Detailed information for compound 431640

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 385.358 | Formula: C21H15F4N3
  • H donors: 0 H acceptors: 2 LogP: 4.61 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(c1F)c1nc2c(n1)cn(cc2)Cc1ccc(cc1)C(F)(F)F
  • InChi: 1S/C21H15F4N3/c1-13-3-2-4-16(19(13)22)20-26-17-9-10-28(12-18(17)27-20)11-14-5-7-15(8-6-14)21(23,24)25/h2-10,12H,11H2,1H3
  • InChiKey: FWGNPKRFTSINNY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0145 0.0475
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.0243 0.0269
Loa Loa (eye worm) hypothetical protein 0.0023 0.002 0.0029
Schistosoma mansoni chromobox protein 0.0095 0.0799 0.1051
Echinococcus granulosus zinc finger protein 0.0023 0.0024 0.0033
Brugia malayi Nuclear hormone receptor-like 1 0.0584 0.6079 0.6738
Trypanosoma brucei unspecified product 0.0023 0.002 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0243 0.0833
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0578 0.6016 0.7912
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0024 0.0031 0.0034
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0077 0.0609 0.0675
Schistosoma mansoni hypothetical protein 0.0056 0.0385 0.0506
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0034 0.0147 0.198
Toxoplasma gondii 6-phosphofructokinase 0.0034 0.0147 0.198
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0273 0.272 0.272
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0029 0.0095 0.0134
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0405 0.0449
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.0373 0.2895
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.002 0.0176
Brugia malayi SET domain containing protein 0.0028 0.0078 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0578 0.6016 0.6668
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0027 0.0064 0.0071
Mycobacterium tuberculosis Conserved hypothetical protein 0.0024 0.0031 0.0241
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0014 0.0032
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0064 0.0445
Echinococcus multilocularis Chromo domain 0.0027 0.0064 0.0064
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0014 0.0032
Schistosoma mansoni hypothetical protein 0.0198 0.1913 0.2516
Giardia lamblia GTOR 0.0052 0.0343 0.8129
Echinococcus granulosus chromobox protein 1 0.0095 0.0799 0.1101
Loa Loa (eye worm) hypothetical protein 0.0273 0.272 0.3853
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0117 0.013
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0147 0.0484
Loa Loa (eye worm) hypothetical protein 0.0048 0.0291 0.0412
Brugia malayi nuclear receptor NHR-67 0.0273 0.272 0.3015
Mycobacterium ulcerans hypothetical protein 0.0029 0.0086 0.0748
Echinococcus granulosus intermediate filament protein 0.0032 0.0117 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0343 0.1198
Brugia malayi ecdysteroid receptor 0.0578 0.6016 0.6668
Brugia malayi Bromodomain containing protein 0.0037 0.0174 0.0193
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0115 0.0369
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0578 0.6016 0.6668
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0153 0.0202
Toxoplasma gondii target of rapamycin (TOR), putative 0.0039 0.0198 0.2668
Plasmodium falciparum phd finger protein, putative 0.0034 0.0144 0.1789
Brugia malayi chromobox protein homolog 3 0.0059 0.0413 0.0458
Brugia malayi Steroid receptor seven-up type 2 0.0578 0.6016 0.6668
Loa Loa (eye worm) glutathione reductase 0.0055 0.0373 0.0528
Echinococcus multilocularis chromobox protein 1 0.0095 0.0799 0.0799
Echinococcus multilocularis nuclear receptor nhr 48 0.0273 0.272 0.272
Loa Loa (eye worm) hypothetical protein 0.0578 0.6016 0.8522
Onchocerca volvulus 0.0036 0.0163 0.022
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.0243 0.0243
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0019 0.0024
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.009 0.0743 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.006 0.0419 0.0949
Entamoeba histolytica hypothetical protein 0.0027 0.0064 0.0445
Loa Loa (eye worm) hypothetical protein 0.0305 0.3073 0.4353
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0034 0.0144 0.019
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0243 0.0243
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.002 0.0176
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0147 0.0484
Echinococcus granulosus Chromo domain 0.0027 0.0064 0.0089
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0273 0.272 0.4493
Brugia malayi Pre-SET motif family protein 0.0243 0.2401 0.2661
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0207 0.0229
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.023 0.0317
Echinococcus multilocularis dna polymerase kappa 0.0023 0.002 0.002
Trypanosoma brucei hypothetical protein, conserved 0.0249 0.2459 0.5564
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.009 0.0743 0.5768
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0198 0.067
Onchocerca volvulus 0.0273 0.272 0.4493
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0052 0.0343 0.0777
Brugia malayi Associated with TFs and helicases family protein 0.0027 0.0064 0.0071
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0061 0.0084
Schistosoma mansoni zinc finger protein 0.0023 0.0024 0.0031
Entamoeba histolytica hypothetical protein 0.0042 0.023 0.191
Brugia malayi nuclear hormone receptor 0.0578 0.6016 0.6668
Echinococcus multilocularis zinc finger protein 0.0023 0.0024 0.0024
Schistosoma mansoni rab6-interacting 0.0069 0.0523 0.0687
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.0019 0.0026
Loa Loa (eye worm) hypothetical protein 0.005 0.0315 0.0446
Brugia malayi steroid hormone receptor 0.0578 0.6016 0.6668
Echinococcus multilocularis PHD finger protein rhinoceros 0.0034 0.0144 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0064 0.0183
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0027 0.0064 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0082 0.0249
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0144 0.1789
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0126 0.0406
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0052 0.0343 0.0343
Echinococcus multilocularis thyroid hormone receptor alpha 0.0725 0.7603 0.7603
Entamoeba histolytica hypothetical protein 0.0027 0.0064 0.0445
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.002 0.0046
Loa Loa (eye worm) hypothetical protein 0.022 0.215 0.3045
