Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Curated by TDR Targets | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | = 0.8 uM | compound was tested for antiherpes activity against HCMV(AD 169) in tissue culture by plaque reduction assay | ChEMBL. | 1849998 |
ID50 (functional) | = 2 uM | compound was tested for antiherpes activity against VZV(Ellen) in tissue culture by plaque reduction assay | ChEMBL. | 1849998 |
ID50 (functional) | = 2 uM | compound was tested for antiherpes activity against MCMV(Smith) in tissue culture by plaque reduction assay | ChEMBL. | 1849998 |
ID50 (functional) | = 8 uM | compound was tested for antiherpes activity against HSV-1(Schooler) in tissue culture by plaque reduction assay | ChEMBL. | 1849998 |
ID50 (functional) | = 8 uM | compound was tested for antiherpes activity against HSV-2(186) in tissue culture by plaque reduction assay | ChEMBL. | 1849998 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.