Detailed information for compound 432486

Basic information

Technical information
  • TDR Targets ID: 432486
  • Name: 2-[[2-[bis(2-hydroxyethyl)amino]-4,8-bis(diet hylamino)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hy droxyethyl)amino]ethanol
  • MW: 480.604 | Formula: C22H40N8O4
  • H donors: 4 H acceptors: 8 LogP: 0.46 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCN(c1nc(N(CC)CC)c2c(n1)c(nc(n2)N(CCO)CCO)N(CC)CC)CCO
  • InChi: 1S/C22H40N8O4/c1-5-27(6-2)19-17-18(24-21(25-19)29(9-13-31)10-14-32)20(28(7-3)8-4)26-22(23-17)30(11-15-33)12-16-34/h31-34H,5-16H2,1-4H3
  • InChiKey: XZPRHYSYSHRQKX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[[2-[bis(2-hydroxyethyl)amino]-4,8-bis(diethylamino)-6-pyrimido[5,4-d]pyrimidinyl]-(2-hydroxyethyl)amino]ethanol
  • 2-[[2-(bis(2-hydroxyethyl)amino)-4,8-bis(diethylamino)pyrimido[6,5-e]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol
  • 2-[[2-(bis(2-hydroxyethyl)amino)-4,8-bis(diethylamino)-6-pyrimido[6,5-e]pyrimidinyl]-(2-hydroxyethyl)amino]ethanol
  • 16908-48-8
  • NSC516472

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 29 (equilibrative nucleoside transporter), member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis equilibrative nucleoside transporter, putative Get druggable targets OG5_127378 All targets in OG5_127378
Echinococcus multilocularis equilibrative nucleoside transporter 3 Get druggable targets OG5_127378 All targets in OG5_127378
Candida albicans possible nucleoside transporter Get druggable targets OG5_127378 All targets in OG5_127378
Brugia malayi Nucleoside transporter family protein Get druggable targets OG5_127378 All targets in OG5_127378
Schistosoma japonicum Equilibrative nucleoside transporter 3, putative Get druggable targets OG5_127378 All targets in OG5_127378
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127378 All targets in OG5_127378
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog Get druggable targets OG5_127378 All targets in OG5_127378
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog Get druggable targets OG5_127378 All targets in OG5_127378
Echinococcus multilocularis equilibrative nucleoside transporter 3 Get druggable targets OG5_127378 All targets in OG5_127378
Candida albicans possible nucleoside transporter Get druggable targets OG5_127378 All targets in OG5_127378
Entamoeba histolytica nucleoside transporter, putative Get druggable targets OG5_127378 All targets in OG5_127378
Echinococcus granulosus equilibrative nucleoside transporter Get druggable targets OG5_127378 All targets in OG5_127378
Brugia malayi hypothetical protein Get druggable targets OG5_127378 All targets in OG5_127378
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127378 All targets in OG5_127378
Echinococcus multilocularis equilibrative nucleoside transporter protein Get druggable targets OG5_127378 All targets in OG5_127378
Trichomonas vaginalis equilibrative nucleoside transporter, putative Get druggable targets OG5_127378 All targets in OG5_127378
Trichomonas vaginalis equilibrative nucleoside transporter, putative Get druggable targets OG5_127378 All targets in OG5_127378
Giardia lamblia Hypothetical protein Get druggable targets OG5_127378 All targets in OG5_127378
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127378 All targets in OG5_127378
Trichomonas vaginalis equilibrative nucleoside transporter, putative Get druggable targets OG5_127378 All targets in OG5_127378
Echinococcus granulosus equilibrative nucleoside transporter 3 Get druggable targets OG5_127378 All targets in OG5_127378
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei purine nucleoside transporter solute carrier family 29 (equilibrative nucleoside transporter), member 1 456 aa 396 aa 24.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0098 0.1573 0.3633
Schistosoma mansoni hypothetical protein 0.0066 0.0974 0.1113
Onchocerca volvulus 0.0059 0.0838 0.3113
Onchocerca volvulus 0.0028 0.0276 0.0932
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0037 0.044 0.0956
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0028 0.0276 0.0285
Brugia malayi nuclear hormone receptor 0.0033 0.0356 0.0986
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0838 0.0951
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Echinococcus granulosus neurogenic locus notch protein 4 0.0066 0.0974 0.1113
Echinococcus granulosus cpg binding protein 0.003 0.0306 0.0321
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0098 0.1573 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.0356 0.0986
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0059 0.0838 0.0951
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0838 0.0951
Echinococcus multilocularis serotonin receptor 0.0059 0.0838 0.0806
Onchocerca volvulus Bile acid receptor homolog 0.0033 0.0356 0.1245
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.0356 0.0381
Loa Loa (eye worm) hypothetical protein 0.008 0.1237 0.2839
Onchocerca volvulus 0.008 0.1237 0.4661
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Echinococcus multilocularis tar DNA binding protein 0.0053 0.0727 0.0695
Schistosoma mansoni neuropeptide receptor 0.0059 0.0838 0.0951
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0059 0.0838 0.0806
Loa Loa (eye worm) hypothetical protein 0.0066 0.0974 0.2217
Loa Loa (eye worm) hypothetical protein 0.0066 0.0974 0.2217
Loa Loa (eye worm) STE/STE11/ASK protein kinase 0.0063 0.0918 0.2084
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.0356 0.0986
Loa Loa (eye worm) hypothetical protein 0.008 0.1237 0.2839
Loa Loa (eye worm) hypothetical protein 0.0033 0.0356 0.0758
Brugia malayi Trypsin family protein 0.0028 0.0276 0.0763
