Detailed information for compound 431403

Basic information

Technical information
  • TDR Targets ID: 431403
  • Name: 6-(5-methoxypyridin-3-yl)-3,6-diazabicyclo[2. 2.1]heptane
  • MW: 205.256 | Formula: C11H15N3O
  • H donors: 1 H acceptors: 1 LogP: 0.55 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cncc(c1)N1CC2CC1CN2
  • InChi: 1S/C11H15N3O/c1-15-11-3-10(4-12-6-11)14-7-8-2-9(14)5-13-8/h3-4,6,8-9,13H,2,5,7H2,1H3
  • InChiKey: WTIVOXCWVQKFER-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-(5-methoxy-3-pyridyl)-3,6-diazabicyclo[2.2.1]heptane

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Starlite/ChEMBL References
Homo sapiens cholinergic receptor, nicotinic, alpha 4 (neuronal) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 Get druggable targets OG5_128160 All targets in OG5_128160
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit Get druggable targets OG5_128160 All targets in OG5_128160
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit Get druggable targets OG5_128160 All targets in OG5_128160
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128160 All targets in OG5_128160
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 Get druggable targets OG5_128160 All targets in OG5_128160
Onchocerca volvulus Putative nachr subunit Get druggable targets OG5_128160 All targets in OG5_128160
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit Get druggable targets OG5_128160 All targets in OG5_128160
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit Get druggable targets OG5_128160 All targets in OG5_128160
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative Get druggable targets OG5_128160 All targets in OG5_128160
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit Get druggable targets OG5_128160 All targets in OG5_128160
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus BC026374 protein S09 family 0.0022 0.0252 0.0252
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0239 0.0414
Mycobacterium ulcerans carboxylesterase, LipT 0.0022 0.0252 0.039
Schistosoma mansoni acetylcholine receptor subunit beta 0.0017 0.0134 0.0134
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0201 0.0065
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0017 0.0134 0.0178
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.1514 1
Onchocerca volvulus 0.0038 0.063 0.109
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0201 0.2587
Schistosoma mansoni hypothetical protein 0.0421 1 1
Brugia malayi CHD4 protein 0.0015 0.0083 0.0164
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0123 0.272 0.272
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0239 0.0239
Brugia malayi RNA, U transporter 1 0.0085 0.1798 0.3566
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0022 0.0239 0.0291
Loa Loa (eye worm) hypothetical protein 0.0074 0.1514 0.2005
Loa Loa (eye worm) hypothetical protein 0.0022 0.0239 0.0317
Echinococcus multilocularis tar DNA binding protein 0.0198 0.4555 0.4555
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0017 0.0134 0.0134
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0239 0.0291
Brugia malayi hypothetical protein 0.0017 0.0134 0.0266
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0239 0.0291
Loa Loa (eye worm) hypothetical protein 0.0017 0.0134 0.0178
Loa Loa (eye worm) hypothetical protein 0.0032 0.0502 0.0664
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0039 0.0067
Loa Loa (eye worm) hypothetical protein 0.0017 0.0134 0.0178
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0239 0.0291
Brugia malayi Carboxylesterase family protein 0.0022 0.0252 0.05
Loa Loa (eye worm) beta-lactamase 0.0038 0.0638 0.0845
Loa Loa (eye worm) hypothetical protein 0.0038 0.063 0.0834
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0017 0.0134 0.0134
Schistosoma mansoni tar DNA-binding protein 0.0198 0.4555 0.4555
Plasmodium vivax acyl-CoA synthetase, putative 0.0055 0.1058 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0615 0.0615
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.0239 0.1581
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.1514 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0239 0.0291
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0074 0.1514 1
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0239 0.0475
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0099 0.0099
Schistosoma mansoni acetylcholine receptor-related 0.0017 0.0134 0.0134
Brugia malayi Pre-SET motif family protein 0.0218 0.5043 1
Mycobacterium ulcerans acetyl-CoA synthetase 0.0022 0.0239 0.0291
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0239 0.0134
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0638 0.1105
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0038 0.063 0.063
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0638 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0638 0.0845
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0239 0.0134
Loa Loa (eye worm) hypothetical protein 0.0038 0.0638 0.0845
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0039 0.0067
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0638 0.0863
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0099 0.0099
