Detailed information for compound 432251

Basic information

Technical information
  • TDR Targets ID: 432251
  • Name: N-[4-cyano-3-(trifluoromethyl)phenyl]-3-methy l-5-(trifluoromethyl)-1,4-dihydropyrazole-5-c arboxamide
  • MW: 364.246 | Formula: C14H10F6N4O
  • H donors: 2 H acceptors: 2 LogP: 2.62 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(cc1C(F)(F)F)NC(=O)C1(NN=C(C1)C)C(F)(F)F
  • InChi: 1S/C14H10F6N4O/c1-7-5-12(24-23-7,14(18,19)20)11(25)22-9-3-2-8(6-21)10(4-9)13(15,16)17/h2-4,24H,5H2,1H3,(H,22,25)
  • InChiKey: KPYWWPHSQAGLAM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-cyano-3-(trifluoromethyl)phenyl]-5-methyl-3-(trifluoromethyl)-2-pyrazoline-3-carboxamide
  • N-[4-cyano-3-(trifluoromethyl)phenyl]-5-methyl-3-(trifluoromethyl)-2,4-dihydropyrazole-3-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Reverse transcriptase/endonuclease 0.0011 0.0012 0.003
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0461 0.6389 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.012 0.1566 0.256
Brugia malayi 6-phosphofructokinase 0.0121 0.158 0.1579
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0609 0.1143
Schistosoma mansoni hypothetical protein 0.0011 0.0012 0.0017
Echinococcus granulosus tachykinin peptides receptor 99D 0.0461 0.6389 1
Trypanosoma brucei cytochrome P450, putative 0.0014 0.0056 0.0068
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0326 0.0352
Brugia malayi hypothetical protein 0.0461 0.6389 0.6389
Toxoplasma gondii DNA polymerase 0.0017 0.0098 0.0209
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0011 0.0012 0.0017
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0461 0.6389 1
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0439 0.6084 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0121 0.0109
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0174 0.0434
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0121 0.0236
Plasmodium falciparum glutathione reductase 0.0053 0.0609 0.1311
Brugia malayi hypothetical protein 0.0461 0.6389 0.6389
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Loa Loa (eye worm) hypothetical protein 0.0022 0.018 0.018
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0461 0.6389 0.9891
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0256 0.0652
Trypanosoma brucei ingi protein (ORF1) 0.0056 0.066 0.1005
Brugia malayi Cytochrome P450 family protein 0.0014 0.0056 0.0055
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0028 0.0256 0.0526
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0461 0.6389 1
Wolbachia endosymbiont of Brugia malayi hypothetical protein 0.0018 0.0117 0.0001
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0326 0.0842
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0461 0.6389 0.9891
Onchocerca volvulus 0.0461 0.6389 1
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Schistosoma mansoni intermediate filament proteins 0.003 0.0286 0.0441
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0017 0.0098 0.0152
Brugia malayi hypothetical protein 0.0022 0.018 0.0179
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0012 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0461 0.6389 0.9891
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0461 0.6389 0.9891
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0017 0.0098 0.0229
Onchocerca volvulus 0.0461 0.6389 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0174 0.0357
Loa Loa (eye worm) G-protein coupled receptor 0.0461 0.6389 0.6389
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Echinococcus multilocularis thymidylate synthase 0.0104 0.1337 0.2092
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.018 0.028
Plasmodium falciparum thioredoxin reductase 0.0053 0.0609 0.1311
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.018 0.0277
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0012 0.0011
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0121 0.158 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.018 0.028
Echinococcus granulosus orexin receptor type 2 0.0461 0.6389 1
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Echinococcus multilocularis rhodopsin orphan GPCR 0.0461 0.6389 1
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0197 0.0497
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0046 0.051 1
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.018 0.045
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0461 0.6389 0.6389
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0121 0.0236
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0011 0.0012 0.003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0461 0.6389 0.9891
Brugia malayi sulfakinin receptor protein 0.0461 0.6389 0.6389
Onchocerca volvulus 0.0461 0.6389 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0121 0.0071
Brugia malayi 6-phosphofructokinase 0.0121 0.158 0.1579
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.018 0.0179
Plasmodium falciparum DNA polymerase alpha catalytic subunit A 0.0017 0.0104 0.0221
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.018 0.018
Echinococcus granulosus dro:myosuppressin receptor 0.0461 0.6389 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0121 0.0189
Echinococcus granulosus KRAB A domain containing protein 0.0011 0.0012 0.0017
Brugia malayi RNase H family protein 0.0046 0.051 0.051
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0104 0.1337 0.2183
Loa Loa (eye worm) 6-phosphofructokinase 0.0121 0.158 0.158
Echinococcus granulosus neuropeptide receptor A26 0.0461 0.6389 1
