Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0725 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0725 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0725 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0448 | 0.2407 | 0.2407 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0365 | 0.0151 | 0.0151 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0725 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.036 | 0 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0725 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0448 | 0.2407 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0448 | 0.2407 | 0.0803 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0725 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0725 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0448 | 0.2407 | 0.0803 |
Leishmania major | cytochrome P450 reductase, putative | 0.0643 | 0.7743 | 0.7267 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0725 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0643 | 0.7743 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0725 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0725 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0725 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0725 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0725 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0725 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0725 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0725 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0725 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0725 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0725 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0725 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0725 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0725 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0643 | 0.7743 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.036 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 300 uM | Antiviral activity against SARS-CoV Frankfurt1 in Vero E6 cells by plaque reduction assay | ChEMBL. | 17336519 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.