TDR Targets

Basic information

Technical information

TDR Targets ID: 431691
Name: N-[[(5S)-3-[3-fluoro-4-[(E)-3-pyridin-2-ylpro p-2-enoyl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]m ethyl]acetamide
MW: 383.373 | Formula: C20H18FN3O4
H donors: 1 H acceptors: 4 LogP: 1.67 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)NC[C@H]1CN(C(=O)O1)c1ccc(c(c1)F)C(=O)/C=C/c1ccccn1
InChi: 1S/C20H18FN3O4/c1-13(25)23-11-16-12-24(20(27)28-16)15-6-7-17(18(21)10-15)19(26)8-5-14-4-2-3-9-22-14/h2-10,16H,11-12H2,1H3,(H,23,25)/b8-5+/t16-/m0/s1
InChiKey: OFTOOJFWLSMVFT-WHWKNOJMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[[(5S)-3-[3-fluoro-4-[(E)-3-(2-pyridyl)prop-2-enoyl]phenyl]-2-oxo-oxazolidin-5-yl]methyl]acetamide
N-[[(5S)-3-[3-fluoro-4-[(E)-1-oxo-3-(2-pyridyl)allyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide
N-[[(5S)-3-[3-fluoro-4-[(E)-3-pyridin-2-ylprop-2-enoyl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]ethanamide
N-[[(5S)-3-[3-fluoro-4-[(E)-3-(2-pyridyl)acryloyl]phenyl]-2-keto-oxazolidin-5-yl]methyl]acetamide
N-[[(5S)-3-[3-fluoro-4-[(E)-1-oxo-3-(2-pyridyl)prop-2-enyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	conserved hypotetical protein	0.001	0.0224	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Loa Loa (eye worm)	hypothetical protein	0.001	0.0224	0.0004
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0677	1
Schistosoma mansoni	neuropeptide receptor	0.0119	0.4886	1
Schistosoma mansoni	hypothetical protein	0.0119	0.4886	1
Brugia malayi	RE15519p	0.0119	0.4886	0.4773
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0021	0.0687	0.0556
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0119	0.4886	0.4773
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.0677	0.5
Brugia malayi	Steroid receptor seven-up type 2	0.0021	0.0687	0.0483
Onchocerca volvulus		0.0119	0.4886	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0119	0.4886	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0021	0.0687	0.0478
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0021	0.0687	0.1406
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.001	0.0224	0.0086
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0021	0.0687	0.0478
Brugia malayi	photoreceptor-specific nuclear receptor	0.0021	0.0687	0.0483
Echinococcus granulosus	neuropeptide FF receptor 2	0.0119	0.4886	0.4813
Echinococcus granulosus	rhodopsin orphan GPCR	0.0119	0.4886	0.4813
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0021	0.0687	0.0556
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.0687	0.0483
Echinococcus multilocularis	serotonin receptor	0.0119	0.4886	0.4813
Brugia malayi	sulfakinin receptor protein	0.0119	0.4886	0.4773
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0687	0.0556
Echinococcus multilocularis	neuropeptide receptor A26	0.0119	0.4886	0.4813
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0119	0.4886	0.4813
Brugia malayi	ecdysteroid receptor	0.0021	0.0687	0.0483
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0021	0.0687	0.1406
Onchocerca volvulus		0.0119	0.4886	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0119	0.4886	0.4813
Brugia malayi	hypothetical protein	0.0119	0.4886	0.4773
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0017	0.0539	0.0326
Onchocerca volvulus		0.0119	0.4886	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0021	0.0687	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0273	0.0055
Echinococcus multilocularis	ecdysone induced protein 78C	0.0021	0.0687	0.0556
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0066	0.2619	0.5361
Loa Loa (eye worm)	hypothetical protein	0.001	0.0224	0.0004
Echinococcus multilocularis	dro:myosuppressin receptor	0.0119	0.4886	0.4813
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0119	0.4886	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Brugia malayi	hypothetical protein	0.0119	0.4886	0.4773
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0687	0.0478
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0119	0.4886	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0119	0.4886	1
Onchocerca volvulus	Bile acid receptor homolog	0.0021	0.0687	0.0994
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0021	0.0687	0.0478
Schistosoma mansoni	amine GPCR	0.0119	0.4886	1
Schistosoma mansoni	transcription factor LCR-F1	0.0109	0.4468	0.9146
