TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 362.389 | Formula: C18H18N8O
H donors: 3 H acceptors: 5 LogP: 2.1 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1cnn2c1nc(Nc1cccc(c1)NC(=O)C)nc2NC1CCC1
InChi: 1S/C18H18N8O/c1-11(27)21-14-6-3-7-15(8-14)22-17-24-16-12(9-19)10-20-26(16)18(25-17)23-13-4-2-5-13/h3,6-8,10,13H,2,4-5H2,1H3,(H,21,27)(H2,22,23,24,25)
InChiKey: FJBWNYUATWULDT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	casein kinase 2, alpha 1 polypeptide	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania major	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Leishmania braziliensis	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Trypanosoma cruzi	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Plasmodium knowlesi	casein kinase 2, alpha subunit, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Echinococcus multilocularis	casein kinase ii subunit alpha	Get druggable targets OG5_126901	All targets in OG5_126901
Candida albicans	Casein kinase II alpha' subunit	Get druggable targets OG5_126901	All targets in OG5_126901
Trypanosoma brucei	Casein kinase II	Get druggable targets OG5_126901	All targets in OG5_126901
Neospora caninum	hypothetical protein	Get druggable targets OG5_126901	All targets in OG5_126901
Babesia bovis	casein kinase II, alpha chain (CK II)	Get druggable targets OG5_126901	All targets in OG5_126901
Trypanosoma brucei gambiense	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Plasmodium berghei	casein kinase 2, alpha subunit	Get druggable targets OG5_126901	All targets in OG5_126901
Plasmodium vivax	casein kinase 2, alpha subunit, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Schistosoma japonicum	ko:K03097 casein kinase 2, alpha polypeptide, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Trypanosoma congolense	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Giardia lamblia	Kinase, CMGC CK2	Get druggable targets OG5_126901	All targets in OG5_126901
Candida albicans	Casein kinase II alpha' subunit	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Loa Loa (eye worm)	CMGC/CK2 protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Toxoplasma gondii	CMGC kinase, CK2 family	Get druggable targets OG5_126901	All targets in OG5_126901
Leishmania infantum	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Echinococcus granulosus	casein kinase ii subunit alpha	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Leishmania mexicana	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Entamoeba histolytica	casein kinase, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Schistosoma mansoni	protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Theileria parva	casein kinase II, alpha chain	Get druggable targets OG5_126901	All targets in OG5_126901
Cryptosporidium parvum	casein kinase II, alpha subunit, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Plasmodium falciparum	casein kinase 2, alpha subunit	Get druggable targets OG5_126901	All targets in OG5_126901
Plasmodium yoelii	Protein kinase domain	Get druggable targets OG5_126901	All targets in OG5_126901
Plasmodium vivax	unspecified product	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Candida albicans	likely protein kinase similar to S. cerevisiae CKA1 (YIL035C) alpha subunit of protein kinase 2, aka casein kinase II	Get druggable targets OG5_126901	All targets in OG5_126901
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126901	All targets in OG5_126901
Cryptosporidium hominis	protein kinase domain	Get druggable targets OG5_126901	All targets in OG5_126901
Brugia malayi	Casein kinase II, alpha chain	Get druggable targets OG5_126901	All targets in OG5_126901
Leishmania donovani	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma cruzi	casein kinase II, alpha chain, putative	casein kinase 2, alpha 1 polypeptide	391 aa	316 aa	51.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.013	0.0772
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0587	0.0801
Echinococcus granulosus	sodium:glucose cotransporter 2	0.0043	0.0647	0.058
Brugia malayi	cytoplasmic intermediate filament protein	0.0047	0.0761	0.0761
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.0071	0.0071
Leishmania major	casein kinase II, putative	0.0082	0.1684	1
Echinococcus granulosus	geminin	0.0383	0.9787	0.9786
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0071	0.0423
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0056	0.0983	0.0983
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0587	0.0587
Echinococcus granulosus	carbonic anhydrase	0.0027	0.0218	0.0148
