TDR Targets

Basic information

Technical information

TDR Targets ID: 432667
Name: 4-(2-hydroxyanilino)naphthalene-1,2-dione
MW: 265.263 | Formula: C16H11NO3
H donors: 2 H acceptors: 3 LogP: 2.39 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Oc1ccccc1NC1=CC(=O)C(=O)c2c1cccc2
InChi: 1S/C16H11NO3/c18-14-8-4-3-7-12(14)17-13-9-15(19)16(20)11-6-2-1-5-10(11)13/h1-9,17-18H
InChiKey: BNOCMOBNZBUGRY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[(2-hydroxyphenyl)amino]naphthalene-1,2-dione
4-(2-hydroxyanilino)-1,2-naphthoquinone
4-[(2-hydroxyphenyl)amino]-1,2-naphthoquinone
SDCCGMLS-0065892.P001
STOCK1S-49357
4-(2-Hydroxy-phenylamino)-[1,2]naphthoquinone
MLS000550900
SMR000145028
ZINC02269755

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0067	0.0588	0.0694
Echinococcus granulosus	thioredoxin glutathione reductase	0.004	0.0246	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0275	0.0402
Brugia malayi	RNA, U transporter 1	0.0081	0.0765	0.1119
Brugia malayi	Cytochrome P450 family protein	0.0029	0.01	0.0146
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0388	0.0458
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.004	0.0248	0.0292
Brugia malayi	Animal haem peroxidase family protein	0.0452	0.5495	0.8039
Schistosoma mansoni	hypothetical protein	0.0358	0.4292	0.5067
Echinococcus multilocularis	Ribosomal protein S1, RNA binding domain	0.0083	0.079	0.079
Echinococcus multilocularis	slit 2 protein	0.0146	0.1594	0.1594
Loa Loa (eye worm)	CYP4Cod1	0.0029	0.01	0.0146
Schistosoma mansoni	slit	0.0146	0.1594	0.1882
Entamoeba histolytica	hypothetical protein	0.0038	0.0215	0.7825
Leishmania major	extracellular receptor, putative	0.0043	0.0275	0.0727
Brugia malayi	Animal haem peroxidase family protein	0.0452	0.5495	0.8039
Echinococcus granulosus	glutamate receptor 2	0.0043	0.0275	0.0324
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0318	0.3779	1
Echinococcus granulosus	protein jagged 1	0.0146	0.1594	0.1882
Trypanosoma brucei	cytochrome P450, putative	0.0029	0.01	0.0265
Echinococcus multilocularis	neurogenic locus protein delta	0.0146	0.1594	0.1594
Echinococcus granulosus	glutamate receptor NMDA	0.0212	0.2434	0.2874
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0034	0.016	0.0189
Schistosoma mansoni	cell polarity protein	0.0146	0.1594	0.1882
Echinococcus granulosus	zinc finger protein	0.0022	0.0013	0.0016
Echinococcus granulosus	receptor type guanylyl cyclase	0.0043	0.0275	0.0324
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0041	0.0251	0.1572
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0096	0.0096
Schistosoma mansoni	glutamate receptor kainate	0.0083	0.079	0.0932
Chlamydia trachomatis	glutamine binding protein	0.0213	0.2441	0.5
Onchocerca volvulus		0.0146	0.1594	0.2688
Schistosoma mansoni	peroxidasin	0.0452	0.5495	0.6487
Plasmodium vivax	glutathione reductase, putative	0.004	0.024	1
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0096	0.0601
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1594	0.2333
Schistosoma mansoni	metabotropic glutamate receptor	0.0043	0.0275	0.0324
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0125	0.1331	0.1572
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0275	0.0402
Mycobacterium ulcerans	glutamine-binding lipoprotein GlnH	0.0213	0.2441	0.3476
Schistosoma mansoni	hypothetical protein	0.0038	0.0215	0.0254
Echinococcus granulosus	lysosomal alpha glucosidase	0.0183	0.2066	0.2439
Brugia malayi	Animal haem peroxidase family protein	0.0452	0.5495	0.8039
Plasmodium vivax	SET domain protein, putative	0.0034	0.016	0.6694
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0215	0.0254
Schistosoma mansoni	notch	0.0146	0.1594	0.1882
Echinococcus granulosus	nmda type glutamate receptor	0.0255	0.2976	0.3514
Onchocerca volvulus		0.0266	0.3125	0.5558
Loa Loa (eye worm)	animal heme peroxidase	0.0452	0.5495	0.8039
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0388	0.0388
Echinococcus multilocularis	atrial natriuretic peptide receptor	0.0043	0.0275	0.0275