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0035 0.0098
Brugia malayi RNA binding protein 0.0053 0.0727 0.2014
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.0838 0.0951
Schistosoma mansoni amine GPCR 0.0059 0.0838 0.0951
Echinococcus granulosus biogenic amine 5HT receptor 0.0059 0.0838 0.0951
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0059 0.0838 0.0951
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Schistosoma mansoni egf-like domain protein 0.0154 0.2614 0.3056
Loa Loa (eye worm) hypothetical protein 0.0033 0.0356 0.0758
Schistosoma mansoni protein kinase 0.0208 0.3612 0.424
Loa Loa (eye worm) hypothetical protein 0.0021 0.0138 0.0243
Schistosoma mansoni cell polarity protein 0.0066 0.0974 0.1113
Schistosoma mansoni hypothetical protein 0.0059 0.0838 0.0951
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0154 0.2614 0.609
Brugia malayi EGF-like domain containing protein 0.0066 0.0974 0.2697
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0138 0.0852
Echinococcus granulosus equilibrative nucleoside transporter 3 0.0098 0.1573 0.1823
Brugia malayi hypothetical protein 0.0059 0.0838 0.232
Loa Loa (eye worm) hypothetical protein 0.0028 0.0276 0.0568
Brugia malayi hypothetical protein 0.008 0.1237 0.3425
Echinococcus multilocularis neurogenic locus protein delta 0.0066 0.0974 0.0942
Onchocerca volvulus 0.0059 0.0838 0.3113
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0028 0.0276 0.0285
Loa Loa (eye worm) hypothetical protein 0.0066 0.0974 0.2217
Echinococcus granulosus g protein coupled receptor 0.0059 0.0838 0.0951
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0028 0.0276 0.0285
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.0356 0.0986
Loa Loa (eye worm) hypothetical protein 0.0017 0.007 0.0081
Brugia malayi nuclear receptor NHR-67 0.0015 0.0035 0.0098
Echinococcus granulosus neuropeptide receptor 0.0059 0.0838 0.0951
Loa Loa (eye worm) neuropeptide F receptor 0.0059 0.0838 0.1896
Echinococcus granulosus C type lectin domian containing protein 0.008 0.1237 0.1425
Onchocerca volvulus 0.0059 0.0838 0.3113
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0059 0.0838 0.0951
Loa Loa (eye worm) hypothetical protein 0.0017 0.0065 0.0071
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0276 0.0285
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Brugia malayi hypothetical protein 0.0059 0.0838 0.232
Echinococcus multilocularis somatostatin receptor 0.0059 0.0838 0.0806
Echinococcus multilocularis cpg binding protein 0.003 0.0306 0.0272
Onchocerca volvulus 0.0059 0.0838 0.3113
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0356 0.0381
Echinococcus granulosus Protein patched homolog 1 0.0029 0.0283 0.0293
Brugia malayi hypothetical protein 0.0059 0.0838 0.232
Loa Loa (eye worm) melatonin receptor type 1A 0.0059 0.0838 0.1896
Onchocerca volvulus 0.0028 0.0276 0.0932
Echinococcus multilocularis neuropeptide FF receptor 2 0.0059 0.0838 0.0806
Echinococcus multilocularis protein patched 0.0029 0.0283 0.0248
Loa Loa (eye worm) hypothetical protein 0.0066 0.0974 0.2217
Schistosoma mansoni slit 0.0066 0.0974 0.1113
Schistosoma mansoni hypothetical protein 0.0028 0.0263 0.027
Brugia malayi hypothetical protein 0.008 0.1237 0.3425
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0035 0.0098
Echinococcus granulosus neuropeptide s receptor 0.0059 0.0838 0.0951
Echinococcus multilocularis g protein coupled receptor 0.0059 0.0838 0.0806
Loa Loa (eye worm) hypothetical protein 0.0066 0.0974 0.2217
Onchocerca volvulus 0.008 0.1237 0.4661
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0059 0.0838 0.0806
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.0356 0.0986
Brugia malayi hypothetical protein 0.0059 0.0838 0.232
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.0356 0.0758
Schistosoma mansoni notch 0.0066 0.0974 0.1113
Brugia malayi Cadherin domain containing protein 0.0066 0.0974 0.2697
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.007 0.0081
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.1527 0.1497
Schistosoma mansoni growth hormone secretagogue receptor 0.0059 0.0838 0.0951
Brugia malayi hypothetical protein 0.008 0.1237 0.3425
Schistosoma mansoni adenoreceptor 0.0059 0.0838 0.0951
Echinococcus granulosus sterol regulatory element binding protein 0.0029 0.0283 0.0293
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0356 0.0381
Loa Loa (eye worm) hypothetical protein 0.0208 0.3607 0.8434
Schistosoma mansoni biogenic amine receptor 0.0059 0.0838 0.0951
Brugia malayi G-protein coupled receptor 0.0059 0.0838 0.232
Echinococcus multilocularis neuropeptide receptor 0.0059 0.0838 0.0806
Schistosoma mansoni equilibrative nucleoside transporter 0.0017 0.0065 0.0036
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0059 0.0838 0.0806
Onchocerca volvulus Putative cubilin 0.0066 0.0974 0.3641
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0035 0.0098
Echinococcus granulosus dro:myosuppressin receptor 0.0059 0.0838 0.0951
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0059 0.0838 0.0951
Loa Loa (eye worm) hypothetical protein 0.0029 0.0283 0.0584
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.0356 0.0381
Schistosoma mansoni biogenic amine receptor 0.0059 0.0838 0.0951
Loa Loa (eye worm) hypothetical protein 0.0033 0.0356 0.0758
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0028 0.0276 0.0285
Echinococcus granulosus FTZ F1 alpha 0.0033 0.0356 0.0381
Brugia malayi AKH receptor 0.0059 0.0838 0.232
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0035 0.0098
Brugia malayi putative neuropeptide receptor NPR1 0.0059 0.0838 0.232
