Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0268 | 1 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0166 | 0.2407 | 0.2407 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0268 | 1 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0268 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0268 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0268 | 1 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0135 | 0.0151 | 0.0151 |
Brugia malayi | FAD binding domain containing protein | 0.0268 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0268 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0268 | 1 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0268 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0268 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0268 | 1 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0238 | 0.7743 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0268 | 1 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0268 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0133 | 0 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0166 | 0.2407 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0268 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0238 | 0.7743 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0268 | 1 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0268 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0268 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0268 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0268 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0268 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0268 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0133 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Decrease in sodium nitroprusside-induced caspase-3 activity in SH-SY5Y cells | ChEMBL. | 17300930 | |
Activity (binding) | Decrease in paraquat-induced caspase-3 activity in SH-SY5Y cells | ChEMBL. | 17300930 | |
Activity (binding) | Decrease in paraquat-induced caspase 9 activity in SH-SY5Y cells | ChEMBL. | 17300930 | |
Activity (binding) | Decrease in sodium nitroprusside-induced caspase 9 activity in SH-SY5Y cells | ChEMBL. | 17300930 | |
Activity (binding) | 0 | Decrease in paraquat-induced caspase-3 activity in SH-SY5Y cells | ChEMBL. | 17300930 |
Activity (functional) | 0 | Reduction of sodium nitroprusside-induced cell death in SH-SY5Y cells assessed as subG1 DNA content relative to control | ChEMBL. | 17300930 |
Activity (functional) | 0 | Reduction of paraquat-induced cell death in SH-SY5Y cells assessed as subG1 DNA content relative to control | ChEMBL. | 17300930 |
Activity (binding) | 0 | Decrease in sodium nitroprusside-induced caspase-3 activity in SH-SY5Y cells | ChEMBL. | 17300930 |
Activity (binding) | 0 | Decrease in sodium nitroprusside-induced caspase 9 activity in SH-SY5Y cells | ChEMBL. | 17300930 |
Activity (functional) | 0 | Reduction of nitric oxide-induced intracellular calcium level in SH-SY5Y cells | ChEMBL. | 17300930 |
Activity (binding) | 0 | Decrease in paraquat-induced caspase 9 activity in SH-SY5Y cells | ChEMBL. | 17300930 |
Activity (functional) | 0 | Reduction of sodium nitroprusside-induced nitric oxide production in SH-SY5Y cells | ChEMBL. | 17300930 |
Activity (functional) | = 66.3 % | Inhibition of 2 mM paraquat-induced cell death in SH-SY5Y cells assessed as increase in cell viability at 10 ug/mL after 24 hrs by MTT assay relative to control | ChEMBL. | 17300930 |
Activity (functional) | = 66.3 % | Inhibition of 2 mM paraquat-induced cell death in SH-SY5Y cells assessed as increase in cell viability at 10 ug/mL after 24 hrs by MTT assay relative to control | ChEMBL. | 17300930 |
Activity (functional) | = 78.7 % | Increase in cell viability of SH-SY5Y cells in serum starved conditions at 30 ug/mL after 48 hrs by MTT assay relative to control | ChEMBL. | 17300930 |
Activity (functional) | = 78.7 % | Increase in cell viability of SH-SY5Y cells in serum starved conditions at 30 ug/mL after 48 hrs by MTT assay relative to control | ChEMBL. | 17300930 |
Activity (functional) | = 85.6 % | Inhibition of 2 mM paraquat-induced cell death in SH-SY5Y cells assessed as increase in cell viability at 20 ug/mL after 24 hrs by MTT assay relative to control | ChEMBL. | 17300930 |
Activity (functional) | = 85.6 % | Inhibition of 2 mM paraquat-induced cell death in SH-SY5Y cells assessed as increase in cell viability at 20 ug/mL after 24 hrs by MTT assay relative to control | ChEMBL. | 17300930 |
Activity (functional) | = 88.1 % | Inhibition of 5 mM sodium nitroprusside-induced cell death in SH-SY5Y cells assessed as increase in cell viability at 30 ug/mL after 24 hrs by MTT assay relative to control | ChEMBL. | 17300930 |