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.018 0.028
Trypanosoma brucei unspecified product 0.0056 0.066 0.1005
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0609 0.0953
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0174 0.0267
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0017 0.0098 0.0152
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0326 0.0701
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0564 0.1478
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0197 0.0197
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.018 0.045
Loa Loa (eye worm) hypothetical protein 0.003 0.0286 0.0286
Echinococcus multilocularis lamin dm0 0.003 0.0286 0.0446
Trypanosoma brucei RNA helicase, putative 0.0466 0.646 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0461 0.6389 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0461 0.6389 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0174 0.0174
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0461 0.6389 1
Brugia malayi RNase H family protein 0.0046 0.051 0.051
Echinococcus granulosus alpha 1A adrenergic receptor 0.0461 0.6389 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0121 0.026
Loa Loa (eye worm) CYP4Cod1 0.0014 0.0056 0.0056
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.005 0.0564 0.1192
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0461 0.6389 0.9891
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.0609 0.0984
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0067 0.0103
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0157 0.0336
Schistosoma mansoni phosphoglucomutase 0.0046 0.051 0.0789
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0121 0.0236
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0174 0.035
Leishmania major trypanothione reductase 0.0053 0.0609 0.1234
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0174 0.0462
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0011 0.0012 0.0017
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0326 0.0842
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0012 0.0011
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0326 0.0842
Onchocerca volvulus 0.0461 0.6389 1
Mycobacterium ulcerans 6-phosphofructokinase 0.0121 0.158 0.2528
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0121 0.0187
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0174 0.0434
Schistosoma mansoni alpha-1 adrenergic receptor 0.0461 0.6389 0.9891
Brugia malayi Zinc knuckle family protein 0.0011 0.0012 0.0011
Echinococcus granulosus neuropeptide Y receptor 0.0461 0.6389 1
Brugia malayi hypothetical protein 0.0011 0.0012 0.0011
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0461 0.6389 1
Schistosoma mansoni opsin-like receptor 0.0461 0.6389 0.9891
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0326 0.0521
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0134 0.1756 0.0883
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0461 0.6389 0.9891
Giardia lamblia DNA polymerase alpha subunit A 0.0051 0.0583 0.1554
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0121 0.0236
Brugia malayi RNase H family protein 0.0046 0.051 0.051
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0326 0.0842
Loa Loa (eye worm) hypothetical protein 0.0022 0.018 0.018
Schistosoma mansoni amine GPCR 0.0461 0.6389 0.9891
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0056 0.0056
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0026 0.0234 0.0418
Echinococcus multilocularis neuropeptide FF receptor 2 0.0461 0.6389 1
Echinococcus granulosus p2X purinoceptor 4 0.0272 0.372 0.5822
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0012 0.0011
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0001 0.0001
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0028 0.0256 0.0378
Onchocerca volvulus 0.0461 0.6389 1
Giardia lamblia Thymidine kinase 0.0274 0.3748 1
Brugia malayi ORL1-like opioid receptor 0.0461 0.6389 0.6389
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0121 0.0121
Echinococcus granulosus tm gpcr rhodopsin 0.0461 0.6389 1
Echinococcus granulosus allatostatin A receptor 0.0461 0.6389 1
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0017 0.0098 0.0229
Brugia malayi Dopamine receptor protein 2 0.0461 0.6389 0.6389
Plasmodium falciparum glutathione reductase 0.0018 0.0121 0.026
Echinococcus granulosus RNA directed DNA polymerase 0.0011 0.0012 0.0017
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Echinococcus granulosus tm gpcr rhodopsin 0.0461 0.6389 1
Brugia malayi intermediate filament protein 0.003 0.0286 0.0285
Leishmania major thymidine kinase, putative 0.0274 0.3748 0.8052
Brugia malayi hypothetical protein 0.0011 0.0012 0.0011
Schistosoma mansoni P2X receptor subunit 0.0272 0.372 0.5759
Echinococcus granulosus rhodopsin orphan GPCR 0.0461 0.6389 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.018 0.0179
Entamoeba histolytica DNA repair and recombination protein, putative 0.0028 0.0256 0.0578
Schistosoma mansoni opsin-like receptor 0.0461 0.6389 0.9891
Loa Loa (eye worm) hypothetical protein 0.0022 0.018 0.018
Brugia malayi hypothetical protein 0.0461 0.6389 0.6389
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0059
Brugia malayi hypothetical protein 0.0461 0.6389 0.6389
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.018 0.028
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.018 0.0179
Schistosoma mansoni amine GPCR 0.0461 0.6389 0.9891