Brugia malayi hypothetical protein 0.0273 0.272 0.3015
Schistosoma mansoni hypothetical protein 0.0147 0.1364 0.1794
Echinococcus granulosus nuclear receptor nhr 48 0.0273 0.272 0.3747
Echinococcus multilocularis FTZ F1 alpha 0.0578 0.6016 0.6016
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0243 0.2401 0.3401
Giardia lamblia DINP protein human, muc B family 0.0023 0.002 0.0153
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.0373 0.0514
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0228 0.0777
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.002 0.0157
Schistosoma mansoni hypothetical protein 0.0042 0.023 0.0303
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0536 0.0759
Schistosoma mansoni aryl hydrocarbon receptor 0.0057 0.039 0.0513
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0413 0.1451
Echinococcus granulosus neuropeptide s receptor 0.0551 0.5727 0.7889
Onchocerca volvulus 0.0277 0.2765 0.4568
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0105 0.091 0.091
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0578 0.6016 0.6016
Loa Loa (eye worm) hypothetical protein 0.0578 0.6016 0.8522
Echinococcus granulosus Nuclear hormone receptor HR96 0.0273 0.272 0.3747
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0273 0.272 0.3015
Loa Loa (eye worm) nuclear receptor NHR-67 0.0273 0.272 0.3853
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0095 0.1274
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0027 0.0064 0.0867
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0405 0.0574
Loa Loa (eye worm) runx1 0.0065 0.0477 0.0676
Loa Loa (eye worm) hypothetical protein 0.0578 0.6016 0.8522
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.0019 0.0021
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.053 0.073
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.0243 0.032
Onchocerca volvulus 0.0069 0.0523 0.0821
Trichomonas vaginalis chromobox protein, putative 0.0027 0.0064 0.0183
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0042 0.0228 0.0516
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0014 0.0109
Echinococcus granulosus mitogen activated protein kinase 0.006 0.0419 0.0578
Trypanosoma cruzi C-8 sterol isomerase, putative 0.043 0.4419 1
Echinococcus granulosus survival motor neuron protein 1 0.0276 0.2758 0.38
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0019 0.0021
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0019 0.0026
Loa Loa (eye worm) hypothetical protein 0.0273 0.272 0.3853
Echinococcus granulosus nuclear factor of activated T cells 5 0.0086 0.0705 0.0972
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0578 0.6016 0.8522
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0083 0.025
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0064 0.0183
Brugia malayi hypothetical protein 0.0132 0.1199 0.1329
Schistosoma mansoni DNA polymerase eta 0.0023 0.002 0.0027
Brugia malayi Bromodomain containing protein 0.0045 0.026 0.0288
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0126 0.1137 0.8822
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0243 0.2017
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.0019 0.0026
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0026
Schistosoma mansoni 6-phosphofructokinase 0.0127 0.1147 0.1509
Leishmania major ATP-dependent phosphofructokinase 0.0127 0.1147 0.2596
Loa Loa (eye worm) hypothetical protein 0.0273 0.272 0.3853
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0419 0.1474
Echinococcus granulosus jumonji domain containing protein 0.0047 0.0288 0.0397
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0419 0.1474
Leishmania major hypothetical protein, conserved 0.0029 0.0095 0.0214
Trypanosoma cruzi target of rapamycin kinase 3 0.0042 0.0228 0.0516
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0153 0.2062
Entamoeba histolytica hypothetical protein 0.0042 0.023 0.191
Loa Loa (eye worm) hypothetical protein 0.0273 0.272 0.3853
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0305 0.3073 0.3073
Plasmodium vivax heterochromatin protein 1, putative 0.0027 0.0064 0.0691
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.002 0.0028
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0578 0.6016 0.6016
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0055 0.0368 0.0368
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0019 0.0017
Brugia malayi CHD4 protein 0.0029 0.0089 0.0098
Chlamydia trachomatis endonuclease IV 0.009 0.0743 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0014 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0064 0.0183
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0061 0.008
Loa Loa (eye worm) hypothetical protein 0.0578 0.6016 0.8522
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.014 0.1288 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.023 0.023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0198 0.067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0082 0.0249
Brugia malayi Inositol-1 0.0043 0.0243 0.0269
Echinococcus multilocularis jumonji domain containing protein 0.0047 0.0288 0.0288
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0112 0.0357
Brugia malayi Nuclear hormone receptor E75 0.0273 0.272 0.3015
Echinococcus multilocularis dna polymerase eta 0.0023 0.002 0.002
Echinococcus multilocularis lamin 0.0032 0.0117 0.0117
Schistosoma mansoni hypothetical protein 0.0034 0.0144 0.019
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.002 0.0046
Echinococcus multilocularis RUN 0.0069 0.0523 0.0523
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.0019 0.0021
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.002 0.0022
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0127 0.1147 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0267 0.2656 0.2656
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0034 0.0147 0.3285
Schistosoma mansoni lozenge 0.0065 0.0477 0.0628
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0228 0.0777
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0019 0.0026
Loa Loa (eye worm) hypothetical protein 0.009 0.0743 0.1053
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.023 0.0318
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.002 0.0023
Brugia malayi PXA domain containing protein 0.0022 0.0019 0.0021
Schistosoma mansoni hypothetical protein 0.0024 0.0037 0.0049
Schistosoma mansoni hypothetical protein 0.0069 0.0523 0.0687
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0578 0.6016 0.6668
