Detailed information for compound 430924

Basic information

Technical information
  • TDR Targets ID: 430924
  • Name: ethyl (2S)-2-acetamido-3-[4-(2-carbazol-9-yle thoxy)phenyl]propanoate
  • MW: 444.522 | Formula: C27H28N2O4
  • H donors: 1 H acceptors: 2 LogP: 4.84 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)[C@H](Cc1ccc(cc1)OCCn1c2ccccc2c2c1cccc2)NC(=O)C
  • InChi: 1S/C27H28N2O4/c1-3-32-27(31)24(28-19(2)30)18-20-12-14-21(15-13-20)33-17-16-29-25-10-6-4-8-22(25)23-9-5-7-11-26(23)29/h4-15,24H,3,16-18H2,1-2H3,(H,28,30)/t24-/m0/s1
  • InChiKey: NUOJNQABPUSOIR-DEOSSOPVSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-2-acetamido-3-[4-[2-(9-carbazolyl)ethoxy]phenyl]propanoic acid ethyl ester
  • (2S)-2-acetamido-3-[4-(2-carbazol-9-ylethoxy)phenyl]propionic acid ethyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0153 0.0287 0.0298
Schistosoma mansoni hypothetical protein 0.0035 0.0016 0.0014
Schistosoma mansoni hypothetical protein 0.004 0.0028 0.0025
Schistosoma mansoni pyruvate carboxylase 0.1659 0.3769 0.3767
Schistosoma mansoni lamin 0.003 0.0005 0.0002
Brugia malayi STAT protein, DNA binding domain containing protein 0.0176 0.0342 0.0355
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.059 0.1299 0.2106
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0028 0.0028
Brugia malayi Calcitonin receptor-like protein seb-1 0.0111 0.0192 0.0199
Schistosoma mansoni integrin alpha 0.0061 0.0076 0.0074
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0005 0.0005
Chlamydia trachomatis biotin carboxylase 0.1506 0.3416 1
Schistosoma mansoni hypothetical protein 0.0045 0.004 0.0037
Schistosoma mansoni hypothetical protein 0.0045 0.004 0.0037
Loa Loa (eye worm) beta-lactamase 0.004 0.0028 0.0029
Brugia malayi beta-lactamase 0.004 0.0028 0.0029
Mycobacterium ulcerans pyruvate carboxylase 0.1659 0.3769 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.0174 0.018
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.059 0.1299 0.2905
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.4355 1 1
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.1659 0.3769 1
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0028 0.0045
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.0153 0.0287 0.0287
Loa Loa (eye worm) integrin alpha pat-2 0.0135 0.0247 0.0257
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.059 0.1299 0.2106
Echinococcus granulosus integrin alpha ps 0.0061 0.0076 0.0074
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.1659 0.3769 0.3767
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.059 0.1299 0.3398
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0009
Brugia malayi Niemann-Pick C1 protein precursor 0.011 0.0189 0.0196
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0375 0.0801 0.0801
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.059 0.1299 0.3398
Mycobacterium ulcerans dihydrolipoamide acetyltransferase 0.0153 0.0287 0.0694
Schistosoma mansoni hypothetical protein 0.0035 0.0016 0.0014
Loa Loa (eye worm) hypothetical protein 0.0153 0.0287 0.0298
Onchocerca volvulus 0.0169 0.0325 0.5809
Leishmania major carbamoyl-phosphate synthase, putative 0.0375 0.0801 0.0801
Brugia malayi beta-lactamase family protein 0.004 0.0028 0.0029
Loa Loa (eye worm) transcription factor SMAD2 0.0133 0.0243 0.0252
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.0153 0.0287 0.0287
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0016 0.0017
Plasmodium vivax hypothetical protein, conserved 0.004 0.0028 0.0039
Schistosoma mansoni aspartate carbamoyltransferase 0.0375 0.0801 0.0799
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.0153 0.0287 0.0287
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0016 0.0014
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0153 0.0287 0.0466
Echinococcus multilocularis transfer RNA-Lys 0.004 0.0028 0.0025
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.059 0.1299 0.3398
Onchocerca volvulus 0.0054 0.0059 0.0995
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.011 0.0189 0.0993
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0153 0.0287 0.0285
Schistosoma mansoni hypothetical protein 0.0035 0.0016 0.0014
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.059 0.1299 0.1299
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0153 0.0287 0.0298
Echinococcus granulosus GPCR family 2 0.0035 0.0016 0.0014
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.059 0.1299 0.3398
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.0153 0.0287 0.0287
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0028 0.0045
Loa Loa (eye worm) hypothetical protein 0.0169 0.0325 0.0337
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.059 0.1299 0.3398