Onchocerca volvulus 0.0059 0.0838 0.3113
Echinococcus multilocularis sex peptide receptor 0.0059 0.0838 0.0806
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.0356 0.0758
Brugia malayi Fibulin-1 precursor 0.0154 0.2614 0.7236
Echinococcus granulosus slit 2 protein 0.0066 0.0974 0.1113
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0059 0.0838 0.1896
Echinococcus granulosus sex peptide receptor 0.0059 0.0838 0.0951
Loa Loa (eye worm) hypothetical protein 0.008 0.1237 0.2839
Echinococcus granulosus 7TM GPCR rhodopsin 0.0059 0.0838 0.0951
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.0838 0.0951
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0356 0.0381
Schistosoma mansoni neuropeptide F-like receptor 0.0059 0.0838 0.0951
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0276 0.0285
Schistosoma mansoni biogenic amine (5HT) receptor 0.0059 0.0838 0.0951
Loa Loa (eye worm) TAR-binding protein 0.0053 0.0727 0.1635
Loa Loa (eye worm) hypothetical protein 0.0033 0.0356 0.0758
Onchocerca volvulus 0.008 0.1237 0.4661
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0037 0.044 0.0406
Echinococcus granulosus microtubule associated protein 2 0.047 0.8473 1
Onchocerca volvulus 0.0028 0.0276 0.0932
Brugia malayi hypothetical protein 0.0017 0.0065 0.0181
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0098 0.1573 0.1544
Schistosoma mansoni neuropeptide receptor 0.0059 0.0838 0.0951
Plasmodium vivax apical sushi protein, putative 0.008 0.1237 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0059 0.0838 0.232
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.007 0.0035
Plasmodium falciparum apical sushi protein 0.008 0.1237 1
Loa Loa (eye worm) hypothetical protein 0.0154 0.2614 0.609
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0059 0.0838 0.0951
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0138 0.0852
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Loa Loa (eye worm) hypothetical protein 0.0154 0.2614 0.609
Brugia malayi putative neuropeptide receptor 0.0059 0.0838 0.232
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.044 0.048
Echinococcus granulosus neurogenic locus notch protein 0.0066 0.0974 0.1113
Echinococcus granulosus neurogenic locus protein delta 0.0066 0.0974 0.1113
Loa Loa (eye worm) hypothetical protein 0.0028 0.0276 0.0568
Schistosoma mansoni hypothetical protein 0.0059 0.0838 0.0951
Onchocerca volvulus Neuropeptide F receptor homolog 0.0059 0.0838 0.3113
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0276 0.0285
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0059 0.0838 0.1896
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Echinococcus granulosus neural cadherin 0.0066 0.0974 0.1113
Loa Loa (eye worm) neuropeptide F receptor 0.0059 0.0838 0.1896
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Brugia malayi Delta serrate ligand family protein 0.0066 0.0974 0.2697
Onchocerca volvulus 0.0059 0.0838 0.3113
Echinococcus multilocularis G-protein coupled receptor, putative 0.0059 0.0838 0.0806
Loa Loa (eye worm) hypothetical protein 0.0028 0.0276 0.0568
Brugia malayi Melatonin receptor type 1A 0.0059 0.0838 0.232
Onchocerca volvulus 0.0059 0.0838 0.3113
Echinococcus multilocularis G protein coupled receptor 139 0.0059 0.0838 0.0806
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.0356 0.0381
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.0838 0.0806
Loa Loa (eye worm) hypothetical protein 0.0066 0.0974 0.2217
Echinococcus multilocularis microtubule associated protein 2 0.047 0.8473 0.8467
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0037 0.044 0.048
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0356 0.0986
Echinococcus granulosus G protein coupled receptor 139 0.0059 0.0838 0.0951
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0154 0.2614 0.609
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0059 0.0838 0.0951
Toxoplasma gondii EGF family domain-containing protein 0.0066 0.0974 0.3566
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Echinococcus multilocularis neuropeptide Y receptor 0.0059 0.0838 0.0806
Loa Loa (eye worm) RNA binding protein 0.0053 0.0727 0.1635
Loa Loa (eye worm) hypothetical protein 0.0146 0.2463 0.5733
Brugia malayi Cadherin domain containing protein 0.0066 0.0974 0.2697
Brugia malayi nuclear receptor RXR 0.0017 0.007 0.0193
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0356 0.0381
Schistosoma mansoni notch 0.0066 0.0974 0.1113
Echinococcus granulosus biogenic amine 5HT receptor 0.0059 0.0838 0.0951
Echinococcus granulosus Mastin 0.0028 0.0276 0.0285
Schistosoma mansoni notch 0.0066 0.0974 0.1113
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0838 0.0951
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.008 0.1237 0.2839
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0059 0.0838 0.0951
Schistosoma mansoni notch 0.0066 0.0974 0.1113
Loa Loa (eye worm) hypothetical protein 0.0017 0.007 0.0081
Brugia malayi CXXC zinc finger family protein 0.0028 0.0276 0.0764
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Brugia malayi hypothetical protein 0.0059 0.0838 0.232
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.0356 0.0758
Brugia malayi hypothetical protein 0.008 0.1237 0.3425
Onchocerca volvulus 0.008 0.1237 0.4661
Echinococcus multilocularis dro:myosuppressin receptor 0.0059 0.0838 0.0806
Onchocerca volvulus 0.008 0.1237 0.4661
Loa Loa (eye worm) hypothetical protein 0.0066 0.0974 0.2217
Schistosoma mansoni hypothetical protein 0.0059 0.0838 0.0951
Echinococcus multilocularis fmrfamide receptor 0.0059 0.0838 0.0806
Brugia malayi EGF-like domain containing protein 0.0066 0.0974 0.2697