Echinococcus granulosus hypothetical protein 0.0461 0.6389 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0461 0.6389 0.9891
Brugia malayi reverse transcriptase 0.0011 0.0012 0.0011
Giardia lamblia O-linked GlcNAc transferase 0.0027 0.0238 0.0634
Echinococcus granulosus g protein coupled receptor 0.0461 0.6389 1
Loa Loa (eye worm) neuropeptide F receptor 0.0461 0.6389 0.6389
Brugia malayi RE15519p 0.0461 0.6389 0.6389
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0461 0.6389 0.9891
Echinococcus granulosus 7TM GPCR rhodopsin 0.0461 0.6389 1
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Onchocerca volvulus Neuropeptide F receptor homolog 0.0461 0.6389 1
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.0017 0.0098 0.0019
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0461 0.6389 1
Echinococcus multilocularis RNA directed DNA polymerase 0.0011 0.0012 0.0017
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0286 0.0285
Leishmania major cytochrome p450-like protein 0.0014 0.0056 0.0031
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0028 0.0256 0.0465
Schistosoma mansoni histamine h1 receptor 0.0461 0.6389 0.9891
Onchocerca volvulus 0.0461 0.6389 1
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0326 0.0842
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0174 0.035
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0017 0.0098 0.0185
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0338 0.4644 1
Echinococcus multilocularis fmrfamide receptor 0.0461 0.6389 1
Brugia malayi Dopamine receptor 0.0461 0.6389 0.6389
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0461 0.6389 0.9891
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0011 0.0012 0.0017
Toxoplasma gondii O-linked N-acetylglucosamine transferase 0.0045 0.0505 0.1086
Echinococcus multilocularis p2X purinoceptor 4 0.0272 0.372 0.5822
Onchocerca volvulus 0.0461 0.6389 1
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0022 0.018 0.045
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0017 0.0098 0.0152
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0326 0.0769
Mycobacterium tuberculosis Putative ferredoxin reductase 0.012 0.1566 0.256
Schistosoma mansoni ap endonuclease 0.0022 0.0174 0.0268
Brugia malayi hypothetical protein 0.0461 0.6389 0.6389
Schistosoma mansoni hypothetical protein 0.0466 0.646 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0174 0.0271
Brugia malayi putative neuropeptide receptor 0.0461 0.6389 0.6389
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.018 0.028
Onchocerca volvulus 0.0461 0.6389 1
Brugia malayi dihydrofolate reductase family protein 0.0439 0.6084 0.6083
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.018 0.028
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.018 0.028
Brugia malayi UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 0.0046 0.051 0.0509
Brugia malayi Dihydrofolate reductase 0.0439 0.6084 0.6083
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0461 0.6389 0.9891
Echinococcus multilocularis rhodopsin orphan GPCR 0.0461 0.6389 1
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0041 0.0079
Echinococcus granulosus rhodopsin orphan GPCR 0.0461 0.6389 1
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.018 0.045
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.018 0.028
Schistosoma mansoni neuropeptide f receptor 76f 0.0461 0.6389 0.9891
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0461 0.6389 0.6389
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0121 0.0293
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0028 0.0256 0.0526
Schistosoma mansoni hypothetical protein 0.0461 0.6389 0.9891
Loa Loa (eye worm) hypothetical protein 0.0014 0.0067 0.0067
Loa Loa (eye worm) UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 0.0046 0.051 0.051
Echinococcus granulosus G protein coupled receptor 139 0.0461 0.6389 1
Brugia malayi DNA polymerase alpha catalytic subunit 0.0049 0.0553 0.0552
Schistosoma mansoni biogenic amine receptor 0.0461 0.6389 0.9891
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.018 0.0277
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0028 0.0256 0.0399
Echinococcus granulosus tm gpcr rhodopsin 0.0461 0.6389 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0461 0.6389 1
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0017 0.0098 0.0097
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0089 0.0089
Mycobacterium tuberculosis Probable oxidoreductase 0.0134 0.1756 0.2873
Brugia malayi hypothetical protein 0.0461 0.6389 0.6389
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0017 0.0098 0.015
Loa Loa (eye worm) hypothetical protein 0.0083 0.1032 0.1032
Schistosoma mansoni P2X receptor subunit 0.0272 0.372 0.5759
Leishmania major ATP-dependent phosphofructokinase 0.0121 0.158 0.3342
Echinococcus multilocularis rhodopsin orphan GPCR 0.0461 0.6389 1
Schistosoma mansoni P2X receptor subunit 0.0135 0.1775 0.2748
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0001 0.0000000001356
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0461 0.6389 0.9891
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0033 0.0326 0.0869
Mycobacterium tuberculosis Probable reductase 0.012 0.1566 0.256
Loa Loa (eye worm) hypothetical protein 0.0019 0.013 0.013
Echinococcus multilocularis dro:myosuppressin receptor 0.0461 0.6389 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0716 1 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0461 0.6389 1
Echinococcus multilocularis neuropeptide receptor A26 0.0461 0.6389 1
