Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 1 | 1 |
Echinococcus granulosus | equilibrative nucleoside transporter 3 | 0.0098 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.006 | 0.4377 | 0.5 |
Entamoeba histolytica | nucleoside transporter, putative | 0.0098 | 1 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.006 | 0.4377 | 0.3751 |
Trichomonas vaginalis | equilibrative nucleoside transporter, putative | 0.0098 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.006 | 0.4377 | 1 |
Onchocerca volvulus | Equilibrative nucleoside transporter, putative homolog | 0.0098 | 1 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.006 | 0.4377 | 0.3751 |
Echinococcus multilocularis | equilibrative nucleoside transporter 3 | 0.0098 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.006 | 0.4377 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0098 | 1 | 1 |
Trichomonas vaginalis | equilibrative nucleoside transporter, putative | 0.0098 | 1 | 1 |
Trichomonas vaginalis | equilibrative nucleoside transporter, putative | 0.0098 | 1 | 1 |
Trichomonas vaginalis | equilibrative nucleoside transporter, putative | 0.0098 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 1 | 1 |
Echinococcus granulosus | equilibrative nucleoside transporter | 0.0098 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0098 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.006 | 0.4377 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.4377 | 0.3751 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0037 | 0.1003 | 0.2291 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.006 | 0.4377 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0037 | 0.1003 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.006 | 0.4377 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.006 | 0.4377 | 0.3751 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.006 | 0.4377 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.006 | 0.4377 | 0.3751 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 1 | 1 |
Echinococcus multilocularis | equilibrative nucleoside transporter protein | 0.0098 | 1 | 1 |
Onchocerca volvulus | Equilibrative nucleoside transporter, putative homolog | 0.0098 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.006 | 0.4377 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.006 | 0.4377 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.006 | 0.4377 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.006 | 0.4377 | 0.1514 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.006 | 0.4377 | 0.3751 |
Leishmania major | p450 reductase, putative | 0.006 | 0.4377 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.006 | 0.4377 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.006 | 0.4377 | 0.5 |
Brugia malayi | flavodoxin family protein | 0.006 | 0.4377 | 0.3751 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.006 | 0.4377 | 0.3751 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.006 | 0.4377 | 0.5 |
Echinococcus multilocularis | equilibrative nucleoside transporter 3 | 0.0081 | 0.7492 | 0.7212 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | 0 | Inhibition of ENT1 in human K562 cells by flow cytometric assay | ChEMBL. | 17636949 |
Inhibition (binding) | = 7.56 % | Inhibition of ENT1 in human K562 cells at 10 uM by flow cytometric assay | ChEMBL. | 17636949 |
Inhibition (binding) | = 7.56 % | Inhibition of ENT1 in human K562 cells at 10 uM by flow cytometric assay | ChEMBL. | 17636949 |
Ki (binding) | 0 | Inhibition of ENT1 in human K562 cells by flow cytometric assay | ChEMBL. | 17636949 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.