Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0115 | 0.436 | 0.8837 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0052 | 0.1627 | 0.1194 |
Schistosoma mansoni | kinase | 0.0099 | 0.3656 | 0.4678 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0026 | 0.0496 | 0.046 |
Onchocerca volvulus | 0.0238 | 0.969 | 1 | |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0017 | 0.0145 | 0.0022 |
Schistosoma mansoni | rab6-interacting | 0.0024 | 0.0421 | 0.0508 |
Brugia malayi | Hsp90 protein | 0.0032 | 0.0793 | 0.0767 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0015 | 0.0027 | 0.0027 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.0551 | 0.0532 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0031 | 0.0741 | 0.092 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0194 | 0.7785 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0194 | 0.7785 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0031 | 0.0741 | 0.0716 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0017 | 0.0145 | 0.0118 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0194 | 0.7785 | 1 |
Schistosoma mansoni | heat shock protein | 0.0052 | 0.1627 | 0.2063 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0073 | 0.255 | 0.3319 |
Trypanosoma brucei | heat shock protein 84, putative | 0.0032 | 0.0793 | 0.0848 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.2101 | 0.2673 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0238 | 0.969 | 0.969 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0017 | 0.0113 | 0.0113 |
Brugia malayi | RNA binding protein | 0.0063 | 0.2101 | 0.2079 |
Echinococcus granulosus | geminin | 0.018 | 0.7198 | 0.9243 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0194 | 0.7785 | 0.7779 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2101 | 0.2673 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0073 | 0.255 | 0.3334 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0792 | 0.0985 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0102 | 0.382 | 0.3803 |
Loa Loa (eye worm) | endoplasmin | 0.0052 | 0.1627 | 0.1627 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.7198 | 0.9243 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0115 | 0.436 | 0.8837 |
Plasmodium falciparum | heat shock protein 90, putative | 0.0028 | 0.0617 | 0.0652 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.0794 | 0.0988 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0031 | 0.0741 | 0.0716 |
Plasmodium falciparum | endoplasmin, putative | 0.0038 | 0.1048 | 0.1247 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0031 | 0.0741 | 0.092 |
Schistosoma mansoni | DNA topoisomerase II | 0.0073 | 0.255 | 0.3252 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0031 | 0.0741 | 0.092 |
Trypanosoma brucei | polo-like protein kinase | 0.0194 | 0.7785 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0031 | 0.0741 | 0.092 |
Echinococcus granulosus | heat shock protein 75 kDa mitochondrial | 0.0032 | 0.0793 | 0.0987 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0792 | 0.0985 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0115 | 0.436 | 0.8837 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.1627 | 0.194 |
Toxoplasma gondii | thioredoxin reductase | 0.005 | 0.1569 | 0.1982 |
Brugia malayi | Probable DNA topoisomerase II | 0.0073 | 0.255 | 0.253 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0032 | 0.0794 | 0.085 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0031 | 0.0741 | 0.0716 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0031 | 0.0741 | 0.0716 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0024 | 0.0421 | 0.0508 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0031 | 0.0741 | 0.0716 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0421 | 0.0421 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0016 | 0.0104 | 0.0104 |
Brugia malayi | nuclear receptor RXR | 0.0016 | 0.0104 | 0.0077 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0104 | 0.0104 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0052 | 0.1627 | 0.194 |
Trichomonas vaginalis | heat shock protein, putative | 0.0046 | 0.1372 | 0.1606 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0551 | 0.0561 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0194 | 0.7785 | 1 |
Plasmodium vivax | heat shock protein 86, putative | 0.0052 | 0.1627 | 0.2053 |
Brugia malayi | Isocitrate dehydrogenase | 0.0032 | 0.0794 | 0.0769 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0073 | 0.255 | 0.255 |
Schistosoma mansoni | polycystin 1-related | 0.0024 | 0.0421 | 0.0508 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0957 | 0.0957 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0042 | 0.1196 | 0.1376 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0194 | 0.7785 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0551 | 0.0561 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0031 | 0.0741 | 0.092 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0194 | 0.7785 | 1 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0066 | 0.2263 | 0.2772 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0741 | 0.0741 |