Echinococcus multilocularis	carbonic anhydrase	0.0027	0.0218	0.0148
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.013	0.1321
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0041	0.0587	0.597
Entamoeba histolytica	hypothetical protein	0.004	0.0576	0.3128
Plasmodium falciparum	basic transcription factor 3b, putative	0.0039	0.0545	0.2231
Loa Loa (eye worm)	hypothetical protein	0.0089	0.1866	0.1866
Echinococcus granulosus	TRP transient receptor potential channel	0.0041	0.059	0.0523
Echinococcus multilocularis	muscleblind protein 1	0.0151	0.3535	0.3489
Loa Loa (eye worm)	CMGC/CK2 protein kinase	0.0082	0.1684	0.1684
Onchocerca volvulus		0.0089	0.1866	0.2551
Echinococcus multilocularis	geminin	0.0383	0.9787	0.9786
Echinococcus multilocularis	muscleblind protein	0.0151	0.3535	0.3489
Schistosoma mansoni	carbonic anhydrase-related	0.0027	0.0218	0.0148
Echinococcus multilocularis	carbonic anhydrase	0.0027	0.0218	0.0148
Echinococcus multilocularis	musashi	0.0089	0.1866	0.1807
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0218	0.0218
Giardia lamblia	Kinase, CMGC MAPK	0.0058	0.1059	0.6124
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0104	0.2282	0.2226
Mycobacterium ulcerans	beta-lactamase	0.0041	0.0587	0.597
Echinococcus granulosus	transient receptor potential ion channel A	0.0107	0.2353	0.2298
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.0071	0.0723
Mycobacterium leprae	Probable lipase LipE	0.0041	0.0587	1
Trichomonas vaginalis	CMGC family protein kinase	0.0082	0.1684	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0056	0.0983	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0041	0.0587	0.052
Schistosoma mansoni	hypothetical protein	0.0077	0.1559	0.1498
Trichomonas vaginalis	CMGC family protein kinase	0.0058	0.1059	0.6124
Trypanosoma brucei	Casein kinase II	0.0082	0.1684	1
Echinococcus granulosus	carbonic anhydrase	0.0027	0.0218	0.0148
Toxoplasma gondii	NAC domain-containing protein	0.0039	0.0545	0.2231
Brugia malayi	MAP kinase sur-1	0.0058	0.1059	0.1059
Brugia malayi	beta-lactamase family protein	0.0041	0.0587	0.0587
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0041	0.0587	0.0801
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0056	0.0983	0.0919
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0113	0.2518	0.2518
Schistosoma mansoni	intermediate filament proteins	0.0089	0.1866	0.1807
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0071	0.0423
Echinococcus multilocularis	lamin	0.0089	0.1866	0.1807
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.013	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0277	0.6934	0.6934
Echinococcus multilocularis	transcription factor btf3	0.0039	0.0545	0.0477
Mycobacterium tuberculosis	Probable lipase LipD	0.0041	0.0587	0.0801
Echinococcus granulosus	casein kinase ii subunit alpha	0.0082	0.1684	0.1624
Loa Loa (eye worm)	hypothetical protein	0.0391	1	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0104	0.2282	0.2226
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0041	0.059	0.0523
Brugia malayi	hypothetical protein	0.0277	0.6934	0.6934
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0587	0.32
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0056	0.0983	0.5841
Echinococcus multilocularis	short transient receptor potential channel 6	0.0073	0.1448	0.1387
Brugia malayi	follicle stimulating hormone receptor	0.0263	0.6561	0.6561
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0058	0.1059	0.0995
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0027	0.0218	0.1294
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.013	0.0772
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0027	0.0218	0.0218
Echinococcus granulosus	intermediate filament protein	0.0089	0.1866	0.1807
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.0071	0.0723
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0208	0.5084	0.5049
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0261	0.6513	1
Entamoeba histolytica	hypothetical protein	0.004	0.0576	0.3128
Trypanosoma brucei	DNA polymerase eta, putative	0.0022	0.0071	0.0423
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.013	0.0091
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0587	0.052
Schistosoma mansoni	carbonic anhydrase-related	0.0027	0.0218	0.0148
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0036	0.0446	0.0446
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0047	0.0761	0.0761
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0071	0.0423
Brugia malayi	hypothetical protein	0.004	0.0576	0.0576
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0058	0.1059	0.5736