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.158 0.415
Echinococcus multilocularis neuropeptides capa receptor 0.0461 0.6389 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0121 0.0174
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0017 0.0098 0.0098
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.0017 0.0098 0.0019
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0338 0.4644 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0278 0.0278
Loa Loa (eye worm) TYRA-2 protein 0.0461 0.6389 0.6389
Echinococcus multilocularis g protein coupled receptor 0.0461 0.6389 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0067 0.0103
Schistosoma mansoni hypothetical protein 0.0461 0.6389 0.9891
Echinococcus granulosus p2X purinoceptor 4 0.0272 0.372 0.5822
Echinococcus multilocularis rhodopsin orphan GPCR 0.0461 0.6389 1
Echinococcus granulosus neuropeptides capa receptor 0.0461 0.6389 1
Treponema pallidum ribonuclease H (rnhA) 0.0046 0.051 0.2692
Loa Loa (eye worm) RGS-3 protein 0.0022 0.018 0.018
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0017 0.0098 0.0152
Toxoplasma gondii DNA polymerase family B protein 0.0017 0.0098 0.0209
Schistosoma mansoni amine GPCR 0.0461 0.6389 0.9891
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0461 0.6389 0.6389
Schistosoma mansoni neuropeptide receptor 0.0461 0.6389 0.9891
Echinococcus granulosus bloom syndrome protein 0.0024 0.0197 0.0308
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0461 0.6389 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0326 0.0701
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0461 0.6389 1
Entamoeba histolytica hypothetical protein, conserved 0.0028 0.0256 0.0578
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0338 0.4644 0.7184
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0011 0.0012 0.0017
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.006 0.0714 0.1104
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0053 0.0052
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0012 0.0011
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0461 0.6389 0.9891
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0121 0.017
Echinococcus multilocularis g protein coupled receptor 0.0461 0.6389 1
Echinococcus multilocularis neuropeptide Y receptor 0.0461 0.6389 1
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.018 0.0179
Schistosoma mansoni dihydrofolate reductase 0.0439 0.6084 0.9418
Echinococcus granulosus biogenic amine 5HT receptor 0.0461 0.6389 1
Echinococcus multilocularis allatostatin A receptor 0.0461 0.6389 1
Mycobacterium ulcerans thymidylate synthase 0.0104 0.1337 0.2126
Schistosoma mansoni biogenic amine (5HT) receptor 0.0461 0.6389 0.9891
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0017 0.0098 0.0152
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0121 0.017
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Brugia malayi G-protein coupled receptor 0.0461 0.6389 0.6389
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0121 0.0293
Onchocerca volvulus Ribonuclease H1 homolog 0.0046 0.051 0.0782
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.018 0.045
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0174 0.0271
Brugia malayi neuropeptide F receptor 0.0461 0.6389 0.6389
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0012 0.0011
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0439 0.6084 1
Echinococcus granulosus neuropeptides capa receptor 0.0461 0.6389 1
Giardia lamblia Ribonuclease H 0.0046 0.051 0.136
Schistosoma mansoni neuropeptide F-like receptor 0.0461 0.6389 0.9891
Schistosoma mansoni amine GPCR 0.0461 0.6389 0.9891
Echinococcus granulosus rhodopsin orphan GPCR 0.0461 0.6389 1
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0439 0.6084 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0326 0.0701
Schistosoma mansoni lamin 0.003 0.0286 0.0441
Giardia lamblia DNA polymerase epsilon, catalytic subunit 0.0017 0.0098 0.0259
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0461 0.6389 1
Echinococcus granulosus serotonin receptor 0.0461 0.6389 1
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.158 0.4196
Echinococcus multilocularis neuropeptides capa receptor 0.0461 0.6389 1
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0017 0.0098 0.0122
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0017 0.0098 0.0185
Echinococcus granulosus g protein coupled receptor 0.0461 0.6389 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.012 0.1566 0.256
Plasmodium vivax glutathione reductase, putative 0.0053 0.0609 0.1143
Loa Loa (eye worm) 6-phosphofructokinase 0.0121 0.158 0.158
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0326 0.0352
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0028 0.0256 0.0526
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0121 0.0236
Chlamydia trachomatis dihydrofolate reductase 0.0439 0.6084 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0174 0.0392
Loa Loa (eye worm) melatonin receptor type 1A 0.0461 0.6389 0.6389
Trypanosoma cruzi ribonuclease H1, putative 0.0046 0.051 0.1076
Echinococcus granulosus axis inhibition protein axin 0.0022 0.018 0.028
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0011 0.0012 0.003
Trichomonas vaginalis thymidine kinase, putative 0.0274 0.3748 1
Brugia malayi PXA domain containing protein 0.0022 0.018 0.0179
Mycobacterium tuberculosis Probable dehydrogenase 0.012 0.1566 0.256
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0017 0.0098 0.0134
