Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | phosphofructokinase, putative | 0.0108 | 0.6297 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.3541 | 0.3541 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0093 | 0.5223 | 0.5079 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0069 | 0.3421 | 0.3421 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0158 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0027 | 0.0292 | 0.0292 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0292 | 0.0292 |
Brugia malayi | Carboxylesterase family protein | 0.0027 | 0.0292 | 0.0292 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0108 | 0.6297 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.012 | 0.012 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.3541 | 0.3541 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0093 | 0.5223 | 0.8211 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.012 | 0.012 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0029 | 0.0474 | 0.0303 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0047 | 0.1802 | 0.1802 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0027 | 0.0292 | 0.0292 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0124 | 0.0124 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0108 | 0.6297 | 0.6297 |
Schistosoma mansoni | acetylcholinesterase | 0.0027 | 0.0292 | 0.0292 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0029 | 0.0474 | 0.0303 |
Schistosoma mansoni | neprilysin | 0.0024 | 0.012 | 0.012 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0093 | 0.5223 | 0.5223 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0027 | 0.0292 | 0.0292 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0108 | 0.6297 | 0.6186 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0047 | 0.1802 | 0.1802 |
Toxoplasma gondii | phosphofructokinase PFKII | 0.0029 | 0.0474 | 0.0686 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0047 | 0.1802 | 0.1802 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.3541 | 0.3541 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0158 | 1 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0024 | 0.012 | 0.012 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0292 | 0.0292 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0108 | 0.6297 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.5223 | 0.5223 |
Brugia malayi | Carboxylesterase family protein | 0.0158 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0027 | 0.0292 | 0.0292 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0108 | 0.6297 | 0.6297 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.012 | 0.012 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0292 | 0.0292 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0292 | 0.0292 |
Brugia malayi | phosphofructokinase | 0.0108 | 0.6297 | 0.6297 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1739 | 0.1739 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0093 | 0.5223 | 0.8211 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0292 | 0.0292 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0029 | 0.0474 | 0.0303 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0027 | 0.0292 | 0.0292 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0292 | 0.0292 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0029 | 0.0474 | 1 |
Toxoplasma gondii | peptidase family M13 protein | 0.0093 | 0.5223 | 1 |
Toxoplasma gondii | phosphofructokinase domain-containing protein | 0.0029 | 0.0474 | 0.0686 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0029 | 0.0474 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0158 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0158 | 1 | 1 |
Toxoplasma gondii | 6-phosphofructokinase | 0.0029 | 0.0474 | 0.0686 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0029 | 0.0474 | 1 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0047 | 0.1802 | 0.1802 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0093 | 0.5223 | 0.5079 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.3421 | 0.3421 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0292 | 0.0292 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0029 | 0.0474 | 1 |
Schistosoma mansoni | gliotactin | 0.0027 | 0.0292 | 0.0292 |
Brugia malayi | 6-phosphofructokinase | 0.0108 | 0.6297 | 0.6297 |
Loa Loa (eye worm) | phosphofructokinase | 0.0108 | 0.6297 | 0.6297 |
Giardia lamblia | Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit | 0.0029 | 0.0474 | 0.5 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0108 | 0.6297 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.012 | 0.012 |
Brugia malayi | Peptidase family M13 containing protein | 0.0093 | 0.5223 | 0.5223 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.5223 | 0.5223 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0108 | 0.6297 | 0.6186 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.3421 | 0.3421 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.3541 | 0.3541 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0029 | 0.0474 | 0.0303 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0029 | 0.0474 | 0.0303 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0047 | 0.1802 | 0.1802 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0029 | 0.0474 | 0.5 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0108 | 0.6297 | 1 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0108 | 0.6297 | 0.6297 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0093 | 0.5223 | 0.5223 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0108 | 0.6297 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0158 | 1 | 1 |
Leishmania major | ATP-dependent phosphofructokinase | 0.0108 | 0.6297 | 1 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0108 | 0.6297 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0158 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.012 | 0.012 |
Brugia malayi | Carboxylesterase family protein | 0.0027 | 0.0292 | 0.0292 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0108 | 0.6297 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0029 | 0.0474 | 0.0303 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0108 | 0.6297 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0027 | 0.0292 | 0.0292 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0108 | 0.6297 | 0.6297 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.012 | 0.012 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0027 | 0.0292 | 0.0292 |
Onchocerca volvulus | 0.0046 | 0.1739 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0292 | 0.0292 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.5223 | 0.5223 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.3541 | 0.3541 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0027 | 0.0292 | 0.0292 |
Echinococcus granulosus | acetylcholinesterase | 0.0158 | 1 | 1 |
Trichomonas vaginalis | 6-phosphofructokinase, putative | 0.0029 | 0.0474 | 0.0303 |
Brugia malayi | Carboxylesterase family protein | 0.0027 | 0.0292 | 0.0292 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.3421 | 0.3421 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.3541 | 0.3541 |
Echinococcus granulosus | carboxylesterase 5A | 0.0158 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.3421 | 0.3421 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0108 | 0.6297 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 1 | 1 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0029 | 0.0474 | 0.5 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0124 | 0.0124 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0108 | 0.6297 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0158 | 1 | 1 |
Brugia malayi | 6-phosphofructokinase | 0.0108 | 0.6297 | 0.6297 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0108 | 0.6297 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0108 | 0.6297 | 1 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0069 | 0.3421 | 0.3421 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 uM | Antiproliferative activity against human estrogen receptor positive MCF7 cells after 72 hrs | ChEMBL. | 17656092 |
IC50 (functional) | > 100 uM | Antiproliferative activity against human estrogen receptor negative SKBr3 cells over-expressing Her2 after 72 hrs | ChEMBL. | 17656092 |
IC50 (functional) | > 100 uM | Antiproliferative activity against human estrogen receptor positive MCF7 cells after 72 hrs | ChEMBL. | 17656092 |
IC50 (functional) | > 100 uM | Antiproliferative activity against human estrogen receptor negative SKBr3 cells over-expressing Her2 after 72 hrs | ChEMBL. | 17656092 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.