TDR Targets

Basic information

Technical information

TDR Targets ID: 432315
Name: 1-tert-butyl-3-[2-(2-methoxy-4-methylphenoxy) -5-nitrophenyl]sulfonylurea
MW: 437.467 | Formula: C19H23N3O7S
H donors: 2 H acceptors: 5 LogP: 3.17 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(C)ccc1Oc1ccc(cc1S(=O)(=O)NC(=O)NC(C)(C)C)[N+](=O)[O-]
InChi: 1S/C19H23N3O7S/c1-12-6-8-14(16(10-12)28-5)29-15-9-7-13(22(24)25)11-17(15)30(26,27)21-18(23)20-19(2,3)4/h6-11H,1-5H3,(H2,20,21,23)
InChiKey: NIWAIQPZDQLJNJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-tert-butyl-3-[2-(2-methoxy-4-methyl-phenoxy)-5-nitro-phenyl]sulfonyl-urea

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	thromboxane A2 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0034	0.1055	0.2017
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0034	0.1055	0.2017
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0129	1	1
Brugia malayi	Aldehyde dehydrogenase protein 4	0.0031	0.077	0.1148
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0034	0.1055	0.2017
Trypanosoma brucei	DNA polymerase kappa, putative	0.0078	0.5221	0.4822
Entamoeba histolytica	aldehyde dehydrogenase 1, putative	0.0031	0.077	0.2774
Echinococcus multilocularis	cathepsin L cysteine protease	0.0034	0.1055	0.0572
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0034	0.1055	0.2017
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0129	1	1
Giardia lamblia	DINP protein human, muc B family	0.0059	0.3376	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0034	0.1055	0.2017
Trypanosoma brucei	DNA polymerase kappa, putative	0.0059	0.3376	0.2824
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0034	0.1055	0.2017
Brugia malayi	Cathepsin L-like precursor	0.0034	0.1055	0.1576
Schistosoma mansoni	DNA polymerase eta	0.0077	0.5118	0.5564
Loa Loa (eye worm)	jmjC domain-containing protein	0.0035	0.1127	0.2198
Brugia malayi	polk-prov protein	0.0042	0.1844	0.2758
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.2092	0.1772
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0034	0.1055	0.2017
Trypanosoma brucei	DNA polymerase kappa, putative	0.0078	0.5221	0.4822
Loa Loa (eye worm)	ctsf protein	0.0034	0.1055	0.2057
Schistosoma mansoni	hypothetical protein	0.0029	0.0561	0.0608
Mycobacterium ulcerans	DNA polymerase IV	0.0078	0.5221	0.5282
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0034	0.1055	0.2017
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0129	1	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0121	0.9196	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0129	1	1
Mycobacterium ulcerans	DNA polymerase IV	0.0078	0.5221	0.5282
Plasmodium vivax	vivapain-2	0.0034	0.1055	1
Onchocerca volvulus	Cathepsin L homolog	0.0034	0.1055	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0034	0.1055	0.0572
Onchocerca volvulus		0.0034	0.1055	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0102	0.7404	0.7188
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.2092	0.2272
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.2092	0.2272
Schistosoma mansoni	jumonji domain containing protein	0.0075	0.487	0.5294
Trypanosoma cruzi	DNA polymerase eta, putative	0.0077	0.5118	0.4711
Loa Loa (eye worm)	fibroinase	0.0034	0.1055	0.2057
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0034	0.1055	0.2017
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.1844	0.1164
Onchocerca volvulus	Cathepsin L homolog	0.0034	0.1055	1
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0041	0.1741	0.1894
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0094	0.668	0.7264
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0561	0.1092
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0561	0.061
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0034	0.1055	0.2017
Brugia malayi	Cathepsin L-like precursor	0.0034	0.1055	0.1576
Leishmania major	cathepsin L-like protease	0.0129	1	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0118	0.8948	0.886
Echinococcus granulosus	peregrin	0.0029	0.0561	0.0608
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0052	0.2768	0.5406
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0034	0.1055	0.2017
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.1127	0.1223
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0121	0.9196	1
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0561	0.061
Toxoplasma gondii	aldehyde dehydrogenase	0.0121	0.9196	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0034	0.1055	0.2017
Echinococcus granulosus	dna polymerase eta	0.0077	0.5118	0.5564
Trichomonas vaginalis	DNA polymerase eta, putative	0.0078	0.5221	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0034	0.1055	0.1145
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.0561	0.0608
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0052	0.2768	0.3008
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.2092	0.2272
Trypanosoma cruzi	cruzipain precursor, putative	0.0129	1	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0031	0.077	0.0834