Echinococcus granulosus cpg binding protein 0.0063 0.1247 0.1247
Loa Loa (eye worm) hypothetical protein 0.0055 0.1058 0.1401
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.1514 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0038 0.063 0.1249
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.0239 0.0134
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.1237 0.1237
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0205 0.0407
Brugia malayi Cation transporter family protein 0.0038 0.063 0.1249
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0074 0.1514 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0252 0.0334
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0055 0.1058 0.1629
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0153 0.0264
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0038 0.063 0.0834
Toxoplasma gondii histone lysine methyltransferase SET1 0.0114 0.2492 1
Mycobacterium ulcerans hypothetical protein 0.0038 0.0638 0.333
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0414 0.0717
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0022 0.0239 0.0291
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0638 0.333
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.1514 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0502 0.0502
Mycobacterium tuberculosis Carboxylesterase LipT 0.0022 0.0252 0.0158
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.063 0.1249
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0017 0.0134 0.0266
Toxoplasma gondii ABC1 family protein 0.0038 0.0638 0.2561
Onchocerca volvulus 0.0017 0.0134 0.0232
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0099 0.0099
Brugia malayi Carboxylesterase family protein 0.0022 0.0252 0.05
Loa Loa (eye worm) oxidoreductase 0.0022 0.0239 0.0317
Loa Loa (eye worm) hypothetical protein 0.0022 0.0252 0.0334
Onchocerca volvulus 0.0038 0.063 0.109
Loa Loa (eye worm) TAR-binding protein 0.0198 0.4555 0.6032
Loa Loa (eye worm) hypothetical protein 0.0017 0.0134 0.0178
Schistosoma mansoni tar DNA-binding protein 0.0198 0.4555 0.4555
Schistosoma mansoni hypothetical protein 0.0049 0.0911 0.0911
Onchocerca volvulus 0.0022 0.0239 0.0414
Echinococcus granulosus tar DNA binding protein 0.0198 0.4555 0.4555
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0638 0.0863
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0131 0.2922 0.2922
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0239 0.0291
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0083 0.0083
Brugia malayi AMP-binding enzyme family protein 0.0074 0.1514 0.3002
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0704 0.1218
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.063 0.1249
Schistosoma mansoni cpg binding protein 0.0063 0.1247 0.1247
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.0239 0.0134
Loa Loa (eye worm) hypothetical protein 0.002 0.0205 0.0272
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0205 0.0407
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0074 0.1514 1
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0017 0.0134 0.0134
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.1514 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0329 0.057
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0022 0.0239 0.096
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0201 0.0201
Entamoeba histolytica hypothetical protein 0.0037 0.0615 0.406
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.1237 0.1237
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0911 0.1207
Loa Loa (eye worm) hypothetical protein 0.0038 0.063 0.0834
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0177 0.0306
Loa Loa (eye worm) hypothetical protein 0.0017 0.0134 0.0178
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.1994 0.1994
Onchocerca volvulus 0.0038 0.063 0.109
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0083 0.0083
Onchocerca volvulus 0.002 0.0205 0.0355
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0022 0.0239 0.0291
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0038 0.063 0.063
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.063 0.1249
Echinococcus granulosus acetylcholinesterase 0.0131 0.2922 0.2922
Loa Loa (eye worm) hypothetical protein 0.0038 0.0638 0.0845
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0039 0.0067
Echinococcus multilocularis nAChR subunit 0.002 0.0205 0.0205
Loa Loa (eye worm) hypothetical protein 0.002 0.0201 0.0266
Echinococcus multilocularis importin subunit beta 1 0.003 0.0444 0.0444
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0239 0.0475
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0329 0.057
Onchocerca volvulus 0.0059 0.1164 0.2013
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0017 0.0134 0.0266
Loa Loa (eye worm) hypothetical protein 0.0131 0.2922 0.387
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.0239 0.3235
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0239 0.0317
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0187 0.0187
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0502 0.2013