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0055	0.096	0.096
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0587	0.32
Entamoeba histolytica	hypothetical protein	0.004	0.0576	0.3128
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.013	0.1321
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0104	0.2282	0.2226
Mycobacterium tuberculosis	Probable hydrolase	0.0041	0.0587	0.0801
Onchocerca volvulus		0.0056	0.0998	0.1276
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0058	0.1059	0.6288
Trypanosoma cruzi	transcription factor btf3, putative	0.0039	0.0545	0.3237
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0027	0.0218	0.0218
Trichomonas vaginalis	CMGC family protein kinase	0.0082	0.1684	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0576	0.0508
Brugia malayi	Intermediate filament tail domain containing protein	0.0089	0.1866	0.1866
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.013	0.013
Plasmodium falciparum	casein kinase 2, alpha subunit	0.0082	0.1684	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.0071	0.0071
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0071	0.0423
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.013	0.1321
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1349	0.1349
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0071	0.0423
Echinococcus granulosus	mitogen activated protein kinase	0.0058	0.1059	0.0995
Schistosoma mansoni	transient receptor potential channel	0.011	0.2452	0.2398
Entamoeba histolytica	hypothetical protein	0.004	0.0576	0.3128
Brugia malayi	RNA recognition motif domain containing protein	0.0216	0.5292	0.5292
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0576	0.0508
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0071	0.0423
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.013	0.0364
Trichomonas vaginalis	CMGC family protein kinase	0.0058	0.1059	0.6124
Toxoplasma gondii	transporter, solute:sodium symporter (SSS) family protein	0.0043	0.0647	0.2928
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0208	0.5084	0.5049
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0587	0.32
Mycobacterium leprae	conserved hypothetical protein	0.0041	0.0587	1
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.013	0.013
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.013	0.013
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0027	0.0218	0.0218
Schistosoma mansoni	hypothetical protein	0.0036	0.0446	0.0378
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0027	0.0218	0.0218
Onchocerca volvulus		0.0043	0.0647	0.076
Schistosoma mansoni	hypothetical protein	0.0036	0.0446	0.0378
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0071	0.0423
Echinococcus multilocularis	tar DNA binding protein	0.0216	0.5292	0.5258
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0587	0.3487
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0587	0.0587
Schistosoma mansoni	hypothetical protein	0.004	0.0576	0.0508
Brugia malayi	latrophilin 2 splice variant baaae	0.0077	0.1559	0.1559
Trypanosoma brucei	unspecified product	0.0022	0.0071	0.0423
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0592	0.0592
Schistosoma mansoni	tar DNA-binding protein	0.0216	0.5292	0.5258
Mycobacterium tuberculosis	Probable lipase LipE	0.0041	0.0587	0.0801
Echinococcus multilocularis	transient receptor potential ion channel A	0.0107	0.2353	0.2298
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0545	0.2938
Echinococcus multilocularis	casein kinase ii subunit alpha	0.0082	0.1684	0.1624
Loa Loa (eye worm)	hypothetical protein	0.0024	0.013	0.013
Brugia malayi	Cytochrome P450 family protein	0.0049	0.0806	0.0806
Leishmania major	DNA polymerase kappa, putative	0.0022	0.0071	0.0423
Onchocerca volvulus	Huntingtin homolog	0.0277	0.6934	1
Schistosoma mansoni	hypothetical protein	0.0027	0.0218	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0635	0.0635
Schistosoma mansoni	carbonic anhydrase	0.0027	0.0218	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0151	0.3535	0.3535
Echinococcus granulosus	lamin dm0	0.0089	0.1866	0.1807
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0043	0.0635	0.0568
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0027	0.0218	0.0218
Brugia malayi	beta-NAC-like protein	0.0039	0.0545	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1559	0.1559
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0104	0.2282	0.2226
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0587	0.037
Loa Loa (eye worm)	hypothetical protein	0.0024	0.013	0.013
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0071	0.0423
