta regulatory subunit, putative	0.0076	0.0478	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0076	0.0478	0.0923
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0948	0.0948
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.001	0.0203
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0076	0.0478	1
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0076	0.0478	0.114
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0948	0.0948
Plasmodium falciparum	amino acid transporter, putative	0.0141	0.0948	0.2262
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0012	0.001	0.0175
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0012	0.001	0.0203
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0012	0.001	0.5451
Trypanosoma brucei	protein kinase, putative	0.0012	0.001	0.0203
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0141	0.0948	1
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0588	0.4193	1
Entamoeba histolytica	protein kinase, putative	0.0012	0.001	0.5451
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.001	0.0203
Echinococcus multilocularis	cAMP dependent protein kinase type II regulatory	0.0076	0.0478	0.0923
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0141	0.0948	0.0948
Leishmania major	protein kinase, putative	0.0011	0.0005	0.009
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0141	0.0948	0.0948
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0076	0.0478	0.0478
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0135	0.0906	0.1748
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0948	0.0948
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.001	0.0203
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0141	0.0948	0.0948
Leishmania major	protein kinase, putative	0.0012	0.001	0.0175
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0141	0.0948	0.0948
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0076	0.0478	0.0923
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0076	0.0478	0.0923
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0076	0.0478	0.0478
Schistosoma mansoni	camp-dependent protein kinase type II-alpha regulatory subunit	0.0076	0.0478	0.0478
Mycobacterium ulcerans	hypothetical protein	0.0076	0.0478	0.1161
Entamoeba histolytica	hypothetical protein	0.0012	0.001	0.5451
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.001	0.0203
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0012	0.001	0.5451
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0076	0.0478	0.0923
Trypanosoma cruzi	NIMA-related kinase, putative	0.0012	0.001	0.0203
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0012	0.001	0.0203
Entamoeba histolytica	protein kinase domain containing protein	0.0011	0.0005	0.2808
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0076	0.0478	1
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0076	0.0478	0.0923
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0135	0.0906	0.1748
Leishmania major	cyclic nucleotide-binding protein-like protein	0.0076	0.0478	0.8646
Leishmania major	folate/biopterin transporter, putative	0.0012	0.001	0.0175
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0588	0.4193	0.8091
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0588	0.4193	0.8091
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0141	0.0948	0.0948
Schistosoma mansoni	serine/threonine protein kinase	0.0491	0.3494	0.3494
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0141	0.0948	0.0948
Entamoeba histolytica	protein kinase, putative	0.0012	0.001	0.5451
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0013	0.0018	1
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.001	0.0203
Brugia malayi	Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative	0.0076	0.0478	0.0478
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0076	0.0478	1
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0141	0.0948	0.2262
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0724	0.5182	1
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0012	0.001	0.0023
Plasmodium vivax	hypothetical protein, conserved	0.0141	0.0948	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0011	0.0005	0.0012
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0012	0.001	0.0203
Plasmodium vivax	amine transporter, putative	0.0141	0.0948	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0724	0.5182	0.5182
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.001	0.0203
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0076	0.0478	1
Schistosoma mansoni	serine/threonine protein kinase	0.0588	0.4193	0.4193
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0478	0.0478
Schistosoma mansoni	voltage-gated potassium channel	0.0076	0.0478	0.0478
Mycobacterium leprae	Conserved hypothetical protein	0.0076	0.0478	1