Onchocerca volvulus 0.0248 0.5781 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0239 0.0317
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.063 0.1249
Echinococcus granulosus glycine receptor subunit alpha 1 0.0038 0.063 0.063
Loa Loa (eye worm) hypothetical protein 0.0038 0.063 0.0834
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0123 0.272 0.272
Onchocerca volvulus 0.0044 0.0792 0.137
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0638 0.1105
Schistosoma mansoni hypothetical protein 0.0049 0.0911 0.0911
Schistosoma mansoni chromobox protein 0.0073 0.1484 0.1484
Brugia malayi RNA recognition motif domain containing protein 0.0198 0.4555 0.9032
Onchocerca volvulus 0.002 0.0205 0.0355
Schistosoma mansoni BC026374 protein (S09 family) 0.0022 0.0252 0.0252
Loa Loa (eye worm) GABA receptor subunit 0.002 0.0205 0.0272
Brugia malayi Carboxylesterase family protein 0.0022 0.0252 0.05
Loa Loa (eye worm) hypothetical protein 0.0074 0.1514 0.2005
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.0239 0.0134
Schistosoma mansoni nAChR subunit 0.0038 0.063 0.063
Onchocerca volvulus 0.0038 0.0638 0.1104
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0155 0.3508 0.6957
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0305 0.2379
Trichomonas vaginalis esterase, putative 0.0038 0.0638 0.1105
Schistosoma mansoni neurotransmitter gated ion channel 0.002 0.0205 0.0205
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0638 0.1266
Loa Loa (eye worm) hypothetical protein 0.0123 0.272 0.3603
Brugia malayi CXXC zinc finger family protein 0.0059 0.1164 0.2307
Loa Loa (eye worm) glutamate receptor 0.0014 0.0055 0.0073
Mycobacterium tuberculosis Conserved protein 0.0038 0.0638 0.0863
Loa Loa (eye worm) hypothetical protein 0.0017 0.0134 0.0178
Loa Loa (eye worm) hypothetical protein 0.0041 0.0704 0.0933
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0329 0.057
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.1514 1
Schistosoma mansoni nAChR subunit 0.0017 0.0134 0.0134
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.1514 1
Echinococcus multilocularis glycine receptor subunit beta 0.0038 0.063 0.063
Loa Loa (eye worm) hypothetical protein 0.0017 0.0134 0.0178
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0038 0.063 0.1249
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0239 0.0874
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0008
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0022 0.0252 0.0252
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0123 0.272 0.272
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.1994 0.1994
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.1484 0.1966
Mycobacterium ulcerans lipase LipD 0.0038 0.0638 0.333
Brugia malayi beta-lactamase family protein 0.0038 0.0638 0.1266
Onchocerca volvulus 0.0074 0.1514 0.2619
Schistosoma mansoni nAChR subunit 0.0038 0.063 0.063
Onchocerca volvulus 0.0032 0.0489 0.0847
Brugia malayi AMP-binding enzyme family protein 0.0074 0.1514 0.3002
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0638 1
Onchocerca volvulus 0.0022 0.0252 0.0436
Echinococcus granulosus para nitrobenzyl esterase 0.0022 0.0252 0.0252
Schistosoma mansoni importin beta-1 0.003 0.0444 0.0444
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0239 0.0291
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0055 0.1058 0.6525
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0252 0.0252
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0414 0.0717
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0022 0.0252 0.0437
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0039 0.0067
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.063 0.063
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0177 0.0306
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0074 0.1514 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0134 0.0178
Brugia malayi Carboxylesterase family protein 0.0022 0.0252 0.05
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0201 0.0266
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0444 0.6706
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.1994 0.1994
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.063 0.1249
Entamoeba histolytica hypothetical protein 0.002 0.0205 0.1357
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.0239 0.2263
Loa Loa (eye worm) hypothetical protein 0.0038 0.063 0.0834
Schistosoma mansoni hypothetical protein 0.0037 0.0615 0.0615
Echinococcus granulosus chromobox protein 1 0.0073 0.1484 0.1484
Loa Loa (eye worm) hypothetical protein 0.002 0.0205 0.0272
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0638 0.0863
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.1514 0.2462
Trichomonas vaginalis chromobox protein, putative 0.0044 0.078 0.135
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.5043 0.6679
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0022 0.0252 0.0158
Loa Loa (eye worm) hypothetical protein 0.0038 0.063 0.0834
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0074 0.1514 0.2462
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0201 0.0399
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0638 0.0638
Echinococcus granulosus nAChR subunit 0.002 0.0205 0.0205