Loa Loa (eye worm) hypothetical protein 0.0033 0.0356 0.0758
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0356 0.0986
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.0838 0.0806
Schistosoma mansoni microtubule-associated protein tau 0.047 0.8473 1
Brugia malayi EGF-like domain containing protein 0.0066 0.0974 0.2697
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.0356 0.0322
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.0356 0.0322
Brugia malayi EGF-like domain containing protein 0.0066 0.0974 0.2697
Brugia malayi Niemann-Pick C1 protein precursor 0.0067 0.0993 0.2749
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0028 0.0276 0.0285
Brugia malayi Dopamine receptor protein 1 0.0059 0.0838 0.232
Echinococcus granulosus serotonin receptor 0.0059 0.0838 0.0951
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0208 0.3612 0.424
Brugia malayi EGF-like domain containing protein 0.0066 0.0974 0.2697
Onchocerca volvulus 0.008 0.1237 0.4661
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0037 0.044 0.1218
Onchocerca volvulus 0.0066 0.0974 0.3641
Loa Loa (eye worm) hypothetical protein 0.0154 0.2614 0.609
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0356 0.0986
Loa Loa (eye worm) hypothetical protein 0.0098 0.1573 0.3633
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0441 0.794 0.7932
Brugia malayi Sushi domain 0.008 0.1237 0.3425
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0063 0.0918 1
Echinococcus multilocularis slit 2 protein 0.0066 0.0974 0.0942
Echinococcus granulosus laminin 0.0154 0.2614 0.3056
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.0838 0.0951
Toxoplasma gondii LsmAD domain-containing protein 0.0021 0.0138 0.0285
Echinococcus multilocularis Niemann Pick C1 protein 0.0067 0.0993 0.0961
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.007 0.0041
Onchocerca volvulus 0.0066 0.0974 0.3641
Echinococcus granulosus tm gpcr rhodopsin 0.0059 0.0838 0.0951
Onchocerca volvulus 0.008 0.1237 0.4661
Schistosoma mansoni opsin-like receptor 0.0059 0.0838 0.0951
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.0356 0.0381
Brugia malayi tailless protein 0.0015 0.0035 0.0098
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0033 0.0356 0.1245
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Onchocerca volvulus 0.008 0.1237 0.4661
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0356 0.0986
Brugia malayi hypothetical protein 0.0059 0.0838 0.232
Echinococcus granulosus tm gpcr rhodopsin 0.0059 0.0838 0.0951
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0067 0.0993 0.6152
Brugia malayi steroid hormone receptor 0.0033 0.0356 0.0986
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0059 0.0838 0.0806
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0276 0.0285
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Echinococcus granulosus c4b binding protein beta chain 0.008 0.1237 0.1425
Schistosoma mansoni hypothetical protein 0.0066 0.0974 0.1113
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0098 0.1573 1
Brugia malayi Dopamine receptor 0.0059 0.0838 0.232
Toxoplasma gondii rhoptry neck protein RON1 0.008 0.1237 0.4598
Loa Loa (eye worm) hypothetical protein 0.0067 0.0993 0.2262
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.0838 0.0951
Toxoplasma gondii rhoptry neck protein RON9 0.008 0.1237 0.4598
Echinococcus granulosus neuropeptides capa receptor 0.0059 0.0838 0.0951
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0276 0.0285
Loa Loa (eye worm) hypothetical protein 0.008 0.1237 0.2839
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.0838 0.0806
Echinococcus granulosus fmrfamide receptor 0.0059 0.0838 0.0951
Echinococcus granulosus peptide allatostatin:somatostatin 0.0059 0.0838 0.0951
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.0838 0.0806
Brugia malayi hypothetical protein 0.0059 0.0838 0.232
Loa Loa (eye worm) hypothetical protein 0.0066 0.0974 0.2217
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0276 0.0285
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0276 0.0285
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0059 0.0838 0.232
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Brugia malayi follicle stimulating hormone receptor 0.0059 0.0838 0.232
Loa Loa (eye worm) hypothetical protein 0.0028 0.0276 0.0568
Echinococcus granulosus alpha 1A adrenergic receptor 0.0059 0.0838 0.0951
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.0356 0.0322
Brugia malayi hypothetical protein 0.0017 0.007 0.0193
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0154 0.2614 0.609
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0838 0.0951
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0727 0.082
Echinococcus multilocularis g-protein coupled receptor 0.0059 0.0838 0.0806
Echinococcus granulosus equilibrative nucleoside transporter 0.0098 0.1573 0.1823
Echinococcus granulosus notch 0.0066 0.0974 0.1113
Echinococcus multilocularis neuropeptide receptor A26 0.0059 0.0838 0.0806
Brugia malayi Trypsin family protein 0.0028 0.0276 0.0763
Schistosoma mansoni patched 1 0.0029 0.0283 0.0293
Echinococcus multilocularis neural cadherin 0.0066 0.0974 0.0942
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0059 0.0838 0.0806
Schistosoma mansoni hypothetical protein 0.0028 0.0263 0.027
Brugia malayi pregnancy-associated plasma protein-A 0.008 0.1237 0.3425
Loa Loa (eye worm) hypothetical protein 0.008 0.1237 0.2839
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.0356 0.0381
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.0356 0.0381
Echinococcus multilocularis protein jagged 1 0.0066 0.0974 0.0942
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0059 0.0838 0.0806