Schistosoma mansoni axis inhibition protein axin 0.0022 0.018 0.0277
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0326 0.0701
Echinococcus multilocularis neuropeptide receptor 0.0461 0.6389 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0174 0.0196
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0134 0.1756 0.2873
Echinococcus granulosus neuropeptide receptor 0.0461 0.6389 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0461 0.6389 1
Echinococcus granulosus sex peptide receptor 0.0461 0.6389 1
Echinococcus multilocularis neuropeptide receptor 0.0461 0.6389 1
Echinococcus multilocularis sex peptide receptor 0.0461 0.6389 1
Schistosoma mansoni hypothetical protein 0.0461 0.6389 0.9891
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0286 0.0286
Brugia malayi Thioredoxin reductase 0.0053 0.0609 0.0609
Loa Loa (eye worm) hypothetical protein 0.0022 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0056 0.0056
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0461 0.6389 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0174 0.0288
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0121 0.018
Brugia malayi G-protein coupled receptor 0.0461 0.6389 0.6389
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0012 0.0011
Brugia malayi GnHR receptor homolog 0.0461 0.6389 0.6389
Loa Loa (eye worm) glutathione reductase 0.0053 0.0609 0.0609
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.006 0.0714 0.1116
Loa Loa (eye worm) dihydrofolate reductase 0.0439 0.6084 0.6084
Schistosoma mansoni regulator of G protein signaling 0.0022 0.018 0.0277
Onchocerca volvulus 0.0461 0.6389 1
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0017 0.0098 0.0152
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0461 0.6389 0.9891
Schistosoma mansoni neuropeptide F-like receptor 0.0461 0.6389 0.9891
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0017 0.0098 0.0152
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.018 0.028
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0461 0.6389 1
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0461 0.6389 0.9891
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0017 0.0098 0.0122
Echinococcus multilocularis O glycosyltransferase 0.0046 0.0512 0.08
Echinococcus multilocularis rhodopsin orphan GPCR 0.0461 0.6389 1
Schistosoma mansoni 6-phosphofructokinase 0.0121 0.158 0.2444
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0121 0.026
Brugia malayi reverse transcriptase 0.0011 0.0012 0.0011
Echinococcus granulosus dihydrofolate reductase 0.0439 0.6084 0.9522
Brugia malayi AKH receptor 0.0461 0.6389 0.6389
Loa Loa (eye worm) neuropeptide F receptor 0.0461 0.6389 0.6389
Treponema pallidum NADH oxidase 0.0018 0.0121 0.0033
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.018 0.018
Schistosoma mansoni hypothetical protein 0.0011 0.0012 0.0017
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0121 0.0121
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0127 0.0195
Brugia malayi DNA polymerase family B containing protein 0.0017 0.0098 0.0097
Trichomonas vaginalis thymidine kinase, putative 0.0274 0.3748 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0121 0.0174
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.018 0.018
Trichomonas vaginalis thymidine kinase, putative 0.0274 0.3748 1
Brugia malayi Dopamine receptor protein 1 0.0461 0.6389 0.6389
Toxoplasma gondii thioredoxin reductase 0.0053 0.0609 0.1311
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0012 0.0011
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.0056 0.0094
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0134 0.1756 0.2873
Echinococcus multilocularis 6 phosphofructokinase 0.0121 0.158 0.2471
Echinococcus multilocularis p2X purinoceptor 4 0.0272 0.372 0.5822
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0011 0.0012 0.0017
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0086 0.0184
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0461 0.6389 1
Brugia malayi thymidylate synthase 0.0104 0.1337 0.1336
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0609 0.0609
Brugia malayi Tachykinin-like peptides receptor 99D 0.0461 0.6389 0.6389
Trypanosoma cruzi ribonuclease H1, putative 0.0046 0.051 0.1076
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0121 0.158 0.2582
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0121 0.0174
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0059
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0017 0.0098 0.0229
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0461 0.6389 0.9891
Schistosoma mansoni hypothetical protein 0.0028 0.0256 0.0395
Schistosoma mansoni neuropeptide receptor 0.0461 0.6389 0.9891
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0017 0.0098 0.0133
Schistosoma mansoni opsin-like receptor 0.0461 0.6389 0.9891
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0011 0.0012 0.0017
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0012 0.0011
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0121 0.158 0.3384
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0121 0.0236
Plasmodium falciparum thioredoxin reductase 0.0018 0.0121 0.026
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.018 0.028
Echinococcus granulosus expressed protein 0.0436 0.6043 0.9458
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0017 0.0098 0.0209
Brugia malayi Serotonin receptor 0.0461 0.6389 0.6389
Echinococcus multilocularis g-protein coupled receptor 0.0461 0.6389 1