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0144 0.1944
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.002 0.0027
Onchocerca volvulus 0.0032 0.0117 0.0143
Loa Loa (eye worm) hypoxia-induced factor 1 0.0176 0.1675 0.2373
Mycobacterium ulcerans putative regulatory protein 0.0042 0.0231 0.2012
Trichomonas vaginalis chromobox protein, putative 0.0062 0.045 0.1587
Onchocerca volvulus Alhambra homolog 0.0034 0.0144 0.019
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0019 0.0024
Echinococcus granulosus chromobox protein 2 0.0027 0.0064 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0578 0.6016 0.8522
Brugia malayi nuclear hormone receptor 0.0273 0.272 0.3015
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0243 0.0833
Brugia malayi hypothetical protein 0.0305 0.3073 0.3406
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0228 0.0777
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0198 0.067
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0029 0.0089 0.0116
Schistosoma mansoni rab6-interacting 0.0069 0.0523 0.0687
Loa Loa (eye worm) hypothetical protein 0.0027 0.0064 0.0091
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0029 0.0086 0.0194
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.0019 0.0024
Loa Loa (eye worm) hypothetical protein 0.0069 0.0523 0.074
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0027 0.0064 0.0691
Giardia lamblia Kinase, CMGC MAPK 0.006 0.0419 1
Entamoeba histolytica hypothetical protein 0.0042 0.023 0.191
Mycobacterium ulcerans epimerase 0.0024 0.0031 0.0271
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0578 0.6016 0.8522
Echinococcus granulosus ecdysone induced protein 78C 0.0578 0.6016 0.8288
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0147 0.0484
Brugia malayi jmjC domain containing protein 0.0112 0.0981 0.1087
Loa Loa (eye worm) hypothetical protein 0.0058 0.0405 0.0574
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0052 0.0343 0.0777
Loa Loa (eye worm) 6-phosphofructokinase 0.0127 0.1147 0.1625
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0026
Loa Loa (eye worm) hypothetical protein 0.0273 0.272 0.3853
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.0609 0.1378
Toxoplasma gondii endonuclease IV APN 0.009 0.0743 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.006 0.0419 0.0594
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.002 0.0022
Loa Loa (eye worm) CYP4Cod1 0.0031 0.011 0.0156
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0147 0.1364 0.1364
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0127 0.1147 0.8904
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0273 0.272 0.4493
Brugia malayi Pre-SET motif family protein 0.0035 0.0153 0.017
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0243 0.0243
Loa Loa (eye worm) cytochrome P450 family protein 0.0065 0.0481 0.0682
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0019 0.0024
Schistosoma mansoni ap endonuclease 0.0022 0.0014 0.0018
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0105 0.091 0.1254
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0373 0.0844
Echinococcus multilocularis lysine specific demethylase 5A 0.0041 0.0222 0.0222
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0029 0.0086 0.0748
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.1147 0.4122
Schistosoma mansoni steroid hormone receptor ad4bp 0.0578 0.6016 0.7912
Loa Loa (eye worm) hypothetical protein 0.0024 0.0031 0.0044
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0043 0.0243 0.055
Onchocerca volvulus Bile acid receptor homolog 0.0578 0.6016 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0243 0.0243
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0019 0.0019
Echinococcus granulosus PHD finger protein rhinoceros 0.0034 0.0144 0.0199
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0198 0.067
Echinococcus granulosus lamin dm0 0.0032 0.0117 0.0161
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.006 0.0419 0.0949
Brugia malayi nuclear receptor RXR 0.0305 0.3073 0.3406
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0064 0.0183
Brugia malayi nuclear receptor RXR 0.0273 0.272 0.3015
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0019 0.0019
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0029 0.0086 0.0748
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0019 0.0017
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0052 0.0343 0.0777
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.0373 0.0373
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0083 0.025
Mycobacterium ulcerans endonuclease IV 0.009 0.0743 0.6478
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0243 0.055
Entamoeba histolytica hypothetical protein 0.0022 0.0019 0.004
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0419 0.1474
Schistosoma mansoni hypothetical protein 0.004 0.0207 0.0272
Toxoplasma gondii phosphofructokinase PFKII 0.0034 0.0147 0.198
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0273 0.272 0.3853
Loa Loa (eye worm) hypothetical protein 0.0273 0.272 0.3853
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0419 0.0949
Echinococcus multilocularis tumor protein p63 0.0395 0.4037 0.4037
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0027 0.0064 0.0085
Loa Loa (eye worm) hypothetical protein 0.0058 0.0407 0.0577
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0117 0.0166
Loa Loa (eye worm) hypothetical protein 0.0675 0.7059 1
Loa Loa (eye worm) nuclear hormone receptor 0.0273 0.272 0.3853
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0019 0.0019
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0019 0.0024
Brugia malayi hypothetical protein 0.0191 0.1834 0.2033
Onchocerca volvulus 0.0062 0.0441 0.0685
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0243 0.0549
Mycobacterium tuberculosis Probable reductase 0.0126 0.1137 0.8822
Echinococcus granulosus chromobox protein 1 0.0095 0.0799 0.1101
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0126 0.1137 0.8822
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0578 0.6016 0.6668
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0055 0.0368 0.0484
Brugia malayi hypothetical protein 0.0305 0.3073 0.3406
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0578 0.6016 0.7912
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0027 0.0064 0.0867
Loa Loa (eye worm) hypothetical protein 0.0578 0.6016 0.8522
Schistosoma mansoni bromodomain containing protein 0.0074 0.0575 0.0756
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.0609 0.1378