Giardia lamblia | DNA topoisomerase II | 0.0063 | 0.2119 | 0.2584 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0016 | 0.0104 | 0.0077 |
Mycobacterium ulcerans | heat shock protein 90 | 0.0046 | 0.1372 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0031 | 0.0741 | 0.0741 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0031 | 0.0741 | 0.092 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.1627 | 0.194 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0027 | 0.0027 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0194 | 0.7785 | 1 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0017 | 0.0145 | 0.0022 |
Brugia malayi | Smad1 | 0.0017 | 0.0113 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.2419 | 0.2419 |
Onchocerca volvulus | 0.0031 | 0.0741 | 0.0739 | |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0017 | 0.0113 | 0.011 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0059 | 0.194 | 0.235 |
Brugia malayi | MH1 domain containing protein | 0.0017 | 0.0113 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0027 | 0.0027 |
Schistosoma mansoni | loxhd1 | 0.0024 | 0.0421 | 0.0508 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0421 | 0.0508 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0792 | 0.0985 |
Loa Loa (eye worm) | RecQ helicase | 0.0026 | 0.0496 | 0.0496 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0029 | 0.0634 | 0.0696 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0031 | 0.0741 | 0.0741 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0017 | 0.0113 | 0.0113 |
Giardia lamblia | Kinase, PLK | 0.0194 | 0.7785 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0128 | 0.4915 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0031 | 0.0741 | 0.092 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.005 | 0.1569 | 0.1864 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0194 | 0.7785 | 0.7785 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.1627 | 0.194 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0017 | 0.0145 | 0.001 |
Echinococcus multilocularis | geminin | 0.018 | 0.7198 | 0.9243 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0017 | 0.0145 | 0.0152 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0073 | 0.255 | 0.3326 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0032 | 0.0792 | 0.0767 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.1627 | 0.194 |
Echinococcus multilocularis | heat shock protein | 0.0052 | 0.1627 | 0.2063 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0031 | 0.0741 | 0.0716 |
Loa Loa (eye worm) | heat shock protein 75 | 0.0032 | 0.0793 | 0.0793 |
Leishmania major | DNA topoisomerase ii | 0.0066 | 0.2263 | 0.2772 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0104 | 0.0077 |
Brugia malayi | hypothetical protein | 0.0017 | 0.014 | 0.0113 |
Echinococcus multilocularis | heat shock protein 90 | 0.0052 | 0.1627 | 0.2063 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0017 | 0.0113 | 0.011 |
Echinococcus multilocularis | smad | 0.0017 | 0.0113 | 0.011 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0421 | 0.0395 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0027 | 0.0027 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0031 | 0.0741 | 0.092 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0066 | 0.2263 | 0.2772 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0073 | 0.255 | 0.3252 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0032 | 0.0794 | 0.0794 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0115 | 0.436 | 0.8837 |
Trypanosoma brucei | heat shock protein, putative | 0.0052 | 0.1627 | 0.194 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0245 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1306 | 0.1306 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0027 | 0.0027 |
Echinococcus multilocularis | endoplasmin | 0.0046 | 0.1372 | 0.1733 |
Brugia malayi | glutathione reductase | 0.005 | 0.1569 | 0.1546 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0029 | 0.0634 | 0.3991 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0031 | 0.0741 | 0.092 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.2419 | 0.3082 |
Onchocerca volvulus | 0.0024 | 0.0421 | 0.0408 | |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0066 | 0.2263 | 0.2772 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0031 | 0.0741 | 0.092 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0017 | 0.0113 | 0.011 |
Mycobacterium tuberculosis | Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) | 0.0046 | 0.1372 | 0.2572 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0115 | 0.436 | 0.8435 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0031 | 0.0741 | 0.0716 |
Loa Loa (eye worm) | Smad1 | 0.0017 | 0.0113 | 0.0113 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0059 | 0.194 | 0.235 |
Trichomonas vaginalis | heat shock protein, putative | 0.0052 | 0.1627 | 0.194 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0421 | 0.0421 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0027 | 0.0027 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.4958 | 0.4958 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 0.0551 | 0.0582 |