Entamoeba histolytica	hypothetical protein	0.0109	0.4468	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0119	0.4886	0.4813
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.001	0.0224	0.0086
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0687	0.0483
Loa Loa (eye worm)	TYRA-2 protein	0.0119	0.4886	0.4771
Echinococcus granulosus	ecdysone induced protein 78C	0.0021	0.0687	0.0556
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0119	0.4886	0.4773
Echinococcus granulosus	fmrfamide receptor	0.0119	0.4886	0.4813
Schistosoma mansoni	opsin-like receptor	0.0119	0.4886	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0021	0.0687	0.0994
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.049	0.0356
Echinococcus granulosus	biogenic amine 5HT receptor	0.0119	0.4886	0.4813
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Schistosoma mansoni	myosin xvIII	0.0119	0.4886	1
Schistosoma mansoni	nuclear receptor	0.001	0.0224	0.0458
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0021	0.0687	0.0478
Brugia malayi	G protein-coupled receptor F59B2.13	0.0119	0.4886	0.4773
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0119	0.4886	0.4813
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0021	0.0687	0.0478
Echinococcus multilocularis	neuropeptide s receptor	0.0119	0.4886	0.4813
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0021	0.0687	0.0478
Brugia malayi	nuclear receptor RXR	0.0011	0.0273	0.006
Echinococcus granulosus	7tm_1 domain containing protein	0.0119	0.4886	0.4813
Echinococcus granulosus	rhodopsin orphan GPCR	0.0119	0.4886	0.4813
Echinococcus multilocularis	neuropeptide Y receptor	0.0119	0.4886	0.4813
Schistosoma mansoni	neuropeptide receptor	0.0119	0.4886	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0021	0.0687	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.049	0.0276
Echinococcus granulosus	neuropeptide receptor A26	0.0119	0.4886	0.4813
Schistosoma mansoni	survival motor neuron protein	0.0049	0.1888	0.3865
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0119	0.4886	0.4813
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1279	0.1083
Schistosoma mansoni	amine GPCR	0.0119	0.4886	1
Entamoeba histolytica	hypothetical protein	0.0109	0.4468	1
Onchocerca volvulus		0.0119	0.4886	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.001	0.0224	0.0086
Schistosoma mansoni	neuropeptide receptor	0.0119	0.4886	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0119	0.4886	0.4813
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Schistosoma mansoni	neuropeptide f receptor 76f	0.0119	0.4886	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Echinococcus multilocularis	neuropeptides capa receptor	0.0119	0.4886	0.4813
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0017	0.0539	0.0405
Loa Loa (eye worm)	nuclear hormone receptor	0.001	0.0224	0.0004
Brugia malayi	G-protein coupled receptor	0.0119	0.4886	0.4773
Schistosoma mansoni	thyroid hormone receptor	0.0021	0.0687	0.1406
Schistosoma mansoni	thyroid hormone receptor	0.0021	0.0687	0.1406
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0687	0.0483
Schistosoma mansoni	amine GPCR	0.0119	0.4886	1
Brugia malayi	nuclear receptor NHR-88	0.0021	0.0687	0.0483
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0273	0.006
Brugia malayi	hypothetical protein	0.001	0.0224	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Echinococcus multilocularis	cpg binding protein	0.0033	0.121	0.1086
Brugia malayi	AKH receptor	0.0119	0.4886	0.4773
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0119	0.4886	0.4771
Loa Loa (eye worm)	neuropeptide F receptor	0.0119	0.4886	0.4771
Echinococcus multilocularis	FTZ F1 alpha	0.0021	0.0687	0.0556
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0119	0.4886	0.4813
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0021	0.0687	0.0994
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0021	0.0687	0.0556
Loa Loa (eye worm)	hypothetical protein	0.001	0.0224	0.0004
Loa Loa (eye worm)	nuclear receptor NHR-67	0.001	0.0224	0.0004
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0119	0.4886	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.1958	0.1778
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0011	0.0273	0.0559
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0109	0.4468	0.439
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Loa Loa (eye worm)	neuropeptide F receptor	0.0119	0.4886	0.4771