Loa Loa (eye worm) hypothetical protein 0.0031 0.0111 0.0157
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0027 0.0064 0.0691
Echinococcus multilocularis Polycystic kidney disease protein 0.0069 0.0523 0.0523
Echinococcus multilocularis citrate lyase subunit beta protein 0.0029 0.0086 0.0086
Echinococcus multilocularis musashi 0.0032 0.0117 0.0117
Echinococcus granulosus lipoxygenase domain containing protein 0.0069 0.0523 0.072
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.002 0.0046
Mycobacterium ulcerans hypothetical protein 0.0029 0.0086 0.0748
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0064 0.0445
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0014 0.002
Onchocerca volvulus 0.0069 0.0523 0.0821
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0578 0.6016 0.7912
Brugia malayi Thioredoxin reductase 0.0055 0.0373 0.0413
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.002 0.0027
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.002 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0343 0.1198
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.1147 0.4122
Brugia malayi Cytochrome P450 family protein 0.0065 0.0481 0.0533
Brugia malayi Cytochrome P450 family protein 0.0031 0.011 0.0122
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.0144 0.0205
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0693 0.7259 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0578 0.6016 0.6016
Brugia malayi nuclear hormone receptor family member odr-7 0.0273 0.272 0.3015
Onchocerca volvulus 0.0132 0.1197 0.1949
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0064 0.0183
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0014 0.0014
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0273 0.272 0.3747
Brugia malayi PHD-finger family protein 0.0029 0.0091 0.0101
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0153 0.0153
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.002 0.0046
Brugia malayi photoreceptor-specific nuclear receptor 0.0578 0.6016 0.6668
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0077 0.0609 0.0863
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0077 0.0609 0.5251
Loa Loa (eye worm) hypothetical protein 0.0273 0.272 0.3853
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.023 0.023
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0405 0.0449
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0578 0.6016 0.6668
Loa Loa (eye worm) hypothetical protein 0.0027 0.0064 0.0091
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0022 0.0019 0.0017
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.014 0.1288 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.014 0.1288 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0064 0.0183
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.0373 0.4923
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0112 0.0357
Loa Loa (eye worm) hypothetical protein 0.0305 0.3073 0.4353
Loa Loa (eye worm) hypothetical protein 0.0578 0.6016 0.8522
Onchocerca volvulus 0.0132 0.1197 0.1949
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0246 0.0323
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0115 0.0369
Schistosoma mansoni intermediate filament proteins 0.0032 0.0117 0.0154
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.1147 0.4122
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0578 0.6016 0.6668
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0037 0.0052
Trypanosoma brucei trypanothione reductase 0.0055 0.0373 0.0844
Loa Loa (eye worm) hypothetical protein 0.0027 0.0064 0.0091
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0273 0.272 0.272
Echinococcus multilocularis survival motor neuron protein 1 0.0276 0.2758 0.2758
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0243 0.055
Plasmodium falciparum heterochromatin protein 1 0.0027 0.0064 0.0691
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0578 0.6016 0.7912
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0126 0.1137 0.8822
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.0019 0.0021
Brugia malayi PXA domain containing protein 0.0022 0.0019 0.0021
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0126 0.1137 0.8822
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0019 0.0026
Schistosoma mansoni nuclear receptor nhr-48 0.0273 0.272 0.3577
Loa Loa (eye worm) CHromoDomain protein family member 0.0029 0.0089 0.0125
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0024 0.0032
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0029 0.0086 0.0666
Echinococcus multilocularis Chromobox protein 3 0.0027 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0273 0.272 0.3853
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.002 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.002 0.0046
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.006 0.0419 0.0949
Schistosoma mansoni lamin 0.0032 0.0117 0.0154
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.0609 0.1378
Schistosoma mansoni hypothetical protein 0.0027 0.0064 0.0085
Toxoplasma gondii thioredoxin reductase 0.0055 0.0373 0.5019
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0112 0.0981 0.1351
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0052 0.0343 0.0777
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0019 0.0017
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.006 0.0419 0.0949
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0095 0.0214
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0064 0.0183
Brugia malayi nuclear hormone receptor family member nhr-6 0.0273 0.272 0.3015
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.0243 0.032
Echinococcus granulosus Nuclear hormone receptor HR96 0.0273 0.272 0.3747
Loa Loa (eye worm) doublecortin family protein 0.0069 0.0523 0.074
Echinococcus granulosus dna polymerase kappa 0.0023 0.002 0.0028
Trichomonas vaginalis Heterochromatin protein, putative 0.0027 0.0064 0.0183
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0305 0.3073 0.4042
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0112 0.0981 0.0981
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0419 0.1474
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0059 0.0413 0.0638
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0029 0.0089 0.0089
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0273 0.272 0.272
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0413 0.1451
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0064 0.0183
Onchocerca volvulus 0.0517 0.5361 0.8906