Echinococcus granulosus neuropeptide receptor 0.0461 0.6389 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0033 0.0326 0.1434
Echinococcus granulosus neuropeptide s receptor 0.0461 0.6389 1
Onchocerca volvulus 0.0461 0.6389 1
Mycobacterium tuberculosis Hypothetical protein 0.005 0.0564 0.0909
Brugia malayi PXA domain containing protein 0.0022 0.018 0.0179
Brugia malayi neuropeptide F receptor 0.0461 0.6389 0.6389
Brugia malayi hypothetical protein 0.0461 0.6389 0.6389
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0121 0.0174
Brugia malayi hypothetical protein 0.0461 0.6389 0.6389
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0121 0.026
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0011 0.0012 0.0017
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0461 0.6389 1
Schistosoma mansoni axis inhibition protein axin 0.0022 0.018 0.0277
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0326 0.0842
Echinococcus multilocularis fmrfamide receptor 0.0461 0.6389 1
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0121 0.158 0.2431
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0083 0.1032 0.16
Echinococcus multilocularis ribonuclease H1 0.0046 0.051 0.0798
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Toxoplasma gondii exonuclease III APE 0.0022 0.0174 0.0373
Onchocerca volvulus 0.0461 0.6389 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0461 0.6389 0.9891
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0338 0.4644 1
Onchocerca volvulus 0.0461 0.6389 1
Onchocerca volvulus 0.0104 0.1337 0.2078
Echinococcus multilocularis serotonin receptor 0.0461 0.6389 1
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0026 0.0234 0.0595
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.018 0.028
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0017 0.0098 0.015
Echinococcus granulosus p2X purinoceptor 4 0.0272 0.372 0.5822
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0121 0.0236
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Onchocerca volvulus 0.003 0.0286 0.0429
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0461 0.6389 0.9891
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0011 0.0012 0.0017
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.012 0.1566 0.0483
Schistosoma mansoni myosin xvIII 0.0461 0.6389 0.9891
Schistosoma mansoni regulator of G protein signaling 0.0022 0.018 0.0277
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0011 0.0012 0.0017
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0121 0.0071
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.158 0.4196
Brugia malayi larval opioid receptor 0.0461 0.6389 0.6389
Brugia malayi putative neuropeptide receptor NPR1 0.0461 0.6389 0.6389
Brugia malayi glutathione reductase 0.0053 0.0609 0.0609
Echinococcus granulosus rhodopsin orphan GPCR 0.0461 0.6389 1
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Echinococcus multilocularis neuropeptide Y receptor 0.0461 0.6389 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0461 0.6389 1
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0338 0.4644 1
Echinococcus multilocularis expressed protein 0.0436 0.6043 0.9458
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0053 0.0052
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0461 0.6389 1
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Echinococcus granulosus 7tm_1 domain containing protein 0.0461 0.6389 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.012 0.1566 0.256
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.0056 0.0094
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.018 0.028
Trypanosoma brucei ingi protein (ORF1) 0.0056 0.066 0.1005
Echinococcus granulosus neuropeptide Y receptor 0.0461 0.6389 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0121 0.158 0.0511
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.018 0.028
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.018 0.0277
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.158 0.415
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0461 0.6389 0.6389
Echinococcus granulosus lamin dm0 0.003 0.0286 0.0446
Schistosoma mansoni adenoreceptor 0.0461 0.6389 0.9891
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0121 0.0236
Leishmania major ribonuclease H1, putative 0.0046 0.051 0.1019
Loa Loa (eye worm) phosphofructokinase 0.0121 0.158 0.158
Echinococcus granulosus g protein coupled receptor 0.0461 0.6389 1
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0017 0.0098 0.0019
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Brugia malayi hypothetical protein 0.0461 0.6389 0.6389
Echinococcus granulosus lamin 0.003 0.0286 0.0446
Trypanosoma brucei trypanothione reductase 0.0053 0.0609 0.0927
Entamoeba histolytica DNA polymerase alpha catalytic subunit, putative 0.0017 0.0104 0.0168
Echinococcus multilocularis lamin 0.003 0.0286 0.0446
Brugia malayi reverse transcriptase 0.0011 0.0012 0.0011
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0174 0.0173
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.018 0.028
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.018 0.045
Brugia malayi G protein-coupled receptor 0.0461 0.6389 0.6389
Echinococcus multilocularis musashi 0.003 0.0286 0.0446
Giardia lamblia O-linked GlcNAc transferase 0.0045 0.0505 0.1345
Onchocerca volvulus 0.0461 0.6389 1
Echinococcus granulosus intermediate filament protein 0.003 0.0286 0.0446
Schistosoma mansoni neuropeptide receptor 0.0461 0.6389 0.9891
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0121 0.0322