Loa Loa (eye worm) hypothetical protein 0.004 0.0028 0.0029
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.4355 1 1
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0375 0.0801 0.1476
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.059 0.1299 0.1296
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0028 0.0025
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0153 0.0287 0.0466
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0044 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0257 0.0529 0.1339
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0016 0.0017
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.1659 0.3769 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0016 0.0014
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.1659 0.3769 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0028 0.0029
Loa Loa (eye worm) hypothetical protein 0.004 0.0028 0.0029
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0111 0.0192 0.0199
Loa Loa (eye worm) hypothetical protein 0.003 0.0003 0.0003
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0153 0.0287 0.0466
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.1659 0.3769 0.3769
Onchocerca volvulus 0.004 0.0028 0.0423
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0153 0.0287 0.0287
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.1659 0.3769 0.6112
Loa Loa (eye worm) hypothetical protein 0.0153 0.0287 0.0298
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.059 0.1299 0.3233
Plasmodium falciparum carbamoyl phosphate synthetase 0.0375 0.0801 0.111
Schistosoma mansoni integrin alpha-ps 0.0032 0.0009 0.0006
Echinococcus multilocularis GPCR, family 2 0.0035 0.0016 0.0014
Echinococcus multilocularis survival motor neuron protein 1 0.0264 0.0545 0.0543
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0153 0.0287 0.0285
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0028 0.0025
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.059 0.1299 0.3398
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0375 0.0801 0.2068
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.059 0.1299 0.3398
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.3152 0.7219 1
Onchocerca volvulus 0.004 0.0028 0.0423
Brugia malayi Carboxyl transferase domain containing protein 0.4203 0.9647 1
Echinococcus granulosus Niemann Pick C1 protein 0.0157 0.0298 0.0295
Echinococcus multilocularis Niemann Pick C1 protein 0.011 0.0189 0.0186
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0111 0.0192 0.0199
Echinococcus multilocularis protein patched 0.0047 0.0044 0.0041
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.0153 0.0287 0.0287
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0047 0.0044 0.0046
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0153 0.0287 0.0287
Leishmania major hypothetical protein, conserved 0.004 0.0028 0.0028
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0153 0.0287 0.0285
Mycobacterium leprae Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB 0.0153 0.0287 0.0694
Treponema pallidum pyruvate carboxylase subunit B 0.0153 0.0287 0.5
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0028 0.0029
Loa Loa (eye worm) STAT protein 0.0176 0.0342 0.0355
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0153 0.0287 0.0285
Echinococcus granulosus lamin dm0 0.003 0.0005 0.0002
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.0153 0.0287 0.0287
Echinococcus granulosus survival motor neuron protein 1 0.0264 0.0545 0.0543
Leishmania major propionyl-coa carboxylase beta chain, putative 0.059 0.1299 0.1299
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0059 0.0062
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.059 0.1299 0.2106
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0028 0.0025
Brugia malayi hypothetical protein 0.0264 0.0545 0.0565
Echinococcus granulosus expressed conserved protein 0.0103 0.0174 0.0171
Trypanosoma cruzi acetyl-CoA carboxylase 0.2696 0.6166 1
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.1659 0.3769 1
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.1659 0.3769 0.3767
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0028 0.0025
Echinococcus granulosus Niemann Pick C1 protein 0.011 0.0189 0.0186
Schistosoma mansoni hypothetical protein 0.0045 0.004 0.0037
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.0153 0.0287 0.0287
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0028 0.0025
Loa Loa (eye worm) pax transcription factor protein 2 0.0269 0.0556 0.0576
Schistosoma mansoni acetyl-CoA carboxylase 0.4355 1 1
Brugia malayi hypothetical protein 0.004 0.0028 0.0029
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.059 0.1299 0.1296