Trichomonas vaginalis	alpha-glucosidase, putative	0.0041	0.0251	0.0367
Brugia malayi	Receptor family ligand binding region containing protein	0.0043	0.0275	0.0402
Schistosoma mansoni	glutamate receptor NMDA	0.0338	0.4033	0.4761
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0146	0.1594	0.2333
Brugia malayi	Glutamate receptor 2 precursor	0.0083	0.079	0.1155
Echinococcus granulosus	Ribosomal protein S1 RNA binding domain	0.0083	0.079	0.0932
Plasmodium vivax	thioredoxin reductase, putative	0.004	0.024	1
Schistosoma mansoni	alpha glucosidase	0.0041	0.0251	0.0296
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0101	0.1018	0.3534
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1594	0.2333
Brugia malayi	metabotropic glutamate receptor type 2	0.0043	0.0275	0.0402
Loa Loa (eye worm)	animal heme peroxidase	0.0452	0.5495	0.8039
Onchocerca volvulus	Slit protein homolog	0.0146	0.1594	0.2688
Onchocerca volvulus	Putative cubilin	0.0146	0.1594	0.2688
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0043	0.0275	0.0324
Schistosoma mansoni	hypothetical protein	0.0023	0.0028	0.0034
Toxoplasma gondii	thioredoxin reductase	0.004	0.024	0.1503
Echinococcus multilocularis	peroxidasin	0.0452	0.5495	0.5495
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0388	0.0388
Echinococcus granulosus	snurportin 1	0.0304	0.3606	0.4258
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0125	0.1331	0.1331
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0146	0.1594	0.2688
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0177	0.1993	0.1993
Onchocerca volvulus		0.0043	0.0275	0.0214
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0251	0.0663
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1594	0.2333
Loa Loa (eye worm)	hypothetical protein	0.0452	0.5495	0.8039
Brugia malayi	EGF-like domain containing protein	0.0146	0.1594	0.2333
Brugia malayi	Cytochrome P450 family protein	0.007	0.0625	0.0914
Schistosoma mansoni	hypothetical protein	0.0146	0.1594	0.1882
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1594	0.2333
Loa Loa (eye worm)	hypothetical protein	0.008	0.0746	0.1091
Trypanosoma cruzi	extracellular receptor, putative	0.0043	0.0275	0.0727
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0344	0.0503
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0043	0.0275	0.0402
Schistosoma mansoni	microtubule-associated protein tau	0.0686	0.847	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0041	0.0251	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1594	0.2333
Brugia malayi	Guanylyl cyclase protein 23	0.0043	0.0275	0.0402
Echinococcus multilocularis	glutamate receptor subunit protein glur	0.0083	0.079	0.079
Loa Loa (eye worm)	metabotropic glutamate receptor 8	0.0043	0.0275	0.0402
Trypanosoma brucei	trypanothione reductase	0.004	0.024	0.0634
Schistosoma mansoni	hypothetical protein	0.0358	0.4292	0.5067
Schistosoma mansoni	metabotropic glutamate receptor	0.0043	0.0275	0.0324
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0043	0.0275	0.0402
Onchocerca volvulus	Peroxidase homolog	0.0452	0.5495	1
Brugia malayi	Cadherin domain containing protein	0.0146	0.1594	0.2333
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0177	0.1993	0.2353
Leishmania major	cytochrome p450-like protein	0.0029	0.01	0.0265
Schistosoma mansoni	ATP-binding cassette transporter	0.0083	0.079	0.0932
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0125	0.1331	0.1572
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0146	0.1594	0.1594
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0053	0.0405	0.0478
Echinococcus granulosus	tyrosine kinase	0.0043	0.0275	0.0324
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0125	0.1331	0.1331
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0041	0.0251	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1594	0.2333
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0101	0.1018	0.3534