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0578 0.6016 0.7912
Loa Loa (eye worm) hypothetical protein 0.0032 0.0117 0.0166
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.011 0.0156
Loa Loa (eye worm) hypothetical protein 0.0191 0.1834 0.2599
Entamoeba histolytica phosphofructokinase, putative 0.0127 0.1147 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0343 0.1198
Brugia malayi hypothetical protein 0.0022 0.0019 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0083 0.025
Entamoeba histolytica hypothetical protein 0.0022 0.0019 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.002 0.0046
Echinococcus granulosus Chromobox protein 3 0.0027 0.0064 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0578 0.6016 0.6668
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.002 0.0157
Onchocerca volvulus 0.0058 0.04 0.0617
Brugia malayi phosphofructokinase 0.0127 0.1147 0.1272
Echinococcus granulosus single minded 2 0.0042 0.0231 0.0318
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0086 0.0705 0.0705
Schistosoma mansoni nuclear receptor 0.0273 0.272 0.3577
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.0019 0.0026
Schistosoma mansoni nuclear hormone receptor 0.0578 0.6016 0.7912
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0029 0.0086 0.0261
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.1147 0.4122
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0064 0.0183
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0064 0.0183
Schistosoma mansoni nuclear hormone receptor 0.0273 0.272 0.3577
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0578 0.6016 0.6668
Loa Loa (eye worm) hypothetical protein 0.0305 0.3073 0.4353
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.023 0.0303
Plasmodium falciparum thioredoxin reductase 0.0055 0.0373 0.4923
Echinococcus granulosus peregrin 0.0037 0.0174 0.024
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0243 0.0549
Trypanosoma brucei C-8 sterol isomerase, putative 0.043 0.4419 1
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.0243 0.0335
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.053 0.053
Entamoeba histolytica phosphofructokinase, putative 0.0127 0.1147 1
Brugia malayi small heat shock protein 0.0675 0.7059 0.7824
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0246 0.0323
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0019 0.0019
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0064 0.0183
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0064 0.0183
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0077 0.0609 0.0801
Loa Loa (eye worm) hypothetical protein 0.0273 0.272 0.3853
Echinococcus granulosus lipoxygenase domain containing protein 0.0069 0.0523 0.072
Schistosoma mansoni RAR-like nuclear receptor 0.0578 0.6016 0.7912
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0273 0.272 0.272
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0127 0.1147 0.2596
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0064 0.0691
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0147 0.0484
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0019 0.0024
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0243 0.0831
Loa Loa (eye worm) 6-phosphofructokinase 0.0127 0.1147 0.1625
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0388 0.3963 0.3963
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0147 0.0484
Brugia malayi hypothetical protein 0.0069 0.0523 0.0579
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0064 0.0183
Brugia malayi M-phase phosphoprotein, mpp8 0.0132 0.1197 0.1327
Brugia malayi hypothetical protein 0.0517 0.5361 0.5942
Loa Loa (eye worm) hypothetical protein 0.0273 0.272 0.3853
Loa Loa (eye worm) hypothetical protein 0.0551 0.5726 0.8112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0115 0.0369
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0052 0.0343 0.0381
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0061 0.0061
Brugia malayi PHD-finger family protein 0.0034 0.0144 0.016
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0419 0.0949
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0578 0.6016 0.8288
Echinococcus multilocularis lipoxygenase domain containing protein 0.0069 0.0523 0.0523
Trypanosoma brucei protein kinase, putative 0.006 0.0419 0.0949
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.0243 1
Echinococcus multilocularis chromobox protein 2 0.0027 0.0064 0.0064
Brugia malayi tailless protein 0.0273 0.272 0.3015
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0064 0.0183
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.006 0.0419 0.0949
Loa Loa (eye worm) hypothetical protein 0.0055 0.0368 0.0522
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0026
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0243 0.0335
Brugia malayi hypothetical protein 0.0029 0.0095 0.0105
Schistosoma mansoni jumonji domain containing protein 0.0089 0.0733 0.0964
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0147 0.0484
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0052 0.0343 0.2907
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0026
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0578 0.6016 0.6668
Brugia malayi nuclear receptor NHR-88 0.0578 0.6016 0.6668
Loa Loa (eye worm) hypothetical protein 0.0305 0.3073 0.4353
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0077 0.0609 0.0839
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.002 0.0046
Brugia malayi Bromodomain containing protein 0.0088 0.0722 0.0801
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.0019 0.0024
Loa Loa (eye worm) hypothetical protein 0.0517 0.5361 0.7595
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0064 0.0183
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0105 0.091 0.1197
Brugia malayi ERG2 and Sigma1 receptor like protein 0.043 0.4419 0.4898
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0441 0.058
Loa Loa (eye worm) phosphofructokinase 0.0127 0.1147 0.1625
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0019 0.0021
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0243 0.2114
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0043 0.0243 0.5653
Loa Loa (eye worm) hypothetical protein 0.0045 0.0261 0.0369
Echinococcus multilocularis lipoxygenase domain containing protein 0.0069 0.0523 0.0523
Echinococcus granulosus geminin 0.0198 0.1913 0.2636
Echinococcus granulosus lamin 0.0032 0.0117 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0157 0.052