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.1659 0.3769 0.3767
Schistosoma mansoni patched 1 0.0047 0.0044 0.0041
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0153 0.0287 0.0285
Brugia malayi hypoxia-induced factor 1 0.0168 0.0324 0.0335
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase 0.0153 0.0287 0.0694
Loa Loa (eye worm) hypothetical protein 0.0029 0.0003 0.0003
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0112 0.0193 0.019
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0103 0.0174 0.018
Schistosoma mansoni hypothetical protein 0.0189 0.0372 0.037
Trypanosoma brucei unspecified product 0.1091 0.2455 0.2455
Mycobacterium tuberculosis Biotinylated protein TB7.3 0.0153 0.0287 0.0694
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0743 0.1651 0.5
Schistosoma mansoni hypothetical protein 0.0035 0.0016 0.0014
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0153 0.0287 0.0285
Loa Loa (eye worm) hypothetical protein 0.004 0.0028 0.0029
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.1659 0.3769 0.3769
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.0153 0.0287 0.0398
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.0153 0.0287 0.0398
Mycobacterium tuberculosis Probable branched-chain keto acid dehydrogenase E2 component BkdC 0.0153 0.0287 0.0694
Echinococcus multilocularis geminin 0.0189 0.0372 0.037
Schistosoma mansoni hypothetical protein 0.0189 0.0372 0.037
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0375 0.0801 0.0799
Schistosoma mansoni hypothetical protein 0.0076 0.0111 0.0108
Schistosoma mansoni aryl hydrocarbon receptor 0.0054 0.006 0.0058
Schistosoma mansoni survival motor neuron protein 0.0054 0.0059 0.0057
Brugia malayi CHE-14 protein 0.0047 0.0044 0.0046
Brugia malayi Integrin alpha pat-2 precursor 0.0061 0.0076 0.0079
Schistosoma mansoni hypothetical protein 0.0054 0.0059 0.0057
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0375 0.0801 0.13
Leishmania major acetyl-CoA carboxylase, putative 0.4355 1 1
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0153 0.0287 0.0298
Loa Loa (eye worm) hypothetical protein 0.0058 0.0069 0.0071
Echinococcus multilocularis Niemann Pick C1 protein 0.0157 0.0298 0.0295
Schistosoma mansoni single-minded 0.0054 0.006 0.0058
Echinococcus granulosus sterol regulatory element binding protein 0.0047 0.0044 0.0041
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.1659 0.3769 0.3769
Echinococcus multilocularis musashi 0.003 0.0005 0.0002
Toxoplasma gondii ABC1 family protein 0.004 0.0028 0.0028
Echinococcus multilocularis protein dispatched 1 0.0054 0.0059 0.0057
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0906 0.2028 0.2026
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0153 0.0287 0.0298
Echinococcus multilocularis integrin alpha ps 0.0061 0.0076 0.0074
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0153 0.0287 0.0285
Loa Loa (eye worm) intermediate filament protein 0.003 0.0005 0.0005
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0375 0.0801 0.0799
Onchocerca volvulus 0.0269 0.0556 1
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0153 0.0287 0.0466
Schistosoma mansoni hypothetical protein 0.0045 0.004 0.0037
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.1659 0.3769 0.6112
Echinococcus granulosus Biotin lipoyl attachment 0.0153 0.0287 0.0285
Mycobacterium leprae Probable biotinylated protein homolog TB7.3 0.0153 0.0287 0.0694
Leishmania major carboxylase, putative 0.1659 0.3769 0.3769
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.0153 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.004 0.0028 0.0029
Loa Loa (eye worm) hypothetical protein 0.0035 0.0016 0.0017
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.0153 0.0287 0.0287
Echinococcus granulosus lamin 0.003 0.0005 0.0002
Echinococcus granulosus Protein patched homolog 1 0.0047 0.0044 0.0041
Mycobacterium ulcerans branched-chain alpha-keto acid dehydrogenase subunit E2 0.0153 0.0287 0.0694
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.0153 0.0287 0.0466
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.1659 0.3769 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0009
Onchocerca volvulus 0.004 0.0028 0.0423
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.4355 1 1
Echinococcus granulosus intermediate filament protein 0.003 0.0005 0.0002
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.0153 0.0287 0.0287
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0016 0.0014
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.4203 0.9647 1
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.1659 0.3769 1
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.059 0.1299 0.1299
Brugia malayi MH2 domain containing protein 0.0133 0.0243 0.0252