Brugia malayi	Cathepsin L-like precursor	0.0034	0.1055	0.1576
Trypanosoma cruzi	cysteine peptidase, putative	0.0129	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0034	0.1055	0.2017
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0034	0.1055	0.1145
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0034	0.1055	0.2057
Echinococcus multilocularis	cathepsin L cysteine protease	0.0034	0.1055	0.0572
Echinococcus granulosus	aldehyde dehydrogenase family 3 member B1	0.0031	0.077	0.0834
Trypanosoma brucei	DNA polymerase IV, putative	0.0078	0.5221	0.4822
Echinococcus multilocularis	lysine specific demethylase 5A	0.0035	0.1127	0.0655
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0078	0.5221	0.4822
Schistosoma mansoni	aldehyde dehydrogenase	0.0121	0.9196	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0034	0.1055	0.2057
Onchocerca volvulus		0.0034	0.1055	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0129	1	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0121	0.9196	1
Brugia malayi	Bromodomain containing protein	0.0029	0.0561	0.0837
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0078	0.5221	0.4822
Echinococcus multilocularis	aldehyde dehydrogenase family 3 member B1	0.0031	0.077	0.0241
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0034	0.1055	0.2017
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1055	0.2057
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0094	0.668	0.7087
Brugia malayi	jmjC domain containing protein	0.0035	0.1127	0.1684
Onchocerca volvulus		0.0034	0.1055	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0034	0.1055	1
Onchocerca volvulus		0.0034	0.1055	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0034	0.1055	0.2017
Onchocerca volvulus	Alhambra homolog	0.0029	0.0561	0.5308
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0034	0.1055	0.2017
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0052	0.2768	0.3008
Loa Loa (eye worm)	hypothetical protein	0.0077	0.5118	1
Trypanosoma brucei	unspecified product	0.0072	0.4612	0.4163
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0034	0.1055	1
Echinococcus multilocularis	cysteine protease	0.0034	0.1055	0.0572
Schistosoma mansoni	cathepsin F (C01 family)	0.0034	0.1055	0.1145
Loa Loa (eye worm)	aldehyde dehydrogenase 4	0.0031	0.077	0.1499
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0121	0.9196	1
Echinococcus multilocularis	Fatty aldehyde dehydrogenase	0.0031	0.077	0.0241
Echinococcus multilocularis	jumonji domain containing protein	0.004	0.1615	0.122
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.2092	0.4084
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0052	0.2768	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0034	0.1055	0.2017
Echinococcus granulosus	dna polymerase kappa	0.0078	0.5221	0.5676
Onchocerca volvulus	Cathepsin F homolog	0.0034	0.1055	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0034	0.1055	1
Plasmodium vivax	vivapain-2	0.0034	0.1055	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0129	1	1
Loa Loa (eye worm)	PHD-finger family protein	0.0029	0.0561	0.1092
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.1127	0.1223
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.2092	0.2272
Echinococcus multilocularis	cysteine protease	0.0034	0.1055	0.0572
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0121	0.9196	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0129	1	1
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0052	0.2768	0.2555
Mycobacterium leprae	PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT	0.0031	0.077	0.5
Loa Loa (eye worm)	jmjC domain-containing protein	0.0059	0.3425	0.6691
Leishmania major	DNA polymerase eta, putative	0.0077	0.5118	0.4542
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0078	0.5221	0.4822
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0121	0.9196	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0121	0.9196	0.9101
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0034	0.1055	0.2017
Trypanosoma brucei	DNA polymerase kappa, putative	0.0078	0.5221	0.4822
Loa Loa (eye worm)	cysteine protease	0.0034	0.1055	0.2057
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0078	0.5221	0.4822
Brugia malayi	Cathepsin L-like precursor	0.0034	0.1055	0.1576
Schistosoma mansoni	cathepsin F (C01 family)	0.0034	0.1055	0.1145
Onchocerca volvulus	Aldehyde dehydrogenase homolog	0.0031	0.077	0.7287
Echinococcus granulosus	jumonji domain containing protein	0.004	0.1615	0.1753
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0129	1	1
Entamoeba histolytica	cysteine protease, putative	0.0034	0.1055	0.3806
Echinococcus granulosus	Fatty aldehyde dehydrogenase	0.0031	0.077	0.0834
Leishmania major	DNA polymerase kappa, putative	0.0059	0.3376	0.2595
Toxoplasma gondii	cathepsin CPL	0.0034	0.1055	0.1147
Trypanosoma brucei	DNA polymerase IV, putative	0.0078	0.5221	0.4822
Loa Loa (eye worm)	hypothetical protein	0.0049	0.2483	0.4849
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.1857	0.1178
Trypanosoma cruzi	cysteine peptidase, putative	0.0129	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0034	0.1055	0.2017