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0041	0.0587	0.052
Brugia malayi	hypothetical protein	0.0269	0.6709	0.6709
Echinococcus multilocularis	tumor protein p63	0.0384	0.9807	0.9805
Brugia malayi	Muscleblind-like protein	0.0151	0.3535	0.3535
Echinococcus granulosus	sodium:myo inositol cotransporter	0.0043	0.0647	0.058
Loa Loa (eye worm)	hypothetical protein	0.0285	0.7155	0.7155
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0041	0.0587	0.0587
Onchocerca volvulus		0.0055	0.096	0.1221
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0058	0.1059	0.6288
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0446	0.0446
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0104	0.2282	0.2226
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.013	0.0364
Echinococcus multilocularis	transient receptor potential gamma protein	0.011	0.2452	0.2398
Echinococcus multilocularis	carbonic anhydrase	0.0027	0.0218	0.0148
Trichomonas vaginalis	CMGC family protein kinase	0.0058	0.1059	0.6124
Loa Loa (eye worm)	TAR-binding protein	0.0216	0.5292	0.5292
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0022	0.0071	0.0423
Schistosoma mansoni	hypothetical protein	0.0036	0.0446	0.0378
Echinococcus granulosus	muscleblind protein	0.0151	0.3535	0.3489
Schistosoma mansoni	lamin	0.0089	0.1866	0.1807
Trichomonas vaginalis	CMGC family protein kinase	0.0082	0.1684	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0036	0.0446	0.0378
Echinococcus multilocularis	GPCR, family 2	0.0036	0.0446	0.0378
Entamoeba histolytica	casein kinase, putative	0.0082	0.1684	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0576	0.0508
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.013	0.1321
Brugia malayi	Casein kinase II, alpha chain	0.0082	0.1684	0.1684
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0041	0.0587	0.0801
Echinococcus multilocularis	high affinity choline transporter 1	0.0391	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0216	0.5292	0.5258
Brugia malayi	beta-lactamase family protein	0.0041	0.0587	0.0587
Trichomonas vaginalis	CMGC family protein kinase	0.0082	0.1684	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0218	0.0218
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0545	0.2938
Loa Loa (eye worm)	hypothetical protein	0.0151	0.3535	0.3535
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0056	0.0983	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0587	0.0587
Entamoeba histolytica	transcription factor BTF3, putative	0.0039	0.0545	0.2938
Trypanosoma cruzi	DNA polymerase eta, putative	0.0022	0.0071	0.0423
Schistosoma mansoni	protein kinase	0.0082	0.1684	0.1624
Trichomonas vaginalis	CMGC family protein kinase	0.0082	0.1684	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0049	0.0806	0.0806
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0089	0.1866	0.1866
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0056	0.0983	0.1416
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0587	0.32
Schistosoma mansoni	sodium/solute symporter	0.0043	0.0647	0.058
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0071	0.0423
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0104	0.2282	0.2226
Schistosoma mansoni	hypothetical protein	0.0036	0.0446	0.0378
Echinococcus multilocularis	sodium coupled monocarboxylate transporter 1	0.0043	0.0647	0.058
Echinococcus granulosus	carbonic anhydrase II	0.0027	0.0218	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0998	0.0998
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0592	0.0592
Trichomonas vaginalis	CMGC family protein kinase	0.0082	0.1684	1
Onchocerca volvulus	Huntingtin homolog	0.0277	0.6934	1
Trypanosoma cruzi	transcription factor btf3, putative	0.0039	0.0545	0.3237
Schistosoma mansoni	hypothetical protein	0.0055	0.096	0.0896
Toxoplasma gondii	CMGC kinase, CK2 family	0.0082	0.1684	1
Echinococcus granulosus	carbonic anhydrase	0.0027	0.0218	0.0148
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0587	0.0801
Schistosoma mansoni	inositol transporter	0.0043	0.0647	0.058
Echinococcus granulosus	survival motor neuron protein 1	0.0269	0.6709	0.6686
Schistosoma mansoni	hypothetical protein	0.0383	0.9787	0.9786
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0104	0.2282	0.2226
Echinococcus multilocularis	carbonic anhydrase II	0.0027	0.0218	0.0148
Echinococcus multilocularis	sodium:myo inositol cotransporter	0.0043	0.0647	0.058
Leishmania major	carbonic anhydrase-like protein	0.0027	0.0218	0.1294
Schistosoma mansoni	transient receptor potential channel 4	0.011	0.2452	0.2398
Schistosoma mansoni	survival motor neuron protein	0.0055	0.096	0.0896