Loa Loa (eye worm) RNA binding protein 0.0198 0.4555 0.6032
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0123 0.272 0.272
Brugia malayi AMP-binding enzyme family protein 0.0074 0.1514 0.3002
Echinococcus multilocularis snurportin 1 0.0321 0.7551 0.7551
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0038 0.063 0.063
Echinococcus multilocularis nAChR subunit 0.0038 0.063 0.063
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0198 0.4555 0.6032
Onchocerca volvulus 0.0022 0.0239 0.0414
Echinococcus multilocularis chromobox protein 1 0.0073 0.1484 0.1484
Loa Loa (eye worm) carboxylesterase 0.0022 0.0252 0.0334
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0638 0.0863
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0638 0.0863
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.0239 0.0134
Loa Loa (eye worm) hypothetical protein 0.0017 0.0134 0.0178
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0038 0.063 0.063
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.1514 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1994 0.1994
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.1514 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0055 0.1058 0.5
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0022 0.0239 0.0291
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.063 0.063
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.063 0.1249
Loa Loa (eye worm) hypothetical protein 0.0017 0.0134 0.0178
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0201 0.0201
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0027 0.0367 0.0367
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0638 0.0863
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0321 0.7551 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0201 0.2587
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0038 0.063 0.0834
Loa Loa (eye worm) hypothetical protein 0.002 0.0205 0.0272
Echinococcus granulosus chromobox protein 1 0.0073 0.1484 0.1484
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0239 0.0475
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0201 0.2587
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.002 0.0205 0.0407
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0638 0.313
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0155 0.3508 0.4646
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0239 0.0874
Brugia malayi Cation transporter family protein 0.0038 0.063 0.1249
Mycobacterium tuberculosis Conserved protein 0.0038 0.0638 0.0863
Schistosoma mansoni nAChR subunit 0.0038 0.063 0.063
Trypanosoma brucei unspecified product 0.002 0.0201 0.2587
Echinococcus granulosus carboxylesterase 5A 0.0131 0.2922 0.2922
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0038 0.063 0.063
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0017 0.0134 0.0134
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.1237 0.4964
Toxoplasma gondii propionate-CoA ligase 0.0022 0.0239 0.096
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0039 0.0067
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1237 0.7891
Echinococcus multilocularis neuroligin 0.0022 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0074 0.1514 0.2005
Schistosoma mansoni acetylcholinesterase 0.0022 0.0252 0.0252
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0911 0.0911
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0615 0.0615
Loa Loa (eye worm) acetylcholinesterase 1 0.0131 0.2922 0.387
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0201 0.0348
Loa Loa (eye worm) carboxylesterase 0.0022 0.0252 0.0334
Schistosoma mansoni cpg binding protein 0.0059 0.1164 0.1164
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.1237 0.1956
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0329 0.057
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.063 0.1249
Brugia malayi hypothetical protein 0.0037 0.0615 0.1219
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0038 0.063 0.1249
Echinococcus multilocularis GPCR, family 2 0.0049 0.0911 0.0911
Loa Loa (eye worm) hypothetical protein 0.0038 0.063 0.0834
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0502 0.0502
Echinococcus granulosus glycine receptor subunit alpha 1 0.0038 0.063 0.063
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0444 0.1782
Loa Loa (eye worm) hypothetical protein 0.0038 0.063 0.0834
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0014 0.0055 0.0073
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0239 0.0291
Schistosoma mansoni nAChR subunit 0.0038 0.063 0.063
Schistosoma mansoni metabotropic glutamate receptor 0.0027 0.0367 0.0367
Brugia malayi hypothetical protein 0.0017 0.0134 0.0266
Echinococcus multilocularis dnaJ subfamily B 0.0421 1 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.1164 0.1541
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0638 0.0863
Loa Loa (eye worm) hypothetical protein 0.0022 0.0252 0.0334
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0201 0.0348
Brugia malayi Receptor family ligand binding region containing protein 0.0014 0.0055 0.011
Loa Loa (eye worm) hypothetical protein 0.0038 0.0638 0.0845