Onchocerca volvulus 0.0028 0.0276 0.0934
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0059 0.0838 0.0951
Loa Loa (eye worm) hypothetical protein 0.0243 0.4269 1
Echinococcus granulosus neuropeptides capa receptor 0.0059 0.0838 0.0951
Mycobacterium ulcerans hypothetical protein 0.0028 0.0276 0.5
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0276 0.0285
Loa Loa (eye worm) TYRA-2 protein 0.0059 0.0838 0.1896
Onchocerca volvulus Slit protein homolog 0.0066 0.0974 0.3641
Echinococcus multilocularis fmrfamide receptor 0.0059 0.0838 0.0806
Brugia malayi hypothetical protein 0.0098 0.1573 0.4356
Echinococcus granulosus protein jagged 1 0.0066 0.0974 0.1113
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Loa Loa (eye worm) hypothetical protein 0.0017 0.007 0.0081
Schistosoma mansoni hypothetical protein 0.0028 0.0276 0.0285
Trypanosoma brucei PAB1-binding protein , putative 0.0021 0.0138 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0974 0.2217
Brugia malayi RNA recognition motif domain containing protein 0.0053 0.0727 0.2014
Loa Loa (eye worm) hypothetical protein 0.0066 0.0974 0.2217
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0154 0.2614 0.3056
Schistosoma mansoni opsin-like receptor 0.0059 0.0838 0.0951
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.0356 0.0986
Onchocerca volvulus 0.008 0.1237 0.4661
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0059 0.0838 0.0951
Brugia malayi G protein-coupled receptor F59B2.13 0.0059 0.0838 0.232
Echinococcus multilocularis neuropeptide receptor 0.0059 0.0838 0.0806
Echinococcus multilocularis orexin receptor type 2 0.0059 0.0838 0.0806
Brugia malayi Trypsin family protein 0.0028 0.0276 0.0763
Onchocerca volvulus 0.0028 0.0276 0.0932
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0276 0.0285
Brugia malayi Muscle positioning protein 4 0.0066 0.0974 0.2697
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0059 0.0838 0.0806
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.0356 0.0381
Loa Loa (eye worm) hypothetical protein 0.0066 0.0974 0.2217
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0059 0.0838 0.0951
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0028 0.0276 0.0285
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0098 0.1573 0.5965
Echinococcus granulosus hypothetical protein 0.0059 0.0838 0.0951
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.0838 0.0951
Echinococcus granulosus protein jagged 2 0.0066 0.0974 0.1113
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0059 0.0838 0.0806
Leishmania major hypothetical protein, conserved 0.0021 0.0138 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0974 0.2217
Onchocerca volvulus 0.0059 0.0838 0.3113
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0059 0.0838 0.1896
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.007 0.0193
Schistosoma mansoni neuropeptide receptor 0.0059 0.0838 0.0951
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0838 0.0951
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0059 0.0838 0.0951
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0028 0.0276 0.0241
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0276 0.0285
Schistosoma mansoni laminin gamma-3 chain 0.0066 0.0974 0.1113
Schistosoma mansoni hypothetical protein 0.0066 0.0974 0.1113
Brugia malayi hypothetical protein 0.0059 0.0838 0.232
Schistosoma mansoni amine GPCR 0.0059 0.0838 0.0951
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Loa Loa (eye worm) hypothetical protein 0.0033 0.0356 0.0758
Onchocerca volvulus Protein ultraspiracle homolog 0.0033 0.0356 0.1245
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0458 0.8261 0.9749
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0867 0.0986
Loa Loa (eye worm) hypothetical protein 0.0098 0.1573 0.3633
Echinococcus multilocularis protein jagged 1 0.0066 0.0974 0.0942
Echinococcus multilocularis Mastin 0.0028 0.0276 0.0241
Loa Loa (eye worm) hypothetical protein 0.0066 0.0974 0.2217
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.0356 0.0322
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0028 0.0276 0.0763
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Loa Loa (eye worm) hypothetical protein 0.008 0.1237 0.2839
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.0356 0.0758
Brugia malayi hypothetical protein 0.0028 0.0276 0.0763
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Brugia malayi Trypsin family protein 0.0028 0.0276 0.0763
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0356 0.0381
Loa Loa (eye worm) G-protein coupled receptor 0.0059 0.0838 0.1896
Loa Loa (eye worm) hypothetical protein 0.0028 0.0276 0.0568
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.007 0.0041
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Schistosoma mansoni c4b-binding protein beta chain 0.008 0.1237 0.1425
Brugia malayi sulfakinin receptor protein 0.0059 0.0838 0.232
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0059 0.0838 0.0951
Loa Loa (eye worm) hypothetical protein 0.0033 0.0356 0.0758
Schistosoma mansoni septate junction protein 0.0066 0.0974 0.1113
Echinococcus multilocularis laminin 0.0154 0.2614 0.2588
Echinococcus multilocularis expressed conserved protein 0.0063 0.0918 0.0886
Brugia malayi G-protein coupled receptor 0.0059 0.0838 0.232
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0059 0.0838 0.0806
Schistosoma mansoni cpg binding protein 0.003 0.0306 0.0321
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.0356 0.0758
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.1527 0.1768
Brugia malayi larval opioid receptor 0.0059 0.0838 0.232
Loa Loa (eye worm) hypothetical protein 0.0017 0.007 0.0081