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0587	0.052
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0071	0.0423
Echinococcus multilocularis	sodium:glucose cotransporter 2	0.0043	0.0647	0.058
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0071	0.0423
Echinococcus granulosus	transcription factor btf3	0.0039	0.0545	0.0477
Entamoeba histolytica	protein kinase domain containing protein	0.0082	0.1684	1
Schistosoma mansoni	lamin	0.0089	0.1866	0.1807
Schistosoma mansoni	hypothetical protein	0.0383	0.9787	0.9786
Trichomonas vaginalis	esterase, putative	0.0041	0.0587	0.32
Mycobacterium tuberculosis	Probable esterase LipL	0.0041	0.0587	0.0801
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0104	0.2282	0.2282
Loa Loa (eye worm)	RNA binding protein	0.0216	0.5292	0.5292
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0027	0.0218	0.0148
Brugia malayi	Sodium:solute symporter family protein	0.0043	0.0647	0.0647
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0071	0.0423
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0587	0.0801
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0071	0.0423
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0036	0.0446	0.0446
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0058	0.1059	0.1059
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0113	0.2518	0.2518
Echinococcus granulosus	transient receptor potential gamma protein	0.011	0.2452	0.2398
Toxoplasma gondii	ABC1 family protein	0.0041	0.0587	0.2519
Echinococcus granulosus	sodium:glucose cotransporter	0.0043	0.0647	0.058
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.013	0.0364
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0491	0.0491
Echinococcus granulosus	short transient receptor potential channel 6	0.0073	0.1448	0.1387
Loa Loa (eye worm)	intermediate filament protein	0.0089	0.1866	0.1866
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0027	0.0218	0.0218
Echinococcus multilocularis	lamin dm0	0.0089	0.1866	0.1807
Schistosoma mansoni	cellular tumor antigen P53	0.0056	0.0998	0.0933
Mycobacterium ulcerans	lipase LipD	0.0041	0.0587	0.597
Echinococcus granulosus	GPCR family 2	0.0036	0.0446	0.0378
Schistosoma mansoni	tar DNA-binding protein	0.0216	0.5292	0.5258
Loa Loa (eye worm)	hypothetical protein	0.0041	0.059	0.059
Trypanosoma brucei	hypothetical protein, conserved	0.0041	0.0587	0.3487
Brugia malayi	Latrophilin receptor protein 2	0.0036	0.0446	0.0446
Mycobacterium ulcerans	hypothetical protein	0.0024	0.013	0.1321
Brugia malayi	TAR-binding protein	0.0216	0.5292	0.5292
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0587	0.32
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0058	0.1059	0.6288
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0027	0.0218	0.1294
Schistosoma mansoni	transcription factor btf3	0.0039	0.0545	0.0477
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0056	0.0983	0.0919
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0027	0.0218	0.0218
Echinococcus granulosus	mitogen activated protein kinase 3	0.0058	0.1059	0.0995
Schistosoma mansoni	transient receptor potential channel	0.0073	0.1448	0.1387
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.013	0.1321
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0587	0.0587
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0545	0.2938
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.013	0.1321
Loa Loa (eye worm)	hypothetical protein	0.0269	0.6709	0.6709
Loa Loa (eye worm)	ICD-1 protein	0.0039	0.0545	0.0545
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0022	0.0071	0.0071
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0058	0.1059	0.6288
Entamoeba histolytica	hypothetical protein	0.0039	0.0545	0.2938
Echinococcus granulosus	high affinity choline transporter 1	0.0391	1	1
Onchocerca volvulus		0.0041	0.0587	0.0672
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0587	0.3487
Echinococcus multilocularis	survival motor neuron protein 1	0.0269	0.6709	0.6686
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0218	0.0218
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0216	0.5292	0.5292
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0058	0.1059	0.6288
Echinococcus multilocularis	mitogen activated protein kinase	0.0058	0.1059	0.0995
Echinococcus granulosus	short transient receptor potential channel 6	0.0073	0.1448	0.1387
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0027	0.0218	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0071	0.0071
Trypanosoma brucei	transcription factor BTF3, putative	0.0039	0.0545	0.3237