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0119	0.4886	0.4813
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Brugia malayi	Dopamine receptor	0.0119	0.4886	0.4773
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.0677	1
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0677	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0119	0.4886	0.4813
Echinococcus granulosus	g protein coupled receptor	0.0119	0.4886	0.4813
Brugia malayi	larval opioid receptor	0.0119	0.4886	0.4773
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0539	0.0405
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0119	0.4886	1
Loa Loa (eye worm)	DR-78	0.001	0.0224	0.0004
Echinococcus granulosus	sex peptide receptor	0.0119	0.4886	0.4813
Brugia malayi	nuclear receptor NHR-88	0.001	0.0224	0.0009
Echinococcus multilocularis	fmrfamide receptor	0.0119	0.4886	0.4813
Echinococcus granulosus	g protein coupled receptor	0.0119	0.4886	0.4813
Schistosoma mansoni	cpg binding protein	0.0031	0.1134	0.2322
Echinococcus granulosus	biogenic amine 5HT receptor	0.0119	0.4886	0.4813
Loa Loa (eye worm)	hypothetical protein	0.001	0.0224	0.0004
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.001	0.0224	0.0458
Onchocerca volvulus		0.0119	0.4886	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0119	0.4886	1
Brugia malayi	nuclear hormone receptor family member odr-7	0.001	0.0224	0.0009
Onchocerca volvulus		0.0119	0.4886	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0119	0.4886	0.4813
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0687	0.0556
Schistosoma mansoni	hypothetical protein	0.0034	0.1279	0.2617
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0224	0.0086
Brugia malayi	hypothetical protein	0.0119	0.4886	0.4773
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0677	0.0468
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0119	0.4886	0.4813
Onchocerca volvulus		0.0119	0.4886	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0021	0.0687	0.0556
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0119	0.4886	0.4773
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0119	0.4886	0.4813
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Echinococcus granulosus	neuropeptide Y receptor	0.0119	0.4886	0.4813
Schistosoma mansoni	ap endonuclease	0.002	0.0677	0.1386
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0119	0.4886	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0687	0.0483
Echinococcus granulosus	neuropeptide Y receptor	0.0119	0.4886	0.4813
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0021	0.0687	0.0556
Brugia malayi	putative neuropeptide receptor NPR1	0.0119	0.4886	0.4773
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0119	0.4886	1
Echinococcus granulosus	neuropeptide s receptor	0.0119	0.4886	0.4813
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0011	0.0273	0.0136
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0119	0.4886	0.4813
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0677	0.0473
Echinococcus granulosus	survival motor neuron protein 1	0.0239	1	1
Brugia malayi	hypothetical protein	0.0119	0.4886	0.4773
Schistosoma mansoni	opsin-like receptor	0.0119	0.4886	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0119	0.4886	0.4813
Brugia malayi	hypothetical protein	0.0119	0.4886	0.4773
Echinococcus granulosus	GPCR family 2	0.0016	0.049	0.0356
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.0677	1
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0677	1
Brugia malayi	nuclear receptor RXR	0.001	0.0224	0.0009
Brugia malayi	Nuclear hormone receptor E75	0.001	0.0224	0.0009
Brugia malayi	Nuclear hormone receptor E75	0.001	0.0224	0.0009
Schistosoma mansoni	zinc finger protein	0.001	0.0224	0.0458
Echinococcus granulosus	somatostatin receptor	0.0119	0.4886	0.4813
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0021	0.0687	0.0556
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Brugia malayi	nuclear receptor NHR-67	0.001	0.0224	0.0009
Echinococcus granulosus	FTZ F1 alpha	0.0021	0.0687	0.0556
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0021	0.0687	0.1406
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0273	0.006
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0119	0.4886	0.4813
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0139	0.0285
Loa Loa (eye worm)	hypothetical protein	0.001	0.0224	0.0004