Loa Loa (eye worm) hypothetical protein 0.0066 0.0974 0.2217
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Brugia malayi TAR-binding protein 0.0053 0.0727 0.2014
Brugia malayi Calcium binding EGF domain containing protein 0.0066 0.0974 0.2697
Brugia malayi neuropeptide F receptor 0.0059 0.0838 0.232
Toxoplasma gondii calcium binding egf domain-containing protein 0.0154 0.2614 1
Schistosoma mansoni hypothetical protein 0.0028 0.0276 0.0285
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0066 0.0974 0.2697
Schistosoma mansoni hypothetical protein 0.0028 0.0263 0.027
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0063 0.0918 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Echinococcus granulosus protein jagged 2 0.0066 0.0974 0.1113
Brugia malayi hypothetical protein 0.0021 0.0138 0.0382
Schistosoma mansoni notch 0.0066 0.0974 0.1113
Echinococcus multilocularis sterol regulatory element binding protein 0.0029 0.0283 0.0248
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0838 0.0951
Schistosoma mansoni opsin-like receptor 0.0059 0.0838 0.0951
Loa Loa (eye worm) hypothetical protein 0.0028 0.0276 0.0568
Onchocerca volvulus 0.0059 0.0838 0.3113
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0059 0.0838 0.232
Echinococcus granulosus g protein coupled receptor 0.0059 0.0838 0.0951
Loa Loa (eye worm) hypothetical protein 0.008 0.1237 0.2839
Echinococcus granulosus neuropeptide receptor 0.0059 0.0838 0.0951
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.0356 0.0986
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0037 0.044 0.0406
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.0356 0.0758
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0059 0.0838 0.0951
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0059 0.0838 0.1896
Echinococcus granulosus neuropeptide receptor A26 0.0059 0.0838 0.0951
Giardia lamblia Hypothetical protein 0.0098 0.1573 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0059 0.0838 0.0951
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0066 0.0974 0.1113
Brugia malayi hypothetical protein 0.008 0.1237 0.3425
Schistosoma mansoni protein kinase 0.0017 0.0071 0.0043
Echinococcus multilocularis equilibrative nucleoside transporter protein 0.0098 0.1573 0.1544
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0727 0.082
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.0356 0.0322
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0066 0.0974 0.3641
Brugia malayi Calcium binding EGF domain containing protein 0.0066 0.0974 0.2697
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Brugia malayi hypothetical protein 0.0017 0.007 0.0193
Echinococcus granulosus Niemann Pick C1 protein 0.0067 0.0993 0.1135
Brugia malayi Neuronal symmetry protein 1 0.0208 0.3612 1
Schistosoma mansoni amine GPCR 0.0059 0.0838 0.0951
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.0356 0.0381
Loa Loa (eye worm) hypothetical protein 0.0066 0.0974 0.2217
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Echinococcus multilocularis neurogenic locus notch protein 0.0066 0.0974 0.0942
Echinococcus granulosus g-protein coupled receptor 0.0059 0.0838 0.0951
Loa Loa (eye worm) hypothetical protein 0.0154 0.2614 0.609
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.0356 0.0986
Echinococcus granulosus g protein coupled receptor 0.0059 0.0838 0.0951
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0059 0.0838 0.232
Schistosoma mansoni alpha-1 adrenergic receptor 0.0059 0.0838 0.0951
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.0838 0.0806
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Onchocerca volvulus 0.0059 0.0838 0.3113
Brugia malayi EGF-like domain containing protein 0.0066 0.0974 0.2697
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Brugia malayi conserved hypotetical protein 0.0015 0.0035 0.0098
Schistosoma mansoni protein kinase 0.0208 0.3612 0.424
Echinococcus granulosus tachykinin peptides receptor 99D 0.0059 0.0838 0.0951
Loa Loa (eye worm) hypothetical protein 0.0066 0.0974 0.2217
Echinococcus granulosus fibropellin Ia 0.0066 0.0974 0.1113
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.0838 0.0951
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.044 0.048
Onchocerca volvulus 0.0028 0.0276 0.0932
Echinococcus multilocularis transmembrane protease serine 3 0.0028 0.0276 0.0241
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0059 0.0838 0.0806
Loa Loa (eye worm) hypothetical protein 0.0028 0.0276 0.0568
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0059 0.0838 0.0806
Brugia malayi nuclear hormone receptor 0.0015 0.0035 0.0098
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.0838 0.0806
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0727 0.082
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0098 0.1573 0.5965
Schistosoma mansoni amine GPCR 0.0059 0.0838 0.0951
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0727 0.082
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0028 0.0276 0.0285
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0059 0.0838 0.1896
Echinococcus multilocularis c4b binding protein beta chain 0.008 0.1237 0.1206
Schistosoma mansoni cpg binding protein 0.003 0.0306 0.0321
Onchocerca volvulus 0.0066 0.0974 0.3641
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Echinococcus multilocularis neurogenic locus notch protein 4 0.0066 0.0974 0.0942
Echinococcus multilocularis thyroid hormone receptor alpha 0.0033 0.0356 0.0322
Brugia malayi Serotonin receptor 0.0059 0.0838 0.232
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0059 0.0838 0.0806
Echinococcus granulosus somatostatin receptor 0.0059 0.0838 0.0951
