Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0124 | 0.1292 | 0.2555 |
Echinococcus granulosus | acetylcholinesterase | 0.0371 | 0.5056 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0124 | 0.1292 | 0.2555 |
Echinococcus multilocularis | acetylcholinesterase | 0.0371 | 0.5056 | 1 |
Onchocerca volvulus | 0.0124 | 0.1292 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0124 | 0.1292 | 0.2555 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0124 | 0.1292 | 0.2555 |
Giardia lamblia | Hypothetical protein | 0.0039 | 0 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0124 | 0.1292 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.5056 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0124 | 0.1292 | 0.2555 |
Onchocerca volvulus | 0.0124 | 0.1292 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0124 | 0.1292 | 0.2555 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0124 | 0.1292 | 0.2555 |
Brugia malayi | Carboxylesterase family protein | 0.0371 | 0.5056 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0124 | 0.1292 | 0.2555 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0124 | 0.1292 | 0.1292 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0124 | 0.1292 | 0.1292 |
Brugia malayi | Carboxylesterase family protein | 0.0371 | 0.5056 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0124 | 0.1292 | 0.2555 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0124 | 0.1292 | 0.2555 |
Loa Loa (eye worm) | carboxylesterase | 0.0371 | 0.5056 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0124 | 0.1292 | 0.2555 |
Onchocerca volvulus | 0.0124 | 0.1292 | 1 | |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0124 | 0.1292 | 0.2555 |
Echinococcus multilocularis | neuroligin | 0.0124 | 0.1292 | 0.2555 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0371 | 0.5056 | 1 |
Brugia malayi | hypothetical protein | 0.0124 | 0.1292 | 0.2555 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0371 | 0.5056 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0124 | 0.1292 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0371 | 0.5056 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0695 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.5056 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0039 | 0 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0124 | 0.1292 | 0.2555 |
Echinococcus granulosus | carboxylesterase 5A | 0.0371 | 0.5056 | 1 |
Onchocerca volvulus | 0.0124 | 0.1292 | 1 | |
Mycobacterium leprae | Conserved hypothetical protein | 0.0039 | 0 | 0.5 |
Onchocerca volvulus | 0.0124 | 0.1292 | 1 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0371 | 0.5056 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0124 | 0.1292 | 0.2555 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0124 | 0.1292 | 0.2555 |
Schistosoma mansoni | gliotactin | 0.0124 | 0.1292 | 0.2555 |
Brugia malayi | Carboxylesterase family protein | 0.0124 | 0.1292 | 0.2555 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0124 | 0.1292 | 0.2555 |
Echinococcus granulosus | acetylcholinesterase | 0.0371 | 0.5056 | 1 |
Giardia lamblia | Transglutaminase/protease, putative | 0.0039 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | 0 | Binding affinity to human androgen receptor expressed in CV1 cells | ChEMBL. | 17257838 |
Efficacy (functional) | = 70 % | Antagonist activity at human androgen receptor expressed in CV1 cells assessed as inhibition of DHT-induced response | ChEMBL. | 17257838 |
IC50 (functional) | = 50 nM | Antagonist activity at human androgen receptor expressed in CV1 cells | ChEMBL. | 17257838 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.