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0119	0.4886	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0021	0.0687	0.0483
Schistosoma mansoni	amine GPCR	0.0119	0.4886	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0119	0.4886	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0273	0.0055
Schistosoma mansoni	hypothetical protein	0.0016	0.049	0.1002
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0119	0.4886	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Schistosoma mansoni	hypothetical protein	0.0016	0.049	0.1002
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.1958	0.1782
Brugia malayi	neuropeptide F receptor	0.0119	0.4886	0.4773
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0021	0.0687	0.0556
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0021	0.0687	0.0483
Brugia malayi	hypothetical protein	0.0119	0.4886	0.4773
Loa Loa (eye worm)	steroid hormone receptor	0.0021	0.0687	0.0478
Toxoplasma gondii	exonuclease III APE	0.002	0.0677	0.0779
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Echinococcus multilocularis	GPCR, family 2	0.0016	0.049	0.0356
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0021	0.0687	0.1406
Brugia malayi	hypothetical protein	0.0119	0.4886	0.4773
Loa Loa (eye worm)	G-protein coupled receptor	0.0119	0.4886	0.4771
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0017	0.0539	0.0405
Echinococcus granulosus	neuropeptide receptor	0.0119	0.4886	0.4813
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0687	0.0478
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.0677	1
Echinococcus granulosus	g-protein coupled receptor	0.0119	0.4886	0.4813
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.022	0.0082
Schistosoma mansoni	amine GPCR	0.0119	0.4886	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0119	0.4886	0.4813
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0119	0.4886	0.4813
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0687	0.0556
Echinococcus granulosus	thyroid hormone receptor alpha	0.001	0.0224	0.0086
Loa Loa (eye worm)	hypothetical protein	0.001	0.0224	0.0004
Onchocerca volvulus		0.0119	0.4886	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Brugia malayi	tailless protein	0.001	0.0224	0.0009
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0119	0.4886	0.4813
Brugia malayi	follicle stimulating hormone receptor	0.0119	0.4886	0.4773
Entamoeba histolytica	hypothetical protein	0.0109	0.4468	1
Schistosoma mansoni	coup transcription factor	0.0021	0.0687	0.1406
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.001	0.0224	0.0009
Schistosoma mansoni	biogenic amine receptor	0.0119	0.4886	1
Brugia malayi	Serotonin receptor	0.0119	0.4886	0.4773
Brugia malayi	isocitrate dehydrogenase	0.0017	0.0539	0.0331
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0119	0.4886	0.4771
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0224	0.0458
Schistosoma mansoni	opsin-like receptor	0.0119	0.4886	1
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0677	1
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.049	0.0281
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0119	0.4886	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0687	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0239	1	1
Onchocerca volvulus		0.0119	0.4886	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0119	0.4886	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0119	0.4886	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0021	0.0687	0.0483
Schistosoma mansoni	neuropeptide receptor	0.0119	0.4886	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0119	0.4886	0.4813
Onchocerca volvulus		0.0031	0.1134	0.1953
Brugia malayi	nuclear hormone receptor family member nhr-6	0.001	0.0224	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Echinococcus multilocularis	g protein coupled receptor	0.0119	0.4886	0.4813
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0021	0.0687	0.1406
Brugia malayi	Dopamine receptor protein 2	0.0119	0.4886	0.4773
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0021	0.0687	0.0483
Schistosoma mansoni	nuclear receptor	0.001	0.0224	0.0458
Schistosoma mansoni	biogenic amine receptor	0.0119	0.4886	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Schistosoma mansoni	hypothetical protein	0.0119	0.4886	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0119	0.4886	0.4773
Schistosoma mansoni	cpg binding protein	0.0033	0.121	0.2476