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1994 0.1994
Brugia malayi hypothetical protein 0.0017 0.0134 0.0266
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0638 1
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0911 0.1807
Loa Loa (eye worm) hypothetical protein 0.002 0.0205 0.0272
Onchocerca volvulus 0.0038 0.0638 0.1104
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0239 0.0291
Loa Loa (eye worm) hypothetical protein 0.0032 0.0489 0.0648
Schistosoma mansoni nAChR subunit 0.0038 0.063 0.063
Schistosoma mansoni tar DNA-binding protein 0.0198 0.4555 0.4555
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0038 0.063 0.0834
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0329 0.057
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0239 0.0874
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0638 0.1105
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0704 0.122
Loa Loa (eye worm) hypothetical protein 0.0038 0.063 0.0834
Mycobacterium leprae Probable lipase LipE 0.0038 0.0638 0.313
Brugia malayi metabotropic glutamate receptor type 2 0.0027 0.0367 0.0728
Brugia malayi TAR-binding protein 0.0198 0.4555 0.9032
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0911 0.0911
Onchocerca volvulus 0.0022 0.0252 0.0436
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.1237 0.7891
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0239 0.3235
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0201 0.2587
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0099 0.0099
Brugia malayi Cation transporter family protein 0.0038 0.063 0.1249
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0039 0.0067
Entamoeba histolytica hypothetical protein 0.0037 0.0615 0.406
Brugia malayi Importin beta-1 subunit 0.003 0.0444 0.0881
Echinococcus multilocularis acetylcholinesterase 0.0131 0.2922 0.2922
Loa Loa (eye worm) hypothetical protein 0.002 0.0205 0.0272
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0038 0.063 0.0834
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0038 0.063 0.1249
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0123 0.272 0.272
Onchocerca volvulus 0.0038 0.063 0.109
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.0239 0.0134
Schistosoma mansoni chromobox protein 0.0073 0.1484 0.1484
Entamoeba histolytica acyl-coA synthetase, putative 0.0074 0.1514 1
Onchocerca volvulus Putative nachr subunit 0.0123 0.272 0.4706
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0038 0.063 0.063
Loa Loa (eye worm) hypothetical protein 0.0038 0.0638 0.0845
Loa Loa (eye worm) hypothetical protein 0.003 0.0444 0.0588
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0201 0.0201
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0201 0.1328
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0704 0.122
Trichomonas vaginalis chromobox protein, putative 0.0044 0.078 0.135
Loa Loa (eye worm) hypothetical protein 0.0027 0.0367 0.0486
Echinococcus multilocularis chromobox protein 1 0.0073 0.1484 0.1484
Trichomonas vaginalis set domain proteins, putative 0.0248 0.5775 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0017 0.0134 0.0134
Entamoeba histolytica hypothetical protein 0.0024 0.0305 0.2015
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0911 0.0911
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0502 0.0502
Brugia malayi excitatory GABA receptor EXP-1A 0.0038 0.063 0.1249
Onchocerca volvulus 0.0022 0.0252 0.0436
Plasmodium falciparum importin beta, putative 0.003 0.0444 0.4197
Brugia malayi Heterochromatin protein 1 0.0073 0.1484 0.2943
Loa Loa (eye worm) hypothetical protein 0.0049 0.0911 0.1207
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0099 0.0099
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0239 0.0291
Schistosoma mansoni neuroligin 3 (S09 family) 0.0022 0.0252 0.0252
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0638 0.0638
Onchocerca volvulus 0.0022 0.0252 0.0436
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0022 0.0252 0.0158
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.1994 0.1994
Loa Loa (eye worm) hypothetical protein 0.0022 0.0252 0.0334
Echinococcus multilocularis dna polymerase kappa 0.002 0.0201 0.0201
Echinococcus granulosus dna polymerase kappa 0.002 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0017 0.0134 0.0178
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0239 0.0291
Loa Loa (eye worm) hypothetical protein 0.0017 0.0134 0.0178
Echinococcus multilocularis cpg binding protein 0.0063 0.1247 0.1247
Loa Loa (eye worm) LGC-31 protein 0.0038 0.063 0.0834
Brugia malayi Calcitonin receptor-like protein seb-1 0.0155 0.3508 0.6957
Trichomonas vaginalis spcc417.12 protein, putative 0.0022 0.0252 0.0437
Brugia malayi beta-lactamase family protein 0.0038 0.0638 0.1266
Loa Loa (eye worm) acetylcholine receptor protein 0.0017 0.0134 0.0178
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0017 0.0134 0.0266
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.2306 0.4573
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.0239 0.2263
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0792 0.0792
Loa Loa (eye worm) hypothetical protein 0.0038 0.0638 0.0845
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0201 0.2587