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0041	0.0251	0.9127
Loa Loa (eye worm)	hypothetical protein	0.0452	0.5495	0.8039
Plasmodium falciparum	thioredoxin reductase	0.004	0.024	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.016	0.0189
Echinococcus granulosus	glutamate receptor ionotropic kainate 3	0.0083	0.079	0.0932
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0032	0.0145	0.0171
Echinococcus granulosus	delta-like protein 1	0.0146	0.1594	0.1882
Schistosoma mansoni	tyrosine kinase	0.0043	0.0275	0.0324
Schistosoma mansoni	alpha-glucosidase	0.0158	0.1741	0.2056
Loa Loa (eye worm)	hypothetical protein	0.0452	0.5495	0.8039
Echinococcus multilocularis	tyrosine kinase	0.0043	0.0275	0.0275
Brugia malayi	EGF-like domain containing protein	0.0146	0.1594	0.2333
Trichomonas vaginalis	set domain proteins, putative	0.0266	0.3125	0.4572
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0183	0.2066	0.2066
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0045	0.0302	0.0799
Echinococcus granulosus	neurogenic locus notch protein	0.0146	0.1594	0.1882
Schistosoma mansoni	septate junction protein	0.0146	0.1594	0.1882
Echinococcus multilocularis	glutamate receptor 2	0.0043	0.0275	0.0275
Schistosoma mansoni	notch	0.0146	0.1594	0.1882
Echinococcus multilocularis	protein jagged 1	0.0146	0.1594	0.1594
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0304	0.3606	0.5277
Brugia malayi	Importin beta-1 subunit	0.0028	0.0096	0.014
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0045	0.0302	0.0799
Schistosoma mansoni	hypothetical protein	0.0146	0.1594	0.1882
Loa Loa (eye worm)	blistered cuticle protein 3	0.0452	0.5495	0.8039
Brugia malayi	Calcium binding EGF domain containing protein	0.0146	0.1594	0.2333
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0275	0.0402
Loa Loa (eye worm)	glutamate receptor	0.0043	0.0275	0.0402
Echinococcus multilocularis	NMDA receptor	0.0083	0.079	0.079
Brugia malayi	Pre-SET motif family protein	0.0034	0.016	0.0235
Brugia malayi	hypothetical protein	0.0452	0.5495	0.8039
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein (hisJ)	0.0213	0.2441	0.5
Onchocerca volvulus		0.0146	0.1594	0.2688
Mycobacterium ulcerans	glutaminase	0.0558	0.6835	1
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0041	0.0251	0.9127
Trypanosoma cruzi	cytochrome P450, putative	0.0029	0.01	0.0265
Schistosoma mansoni	notch	0.0146	0.1594	0.1882
Echinococcus granulosus	neutral alpha glucosidase AB	0.0041	0.0251	0.0296
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein	0.0213	0.2441	0.5
Entamoeba histolytica	hypothetical protein	0.0038	0.0215	0.7825
Onchocerca volvulus		0.0146	0.1594	0.2688
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.0213	0.2441	0.5
Onchocerca volvulus	Neurogenic locus notch homolog	0.0146	0.1594	0.2688
Brugia malayi	Peroxidasin	0.0452	0.5495	0.8039
Loa Loa (eye worm)	animal heme peroxidase	0.0452	0.5495	0.8039
Plasmodium falciparum	glutathione reductase	0.004	0.024	1
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1594	0.2333
Brugia malayi	Calcium binding EGF domain containing protein	0.0146	0.1594	0.2333
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0043	0.0275	0.0402
Echinococcus granulosus	glutamate receptor ionotropic kainate	0.0083	0.079	0.0932
Leishmania major	mitochondrial DNA polymerase beta	0.0318	0.3779	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0043	0.0275	0.0402
Loa Loa (eye worm)	cytochrome P450 family protein	0.0029	0.01	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0452	0.5495	0.8039
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0043	0.0275	0.0324
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0053	0.0405	0.0478
Schistosoma mansoni	bromodomain containing protein	0.0071	0.0639	0.0755
Brugia malayi	Receptor family ligand binding region containing protein	0.0043	0.0275	0.0402
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0183	0.2066	0.2066
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0096	0.0113
