Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | retinoid X receptor, alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | Get druggable targets OG5_130073 | All targets in OG5_130073 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | Get druggable targets OG5_130073 | All targets in OG5_130073 |
Schistosoma mansoni | retinoic acid receptor RXR | Get druggable targets OG5_130073 | All targets in OG5_130073 |
Schistosoma japonicum | ko:K08524 nuclear receptor, subfamily 2, group B, member 1, putative | Get druggable targets OG5_130073 | All targets in OG5_130073 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | retinoid X receptor, alpha | 435 aa | 352 aa | 23.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | cyclin-dependent kinase 7 homolog | 0.0177 | 0.4486 | 0.4486 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0177 | 0.4486 | 0.4486 |
Onchocerca volvulus | 0.0009 | 0 | 0.5 | |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0123 | 0.3045 | 0.6788 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0009 | 0 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0177 | 0.4486 | 0.4486 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0384 | 1 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.0384 | 1 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 7 | 0.0177 | 0.4486 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0128 | 0.3174 | 0.7076 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0128 | 0.3174 | 0.3174 |
Echinococcus granulosus | cyclin dependent kinase 7 | 0.0177 | 0.4486 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK7 protein kinase | 0.0177 | 0.4486 | 0.4486 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.79 uM | Inhibition of 9-cis-retinoic acid-induced RXRalpha transactivation | ChEMBL. | 17651968 |
IC50 (binding) | = 0.79 uM | Inhibition of 9-cis-retinoic acid-induced RXRalpha transactivation | ChEMBL. | 17651968 |
IC50 (binding) | = 0.97 uM | Inhibition of LG100268-induced RXRalpha transactivation | ChEMBL. | 17651968 |
IC50 (binding) | = 0.97 uM | Inhibition of LG100268-induced RXRalpha transactivation | ChEMBL. | 17651968 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.