Brugia malayi MAP kinase sur-1 0.006 0.0419 0.0465
Leishmania major hypothetical protein, conserved 0.0249 0.2459 0.5564
Schistosoma mansoni thyroid hormone receptor 0.0725 0.7603 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0163 0.0231
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0019 0.0019
Plasmodium vivax SET domain protein, putative 0.0035 0.0153 0.191
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0267 0.2656 0.3659
Echinococcus granulosus tumor protein p63 0.0395 0.4037 0.5561
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0064 0.0183
Echinococcus granulosus transcription factor Dp 1 0.0045 0.0259 0.0356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0083 0.025
Mycobacterium ulcerans 6-phosphofructokinase 0.0127 0.1147 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0243 0.0549
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.011 0.0156
Echinococcus multilocularis neuropeptide receptor A26 0.0551 0.5727 0.5727
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0578 0.6016 0.8288
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0077 0.0609 0.1378
Loa Loa (eye worm) hypothetical protein 0.0517 0.5361 0.7595
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0273 0.272 0.3747
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.002 0.0046
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.002 0.0029
Brugia malayi jmjC domain containing protein 0.0043 0.0246 0.0273
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0022 0.0012 0.0028
Trichomonas vaginalis hypothetical protein 0.0027 0.0064 0.0183
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0305 0.3073 0.4042
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0019 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.002 0.0046
Entamoeba histolytica hypothetical protein 0.0027 0.0064 0.0445
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0228 0.0777
Brugia malayi Nuclear hormone receptor E75 0.0273 0.272 0.3015
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0042 0.0228 0.0516
Brugia malayi Nuclear hormone receptor-like 1 0.0584 0.6079 0.6738
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.002 0.0046
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0019 0.0024
Brugia malayi nuclear receptor NHR-88 0.0273 0.272 0.3015
Leishmania major DNA polymerase kappa, putative 0.0023 0.002 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0578 0.6016 0.6668
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0039 0.0194 0.1504
Echinococcus granulosus FTZ F1 alpha 0.0578 0.6016 0.8288
Onchocerca volvulus 0.0273 0.272 0.4493
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0147 0.1826
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0578 0.6016 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0578 0.6016 0.6668
Schistosoma mansoni retinoic acid receptor RXR 0.0693 0.7259 0.9547
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.0019 0.0019
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0014 0.0032
Mycobacterium tuberculosis Probable oxidoreductase 0.014 0.1288 1
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0019 0.0026
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0147 0.1364 0.1879
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0578 0.6016 0.8288
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.002 0.0046
Schistosoma mansoni loxhd1 0.0069 0.0523 0.0687
Loa Loa (eye worm) heterochromatin protein 1 0.0095 0.0799 0.1132
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0023 0.0024 0.0027
Echinococcus granulosus thyroid hormone receptor alpha 0.0273 0.272 0.3747
Brugia malayi Doublecortin family protein 0.0069 0.0523 0.0579
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.002 0.0055
Echinococcus granulosus mitogen activated protein kinase 3 0.006 0.0419 0.0578
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0019 0.0024
Brugia malayi hypoxia-induced factor 1 0.0176 0.1675 0.1857
Echinococcus multilocularis mitogen activated protein kinase 0.006 0.0419 0.0419
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0019 0.0024
Trichomonas vaginalis chromobox protein, putative 0.0095 0.0799 0.2855
Mycobacterium tuberculosis Conserved protein 0.0029 0.0086 0.0666
Loa Loa (eye worm) hypothetical protein 0.0043 0.0243 0.0344
Echinococcus multilocularis chromobox protein 1 0.0095 0.0799 0.0799
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0419 0.0552
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.011 0.025
Schistosoma mansoni nuclear receptor 0.0273 0.272 0.3577
Brugia malayi Nuclear hormone receptor-like 1 0.0857 0.9022 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0127 0.1147 0.8904
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0064 0.0183
Plasmodium vivax multidomain scavenger receptor, putative 0.0069 0.0523 0.6975
Loa Loa (eye worm) hypothetical protein 0.0578 0.6016 0.8522
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0019 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0198 0.067
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0243 0.3264
Brugia malayi conserved hypotetical protein 0.0273 0.272 0.3015
Trichomonas vaginalis set domain proteins, putative 0.0277 0.2763 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0064 0.0183
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0058 0.04 0.0567
Schistosoma mansoni chromobox protein 0.0095 0.0799 0.1051
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0014 0.0016
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0064 0.0183
Onchocerca volvulus 0.0042 0.0231 0.0334
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0095 0.1106
Loa Loa (eye worm) hypothetical protein 0.0276 0.2758 0.3907
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0052 0.0343 0.0777
Loa Loa (eye worm) steroid hormone receptor 0.0578 0.6016 0.8522
Leishmania major trypanothione reductase 0.0055 0.0373 0.0844
Brugia malayi hypothetical protein 0.0273 0.272 0.3015
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0027 0.0064 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0198 0.067
Echinococcus multilocularis peregrin 0.0037 0.0174 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0578 0.6016 0.6668
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0052 0.0343 0.0452
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.009 0.0743 1
Echinococcus multilocularis geminin 0.0198 0.1913 0.1913
Brugia malayi 6-phosphofructokinase 0.0127 0.1147 0.1272
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0077 0.0609 0.0609
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0578 0.6016 0.7912