Leishmania major	protein kinase, putative	0.0086	0.0553	1
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.001	0.0203
Trypanosoma brucei	protein kinase A regulatory subunit	0.0076	0.0478	1
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0076	0.0478	0.0923
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0012	0.001	0.5451
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0011	0.0005	0.0104
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0076	0.0478	0.0478
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0076	0.0478	0.0478
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.001	0.0203
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0076	0.0478	0.0923
Echinococcus multilocularis	cAMP dependent protein kinase regulatory	0.0076	0.0478	0.0923
Schistosoma mansoni	serine/threonine protein kinase	0.0086	0.0553	0.0553
Loa Loa (eye worm)	CAMK/CAMKL/CHK1 protein kinase	0.1387	1	1
Echinococcus multilocularis	serotonin transporter	0.0141	0.0948	0.183
Onchocerca volvulus		0.0141	0.0948	1
Schistosoma mansoni	serine/threonine protein kinase	0.0491	0.3494	0.3494
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.001	0.0203
Entamoeba histolytica	protein kinase, putative	0.0012	0.001	0.5451
Trichomonas vaginalis	conserved hypothetical protein	0.0076	0.0478	1
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0012	0.001	0.0102
Schistosoma mansoni	cyclic nucleotide-gated ion channel	0.0076	0.0478	0.0478
Brugia malayi	hypothetical protein	0.0141	0.0948	0.0948
Echinococcus multilocularis	cyclin dependent kinase 7	0.0491	0.3494	0.6743
Brugia malayi	Protein kinase domain containing protein	0.0012	0.001	0.001
Schistosoma mansoni	tyrosine kinase	0.0133	0.0888	0.0888
Echinococcus granulosus	sodium and chloride dependent glycine	0.0724	0.5182	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0076	0.0478	0.0478
Echinococcus granulosus	cAMP dependent protein kinase regulatory	0.0076	0.0478	0.0923
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0076	0.0478	0.0478
Echinococcus multilocularis	rac serine:threonine kinase	0.0012	0.001	0.0019
Entamoeba histolytica	p21-activated kinase	0.0012	0.001	0.5451
Onchocerca volvulus		0.0141	0.0948	1
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0076	0.0478	0.0478
Treponema pallidum	sodium- and chloride- dependent transporter	0.0141	0.0948	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0076	0.0478	1
Trypanosoma brucei	cAMP response protein 1, putative	0.0076	0.0478	1
Leishmania major	protein kinase A regulatory subunit, putative	0.0076	0.0478	0.8646
Loa Loa (eye worm)	norepinephrine transporter	0.0141	0.0948	0.0948
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0141	0.0948	0.0948
Echinococcus granulosus	cGMP dependent protein kinase	0.0588	0.4193	0.8091
Brugia malayi	N-terminal motif family protein	0.0076	0.0478	0.0478
Onchocerca volvulus		0.0076	0.0478	0.5042
Mycobacterium tuberculosis	Conserved protein	0.0076	0.0478	1
Echinococcus granulosus	cyclin dependent kinase 7	0.0491	0.3494	0.6743
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0724	0.5182	0.5182
Schistosoma mansoni	protein kinase	0.0011	0.0005	0.0005
Leishmania major	serine/threonine-protein kinase a, putative	0.0012	0.001	0.0175
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.001	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0948	0.0948
Schistosoma mansoni	camp-dependent protein kinase type II regulatory subunit	0.0076	0.0478	0.0478
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0012	0.001	0.0203
Leishmania major	regulatory subunit of protein kinase a-like protein	0.0076	0.0478	0.8646
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0012	0.001	0.5451
Mycobacterium ulcerans	hypothetical protein	0.0577	0.4118	1
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0076	0.0478	0.0923
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0141	0.0948	0.183
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0141	0.0948	0.183
Giardia lamblia	CAMP-dependent protein kinase regulatory chain	0.0076	0.0478	1
Leishmania major	protein kinase, putative	0.0086	0.0553	1
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.001	0.0203
Onchocerca volvulus		0.0141	0.0948	1
Loa Loa (eye worm)	hypothetical protein	0.0724	0.5182	0.5182
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0012	0.001	0.0203
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.001	0.0203
Echinococcus granulosus	sodium and chloride dependent glycine	0.0724	0.5182	1
Onchocerca volvulus		0.0013	0.0017	0.0183
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0141	0.0948	0.0948
Schistosoma mansoni	serine/threonine protein kinase	0.0588	0.4193	0.4193
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0076	0.0478	1
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0076	0.0478	0.0478