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0041	0.0587	0.0801
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0027	0.0218	0.0218
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0071	0.0423
Trypanosoma cruzi	casein kinase II, putative	0.0082	0.1684	1
Plasmodium vivax	unspecified product	0.0082	0.1684	1
Echinococcus multilocularis	short transient receptor potential channel 6	0.0073	0.1448	0.1387
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0043	0.0635	0.0568
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0052	0.0883	0.0883
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0036	0.0446	0.0378
Schistosoma mansoni	tar DNA-binding protein	0.0216	0.5292	0.5258
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0285	0.7155	0.7155
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0647	0.0647
Brugia malayi	beta-lactamase	0.0041	0.0587	0.0587
Onchocerca volvulus		0.0089	0.1866	0.2551
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0263	0.6561	0.6561
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0041	0.0587	0.0587
Echinococcus granulosus	solute carrier family 5	0.0043	0.0647	0.058
Loa Loa (eye worm)	hypothetical protein	0.011	0.2452	0.2452
Onchocerca volvulus		0.0041	0.0587	0.0672
Echinococcus granulosus	lamin	0.0089	0.1866	0.1807
Echinococcus granulosus	tumor protein p63	0.0384	0.9807	0.9805
Mycobacterium ulcerans	esterase/lipase LipP	0.0041	0.0587	0.597
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0587	0.0587
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0056	0.0983	0.0919
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0587	0.0587
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.013	0.0772
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.013	0.1321
Loa Loa (eye worm)	hypothetical protein	0.0277	0.6934	0.6934
Brugia malayi	Transient-receptor-potential like protein	0.0041	0.059	0.059
Echinococcus multilocularis	solute carrier family 5	0.0043	0.0647	0.058
Mycobacterium ulcerans	hypothetical protein	0.0041	0.0587	0.597
Loa Loa (eye worm)	carbonic anhydrase 3	0.0027	0.0218	0.0218
Loa Loa (eye worm)	beta-lactamase	0.0041	0.0587	0.0587
Leishmania major	DNA polymerase eta, putative	0.0022	0.0071	0.0423
Schistosoma mansoni	high-affinity choline transporter	0.0391	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0058	0.1059	0.0995
Schistosoma mansoni	inositol transporter	0.0043	0.0647	0.058
Brugia malayi	intermediate filament protein	0.0089	0.1866	0.1866
Leishmania major	hypothetical protein, conserved	0.0041	0.0587	0.3487
Echinococcus granulosus	sodium coupled monocarboxylate transporter 1	0.0043	0.0647	0.058
Trichomonas vaginalis	CMGC family protein kinase	0.0082	0.1684	1
Schistosoma mansoni	carbonic anhydrase-related	0.0027	0.0218	0.0148
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0071	0.0423
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0071	0.0423
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1822	0.1822
Schistosoma mansoni	transient receptor potential channel	0.0073	0.1448	0.1387
Onchocerca volvulus		0.0041	0.0587	0.0672
Leishmania major	basic transcription factor 3a, putative	0.0039	0.0545	0.3237
Echinococcus granulosus	tar DNA binding protein	0.0216	0.5292	0.5258
Trichomonas vaginalis	CMGC family protein kinase	0.0058	0.1059	0.6124
Schistosoma mansoni	tar DNA-binding protein	0.0216	0.5292	0.5258
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0058	0.1059	0.6288
Trypanosoma brucei	protein kinase, putative	0.0058	0.1059	0.6288
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0071	0.0423
Loa Loa (eye worm)	hypothetical protein	0.0024	0.013	0.013
Brugia malayi	RNA binding protein	0.0216	0.5292	0.5292
Trypanosoma brucei	carbonic anhydrase-like protein	0.0027	0.0218	0.1294
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0104	0.2282	0.2282
Plasmodium vivax	casein kinase 2, alpha subunit, putative	0.0082	0.1684	1
Giardia lamblia	Kinase, CMGC CK2	0.0082	0.1684	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0058	0.1059	0.6288
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0027	0.0218	0.0148

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 5.5 uM	Growth inhibition of HCT116 cells by MTT assay	ChEMBL.	17540560
IC50 (functional)	= 5.5 uM	Growth inhibition of HCT116 cells by MTT assay	ChEMBL.	17540560
Ki (binding)	= 0.0019 uM	Inhibition of human CK2 alpha	ChEMBL.	17540560
Ki (binding)	= 0.0019 uM	Inhibition of human CK2 alpha	ChEMBL.	17540560

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	17540560

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL230462

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 430802