Loa Loa (eye worm) trypsin family protein 0.0028 0.0276 0.0568
Brugia malayi hypothetical protein 0.0015 0.0035 0.0098
Loa Loa (eye worm) hypothetical protein 0.0063 0.0912 0.2071
Echinococcus multilocularis Tolloid protein 1 0.0154 0.2614 0.2588
Echinococcus granulosus enteropeptidase 0.0028 0.0276 0.0285
Schistosoma mansoni histamine h1 receptor 0.0059 0.0838 0.0951
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0727 0.082
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0838 0.0951
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0059 0.0838 0.232
Schistosoma mansoni hypothetical protein 0.0066 0.0974 0.1113
Brugia malayi CHE-14 protein 0.0029 0.0283 0.0783
Schistosoma mansoni coup transcription factor 0.0033 0.0356 0.0381
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0356 0.0986
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.0838 0.0806
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0059 0.0838 0.0951
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.0356 0.0986
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0748 0.2678
Loa Loa (eye worm) hypothetical protein 0.0066 0.0974 0.2217
Echinococcus granulosus protein jagged 1 0.0066 0.0974 0.1113
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0276 0.0569
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0154 0.2614 0.7236
Brugia malayi hypothetical protein 0.0059 0.0838 0.232
Onchocerca volvulus 0.0059 0.0838 0.3113
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0283 0.144
Echinococcus multilocularis neurogenic locus protein delta 0.0066 0.0974 0.0942
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0059 0.0838 0.0951
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.0356 0.0322
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.0838 0.0806
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0356 0.0986
Echinococcus multilocularis fat cadherin tumor suppressor 0.0066 0.0974 0.0942
Onchocerca volvulus 0.0059 0.0838 0.3113
Brugia malayi RE15519p 0.0059 0.0838 0.232
Onchocerca volvulus 0.0059 0.0838 0.3113
Echinococcus granulosus allatostatin A receptor 0.0059 0.0838 0.0951
Brugia malayi nuclear receptor RXR 0.0015 0.0035 0.0098
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Echinococcus multilocularis C type lectin domian containing protein 0.008 0.1237 0.1206
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0356 0.0986
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.0356 0.0381
Echinococcus multilocularis neuropeptides capa receptor 0.0059 0.0838 0.0806
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0838 0.0951
Onchocerca volvulus 0.008 0.1237 0.4661
Echinococcus multilocularis neuropeptide s receptor 0.0059 0.0838 0.0806
Echinococcus granulosus delta-like protein 1 0.0066 0.0974 0.1113
Echinococcus granulosus neuropeptide FF receptor 2 0.0059 0.0838 0.0951
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0098 0.1573 1
Toxoplasma gondii calcium binding egf domain-containing protein 0.0154 0.2614 1
Schistosoma mansoni hypothetical protein 0.0066 0.0974 0.1113
Loa Loa (eye worm) hypothetical protein 0.0066 0.0974 0.2217
Loa Loa (eye worm) hypothetical protein 0.0066 0.0974 0.2217
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.007 0.0041
Echinococcus multilocularis glycoprotein Antigen 5 0.0028 0.0276 0.0241
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0838 0.0951
Echinococcus multilocularis g protein coupled receptor 0.0059 0.0838 0.0806
Onchocerca volvulus Arrow homolog 0.0154 0.2614 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Onchocerca volvulus 0.0066 0.0974 0.3641
Echinococcus multilocularis fibropellin Ia 0.0066 0.0974 0.0942
Echinococcus multilocularis protein jagged 2 0.0066 0.0974 0.0942
Schistosoma mansoni hypothetical protein 0.0066 0.0974 0.1113
Brugia malayi hypothetical protein 0.008 0.1237 0.3425
Brugia malayi EGF-like domain containing protein 0.0066 0.0974 0.2697
Schistosoma mansoni biogenic amine (5HT) receptor 0.0059 0.0838 0.0951
Echinococcus granulosus neuropeptide Y receptor 0.0059 0.0838 0.0951
Brugia malayi hypothetical protein 0.0059 0.0838 0.232
Brugia malayi Calcium binding EGF domain containing protein 0.0154 0.2614 0.7236
Echinococcus granulosus glycoprotein Antigen 5 0.0028 0.0276 0.0285
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0276 0.0285
Echinococcus granulosus expressed conserved protein 0.0063 0.0918 0.1046
Schistosoma mansoni biogenic amine receptor 0.0059 0.0838 0.0951
Onchocerca volvulus 0.0059 0.0838 0.3113
Echinococcus granulosus 7tm_1 domain containing protein 0.0059 0.0838 0.0951
Echinococcus multilocularis neuropeptide Y receptor 0.0059 0.0838 0.0806
Echinococcus granulosus neuropeptide Y receptor 0.0059 0.0838 0.0951
Schistosoma mansoni notch 0.0066 0.0974 0.1113
Brugia malayi GnHR receptor homolog 0.0059 0.0838 0.232
Echinococcus multilocularis neuropeptides capa receptor 0.0059 0.0838 0.0806
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0059 0.0838 0.0806
Brugia malayi Trypsin-like protease protein 5 0.0028 0.0276 0.0763
Brugia malayi neuropeptide F receptor 0.0059 0.0838 0.232
Echinococcus multilocularis serotonin receptor 0.0059 0.0838 0.0806
Echinococcus granulosus orexin receptor type 2 0.0059 0.0838 0.0951
Schistosoma mansoni hypothetical protein 0.0028 0.0263 0.027
Echinococcus multilocularis g protein coupled receptor 0.0059 0.0838 0.0806
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0068 0.1012 0.1158
Echinococcus granulosus neurogenic locus notch protein 0.0066 0.0974 0.1113
Loa Loa (eye worm) hypothetical protein 0.0066 0.0974 0.2217
Echinococcus multilocularis allatostatin A receptor 0.0059 0.0838 0.0806