Brugia malayi	Muscle positioning protein 4	0.0146	0.1594	0.2333
Trichomonas vaginalis	alpha-glucosidase, putative	0.0041	0.0251	0.0367
Entamoeba histolytica	hypothetical protein	0.0038	0.0215	0.7825
Echinococcus multilocularis	geminin	0.0358	0.4292	0.4292
Schistosoma mansoni	notch	0.0146	0.1594	0.1882
Onchocerca volvulus		0.0043	0.0275	0.0214
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0388	0.0458
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0043	0.0275	0.0402
Loa Loa (eye worm)	animal heme peroxidase	0.0452	0.5495	0.8039
Loa Loa (eye worm)	hypothetical protein	0.0452	0.5495	0.8039
Loa Loa (eye worm)	hypothetical protein	0.0452	0.5495	0.8039
Trichomonas vaginalis	alpha-glucosidase, putative	0.0041	0.0251	0.0367
Brugia malayi	Bromodomain containing protein	0.0084	0.0807	0.1181
Loa Loa (eye worm)	PHD-finger family protein	0.0023	0.0028	0.0042
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0167	0.1864	0.7378
Schistosoma mansoni	glutaminase	0.0558	0.6835	0.8069
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0067	0.0588	0.0588
Schistosoma mansoni	hypothetical protein	0.0304	0.3606	0.4258
Echinococcus granulosus	slit 2 protein	0.0146	0.1594	0.1882
Trichomonas vaginalis	glutaminase, putative	0.0558	0.6835	1
Mycobacterium tuberculosis	Probable reductase	0.0091	0.0889	0.2949
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0388	0.0458
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1594	0.2333
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.004	0.0248	0.0248
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0045	0.0302	0.0799
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0388	0.0458
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0043	0.0275	0.0275
Schistosoma mansoni	protein kinase	0.0043	0.0275	0.0324
Echinococcus granulosus	histone lysine methyltransferase setb	0.0053	0.0405	0.0478
Toxoplasma gondii	EGF family domain-containing protein	0.0146	0.1594	1
Loa Loa (eye worm)	glutathione reductase	0.004	0.024	0.0351
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.015	0.1648	0.436
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1594	0.2333
Onchocerca volvulus	Peroxidase homolog	0.0452	0.5495	1
Entamoeba histolytica	hypothetical protein	0.0043	0.0275	1
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1594	0.2333
Loa Loa (eye worm)	hypothetical protein	0.0452	0.5495	0.8039
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0275	0.0402
Mycobacterium tuberculosis	Probable dehydrogenase	0.0091	0.0889	0.2949
Loa Loa (eye worm)	glutaminase 2	0.0558	0.6835	1
Echinococcus multilocularis	protein jagged 1	0.0146	0.1594	0.1594
Schistosoma mansoni	hypothetical protein	0.0146	0.1594	0.1882
Echinococcus multilocularis	neurogenic locus notch protein	0.0146	0.1594	0.1594
Mycobacterium tuberculosis	Probable oxidoreductase	0.0101	0.1018	0.3534
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0041	0.0251	0.0367
Schistosoma mansoni	glutamate receptor kainate	0.0083	0.079	0.0932
Trichomonas vaginalis	alpha-glucosidase, putative	0.0041	0.0251	0.0367
Echinococcus multilocularis	glutamate receptor ionotropic kainate	0.0083	0.079	0.079
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0183	0.2066	0.3023
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0275	0.0402
Onchocerca volvulus		0.0452	0.5495	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0043	0.0275	0.0275
Trypanosoma brucei	glucosidase, putative	0.0041	0.0251	0.0663
Echinococcus multilocularis	neural cadherin	0.0146	0.1594	0.1594
Schistosoma mansoni	hypothetical protein	0.0146	0.1594	0.1882
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0282	0.0413
Brugia malayi	hypothetical protein	0.0038	0.0215	0.0314
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0054	0.0426	0.1128
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0025	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0452	0.5495	0.8039
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1594	0.2333