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0687	0.0478
Onchocerca volvulus		0.0119	0.4886	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Loa Loa (eye worm)	hypothetical protein	0.001	0.0224	0.0004
Loa Loa (eye worm)	hypothetical protein	0.001	0.0224	0.0004
Onchocerca volvulus		0.0119	0.4886	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0119	0.4886	0.4813
Echinococcus granulosus	G protein coupled receptor 139	0.0119	0.4886	0.4813
Schistosoma mansoni	neuropeptide F-like receptor	0.0119	0.4886	1
Schistosoma mansoni	hypothetical protein	0.0016	0.049	0.1002
Echinococcus granulosus	Nuclear hormone receptor HR96	0.001	0.0224	0.0086
Brugia malayi	hypothetical protein	0.001	0.0224	0.0009
Brugia malayi	hypothetical protein	0.0011	0.0273	0.006
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0021	0.0687	0.0556
Schistosoma mansoni	nuclear receptor nhr-48	0.001	0.0224	0.0458
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0119	0.4886	0.4813
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Schistosoma mansoni	hypothetical protein	0.0109	0.4468	0.9146
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0687	0.0556
Echinococcus multilocularis	orexin receptor type 2	0.0119	0.4886	0.4813
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0119	0.4886	0.4813
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0119	0.4886	0.4813
Echinococcus granulosus	cpg binding protein	0.0033	0.121	0.1086
Echinococcus granulosus	Nuclear hormone receptor HR96	0.001	0.0224	0.0086
Echinococcus granulosus	nuclear receptor nhr 48	0.001	0.0224	0.0086
Echinococcus multilocularis	nuclear receptor nhr 48	0.001	0.0224	0.0086
Brugia malayi	Melatonin receptor type 1A	0.0119	0.4886	0.4773
Schistosoma mansoni	hypothetical protein	0.0016	0.049	0.1002
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0021	0.0687	0.0556
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0021	0.0687	0.0483
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0119	0.4886	0.4771
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0119	0.4886	0.4813
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0119	0.4886	1
Brugia malayi	GnHR receptor homolog	0.0119	0.4886	0.4773
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0119	0.4886	0.4771
Echinococcus granulosus	neuropeptides capa receptor	0.0119	0.4886	0.4813
Schistosoma mansoni	biogenic amine receptor	0.0119	0.4886	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Loa Loa (eye worm)	hypothetical protein	0.0016	0.049	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0119	0.4886	0.4773
Echinococcus multilocularis	neuropeptide receptor	0.0119	0.4886	0.4813
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.001	0.0224	0.0086
Loa Loa (eye worm)	G-protein coupled receptor	0.0119	0.4886	0.4771
Loa Loa (eye worm)	melatonin receptor type 1A	0.0119	0.4886	0.4771
Loa Loa (eye worm)	hypothetical protein	0.001	0.0224	0.0004
Echinococcus multilocularis	g protein coupled receptor	0.0119	0.4886	0.4813
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0119	0.4886	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0119	0.4886	0.4813
Loa Loa (eye worm)	hypothetical protein	0.001	0.0224	0.0004
Echinococcus multilocularis	sex peptide receptor	0.0119	0.4886	0.4813
Brugia malayi	nuclear hormone receptor	0.001	0.0224	0.0009
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.049	0.0356
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0021	0.0687	0.0483
Onchocerca volvulus		0.0119	0.4886	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0239	1	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0119	0.4886	0.4813
Schistosoma mansoni	hypothetical protein	0.0119	0.4886	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0119	0.4886	0.4813
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0677	0.0546
Echinococcus multilocularis	allatostatin A receptor	0.0119	0.4886	0.4813
Brugia malayi	hypothetical protein	0.0119	0.4886	0.4773
Schistosoma mansoni	growth hormone secretagogue receptor	0.0119	0.4886	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.049	0.0356
Schistosoma mansoni	neuropeptide F-like receptor	0.0119	0.4886	1
Brugia malayi	CXXC zinc finger family protein	0.0031	0.1134	0.094
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0119	0.4886	0.4813
Loa Loa (eye worm)	hypothetical protein	0.005	0.1958	0.1778