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.007 0.0193
Echinococcus multilocularis protein dispatched 1 0.0033 0.0358 0.0324
Schistosoma mansoni hypothetical protein 0.0066 0.0974 0.1113
Brugia malayi notch-like transmembrane receptor 0.0066 0.0974 0.2697
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0053 0.0727 0.1635
Echinococcus granulosus tm gpcr rhodopsin 0.0059 0.0838 0.0951
Brugia malayi Calcium binding EGF domain containing protein 0.0066 0.0974 0.2697
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.0838 0.0951
Echinococcus multilocularis notch 0.0066 0.0974 0.0942
Brugia malayi nuclear receptor NHR-88 0.0015 0.0035 0.0098
Brugia malayi ecdysone receptor 0.0015 0.0035 0.0098
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0037 0.044 0.048
Schistosoma mansoni neuropeptide F-like receptor 0.0059 0.0838 0.0951
Brugia malayi GCC2 and GCC3 family protein 0.0146 0.2463 0.6817
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0059 0.0838 0.232
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0098 0.1573 1
Onchocerca volvulus 0.0059 0.0838 0.3113
Loa Loa (eye worm) notch protein 0.0066 0.0974 0.2217
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0356 0.0381
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0059 0.0838 0.0951
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0059 0.0838 0.3113
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0356 0.0322
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0035 0.0098
Loa Loa (eye worm) hypothetical protein 0.0066 0.0974 0.2217
Brugia malayi ORL1-like opioid receptor 0.0059 0.0838 0.232
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0028 0.0276 0.0285
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.0356 0.0986
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.0356 0.0381
Schistosoma mansoni neuropeptide f receptor 76f 0.0059 0.0838 0.0951
Schistosoma mansoni retinoic acid receptor RXR 0.0458 0.8261 0.9749
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0028 0.0276 0.0285
Echinococcus granulosus tar DNA binding protein 0.0053 0.0727 0.082
Brugia malayi Nucleoside transporter family protein 0.0098 0.1573 0.4356
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0059 0.0838 0.0806
Brugia malayi Serotonin receptor 0.0059 0.0838 0.232
Echinococcus multilocularis fibrillin 1 0.0154 0.2614 0.2588
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.0356 0.0758
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0028 0.0276 0.0285
Brugia malayi hypothetical protein 0.0015 0.0035 0.0098
Loa Loa (eye worm) hypothetical protein 0.0059 0.0838 0.1896
Schistosoma mansoni neuropeptide receptor 0.0059 0.0838 0.0951
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.0356 0.0381
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.0356 0.0381
Onchocerca volvulus Neurogenic locus notch homolog 0.0066 0.0974 0.3641
Echinococcus multilocularis enteropeptidase 0.0028 0.0276 0.0241
Brugia malayi Dopamine receptor protein 2 0.0059 0.0838 0.232
Schistosoma mansoni amine GPCR 0.0059 0.0838 0.0951
Echinococcus granulosus transmembrane protease serine 3 0.0028 0.0276 0.0285
Entamoeba histolytica nucleoside transporter, putative 0.0098 0.1573 1
Brugia malayi ecdysteroid receptor 0.0033 0.0356 0.0986
Brugia malayi G protein-coupled receptor 0.0059 0.0838 0.232
Onchocerca volvulus 0.0059 0.0838 0.3113
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0208 0.3612 0.359
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0059 0.0838 0.0951
Brugia malayi hypothetical protein 0.008 0.1237 0.3425
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.0356 0.0758
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0059 0.0838 0.0951
Echinococcus granulosus Tolloid protein 1 0.0154 0.2614 0.3056
Loa Loa (eye worm) hypothetical protein 0.0035 0.0403 0.0868
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0029 0.0283 0.0584
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0081 0.1257 0.1226
Brugia malayi nuclear receptor NHR-88 0.0033 0.0356 0.0986
Onchocerca volvulus 0.0033 0.0356 0.1245
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.044 0.048
Loa Loa (eye worm) G-protein coupled receptor 0.0059 0.0838 0.1896
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0035 0.0098
Loa Loa (eye worm) hypothetical protein 0.0017 0.007 0.0081
Schistosoma mansoni cpg binding protein 0.0028 0.0276 0.0285
Onchocerca volvulus 0.0066 0.0974 0.3641
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0028 0.0276 0.0241
Schistosoma mansoni hypothetical protein 0.0059 0.0838 0.0951
Onchocerca volvulus 0.0059 0.0838 0.3113
Loa Loa (eye worm) Notch2 0.0066 0.0974 0.2217
Loa Loa (eye worm) hypothetical protein 0.0033 0.0356 0.0758
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0356 0.0322
Schistosoma mansoni myosin xvIII 0.0059 0.0838 0.0951
Echinococcus multilocularis neurogenic locus notch protein 0.0066 0.0974 0.0942
Onchocerca volvulus 0.0028 0.0276 0.0932

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3831 nM Inhibition of ENT1 in human K562 cells by flow cytometric assay ChEMBL. 17636949
IC50 (binding) = 3831 nM Inhibition of ENT1 in human K562 cells by flow cytometric assay ChEMBL. 17636949
Inhibition (binding) = 57 % Inhibition of ENT1 in human K562 cells at 10 uM by flow cytometric assay ChEMBL. 17636949
Inhibition (binding) = 57 % Inhibition of ENT1 in human K562 cells at 10 uM by flow cytometric assay ChEMBL. 17636949
Ki (binding) = 216.4 nM Inhibition of ENT1 in human K562 cells by flow cytometric assay ChEMBL. 17636949
Ki (binding) = 216.4 nM Inhibition of ENT1 in human K562 cells by flow cytometric assay ChEMBL. 17636949

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.