Brugia malayi	Delta serrate ligand family protein	0.0146	0.1594	0.2333
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0125	0.1331	0.1331
Schistosoma mansoni	tyrosine kinase	0.0043	0.0275	0.0324
Brugia malayi	PHD-finger family protein	0.0028	0.009	0.0131
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0388	0.0458
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0318	0.3779	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0146	0.1594	0.2333
Echinococcus multilocularis	fibropellin Ia	0.0146	0.1594	0.1594
Brugia malayi	Bromodomain containing protein	0.0043	0.0281	0.0412
Brugia malayi	hypothetical protein	0.0043	0.0275	0.0402
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0041	0.0251	0.0367
Entamoeba histolytica	hypothetical protein	0.0023	0.0027	0.0989
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0027	0.004
Loa Loa (eye worm)	cytochrome P450 family protein	0.007	0.0625	0.0914
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0025	0.0056	0.0066
Schistosoma mansoni	hypothetical protein	0.0146	0.1594	0.1882
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0215	0.0215
Echinococcus multilocularis	neurogenic locus protein delta	0.0146	0.1594	0.1594
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1594	0.2333
Schistosoma mansoni	notch	0.0146	0.1594	0.1882
Echinococcus granulosus	protein jagged 2	0.0146	0.1594	0.1882
Echinococcus multilocularis	neurogenic locus notch protein	0.0146	0.1594	0.1594
Echinococcus multilocularis	nmda type glutamate receptor	0.0508	0.6199	0.6199
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0251	0.0663
Loa Loa (eye worm)	cytochrome P450 family protein	0.0029	0.01	0.0146
Loa Loa (eye worm)	glutamate receptor 1	0.0083	0.079	0.1155
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.0388	0.0568
Schistosoma mansoni	glutamate receptor AMPA	0.0083	0.079	0.0932
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0146	0.1594	0.1882
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0234	0.2713	0.397
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0091	0.0889	0.2949
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0027	0.004
Brugia malayi	Thioredoxin reductase	0.004	0.024	0.0351
Onchocerca volvulus	Dual oxidase homolog	0.0452	0.5495	1
Brugia malayi	Cytochrome P450 family protein	0.0029	0.01	0.0146
Schistosoma mansoni	hypothetical protein	0.0146	0.1594	0.1882
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0091	0.0889	0.2949
Brugia malayi	Glutamate receptor 1 precursor	0.0083	0.079	0.1155
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0101	0.1018	1
Onchocerca volvulus		0.0106	0.1082	0.1728
Loa Loa (eye worm)	hypothetical protein	0.0452	0.5495	0.8039
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0034	0.016	0.1006
Schistosoma mansoni	peroxidasin	0.0452	0.5495	0.6487
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0215	0.0254
Echinococcus granulosus	microtubule associated protein 2	0.0686	0.847	1
Schistosoma mansoni	alpha-glucosidase	0.0158	0.1741	0.2056
Echinococcus granulosus	protein jagged 2	0.0146	0.1594	0.1882
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0275	0.0402
Brugia malayi	Animal haem peroxidase family protein	0.0452	0.5495	0.8039
Onchocerca volvulus		0.0146	0.1594	0.2688
Brugia malayi	EGF-like domain containing protein	0.0146	0.1594	0.2333
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0091	0.0889	0.2949
Schistosoma mansoni	glutamate receptor kainate	0.0083	0.079	0.0932
Echinococcus granulosus	neurogenic locus protein delta	0.0146	0.1594	0.1882
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0091	0.0889	0.2949
Echinococcus multilocularis	protein jagged 2	0.0146	0.1594	0.1594
Loa Loa (eye worm)	notch protein	0.0146	0.1594	0.2333
Schistosoma mansoni	importin beta-1	0.0028	0.0096	0.0113
Onchocerca volvulus		0.0146	0.1594	0.2688
Echinococcus granulosus	fetal alzheimer antigen falz	0.0025	0.0056	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1594	0.2333