Trichomonas vaginalis | heat shock protein, putative | 0.0028 | 0.0617 | 0.0618 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0024 | 0.0421 | 0.0508 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0027 | 0.0027 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0031 | 0.0741 | 0.0741 |
Brugia malayi | heat shock protein 90 | 0.0052 | 0.1627 | 0.1604 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.1627 | 0.194 |
Brugia malayi | steroid hormone receptor | 0.0031 | 0.0741 | 0.0716 |
Trichomonas vaginalis | heat shock protein, putative | 0.0042 | 0.1196 | 0.1376 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0741 | 0.0741 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0029 | 0.0634 | 0.3991 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.7198 | 0.9243 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0052 | 0.1627 | 0.194 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0031 | 0.0741 | 0.092 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0031 | 0.0741 | 0.0716 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.0551 | 0.0532 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0027 | 0.0027 |
Leishmania major | trypanothione reductase | 0.005 | 0.1569 | 0.1864 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0104 | 0.0104 |
Schistosoma mansoni | endoplasmin | 0.0052 | 0.1627 | 0.2063 |
Trichomonas vaginalis | heat shock protein, putative | 0.0038 | 0.1048 | 0.1183 |
Trypanosoma brucei | Heat shock protein 83, putative | 0.0052 | 0.1627 | 0.194 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0031 | 0.0741 | 0.092 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0128 | 0.4915 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0031 | 0.0741 | 0.0716 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0027 | 0.0027 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.0794 | 0.0988 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0031 | 0.0741 | 0.0716 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.2587 | 0.2567 |
Echinococcus granulosus | FTZ F1 alpha | 0.0031 | 0.0741 | 0.092 |
Brugia malayi | Thioredoxin reductase | 0.005 | 0.1569 | 0.1546 |
Plasmodium falciparum | heat shock protein 90 | 0.0052 | 0.1627 | 0.2046 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0194 | 0.7785 | 1 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0551 | 0.0526 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0741 | 0.0741 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0024 | 0.0421 | 0.0391 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.1627 | 0.194 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0017 | 0.0113 | 0.011 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.1627 | 0.194 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0031 | 0.0741 | 0.092 |
Plasmodium vivax | glutathione reductase, putative | 0.005 | 0.1569 | 0.1973 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0052 | 0.1627 | 0.1194 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0031 | 0.0741 | 0.092 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.1627 | 0.194 |
Brugia malayi | nuclear receptor NHR-88 | 0.0031 | 0.0741 | 0.0716 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0102 | 0.382 | 0.382 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0032 | 0.0794 | 0.0988 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2101 | 0.2673 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0194 | 0.7785 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.005 | 0.1569 | 0.1987 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0031 | 0.0741 | 0.0716 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0194 | 0.7785 | 0.8029 |
Echinococcus multilocularis | bloom syndrome protein | 0.0026 | 0.0496 | 0.0604 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0031 | 0.0741 | 0.0739 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0741 | 0.0741 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0031 | 0.0741 | 0.0741 |
Loa Loa (eye worm) | doublecortin family protein | 0.0024 | 0.0421 | 0.0421 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0027 | 0.0027 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0066 | 0.2263 | 0.2772 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.1627 | 0.194 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0031 | 0.0741 | 0.092 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.2101 | 0.2101 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2101 | 0.2673 |
Toxoplasma gondii | heat shock protein HSP90 | 0.0052 | 0.1627 | 0.2063 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0031 | 0.0741 | 0.092 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0055 | 0.1765 | 0.1799 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0022 | 0.0362 | 0.0299 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0031 | 0.0741 | 0.092 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0059 | 0.194 | 0.235 |
Echinococcus granulosus | smad | 0.0017 | 0.0113 | 0.011 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0741 | 0.0741 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.3546 | 0.4451 |
Trypanosoma brucei | trypanothione reductase | 0.005 | 0.1569 | 0.1864 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0029 | 0.0634 | 0.1026 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0027 | 0.0027 |