Loa Loa (eye worm) hypothetical protein 0.004 0.0207 0.0293
Trypanosoma cruzi hypothetical protein, conserved 0.0249 0.2459 0.5564
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0014 0.0032
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0273 0.272 0.3577
Loa Loa (eye worm) helicase 0.0027 0.0064 0.0091
Leishmania major cytochrome p450-like protein 0.0031 0.011 0.025
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0132 0.1197 0.1696
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.0019 0.0019
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0034 0.0147 0.0484
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0578 0.6016 0.6668
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0031 0.0241
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0273 0.272 0.3577
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.002 0.0046
Plasmodium falciparum LCCL domain-containing protein 0.0069 0.0523 0.6975
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0243 0.0831
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0578 0.6016 0.6016
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0095 0.0214
Toxoplasma gondii exonuclease III APE 0.0022 0.0014 0.0189
Echinococcus multilocularis transcription factor Dp 1 0.0045 0.0259 0.0259
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0139 0.0192
Schistosoma mansoni survival motor neuron protein 0.0056 0.0385 0.0506
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0026
Brugia malayi Cytochrome P450 family protein 0.0031 0.011 0.0122
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0062 0.045 0.0701
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0019 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0082 0.0249
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0126 0.0406
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.002 0.0046
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0043 0.0243 0.2022
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0025 0.0045 0.0102
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0246 0.0348
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0019 0.0026
Mycobacterium tuberculosis Probable dehydrogenase 0.0126 0.1137 0.8822
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0029 0.0086 0.0194
Loa Loa (eye worm) hypothetical protein 0.0027 0.0064 0.0091
Onchocerca volvulus 0.0578 0.6016 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0578 0.6016 0.6016
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0052 0.0343 0.2907
Onchocerca volvulus 0.0056 0.0385 0.0591
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0027 0.0064 0.0085
Echinococcus multilocularis neuropeptide s receptor 0.0551 0.5727 0.5727
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0578 0.6016 0.8288
Echinococcus granulosus histone lysine methyltransferase setb 0.0055 0.0368 0.0507
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0243 0.0833
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.002 0.0046
Schistosoma mansoni inositol monophosphatase 0.0043 0.0243 0.0319
Loa Loa (eye worm) hypothetical protein 0.0027 0.0064 0.0091
Brugia malayi intermediate filament protein 0.0032 0.0117 0.013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0261 0.0897
Entamoeba histolytica hypothetical protein 0.0042 0.023 0.191
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.0373 0.0528
Echinococcus multilocularis lamin dm0 0.0032 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.043 0.4419 0.626
Echinococcus granulosus 6 phosphofructokinase 0.0127 0.1147 0.1581
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0198 0.067
Schistosoma mansoni thyroid hormone receptor 0.0725 0.7603 1
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0019 0.0017
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0034 0.0147 0.1175
Brugia malayi hypothetical protein 0.0069 0.0523 0.0579
Echinococcus granulosus neuropeptide receptor A26 0.0551 0.5727 0.7889
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0243 0.0335
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0034 0.0147 0.1175
Brugia malayi orphan nuclear receptor NR2E1 0.0273 0.272 0.3015
Trypanosoma cruzi hypothetical protein, conserved 0.0249 0.2459 0.5564
Schistosoma mansoni chromobox protein 0.0027 0.0064 0.0085
Onchocerca volvulus Protein ultraspiracle homolog 0.0578 0.6016 1
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0127 0.1147 0.2596
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0095 0.0214
Entamoeba histolytica phosphofructokinase, putative 0.0127 0.1147 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0305 0.3073 0.4233
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0029 0.0089 0.0122
Brugia malayi ecdysone receptor 0.0273 0.272 0.3015
Trichomonas vaginalis chromobox protein, putative 0.0027 0.0064 0.0183
Echinococcus multilocularis expressed protein 0.0436 0.4483 0.4483
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.002 0.0023
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0246 0.0339
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0024 0.0031 0.0271
Schistosoma mansoni polycystin 1-related 0.0069 0.0523 0.0687
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.002 0.0046
Brugia malayi hypothetical protein 0.0276 0.2758 0.3057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0228 0.0777
Schistosoma mansoni 6-phosphofructokinase 0.0127 0.1147 0.1509
Schistosoma mansoni chromobox protein 0.0027 0.0064 0.0085
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.0024 0.0035
Schistosoma mansoni lipoxygenase 0.0142 0.1314 0.1728
Echinococcus granulosus RUN 0.0069 0.0523 0.072
Loa Loa (eye worm) hypothetical protein 0.0069 0.0523 0.074
Echinococcus granulosus dna polymerase eta 0.0023 0.002 0.0028
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0064 0.0445
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0243 0.0334
Loa Loa (eye worm) phosphatidylinositol 3 0.0052 0.0343 0.0487
Schistosoma mansoni ap endonuclease 0.0022 0.0014 0.0018
Brugia malayi hypothetical protein 0.0022 0.0019 0.0021
Schistosoma mansoni coup transcription factor 0.0578 0.6016 0.7912
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0055 0.0368 0.0484
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0029 0.0086 0.0194
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.011 0.025
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0584 0.6079 0.8612
Entamoeba histolytica hypothetical protein 0.0022 0.0019 0.004
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0243 0.0831