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0125	0.1331	0.1331
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.015	0.1648	0.436
Echinococcus granulosus	fibropellin Ia	0.0146	0.1594	0.1882
Echinococcus multilocularis	microtubule associated protein 2	0.0686	0.847	0.847
Brugia malayi	Blistered cuticle protein 3	0.0452	0.5495	0.8039
Loa Loa (eye worm)	glutaminase	0.0558	0.6835	1
Echinococcus multilocularis	zinc finger protein	0.0022	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0275	0.0402
Leishmania major	trypanothione reductase	0.004	0.024	0.0634
Mycobacterium ulcerans	hypothetical protein	0.0167	0.1864	0.2619
Trypanosoma cruzi	trypanothione reductase, putative	0.004	0.024	0.0634
Echinococcus multilocularis	snurportin 1	0.0304	0.3606	0.3606
Echinococcus granulosus	neurogenic locus notch protein 4	0.0146	0.1594	0.1882
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0043	0.0275	0.0402
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0318	0.3779	1
Schistosoma mansoni	hypothetical protein	0.0146	0.1594	0.1882
Echinococcus multilocularis	thioredoxin glutathione reductase	0.004	0.0246	0.0246
Onchocerca volvulus	Peroxidasin homolog	0.0452	0.5495	1
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1594	0.2333
Onchocerca volvulus	Peroxidasin homolog	0.0452	0.5495	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0183	0.2066	0.3023
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0041	0.0251	0.0367
Echinococcus granulosus	protein jagged 1	0.0146	0.1594	0.1882
Loa Loa (eye worm)	Notch2	0.0146	0.1594	0.2333
Brugia malayi	Animal haem peroxidase family protein	0.0452	0.5495	0.8039
Echinococcus granulosus	geminin	0.0358	0.4292	0.5067
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0041	0.0251	0.0251
Echinococcus granulosus	atrial natriuretic peptide receptor	0.0043	0.0275	0.0324
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0096	0.3997
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0275	0.0402
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0034	0.016	0.016
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1594	0.2333
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0125	0.1331	0.1572
Schistosoma mansoni	zinc finger protein	0.0022	0.0013	0.0016
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0045	0.0302	0.0799
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0096	0.014
Brugia malayi	glutathione reductase	0.004	0.024	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0405	0.0592
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0043	0.0275	0.0214
Brugia malayi	glutaminase DH11.1	0.0558	0.6835	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0096	0.0254
Mycobacterium tuberculosis	Probable glutamine-binding lipoprotein GlnH (GLNBP)	0.0213	0.2441	1
Brugia malayi	EGF-like domain containing protein	0.0146	0.1594	0.2333
Schistosoma mansoni	laminin gamma-3 chain	0.0146	0.1594	0.1882
Schistosoma mansoni	notch	0.0146	0.1594	0.1882
Echinococcus multilocularis	notch	0.0146	0.1594	0.1594
Schistosoma mansoni	glutamate receptor AMPA	0.0083	0.079	0.0932
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0043	0.0275	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0452	0.5495	0.8039
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0027	0.0072
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0043	0.0275	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1594	0.2333
Echinococcus granulosus	neurogenic locus notch protein	0.0146	0.1594	0.1882
Onchocerca volvulus	Chorion peroxidase homolog	0.0452	0.5495	1
Echinococcus granulosus	nmda type glutamate receptor	0.0508	0.6199	0.7319
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0125	0.1331	0.1572
Echinococcus granulosus	neural cadherin	0.0146	0.1594	0.1882
Brugia malayi	GCC2 and GCC3 family protein	0.0146	0.1594	0.2333
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0041	0.0251	0.0367
Leishmania major	alpha glucosidase II subunit, putative	0.0041	0.0251	0.0663
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0296	0.3498	0.3498