Schistosoma mansoni | smad1 5 8 and | 0.0017 | 0.0113 | 0.011 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0741 | 0.0741 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.2587 | 0.2567 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0128 | 0.4915 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0741 | 0.0741 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0031 | 0.0741 | 0.092 |
Trypanosoma brucei | heat shock protein, putative | 0.0052 | 0.1627 | 0.194 |
Echinococcus granulosus | heat shock protein 90 | 0.0052 | 0.1627 | 0.2063 |
Brugia malayi | MH2 domain containing protein | 0.0017 | 0.0113 | 0.0086 |
Brugia malayi | Endoplasmin precursor | 0.0052 | 0.1627 | 0.1604 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0027 | 0.0027 |
Toxoplasma gondii | heat shock protein 75, putative | 0.0032 | 0.0793 | 0.0914 |
Echinococcus multilocularis | GPCR, family 2 | 0.0032 | 0.0792 | 0.0985 |
Schistosoma mansoni | lipoxygenase | 0.0142 | 0.5559 | 0.7131 |
Brugia malayi | hypothetical protein | 0.0074 | 0.2587 | 0.2567 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0104 | 0.0104 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.1627 | 0.194 |
Trichomonas vaginalis | heat shock protein, putative | 0.0046 | 0.1372 | 0.1606 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0073 | 0.255 | 0.253 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0074 | 0.2587 | 0.33 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0194 | 0.7785 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.007 | 0.2419 | 0.2398 |
Giardia lamblia | Grp94/Hsp90 | 0.0046 | 0.1372 | 0.1606 |
Plasmodium vivax | heat shock protein, putative | 0.0185 | 0.7392 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0016 | 0.0104 | 0.0099 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.005 | 0.1569 | 0.1987 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0024 | 0.0421 | 0.0508 |
Brugia malayi | isocitrate dehydrogenase | 0.0032 | 0.0794 | 0.0769 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0027 | 0.0027 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.1627 | 0.194 |
Echinococcus multilocularis | heat shock protein 75 kDa, mitochondrial | 0.0032 | 0.0793 | 0.0987 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.1627 | 0.194 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.1627 | 0.194 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.2101 | 0.2673 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0052 | 0.1627 | 0.194 |
Schistosoma mansoni | smad | 0.0017 | 0.0113 | 0.011 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0102 | 0.382 | 0.3803 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0042 | 0.1196 | 0.1376 |
Plasmodium falciparum | glutathione reductase | 0.005 | 0.1569 | 0.1965 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0032 | 0.0794 | 0.0916 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0741 | 0.0741 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0957 | 0.0957 |
Schistosoma mansoni | endoplasmin | 0.0052 | 0.1627 | 0.2063 |
Toxoplasma gondii | heat shock protein 90, putative | 0.0052 | 0.1627 | 0.2063 |
Echinococcus granulosus | Smad4 | 0.0017 | 0.0113 | 0.011 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0031 | 0.0741 | 0.0716 |
Schistosoma mansoni | rab6-interacting | 0.0024 | 0.0421 | 0.0508 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0016 | 0.0104 | 0.0099 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.2101 | 0.2079 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0031 | 0.0741 | 0.0739 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0024 | 0.0421 | 0.0508 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0032 | 0.0794 | 0.0988 |
Brugia malayi | Pax transcription factor protein 2 | 0.0238 | 0.969 | 0.9689 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0194 | 0.7785 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0027 | 0.0027 |
Loa Loa (eye worm) | thioredoxin reductase | 0.005 | 0.1569 | 0.1569 |
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.0046 | 0.1372 | 1 |
Echinococcus multilocularis | RUN | 0.0024 | 0.0421 | 0.0508 |
Brugia malayi | Doublecortin family protein | 0.0024 | 0.0421 | 0.0395 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.2587 | 0.2567 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0031 | 0.0741 | 0.092 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0031 | 0.0741 | 0.092 |
Trypanosoma cruzi | heat shock protein, putative | 0.0032 | 0.0793 | 0.0848 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0031 | 0.0741 | 0.0716 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0023 | 0.04 | 0.0334 |
Plasmodium vivax | heat shock protein 90, putative | 0.0032 | 0.0793 | 0.0903 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0073 | 0.255 | 0.3148 |
Schistosoma mansoni | thyroid hormone receptor | 0.0031 | 0.0741 | 0.092 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0074 | 0.2587 | 0.33 |