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0038 0.063 0.0834
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0305 0.0528
Echinococcus multilocularis acetylcholinesterase 0.0131 0.2922 0.2922
Loa Loa (eye worm) hypothetical protein 0.0038 0.063 0.0834
Echinococcus multilocularis glycine receptor subunit beta 0.0038 0.063 0.063
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0239 0.0475
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0038 0.063 0.063
Plasmodium vivax SET domain protein, putative 0.0032 0.0502 0.4743
Brugia malayi hypothetical protein 0.0017 0.0134 0.0266
Loa Loa (eye worm) hypothetical protein 0.002 0.0205 0.0272
Echinococcus granulosus snurportin 1 0.0321 0.7551 0.7551
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.2822 0.2822
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0638 0.1105
Loa Loa (eye worm) ACC-1 protein 0.0038 0.063 0.0834
Plasmodium falciparum acyl-CoA synthetase 0.0055 0.1058 1
Trichomonas vaginalis helicase, putative 0.0013 0.0039 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0201 0.2587
Schistosoma mansoni nAChR subunit 0.0038 0.063 0.063
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.1994 0.3954
Brugia malayi hypothetical protein 0.0017 0.0134 0.0266
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0038 0.063 0.1249
Loa Loa (eye worm) hypothetical protein 0.0014 0.0055 0.0073
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.063 0.1249
Schistosoma mansoni neurotransmitter gated ion channel 0.0017 0.0134 0.0134
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0083 0.011
Entamoeba histolytica hypothetical protein 0.0037 0.0615 0.406
Schistosoma mansoni hypothetical protein 0.0106 0.2306 0.2306
Schistosoma mansoni gliotactin 0.0022 0.0252 0.0252
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0038 0.063 0.063
Trichomonas vaginalis chromobox protein, putative 0.0073 0.1484 0.257
Loa Loa (eye worm) hypothetical protein 0.0038 0.063 0.0834
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0502 0.0502
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0329 0.057
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0252 0.0252
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0638 0.6034
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0022 0.0239 0.0291
Brugia malayi SET domain containing protein 0.0014 0.006 0.0118
Plasmodium vivax importin-beta 2, putative 0.003 0.0444 0.4197
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0911 0.0911
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0984 0.1494
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0239 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0039 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0039 0.0067
Brugia malayi chromobox protein homolog 3 0.0041 0.0704 0.1397
Echinococcus granulosus importin subunit beta 1 0.003 0.0444 0.0444
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0038 0.063 0.0834
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0017 0.0134 0.0134
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1237 0.7891
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0239 0.0134
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0123 0.272 0.272
Loa Loa (eye worm) ACC-1 protein 0.0038 0.063 0.0834
Echinococcus granulosus glycine receptor subunit beta 0.0038 0.063 0.063
Loa Loa (eye worm) hypothetical protein 0.0055 0.1058 0.1401
Loa Loa (eye worm) hypothetical protein 0.0017 0.0134 0.0178
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0239 0.0291
Schistosoma mansoni tar DNA-binding protein 0.0198 0.4555 0.4555
Loa Loa (eye worm) hypothetical protein 0.002 0.0205 0.0272
Loa Loa (eye worm) histone methyltransferase 0.002 0.0187 0.0248
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0017 0.0134 0.0266
Loa Loa (eye worm) hypothetical protein 0.0106 0.2306 0.3054
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0201 0.2587
Echinococcus multilocularis dna polymerase eta 0.002 0.0201 0.0201
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0329 0.057
Loa Loa (eye worm) hypothetical protein 0.0038 0.063 0.0834
Echinococcus multilocularis BC026374 protein (S09 family) 0.0022 0.0252 0.0252
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0038 0.063 0.063
Echinococcus granulosus GPCR family 2 0.0049 0.0911 0.0911
Schistosoma mansoni nAChR subunit 0.0017 0.0134 0.0134
Giardia lamblia DINP protein human, muc B family 0.002 0.0201 0.5
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0239 0.0475
Loa Loa (eye worm) hypothetical protein 0.0038 0.063 0.0834
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0083 0.0083
Schistosoma mansoni nAChR subunit 0.0038 0.063 0.063
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0022 0.0239 0.096
Onchocerca volvulus 0.0017 0.0134 0.0232
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0017 0.0134 0.0266
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0038 0.063 0.063
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0014 0.0055 0.0073
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0305 0.0528
Onchocerca volvulus 0.0012 0.00000015231 0.00000026346
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0022 0.0239 0.0134