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.059 0.1299 0.1299
Echinococcus multilocularis expressed conserved protein 0.0103 0.0174 0.0171
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0028 0.0025
Toxoplasma gondii pyruvate carboxylase 0.1659 0.3769 0.3769
Echinococcus multilocularis Biotin lipoyl attachment 0.0153 0.0287 0.0285
Loa Loa (eye worm) hypothetical protein 0.0047 0.0044 0.0046
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.0153 0.0287 0.0287
Loa Loa (eye worm) MH2 domain-containing protein 0.0133 0.0243 0.0252
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0016 0.0017
Loa Loa (eye worm) hypoxia-induced factor 1 0.0168 0.0324 0.0335
Schistosoma mansoni integrin alpha-ps 0.0061 0.0076 0.0074
Onchocerca volvulus 0.004 0.0028 0.0423
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.1659 0.3769 1
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.0111 0.0115
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.0153 0.0287 0.0398
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.059 0.1299 0.3398
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0005 0.0005
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0028 0.0025
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.059 0.1299 0.3398
Loa Loa (eye worm) hypothetical protein 0.004 0.0028 0.0029
Loa Loa (eye worm) hypothetical protein 0.011 0.0189 0.0196
Echinococcus granulosus geminin 0.0189 0.0372 0.037
Schistosoma mansoni lamin 0.003 0.0005 0.0002
Echinococcus multilocularis sterol regulatory element binding protein 0.0047 0.0044 0.0041
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.3152 0.7219 1
Brugia malayi Pax transcription factor protein 2 0.0269 0.0556 0.0576
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0375 0.0801 0.111
Brugia malayi beta-lactamase family protein 0.004 0.0028 0.0029
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0153 0.0287 0.0285
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0375 0.0801 0.13
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.059 0.1299 0.3398
Brugia malayi hypothetical protein 0.0182 0.0356 0.0369
Echinococcus multilocularis lamin dm0 0.003 0.0005 0.0002
Trypanosoma brucei acetyl-CoA carboxylase 0.4355 1 1
Brugia malayi bHLH-PAS transcription factor 0.004 0.0028 0.0029
Brugia malayi hypothetical protein 0.0169 0.0325 0.0337
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0016 0.0014
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.059 0.1299 0.1296
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.1659 0.3769 0.3767
Plasmodium falciparum lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 0.0153 0.0287 0.0398
Brugia malayi intermediate filament protein 0.003 0.0005 0.0005
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0153 0.0287 0.0466
Loa Loa (eye worm) hypothetical protein 0.0264 0.0545 0.0565
Brugia malayi PAS domain containing protein 0.0054 0.006 0.0063
Toxoplasma gondii carbamoylphosphate synthetase 0.0375 0.0801 0.0801
Echinococcus multilocularis integrin alpha ps 0.0061 0.0076 0.0074
Loa Loa (eye worm) hypothetical protein 0.0076 0.0111 0.0115
Echinococcus multilocularis lamin 0.003 0.0005 0.0002
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0153 0.0287 0.0466
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0028 0.0029
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0743 0.1651 1
Plasmodium falciparum dihydrolipoamide acyltransferase component E2 0.0153 0.0287 0.0398
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.059 0.1299 0.3398
Schistosoma mansoni intermediate filament proteins 0.003 0.0005 0.0002
Loa Loa (eye worm) hypothetical protein 0.003 0.0005 0.0005
Echinococcus granulosus single minded 2 0.004 0.0028 0.0025
Loa Loa (eye worm) hypothetical protein 0.0111 0.0192 0.0199
Loa Loa (eye worm) hypothetical protein 0.0182 0.0356 0.0369
Mycobacterium ulcerans hypothetical protein 0.0153 0.0287 0.0694

Activities

Activity type Activity value Assay description Source Reference
Fold change (functional) = 1.6 Agonist activity at human recombinant PPARalpha at 50 uM by GAL4 transactivation assay relative to control ChEMBL. 17187904
Fold change (functional) = 5.4 Agonist activity at human recombinant PPARgamma at 30 uM by GAL4 transactivation assay relative to control ChEMBL. 17187904
Fold change (functional) = 1.6 Agonist activity at human recombinant PPARalpha at 50 uM by GAL4 transactivation assay relative to control ChEMBL. 17187904
Fold change (functional) = 5.4 Agonist activity at human recombinant PPARgamma at 30 uM by GAL4 transactivation assay relative to control ChEMBL. 17187904

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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