Schistosoma mansoni | heat shock protein | 0.0052 | 0.1627 | 0.2063 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0031 | 0.0741 | 0.0716 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0052 | 0.1627 | 0.194 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.1627 | 0.194 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0194 | 0.7785 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0031 | 0.0741 | 0.0741 |
Echinococcus granulosus | bloom syndrome protein | 0.0026 | 0.0496 | 0.0604 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.0794 | 0.0988 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0017 | 0.0145 | 0.0152 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0024 | 0.0421 | 0.0508 |
Trypanosoma brucei | heat shock protein, putative | 0.0052 | 0.1627 | 0.194 |
Schistosoma mansoni | coup transcription factor | 0.0031 | 0.0741 | 0.092 |
Trypanosoma brucei | heat shock protein, putative | 0.0052 | 0.1627 | 0.194 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0031 | 0.0741 | 0.0716 |
Leishmania major | heat shock protein, putative | 0.0032 | 0.0793 | 0.0848 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0032 | 0.0794 | 0.085 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0031 | 0.0741 | 0.092 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0792 | 0.0985 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0551 | 0.0532 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.005 | 0.1569 | 0.2985 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0551 | 0.0532 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0024 | 0.0421 | 0.0381 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0104 | 0.0104 |
Echinococcus granulosus | GPCR family 2 | 0.0032 | 0.0792 | 0.0985 |
Onchocerca volvulus | 0.0024 | 0.0421 | 0.0408 | |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0043 | 0.1244 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0792 | 0.0985 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0031 | 0.0741 | 0.0741 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0551 | 0.0551 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0029 | 0.0634 | 0.0675 |
Echinococcus granulosus | RUN | 0.0024 | 0.0421 | 0.0508 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1306 | 0.1306 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.2587 | 0.2567 |
Plasmodium vivax | endoplasmin, putative | 0.0052 | 0.1627 | 0.2053 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0016 | 0.0104 | 0.0099 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.2101 | 0.2101 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0017 | 0.0145 | 0.0152 |
Onchocerca volvulus | Heat shock protein 75 kDa, mitochondrial homolog | 0.0032 | 0.0793 | 0.0792 |
Echinococcus granulosus | endoplasmin | 0.0046 | 0.1372 | 0.1733 |
Toxoplasma gondii | Hsp90 domain-containing protein | 0.0185 | 0.7392 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0029 | 0.0634 | 0.3991 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.1627 | 0.194 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0031 | 0.0741 | 0.092 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0031 | 0.0741 | 0.0741 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0026 | 0.0496 | 0.047 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0792 | 0.0985 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0055 | 0.1765 | 0.1799 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0115 | 0.436 | 0.8837 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0031 | 0.0741 | 0.092 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0016 | 0.0104 | 0.0077 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.2101 | 0.2079 |
Plasmodium falciparum | heat shock protein 90, putative | 0.0185 | 0.7392 | 1 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0015 | 0.0027 | 0.0027 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.0792 | 0.0792 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0032 | 0.0794 | 0.1361 |
Schistosoma mansoni | lipoxygenase | 0.01 | 0.3703 | 0.4738 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.0551 | 0.057 |
Schistosoma mansoni | hypothetical protein | 0.0074 | 0.2587 | 0.33 |
Schistosoma mansoni | smad1 5 8 and | 0.0017 | 0.0113 | 0.011 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0017 | 0.0145 | 0.001 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0074 | 0.2587 | 0.33 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.1627 | 0.194 |
Echinococcus granulosus | heat shock protein | 0.0052 | 0.1627 | 0.2063 |
Trypanosoma brucei | heat shock protein, putative | 0.0052 | 0.1627 | 0.194 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2101 | 0.2673 |
Trichomonas vaginalis | endoplasmin, putative | 0.0038 | 0.1048 | 0.1183 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0031 | 0.0741 | 0.0741 |
Schistosoma mansoni | heat shock protein | 0.0032 | 0.0793 | 0.0987 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.0794 | 0.0988 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0024 | 0.0421 | 0.0508 |
Echinococcus multilocularis | heat shock protein 90 | 0.0042 | 0.1196 | 0.1507 |