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.001	0.0203
Plasmodium falciparum	cGMP-dependent protein kinase	0.0588	0.4193	1
Chlamydia trachomatis	cAMP-dependent protein kinase regulatory subunit	0.0076	0.0478	0.5042
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0076	0.0478	0.114
Schistosoma mansoni	sodium/chloride dependent transporter	0.0141	0.0948	0.0948
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0141	0.0948	0.0948
Schistosoma mansoni	voltage-gated potassium channel	0.0076	0.0478	0.0478
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.001	0.0203
Loa Loa (eye worm)	serotonin transporter b	0.0141	0.0948	0.0948
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0588	0.4193	0.8091
Leishmania major	protein kinase, putative	0.0012	0.001	0.0175
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0012	0.001	0.0203
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0012	0.001	0.0175
Trypanosoma cruzi	cAMP response protein 1	0.0076	0.0478	1
Toxoplasma gondii	hypothetical protein	0.0141	0.0948	0.2262
Trypanosoma cruzi	protein kinase A regulatory subunit	0.0076	0.0478	1
Leishmania major	hypothetical protein, conserved	0.0076	0.0478	0.8646
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0012	0.001	0.0203
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0141	0.0948	0.0948
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0076	0.0478	1
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.001	0.0203
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0012	0.001	0.0203
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0141	0.0948	0.183
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0076	0.0478	1
Entamoeba histolytica	protein kinase, putative	0.0012	0.001	0.5451
Brugia malayi	cyclin-dependent kinase 7 homolog	0.0491	0.3494	0.3494
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.001	0.0203
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0141	0.0948	0.183
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0076	0.0478	0.0923
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0588	0.4193	0.8091
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0076	0.0478	0.5042
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0588	0.4193	0.4193
Mycobacterium tuberculosis	Probable transcriptional regulatory protein Cmr	0.0076	0.0478	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0076	0.0478	0.0478
Plasmodium falciparum	protein kinase, putative	0.0011	0.0005	0.0012
Mycobacterium tuberculosis	Probable conserved transmembrane transport protein	0.0076	0.0478	1
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0141	0.0948	0.2262
Schistosoma mansoni	similar to Protein C20orf152 homolog	0.0076	0.0478	0.0478
Trypanosoma cruzi	Protein kinase B	0.0012	0.001	0.0203
Echinococcus multilocularis	patatin phospholipase domain containing protein	0.0076	0.0478	0.0923
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0076	0.0478	0.0923
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0012	0.001	0.0203
Echinococcus multilocularis	expressed conserved protein	0.0588	0.4193	0.8091
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0011	0.0005	0.0104
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0076	0.0478	0.0923
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0011	0.0005	0.0104
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.001	0.0203
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0076	0.0478	0.0478
Schistosoma mansoni	voltage-gated potassium channel	0.0076	0.0478	0.0478
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0076	0.0478	1
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.001	0.0203
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.001	0.0203
Onchocerca volvulus		0.0076	0.0478	0.5042
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0076	0.0478	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0076	0.0478	1
Mycobacterium ulcerans	transcriptional regulatory protein	0.0076	0.0478	0.1161
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0076	0.0478	0.0923
Schistosoma mansoni	sodium/chloride dependent transporter	0.0724	0.5182	0.5182
Echinococcus granulosus	cAMP dependent protein kinase type II regulatory	0.0076	0.0478	0.0923
Mycobacterium tuberculosis	Probable glutamine-transport ATP-binding protein ABC transporter GlnQ	0.0076	0.0478	1
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.0076	0.0478	0.0478
Brugia malayi	cAMP-dependent protein kinase regulatory chain, putative	0.0076	0.0478	0.0478
Schistosoma mansoni	camp-dependent protein kinase regulatory chain	0.0076	0.0478	0.0478

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: 485283

Bibliographic References

No literature references available for this target.

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Detailed information for compound 430375