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0123 0.272 0.5395
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0201 0.2587
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0022 0.0239 0.0291
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0638 0.0638
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0243 0.5643 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.0239 0.0134
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1994 0.1994
Echinococcus multilocularis Chromobox protein 3 0.0012 0.00000015231 0.00000015231
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0201 0.2587
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0017 0.0134 0.0178
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0022 0.024 0.024
Schistosoma mansoni hypothetical protein 0.0321 0.7551 0.7551
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0201 0.2587
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0123 0.272 0.3603
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0038 0.063 0.1249
Echinococcus multilocularis para nitrobenzyl esterase 0.0022 0.0252 0.0252
Echinococcus multilocularis carboxylesterase 5A 0.0131 0.2922 0.2922
Onchocerca volvulus 0.0017 0.0134 0.0232
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0201 0.2587
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0911 0.1807
Leishmania major hypothetical protein, conserved 0.0038 0.0638 0.333
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.002 0.0205 0.0407
Echinococcus granulosus neuroligin 0.0022 0.0252 0.0252
Echinococcus granulosus glycine receptor subunit beta 0.0038 0.063 0.063
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0638 0.333
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0201 0.2587
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0239 0.0874
Loa Loa (eye worm) hypothetical protein 0.0038 0.063 0.0834
Loa Loa (eye worm) carboxylesterase 0.0131 0.2922 0.387
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0239 0.0317
Mycobacterium ulcerans beta-lactamase 0.0038 0.0638 0.333
Brugia malayi Carboxylesterase family protein 0.0131 0.2922 0.5795
Schistosoma mansoni hypothetical protein 0.0049 0.0911 0.0911
Loa Loa (eye worm) hypothetical protein 0.002 0.0205 0.0272
Onchocerca volvulus 0.0022 0.0252 0.0436
Loa Loa (eye worm) hypothetical protein 0.0038 0.063 0.0834
Echinococcus granulosus metabotropic glutamate receptor 5 0.0027 0.0367 0.0367
Schistosoma mansoni cpg binding protein 0.0063 0.1247 0.1247
Echinococcus granulosus dna polymerase eta 0.002 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0022 0.0252 0.0334
Loa Loa (eye worm) hypothetical protein 0.0155 0.3508 0.4646
Echinococcus granulosus Chromobox protein 3 0.0012 0.00000015231 0.00000015231
Onchocerca volvulus 0.0038 0.063 0.109
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0022 0.0239 0.0291
Onchocerca volvulus 0.0038 0.063 0.109
Onchocerca volvulus 0.0022 0.0239 0.0414
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0638 0.1105
Onchocerca volvulus 0.0038 0.0638 0.1104
Schistosoma mansoni hypothetical protein 0.0049 0.0911 0.0911
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0239 0.0475
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0502 0.0502
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0039 0.0067
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0444 0.6706
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0239 0.0414
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0038 0.063 0.063
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0201 0.0399
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0442 0.0442
Trichomonas vaginalis chromobox protein, putative 0.0073 0.1484 0.257
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1237 0.7891
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.078 0.1349
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.063 0.1249
Brugia malayi beta-lactamase 0.0038 0.0638 0.1266
Leishmania major importin beta-1 subunit, putative 0.0024 0.0305 0.0792
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0329 0.057
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.1514 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.1237 0.1237
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0038 0.063 0.063
Loa Loa (eye worm) hypothetical protein 0.0131 0.2922 0.387
Brugia malayi Carboxylesterase family protein 0.0131 0.2922 0.5795
Loa Loa (eye worm) hypothetical protein 0.0055 0.1058 0.1401
Loa Loa (eye worm) hypothetical protein 0.0055 0.1058 0.1401
Brugia malayi Metabotropic glutamate receptor precursor. 0.0014 0.0055 0.011
Loa Loa (eye worm) hypothetical protein 0.0055 0.1058 0.1401
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0305 0.0528
Echinococcus granulosus acetylcholinesterase 0.0131 0.2922 0.2922
Entamoeba histolytica hypothetical protein 0.0037 0.0615 0.406
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.063 0.063
Echinococcus granulosus nAChR subunit 0.0038 0.063 0.063
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0638 0.0638
Loa Loa (eye worm) hypothetical protein 0.0038 0.063 0.0834
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0984 0.1494