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0578 0.6016 0.8522
Schistosoma mansoni lipoxygenase 0.0267 0.2656 0.3493
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.002 0.0046
Trichomonas vaginalis chromobox protein, putative 0.0027 0.0064 0.0183
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0578 0.6016 0.8288
Schistosoma mansoni inositol monophosphatase 0.0043 0.0243 0.0319
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0095 0.1106
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0578 0.6016 0.8522
Loa Loa (eye worm) DR-78 0.0273 0.272 0.3853
Trichomonas vaginalis chromobox protein, putative 0.0095 0.0799 0.2855
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0064 0.0183
Loa Loa (eye worm) hypothetical protein 0.0305 0.3073 0.4353
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0027 0.0064 0.0064
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0243 0.055
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0147 0.1826
Brugia malayi Valyl-tRNA synthetase 0.0027 0.0064 0.0071
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0243 0.0549
Schistosoma mansoni single-minded 0.0057 0.039 0.0513
Echinococcus multilocularis 6 phosphofructokinase 0.0127 0.1147 0.1147
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0578 0.6016 0.6016
Schistosoma mansoni lamin 0.0032 0.0117 0.0154
Echinococcus multilocularis ecdysone induced protein 78C 0.0578 0.6016 0.6016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0064 0.0183
Loa Loa (eye worm) hypothetical protein 0.0273 0.272 0.3853
Echinococcus multilocularis transfer RNA-Lys 0.0042 0.0231 0.0231
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0024 0.0032
Loa Loa (eye worm) hypothetical protein 0.0083 0.0669 0.0947
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0031 0.011 0.0963
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.002 0.0046
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.009 0.0743 0.0824
Onchocerca volvulus 0.0032 0.0117 0.0143
Echinococcus granulosus citrate lyase subunit beta protein 0.0029 0.0086 0.0118
Plasmodium vivax glutathione reductase, putative 0.0055 0.0373 0.4923
Mycobacterium ulcerans hypothetical protein 0.0024 0.0031 0.0271
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0105 0.091 0.1197
Echinococcus multilocularis mitogen activated protein kinase 3 0.006 0.0419 0.0419
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.009 0.0743 0.5768
Echinococcus granulosus expressed protein 0.0436 0.4483 0.6176
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0064 0.0691
Loa Loa (eye worm) inositol-1 0.0043 0.0243 0.0344
Brugia malayi Protein cec-1. 0.0027 0.0064 0.0071
Echinococcus multilocularis Protein lozenge 0.0065 0.0477 0.0477
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.0024 0.0035
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0024 0.0032
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0385 0.0427
Leishmania major DNA polymerase eta, putative 0.0023 0.002 0.0046
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0052 0.0343 0.0777
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0014 0.0122
Loa Loa (eye worm) hypothetical protein 0.0059 0.0413 0.0585
Schistosoma mansoni zinc finger protein 0.0273 0.272 0.3577
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.002 0.0046
Trypanosoma brucei cytochrome P450, putative 0.0031 0.011 0.025
Loa Loa (eye worm) hypothetical protein 0.0578 0.6016 0.8522
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0147 0.1826
Brugia malayi glutathione reductase 0.0055 0.0373 0.0413
Brugia malayi PAS domain containing protein 0.0057 0.039 0.0433
Trichomonas vaginalis chromobox protein, putative 0.0062 0.045 0.1587
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0578 0.6016 0.8288
Schistosoma mansoni hypothetical protein 0.0198 0.1913 0.2516
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0126 0.1137 0.8822
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0095 0.1106
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0147 0.1826
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0039 0.0194 0.1504
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0064 0.0183
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0026
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.006 0.0419 0.5642
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0019 0.0017
Schistosoma mansoni nuclear hormone receptor 0.0273 0.272 0.3577
Loa Loa (eye worm) RGS-3 protein 0.0022 0.0019 0.0026
Loa Loa (eye worm) hypothetical protein 0.0273 0.272 0.3853
Loa Loa (eye worm) hypothetical protein 0.0132 0.1199 0.1699
Giardia lamblia PHD finger protein 15 0.0034 0.0144 0.3219
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0117 0.0166
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0578 0.6016 0.8522
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0029 0.0086 0.0748
Brugia malayi 6-phosphofructokinase 0.0127 0.1147 0.1272
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0027 0.0064 0.0867
Brugia malayi hypothetical protein 0.0042 0.023 0.0255
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0019 0.0017
Brugia malayi Heterochromatin protein 1 0.0095 0.0799 0.0886
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0052 0.0343 0.0473
Loa Loa (eye worm) hypothetical protein 0.0034 0.0144 0.0205
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0144 0.1944
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0578 0.6016 0.8522
Leishmania major C-8 sterol isomerase-like protein 0.043 0.4419 1
Schistosoma mansoni cellular tumor antigen P53 0.0058 0.04 0.0527
Brugia malayi bHLH-PAS transcription factor 0.0042 0.0231 0.0256
Plasmodium falciparum glutathione reductase 0.0055 0.0373 0.4923
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.0024 0.0034
Echinococcus granulosus Polycystic kidney disease protein 0.0069 0.0523 0.072

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 70 uM Cytotoxicity against Huh 5-2 cells ChEMBL. 17656093
CC50 (ADMET) > 104 uM Cytotoxicity against MDBK cells ChEMBL. 17656093
EC50 (functional) = 0.38 uM Antiviral activity against BVDV in MDBK cells ChEMBL. 17656093
EC50 (functional) = 16 uM Antiviral activity against HCV in Huh 5-2 cells ChEMBL. 17656093
Ratio CC50/EC50 (functional) = 4.4 Selectivity index, ratio of CC50 for Huh 5-2 cells to EC50 for HCV ChEMBL. 17656093
Ratio CC50/EC50 (functional) > 274 Selectivity index, ratio of CC50 for MDBK cells to EC50 for BVDV ChEMBL. 17656093

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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