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0129	1	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0121	0.9196	1
Echinococcus multilocularis	dna polymerase eta	0.0077	0.5118	0.5277
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0034	0.1055	0.2017
Trypanosoma cruzi	cysteine peptidase, putative	0.0034	0.1055	0.0309
Trypanosoma brucei	DNA polymerase kappa, putative	0.0078	0.5221	0.4822
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.1857	0.1178
Brugia malayi	ImpB/MucB/SamB family protein	0.0077	0.5118	0.766
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0129	1	1
Echinococcus multilocularis	dna polymerase kappa	0.0078	0.5221	0.5396
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1844	0.3601
Brugia malayi	ImpB/MucB/SamB family protein	0.0052	0.2768	0.4141
Trypanosoma brucei	DNA polymerase kappa, putative	0.0078	0.5221	0.4822
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0034	0.1055	0.0572
Entamoeba histolytica	cysteine proteinase, putative	0.0034	0.1055	0.3806
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0034	0.1055	0.2017
Trypanosoma brucei	DNA polymerase eta, putative	0.0077	0.5118	0.4711
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0078	0.5221	1
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0029	0.0561	0.0608
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.2092	0.1772
Trypanosoma brucei	unspecified product	0.0036	0.1248	0.0518
Brugia malayi	Cathepsin L-like precursor	0.0034	0.1055	0.1576
Trypanosoma brucei	unspecified product	0.0036	0.1248	0.0518
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0052	0.2768	0.2371
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0034	0.1055	0.2017
Echinococcus granulosus	cathepsin l1	0.0034	0.1055	0.1145
Echinococcus granulosus	lysine specific demethylase 5A	0.0035	0.1127	0.1223
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0034	0.1055	0.2017
Onchocerca volvulus		0.0034	0.1055	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0034	0.1055	0.2017
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.2092	0.2272
Trypanosoma brucei	DNA polymerase IV, putative	0.0072	0.4612	0.4163
Onchocerca volvulus		0.0034	0.1055	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0034	0.1055	0.2017
Trypanosoma brucei	DNA polymerase kappa, putative	0.0078	0.5221	0.4822
Brugia malayi	jmjC domain containing protein	0.0094	0.668	1
Onchocerca volvulus		0.0034	0.1055	1
Brugia malayi	Cathepsin L-like precursor	0.0034	0.1055	0.1576
Brugia malayi	Papain family cysteine protease containing protein	0.0034	0.1055	0.1576
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0129	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.1844	0.1164
Brugia malayi	PHD-finger family protein	0.0029	0.0561	0.0837
Entamoeba histolytica	cysteine proteinase, putative	0.0034	0.1055	0.3806
Trichomonas vaginalis	succinate semialdehyde dehydrogenase, putative	0.0031	0.077	0.147
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0059	0.3376	0.2595
Trypanosoma brucei	DNA polymerase kappa, putative	0.0078	0.5221	0.4822
Leishmania major	DNA polymerase eta, putative	0.0041	0.1741	0.0767
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0059	0.3376	0.3093
Trypanosoma brucei	DNA polymerase kappa, putative	0.0078	0.5221	0.4822
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.2092	0.3128
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0052	0.2768	0.3008
Trypanosoma cruzi	DNA polymerase eta, putative	0.0041	0.1741	0.1053
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.1857	0.1178
Trypanosoma brucei	DNA polymerase kappa, putative	0.0078	0.5221	0.4822
Leishmania major	cathepsin L-like protease	0.0129	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0129	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 52 nM	Antagonist activity at human thromboxane A2 receptor isoform beta expressed in HEK293 cells assessed as inhibition of U46619-induced calcium mobilization	ChEMBL.	17630727
IC50 (functional)	= 52 nM	Antagonist activity at human thromboxane A2 receptor isoform beta expressed in HEK293 cells assessed as inhibition of U46619-induced calcium mobilization	ChEMBL.	17630727
IC50 (functional)	= 528 nM	Antagonist activity at human thromboxane A2 receptor isoform alpha expressed in HEK293 cells assessed as inhibition of U46619-induced calcium mobilization	ChEMBL.	17630727
IC50 (functional)	= 528 nM	Antagonist activity at human thromboxane A2 receptor isoform alpha expressed in HEK293 cells assessed as inhibition of U46619-induced calcium mobilization	ChEMBL.	17630727
Ratio IC50 (functional)	= 10.2	Ratio of IC50 for thromboxane A2 receptor isoform alpha to IC50 for thromboxane A2 receptor isoform beta	ChEMBL.	17630727
Ratio IC50 (functional)	= 10.2	Ratio of IC50 for thromboxane A2 receptor isoform alpha to IC50 for thromboxane A2 receptor isoform beta	ChEMBL.	17630727

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL390899
PubChem: 16755885

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 432315