Mycobacterium ulcerans hypothetical protein 0.0074 0.1514 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0038 0.063 0.063
Loa Loa (eye worm) hypothetical protein 0.0022 0.0252 0.0334
Onchocerca volvulus 0.0022 0.0239 0.0414
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0201 0.0065
Echinococcus granulosus glycine receptor subunit alpha 1 0.0038 0.063 0.063
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0187 0.0187
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0201 0.2587
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0502 0.0502
Mycobacterium tuberculosis Conserved protein 0.0038 0.0638 0.0863
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0182 0.036
Brugia malayi Pre-SET motif family protein 0.0032 0.0502 0.0995
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0022 0.0252 0.0252
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0638 0.0845
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.0239 0.0239
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0615 0.0615
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.1994 0.2641
Loa Loa (eye worm) hypothetical protein 0.002 0.0205 0.0272
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0017 0.0134 0.0178
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0038 0.063 0.063
Schistosoma mansoni tar DNA-binding protein 0.0198 0.4555 0.4555
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0239 0.0291
Loa Loa (eye worm) glutamate receptor 0.0022 0.024 0.0318
Brugia malayi hypothetical protein 0.0012 0.0006 0.0012
Brugia malayi hypothetical protein 0.0022 0.0252 0.05
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0205 0.0205
Loa Loa (eye worm) hypothetical protein 0.0017 0.0134 0.0178
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0984 0.1494
Loa Loa (eye worm) hypothetical protein 0.0017 0.0134 0.0178
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0201 0.2587
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0038 0.063 0.063
Loa Loa (eye worm) hypothetical protein 0.0038 0.063 0.0834
Loa Loa (eye worm) hypothetical protein 0.0022 0.0252 0.0334
Schistosoma mansoni DNA polymerase eta 0.002 0.0201 0.0201
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0984 0.1494
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.002 0.0205 0.0205
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.1237 0.1237
Brugia malayi RNA binding protein 0.0198 0.4555 0.9032
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.0239 0.0239
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0017 0.0134 0.0266
Loa Loa (eye worm) hypothetical protein 0.0038 0.063 0.0834

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = -5.24 Agonist activity at alpha4beta2 in IMR-32cells assessed as calcium influx by FLIPR assay ChEMBL. 17585748
EC50 (functional) = -4.52 Agonist activity at alpha4beta2 in IMR-32cells assessed as calcium influx by FLIPR assay ChEMBL. 17585748
EC50 (functional) = 20 nM Agonist activity at rat striatal tissue assessed as dopamine release ChEMBL. 17585748
EC50 (functional) = 81 nM Agonist activity at rat striatal tissue assessed as dopamine release ChEMBL. 17585748
EC50 (functional) = 5.7 uM Agonist activity at alpha4beta2 in IMR-32cells assessed as calcium influx by FLIPR assay ChEMBL. 17585748
EC50 (functional) = 5.7 uM Agonist activity at alpha4beta2 in IMR-32cells assessed as calcium influx by FLIPR assay ChEMBL. 17585748
EC50 (functional) = 30 uM Agonist activity at alpha4beta2 in IMR-32cells assessed as calcium influx by FLIPR assay ChEMBL. 17585748
EC50 (functional) = 30 uM Agonist activity at alpha4beta2 in IMR-32cells assessed as calcium influx by FLIPR assay ChEMBL. 17585748
Ki (binding) = -9.9 Displacement of [3H]cytisine from alpha4beta2 in rat cerebral cortical membrane ChEMBL. 17585748
Ki (binding) = -9.28 Displacement of [3H]cytisine from alpha4beta2 in rat cerebral cortical membrane ChEMBL. 17585748
Ki (binding) = 0.12 nM Displacement of [3H]cytisine from alpha4beta2 in rat cerebral cortical membrane ChEMBL. 17585748
Ki (binding) = 0.12 nM Displacement of [3H]cytisine from alpha4beta2 in rat cerebral cortical membrane ChEMBL. 17585748
Ki (binding) = 0.53 nM Displacement of [3H]cytisine from alpha4beta2 in rat cerebral cortical membrane ChEMBL. 17585748
Ki (binding) = 0.53 nM Displacement of [3H]cytisine from alpha4beta2 in rat cerebral cortical membrane ChEMBL. 17585748
Log EC50 (functional) = 4.52 Agonist activity at alpha4beta2 in IMR-32cells assessed as calcium influx by FLIPR assay ChEMBL. 17585748
Log EC50 (functional) = 5.24 Agonist activity at alpha4beta2 in IMR-32cells assessed as calcium influx by FLIPR assay ChEMBL. 17585748
Log EC50 (functional) = 7.09 Agonist activity at rat striatal tissue assessed as dopamine release ChEMBL. 17585748
Log EC50 (functional) = 7.7 Agonist activity at rat striatal tissue assessed as dopamine release ChEMBL. 17585748
Log Ki (binding) = 9.28 Displacement of [3H]cytisine from alpha4beta2 in rat cerebral cortical membrane ChEMBL. 17585748
Log Ki (binding) = 9.9 Displacement of [3H]cytisine from alpha4beta2 in rat cerebral cortical membrane ChEMBL. 17585748

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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