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0119	0.4886	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0119	0.4886	0.4813
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0119	0.4886	0.4813
Onchocerca volvulus		0.0119	0.4886	1
Onchocerca volvulus		0.0049	0.1888	0.3571
Onchocerca volvulus		0.0119	0.4886	1
Onchocerca volvulus		0.0119	0.4886	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0021	0.0687	0.1406
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Brugia malayi	steroid hormone receptor	0.0021	0.0687	0.0483
Echinococcus multilocularis	neuropeptide Y receptor	0.0119	0.4886	0.4813
Brugia malayi	G-protein coupled receptor	0.0119	0.4886	0.4773
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0273	0.0055
Schistosoma mansoni	hypothetical protein	0.0119	0.4886	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Onchocerca volvulus		0.0119	0.4886	1
Schistosoma mansoni	hypothetical protein	0.0049	0.1888	0.3865
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.0687	0.1406
Echinococcus granulosus	serotonin receptor	0.0119	0.4886	0.4813
Schistosoma mansoni	RAR-like nuclear receptor	0.0021	0.0687	0.1406
Loa Loa (eye worm)	hypothetical protein	0.001	0.0224	0.0004
Schistosoma mansoni	adenoreceptor	0.0119	0.4886	1
Echinococcus multilocularis	neuropeptide receptor	0.0119	0.4886	0.4813
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0539	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0677	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0687	0.0483
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.022	0.0082
Echinococcus granulosus	rhodopsin orphan GPCR	0.0119	0.4886	0.4813
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0687	0.0478
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.049	0.0281
Schistosoma mansoni	cpg binding protein	0.0033	0.121	0.2476
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0273	0.0559
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0011	0.0273	0.0055
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0119	0.4886	0.4773
Schistosoma mansoni	ap endonuclease	0.002	0.0677	0.1386
Brugia malayi	nuclear hormone receptor	0.0021	0.0687	0.0483
Echinococcus multilocularis	g protein coupled receptor	0.0119	0.4886	0.4813
Brugia malayi	hypothetical protein	0.0119	0.4886	0.4773
Echinococcus granulosus	hypothetical protein	0.0119	0.4886	0.4813
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0109	0.4468	0.439
Echinococcus granulosus	tm gpcr rhodopsin	0.0119	0.4886	0.4813
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.002	0.0677	0.5
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0119	0.4886	0.4813
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0119	0.4886	0.4813
Entamoeba histolytica	hypothetical protein	0.0109	0.4468	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0687	0.0478
Echinococcus multilocularis	G protein coupled receptor 139	0.0119	0.4886	0.4813
Echinococcus granulosus	orexin receptor type 2	0.0119	0.4886	0.4813
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0273	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0119	0.4886	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.001	0.0224	0.0086
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0119	0.4886	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0677	0.0546
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0119	0.4886	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0273	0.0055
Brugia malayi	hypothetical protein	0.0119	0.4886	0.4773
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0119	0.4886	0.4813
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0687	0.0483
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0119	0.4886	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0119	0.4886	0.4813
Echinococcus multilocularis	isocitrate dehydrogenase	0.0017	0.0539	0.0405
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.001	0.0224	0.0004
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.1279	0.1087
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.001	0.0224	0.0458
Loa Loa (eye worm)	hypothetical protein	0.001	0.0224	0.0004
Echinococcus multilocularis	serotonin receptor	0.0119	0.4886	0.4813
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0021	0.0687	0.0556
Echinococcus granulosus	neuropeptides capa receptor	0.0119	0.4886	0.4813
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0119	0.4886	1