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.0017 0.0098 0.0133
Echinococcus multilocularis rhodopsin orphan GPCR 0.0461 0.6389 1
Brugia malayi phosphofructokinase 0.0121 0.158 0.1579
Echinococcus granulosus ribonuclease H1 0.0046 0.051 0.0798
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0121 0.0008
Schistosoma mansoni 6-phosphofructokinase 0.0121 0.158 0.2444
Echinococcus multilocularis orexin receptor type 2 0.0461 0.6389 1
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.158 0.415
Echinococcus granulosus peptide allatostatin:somatostatin 0.0461 0.6389 1
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Echinococcus multilocularis p2X purinoceptor 4 0.0272 0.372 0.5822
Onchocerca volvulus 0.003 0.0286 0.0429
Loa Loa (eye worm) RecQ helicase 0.0024 0.0197 0.0197
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0017 0.0098 0.0185
Echinococcus granulosus g-protein coupled receptor 0.0461 0.6389 1
Echinococcus multilocularis dihydrofolate reductase 0.0439 0.6084 0.9522
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Echinococcus multilocularis somatostatin receptor 0.0461 0.6389 1
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0461 0.6389 0.9891
Trypanosoma cruzi thymidine kinase, putative 0.0274 0.3748 0.8065
Trypanosoma brucei hypothetical protein, conserved 0.0056 0.066 0.1005
Echinococcus granulosus thymidylate synthase 0.0104 0.1337 0.2092
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0461 0.6389 0.6389
Trypanosoma cruzi thymidine kinase, putative 0.0274 0.3748 0.8065
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0041 0.0064
Echinococcus granulosus biogenic amine 5HT receptor 0.0461 0.6389 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0121 0.017
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.006 0.0714 0.1116
Schistosoma mansoni neuropeptide receptor 0.0461 0.6389 0.9891
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.158 0.4196
Onchocerca volvulus 0.0461 0.6389 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0461 0.6389 0.6389
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0028 0.0256 0.0399
Schistosoma mansoni protein kinase 0.0011 0.0012 0.0017
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0197 0.0308
Schistosoma mansoni amine GPCR 0.0461 0.6389 0.9891
Echinococcus multilocularis G-protein coupled receptor, putative 0.0461 0.6389 1
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Brugia malayi hypothetical protein 0.005 0.0564 0.0563
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.158 0.4196
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.018 0.0277
Brugia malayi G protein-coupled receptor F59B2.13 0.0461 0.6389 0.6389
Trichomonas vaginalis DNA polymerase II, putative 0.0026 0.0234 0.0595
Giardia lamblia Rrm3p helicase 0.0028 0.0256 0.068
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Echinococcus multilocularis neuropeptide s receptor 0.0461 0.6389 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.018 0.018
Echinococcus granulosus 6 phosphofructokinase 0.0121 0.158 0.2471
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0028 0.0256 0.0378
Loa Loa (eye worm) hypothetical protein 0.0022 0.018 0.018
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.018 0.045
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0012 0.0017
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0011 0.0012 0.003
Schistosoma mansoni P2X receptor subunit 0.0135 0.1775 0.2748
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0121 0.017
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0461 0.6389 0.9891
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.018 0.018
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0011 0.0012 0.0017
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.018 0.0179
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0011 0.0012 0.0017
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0017 0.0098 0.0259
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0461 0.6389 0.6389
Echinococcus granulosus rhodopsin orphan GPCR 0.0461 0.6389 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0121 0.0109
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.018 0.0277
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0028 0.0256 0.0465
Echinococcus granulosus O glycosyltransferase 0.0046 0.0512 0.08
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0326 0.0701
Echinococcus multilocularis rhodopsin orphan GPCR 0.0461 0.6389 1
Trypanosoma brucei thymidine kinase 0.0274 0.3748 0.5794
Schistosoma mansoni biogenic amine (5HT) receptor 0.0461 0.6389 0.9891
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0197 0.0497
Echinococcus granulosus somatostatin receptor 0.0461 0.6389 1
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0026 0.0234 0.0344
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.018 0.0277
Plasmodium vivax DNA polymerase alpha, putative 0.0049 0.0553 0.1018
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0121 0.0109
Echinococcus multilocularis g protein coupled receptor 0.0461 0.6389 1
Brugia malayi DNA polymerase delta catalytic subunit 0.0017 0.0098 0.0097
Brugia malayi Zinc knuckle family protein 0.0011 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.018 0.028
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0461 0.6389 1
Mycobacterium ulcerans hypothetical protein 0.0018 0.0117 0.0101
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.018 0.0179
Schistosoma mansoni regulator of G protein signaling 0.0022 0.018 0.0277
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.018 0.028