Brugia malayi | MH1 domain containing protein | 0.0017 | 0.0113 | 0.0086 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0194 | 0.7785 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0142 | 0.5559 | 0.7131 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0052 | 0.1627 | 0.194 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0032 | 0.0794 | 0.0905 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0032 | 0.0792 | 0.0767 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.382 | 0.382 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0031 | 0.0741 | 0.0739 |
Brugia malayi | MH2 domain containing protein | 0.0017 | 0.0113 | 0.0086 |
Plasmodium falciparum | thioredoxin reductase | 0.005 | 0.1569 | 0.1965 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0031 | 0.0741 | 0.0716 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0194 | 0.7785 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0052 | 0.1627 | 0.194 |
Schistosoma mansoni | smad1 5 8 and | 0.0017 | 0.0113 | 0.011 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0031 | 0.0741 | 0.0716 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0026 | 0.0496 | 0.046 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.002 | 0.0263 | 0.0304 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0792 | 0.0985 |
Plasmodium vivax | thioredoxin reductase, putative | 0.005 | 0.1569 | 0.1973 |
Echinococcus granulosus | heat shock protein 90 | 0.0042 | 0.1196 | 0.1507 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0792 | 0.0985 |
Echinococcus granulosus | heat shock protein heat shock protein 90 alpha | 0.0042 | 0.1196 | 0.1507 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0031 | 0.0741 | 0.0716 |
Loa Loa (eye worm) | DR-78 | 0.0015 | 0.0027 | 0.0027 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0421 | 0.0395 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0016 | 0.0104 | 0.0099 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0032 | 0.0794 | 0.085 |
Loa Loa (eye worm) | glutathione reductase | 0.005 | 0.1569 | 0.1569 |
Loa Loa (eye worm) | heat shock protein 90 | 0.0052 | 0.1627 | 0.1627 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0032 | 0.0794 | 0.085 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0029 | 0.0634 | 0.4452 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0031 | 0.0741 | 0.092 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0142 | 0.5559 | 0.7131 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0031 | 0.0741 | 0.092 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2101 | 0.2673 |
Trypanosoma brucei | heat shock protein, putative | 0.0052 | 0.1627 | 0.194 |
Echinococcus multilocularis | Smad4 | 0.0017 | 0.0113 | 0.011 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.3546 | 0.4451 |
Schistosoma mansoni | thyroid hormone receptor | 0.0031 | 0.0741 | 0.092 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0059 | 0.194 | 0.235 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0031 | 0.0741 | 0.092 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0032 | 0.0794 | 0.085 |
Schistosoma mansoni | nuclear hormone receptor | 0.0031 | 0.0741 | 0.092 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0015 | 0.0027 | 0.0027 |
Treponema pallidum | heat shock protein 90 | 0.0046 | 0.1372 | 1 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0073 | 0.255 | 0.253 |
Schistosoma mansoni | Smad4 | 0.0017 | 0.0113 | 0.011 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0073 | 0.255 | 0.3252 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0128 | 0.4915 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.1627 | 0.194 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0052 | 0.1627 | 0.194 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0032 | 0.0794 | 0.0916 |
Mycobacterium tuberculosis | Probable reductase | 0.0115 | 0.436 | 0.8837 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0245 | 1 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0073 | 0.255 | 0.2514 |
Trypanosoma brucei | heat shock protein, putative | 0.0052 | 0.1627 | 0.194 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0042 | 0.1196 | 0.1376 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0017 | 0.0113 | 0.011 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0055 | 0.1765 | 0.1799 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0052 | 0.1627 | 0.194 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0792 | 0.0792 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.2101 | 0.2101 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0104 | 0.0077 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0032 | 0.0794 | 0.0988 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0029 | 0.0634 | 0.0685 |
Trypanosoma brucei | heat shock protein, putative | 0.0052 | 0.1627 | 0.194 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0032 | 0.0794 | 0.0896 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0104 | 0.0104 |
Leishmania major | lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative | 0.0046 | 0.1372 | 0.1606 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.9 uM | Inhibition of human recombinant aurora C kinase | ChEMBL. | 17665890 |
IC50 (binding) | = 8 uM | Inhibition of human recombinant aurora B kinase | ChEMBL. | 17665890 |
IC50 (binding) | > 100 uM | Inhibition of human recombinant aurora A kinase | ChEMBL. | 17665890 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.