Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 602 aa | 546 aa | 30.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.2835 | 0.2835 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0508 | 1 | 1 |
Echinococcus granulosus | roundabout 2 | 0.0079 | 0.1061 | 0.3741 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.2835 | 0.2835 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.2835 | 1 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0062 | 0.0709 | 0.0709 |
Onchocerca volvulus | 0.0431 | 0.8401 | 0.9687 | |
Schistosoma mansoni | cell adhesion molecule | 0.0071 | 0.0906 | 0.3196 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0709 | 0.0709 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.2835 | 0.2835 |
Brugia malayi | hypothetical protein | 0.0062 | 0.0709 | 0.0709 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.2835 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0.2835 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0709 | 0.0709 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0709 | 0.0709 |
Schistosoma mansoni | vesicular amine transporter | 0.0062 | 0.0709 | 0.25 |
Echinococcus multilocularis | roundabout 2 | 0.0079 | 0.1061 | 0.3741 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.1061 | 0.1061 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0028 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.2835 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0028 | 0 | 0.5 |
Echinococcus granulosus | defective proboscis extension response | 0.0062 | 0.0709 | 0.25 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0709 | 0.0709 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0709 | 0.0709 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.1061 | 0.1061 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0062 | 0.0709 | 0.25 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 0.2835 | 0.2835 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0.2835 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0028 | 0 | 0.5 |
Echinococcus granulosus | twitchin | 0.0069 | 0.0863 | 0.3045 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0062 | 0.0709 | 0.25 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0062 | 0.0709 | 0.25 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.2835 | 0.2835 |
Echinococcus multilocularis | neuroglian | 0.0069 | 0.0863 | 0.3045 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.2835 | 0.2835 |
Echinococcus granulosus | Immunoglobulin | 0.0062 | 0.0709 | 0.25 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0709 | 0.0709 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.2835 | 1 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0071 | 0.0906 | 0.3196 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0062 | 0.0709 | 0.0709 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0028 | 0 | 0.5 |
Echinococcus multilocularis | Immunoglobulin | 0.0062 | 0.0709 | 0.25 |
Echinococcus granulosus | neuroglian | 0.0069 | 0.0863 | 0.3045 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0444 | 0.8672 | 1 |
Schistosoma mansoni | nephrin | 0.0069 | 0.0863 | 0.3045 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.2835 | 1 |
Echinococcus multilocularis | Immunoglobulin | 0.0062 | 0.0709 | 0.25 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0906 | 0.0906 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 0.00001 nM | Inhibition of human recombinant BChE | ChEMBL. | 17655212 |
IC50 (binding) | > 0.00001 nM | Inhibition of human recombinant BChE | ChEMBL. | 17655212 |
IC50 (binding) | = 714 nM | Inhibition of human recombinant AChE | ChEMBL. | 17655212 |
IC50 (binding) | = 714 nM | Inhibition of human recombinant AChE | ChEMBL. | 17655212 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.