Trypanosoma brucei ribonuclease H1 0.0046 0.051 0.0773
Schistosoma mansoni hypothetical protein 0.0461 0.6389 0.9891
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0174 0.1457
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0104 0.1337 0.2069
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0461 0.6389 0.6389
Trichomonas vaginalis ribonuclease H1, putative 0.0046 0.051 0.1334
Loa Loa (eye worm) G-protein coupled receptor 0.0461 0.6389 0.6389
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0011 0.0012 0.0017
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0041 0.0046
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.0017 0.0098 0.0134
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.0017 0.0098 0.0133
Echinococcus multilocularis G protein coupled receptor 139 0.0461 0.6389 1
Schistosoma mansoni phosphoglucomutase 0.0046 0.051 0.0789
Onchocerca volvulus 0.0461 0.6389 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0121 0.0236
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.018 0.028
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0174 0.0251
Entamoeba histolytica hypothetical protein 0.0022 0.018 0.0374
Entamoeba histolytica hypothetical protein 0.0022 0.018 0.0374
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0461 0.6389 0.6389
Brugia malayi hypothetical protein 0.0011 0.0012 0.0011
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0338 0.4644 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0609 0.0953
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0121 0.026
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0609 0.129
Echinococcus multilocularis serotonin receptor 0.0461 0.6389 1
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0011 0.0012 0.0017
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0121 0.0121
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0056 0.066 0.1005
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0461 0.6389 1
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0011 0.0012 0.0017
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0174 0.0186
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0326 0.0842
Loa Loa (eye worm) intermediate filament protein 0.003 0.0286 0.0286
Brugia malayi Melatonin receptor type 1A 0.0461 0.6389 0.6389
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0461 0.6389 0.9891
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0012 0.0011
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0121 0.0189
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.018 0.0277
Onchocerca volvulus DNA polymerase homolog 0.0017 0.0098 0.0134
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0011 0.0012 0.0017
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0174 0.0373
Schistosoma mansoni o-linked n-acetylglucosamine transferase ogt 0.0046 0.0512 0.0792
Schistosoma mansoni growth hormone secretagogue receptor 0.0461 0.6389 0.9891
Schistosoma mansoni phosphoglucomutase 0.0046 0.051 0.0789
Schistosoma mansoni biogenic amine receptor 0.0461 0.6389 0.9891
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0012 0.0011
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0023 0.0181 0.0279
Brugia malayi Serotonin receptor 0.0461 0.6389 0.6389
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Entamoeba histolytica thymidine kinase, putative 0.0274 0.3748 1
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0017 0.0098 0.015
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0012 0.0011
Entamoeba histolytica hypothetical protein 0.0022 0.018 0.0374
Brugia malayi hypothetical protein 0.0461 0.6389 0.6389
Schistosoma mansoni regulator of G protein signaling 0.0022 0.018 0.0277
Brugia malayi Cytochrome P450 family protein 0.0014 0.0056 0.0055
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0461 0.6389 0.9891
Onchocerca volvulus 0.0461 0.6389 1
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0012 0.0011
Toxoplasma gondii ribonuclease HI protein 0.0046 0.051 0.1097
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0011 0.0012 0.003
Schistosoma mansoni ap endonuclease 0.0022 0.0174 0.0268
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0026 0.0234 0.0479
Brugia malayi hypothetical protein 0.0022 0.018 0.0179
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0461 0.6389 1
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0049 0.0553 0.1189
Onchocerca volvulus 0.0461 0.6389 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0461 0.6389 1
Schistosoma mansoni biogenic amine receptor 0.0461 0.6389 0.9891
Loa Loa (eye worm) hypothetical protein 0.0461 0.6389 0.6389
Loa Loa (eye worm) thymidylate synthase 0.0104 0.1337 0.1337
Echinococcus granulosus fmrfamide receptor 0.0461 0.6389 1
Schistosoma mansoni regulator of G protein signaling 0.0022 0.018 0.0277
Brugia malayi hypothetical protein 0.0011 0.0012 0.0011
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0326 0.0521
Echinococcus granulosus axis inhibition protein axin 0.0022 0.018 0.028
Schistosoma mansoni lamin 0.003 0.0286 0.0441
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0461 0.6389 1

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 46 % Stimulation of prostate weight in castrated immature Sprague-Dawley rat at 2 mg/day, po after 5 days ChEMBL. 17636947
Activity (functional) = 64 % Stimulation of levator ani muscle weight in castrated immature Sprague-Dawley rat at 2 mg/day, po after 5 days ChEMBL. 17636947

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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