Activity (functional) | = 88.1 % | Inhibition of 5 mM sodium nitroprusside-induced cell death in SH-SY5Y cells assessed as increase in cell viability at 30 ug/mL after 24 hrs by MTT assay relative to control | ChEMBL. | 17300930 |
Activity (functional) | = 91.4 % | Increase in cell viability of SH-SY5Y cells in serum starved conditions at 20 ug/mL after 48 hrs by MTT assay relative to control | ChEMBL. | 17300930 |
Activity (functional) | = 91.4 % | Increase in cell viability of SH-SY5Y cells in serum starved conditions at 20 ug/mL after 48 hrs by MTT assay relative to control | ChEMBL. | 17300930 |
Activity (functional) | = 96.1 % | Effect on sodium nitroprusside-induced intracellular calcium level in SH-SY5Y cells after 8 hrs relative to control | ChEMBL. | 17300930 |
Activity (functional) | = 96.1 % | Effect on sodium nitroprusside-induced intracellular calcium level in SH-SY5Y cells after 25 hrs relative to control | ChEMBL. | 17300930 |
Activity (functional) | = 96.1 % | Effect on sodium nitroprusside-induced intracellular calcium level in SH-SY5Y cells after 8 hrs relative to control | ChEMBL. | 17300930 |
Activity (functional) | = 96.1 % | Effect on sodium nitroprusside-induced intracellular calcium level in SH-SY5Y cells after 25 hrs relative to control | ChEMBL. | 17300930 |
Activity (functional) | = 98.3 % | Effect on 2 mM paraquat-induced intracellular calcium level in SH-SY5Y cells after 24 hrs relative to contro | ChEMBL. | 17300930 |
Activity (functional) | = 98.3 % | Effect on 2 mM paraquat-induced intracellular calcium level in SH-SY5Y cells after 24 hrs relative to contro | ChEMBL. | 17300930 |
Activity (functional) | = 99.1 % | Effect on 2 mM paraquat-induced intracellular calcium level in SH-SY5Y cells after 8 hrs relative to control | ChEMBL. | 17300930 |
Activity (functional) | = 99.1 % | Effect on 2 mM paraquat-induced intracellular calcium level in SH-SY5Y cells after 8 hrs relative to control | ChEMBL. | 17300930 |
Activity (functional) | = 102.5 % | Inhibition of 2 mM paraquat-induced cell death in SH-SY5Y cells assessed as increase in cell viability at 30 ug/mL after 24 hrs by MTT assay relative to control | ChEMBL. | 17300930 |
Activity (functional) | = 102.5 % | Inhibition of 2 mM paraquat-induced cell death in SH-SY5Y cells assessed as increase in cell viability at 30 ug/mL after 24 hrs by MTT assay relative to control | ChEMBL. | 17300930 |
Activity (functional) | = 103.4 % | Reduction on sodium nitroprusside-induced ROS production in SH-SY5Y cells | ChEMBL. | 17300930 |
Activity (functional) | = 103.4 % | Reduction on sodium nitroprusside-induced ROS production in SH-SY5Y cells | ChEMBL. | 17300930 |
Activity (functional) | = 103.6 % | Reduction on paraquat-induced ROS production in SH-SY5Y cells | ChEMBL. | 17300930 |
Activity (functional) | = 103.6 % | Reduction on paraquat-induced ROS production in SH-SY5Y cells | ChEMBL. | 17300930 |
Activity (functional) | = 105.7 % | Increase in cell viability of SH-SY5Y cells in serum starved conditions at 10 ug/mL after 48 hrs by MTT assay relative to control | ChEMBL. | 17300930 |
Activity (functional) | = 105.7 % | Increase in cell viability of SH-SY5Y cells in serum starved conditions at 10 ug/mL after 48 hrs by MTT assay relative to control | ChEMBL. | 17300930 |
Activity (functional) | = 108.6 % | Inhibition of 1 mM sodium nitroprusside-induced cell death in SH-SY5Y cells assessed as increase in cell viability at 30 ug/mL after 24 hrs by MTT assay relative to control | ChEMBL. | 17300930 |
Activity (functional) | = 108.6 % | Inhibition of 1 mM sodium nitroprusside-induced cell death in SH-SY5Y cells assessed as increase in cell viability at 30 ug/mL after 24 hrs by MTT assay relative to control | ChEMBL. | 17300930 |
Activity (functional) | = 109.8 % | Inhibition of 3 mM sodium nitroprusside-induced cell death in SH-SY5Y cells assessed as increase in cell viability at 30 ug/mL after 24 hrs by MTT assay relative to control | ChEMBL. | 17300930 |
Activity (functional) | = 109.8 % | Inhibition of 3 mM sodium nitroprusside-induced cell death in SH-SY5Y cells assessed as increase in cell viability at 30 ug/mL after 24 hrs by MTT assay relative to control | ChEMBL. | 17300930 |
Activity (functional) | = 119.3 % | Effect on 3 mM sodium nitroprusside-induced mitochondrial transmembrane potential level in SH-SY5Y cells after 24 hrs | ChEMBL. | 17300930 |
Activity (functional) | = 119.3 % | Effect on 3 mM sodium nitroprusside-induced mitochondrial transmembrane potential level in SH-SY5Y cells after 24 hrs | ChEMBL. | 17300930 |
Activity (functional) | = 128.3 % | Effect on 3 mM sodium nitroprusside-induced mitochondrial transmembrane potential level in SH-SY5Y cells after 8 hrs | ChEMBL. | 17300930 |
Activity (functional) | = 128.3 % | Effect on 3 mM sodium nitroprusside-induced mitochondrial transmembrane potential level in SH-SY5Y cells after 8 hrs | ChEMBL. | 17300930 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.