Echinococcus granulosus	allatostatin A receptor	0.0119	0.4886	0.4813
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.0677	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0539	0.0405
Echinococcus multilocularis	fmrfamide receptor	0.0119	0.4886	0.4813
Brugia malayi	putative neuropeptide receptor	0.0119	0.4886	0.4773
Echinococcus multilocularis	g-protein coupled receptor	0.0119	0.4886	0.4813
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0011	0.0273	0.0136
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0224	0.0458
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0049	0.1888	0.1711
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0.0677	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0119	0.4886	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0677	0.5
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0119	0.4886	0.4771
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0119	0.4886	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0224	0.0086
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0119	0.4886	0.4813
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0119	0.4886	0.4813
Brugia malayi	G protein-coupled receptor	0.0119	0.4886	0.4773
Onchocerca volvulus		0.0021	0.0687	0.0994
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0119	0.4886	0.4813
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.1134	0.0935
Echinococcus granulosus	neuropeptide receptor	0.0119	0.4886	0.4813
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Echinococcus granulosus	g protein coupled receptor	0.0119	0.4886	0.4813
Brugia malayi	orphan nuclear receptor NR2E1	0.001	0.0224	0.0009
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0059	0.2319	1
Brugia malayi	Isocitrate dehydrogenase	0.0017	0.0539	0.0331
Echinococcus granulosus	rhodopsin orphan GPCR	0.0119	0.4886	0.4813
Loa Loa (eye worm)	hypothetical protein	0.001	0.0224	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Brugia malayi	neuropeptide F receptor	0.0119	0.4886	0.4773
Brugia malayi	hypothetical protein	0.0011	0.0273	0.006
Schistosoma mansoni	histamine h1 receptor	0.0119	0.4886	1
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0017	0.0539	0.1102
Echinococcus granulosus	tm gpcr rhodopsin	0.0119	0.4886	0.4813
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Brugia malayi	Serotonin receptor	0.0119	0.4886	0.4773
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0021	0.0687	0.1406
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0119	0.4886	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0119	0.4886	0.4813
Echinococcus multilocularis	somatostatin receptor	0.0119	0.4886	0.4813
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.049	0.0356
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0687	0.0478
Brugia malayi	ORL1-like opioid receptor	0.0119	0.4886	0.4773
Echinococcus granulosus	rhodopsin orphan GPCR	0.0119	0.4886	0.4813
Brugia malayi	Dopamine receptor protein 1	0.0119	0.4886	0.4773
Brugia malayi	ecdysone receptor	0.001	0.0224	0.0009
Brugia malayi	hypothetical protein	0.0109	0.4468	0.4347
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0687	0.0478
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0119	0.4886	1
Onchocerca volvulus		0.0119	0.4886	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0119	0.4886	0.4813
Schistosoma mansoni	retinoic acid receptor RXR	0.0021	0.0687	0.1406
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.1958	0.1782
Loa Loa (eye worm)	hypothetical protein	0.0119	0.4886	0.4771
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0687	0.0478

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	= 4 ug ml-1	Antibacterial activity against Staphylococcus aureus ATCC 33591	ChEMBL.	17150281
MIC (functional)	= 4 ug ml-1	Antibacterial activity against Staphylococcus aureus ATCC 49951	ChEMBL.	17150281
MIC (functional)	= 8 ug ml-1	Antibacterial activity against Staphylococcus aureus ATCC 29213	ChEMBL.	17150281
MIC (functional)	= 16 ug ml-1	Antibacterial activity against Enterococcus faecalis ATCC 29212	ChEMBL.	17150281
MIC (functional)	= 16 ug ml-1	Antibacterial activity against Enterococcus faecalis NCTC 12201	ChEMBL.	17150281
MIC (functional)	= 16 ug ml-1	Antibacterial activity against Enterococcus faecium ATCC 12202	ChEMBL.	17150281

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL388020
PubChem: 16655231

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 431691