Entamoeba histolytica	hypothetical protein	0.0038	0.0215	0.7825
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0096	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0452	0.5495	0.8039
Echinococcus multilocularis	glutamate receptor 2	0.0125	0.1331	0.1331
Brugia malayi	EGF-like domain containing protein	0.0146	0.1594	0.2333
Echinococcus multilocularis	nmda type glutamate receptor	0.0255	0.2976	0.2976
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0275	0.0402
Onchocerca volvulus		0.0452	0.5495	1
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1594	0.2333
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1594	0.2333
Echinococcus multilocularis	glutamate receptor NMDA	0.0212	0.2434	0.2434
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0027	0.004
Echinococcus granulosus	glutamate receptor 2	0.0125	0.1331	0.1572
Echinococcus granulosus	notch	0.0146	0.1594	0.1882
Brugia malayi	Cadherin domain containing protein	0.0146	0.1594	0.2333
Brugia malayi	EGF-like domain containing protein	0.0146	0.1594	0.2333
Trypanosoma cruzi	cytochrome P450, putative	0.0029	0.01	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0316	0.0463
Brugia malayi	Pre-SET motif family protein	0.0234	0.2713	0.397
Brugia malayi	notch-like transmembrane receptor	0.0146	0.1594	0.2333
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1594	0.2333
Loa Loa (eye worm)	hypothetical protein	0.0452	0.5495	0.8039
Loa Loa (eye worm)	hypothetical protein	0.0452	0.5495	0.8039
Giardia lamblia	High cysteine protein	0.0146	0.1594	1
Loa Loa (eye worm)	hypothetical protein	0.0452	0.5495	0.8039
Toxoplasma gondii	hypothetical protein	0.0051	0.0385	0.2418
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.0388	0.0568
Echinococcus granulosus	peroxidasin	0.0452	0.5495	0.6487
Echinococcus multilocularis	glutamate receptor 2	0.0083	0.079	0.079
Loa Loa (eye worm)	thioredoxin reductase	0.004	0.024	0.0351
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0027	0.0072
Echinococcus granulosus	glutamate receptor subunit protein glur	0.0083	0.079	0.0932
Schistosoma mansoni	glutamate receptor NMDA	0.0177	0.1993	0.2353
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1594	0.2333
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1594	0.2333
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0041	0.0251	0.0367
Plasmodium falciparum	importin beta, putative	0.0028	0.0096	0.3997
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1594	0.2333
Brugia malayi	EGF-like domain containing protein	0.0146	0.1594	0.2333
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0053	0.0405	0.0405
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0146	0.1594	0.1594
Onchocerca volvulus		0.0452	0.5495	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.015	0.1648	0.436
Schistosoma mansoni	hypothetical protein	0.0083	0.079	0.0932
Loa Loa (eye worm)	glutamate receptor 2	0.0083	0.079	0.1155

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)		Binding affinity to Pseudomonas aeruginosa MPAO1 wild type apo heme oxygenase by NMR analysis	PATENT.	No reference
Activity (functional)	0	Growth inhibition of Pseudomonas aeruginosa MPA01 at <250 uM	ChEMBL.	17629261
Activity (binding)	0	Inhibition of Neisseria meningitidis heme oxygenase-mediated	ChEMBL.	17629261
Inhibition (binding)		Inhibition of Neisseria meningitidis heme oxygenase expressed in Escherichia coli BL21(DE3) cells assessed as decrease in alpha-biliverdin production at 1500 uM after 16 hrs by HPLC analysis	PATENT.	No reference
Kd (binding)	= 28.8 uM	Binding affinity to Neisseria meningitidis heme oxygenase	ChEMBL.	17629261
Kd (binding)	= 28.8 uM	Binding affinity to Neisseria meningitidis wild type apo heme oxygenase expressed in Escherichia coli BL21(DE3) pLysS by spectrofluorimetric analysis	PATENT.	No reference
Kd (binding)	= 28.8 uM	Binding affinity to Pseudomonas aeruginosa MPAO1 wild type apo heme oxygenase by spectrofluorimetric analysis	PATENT.	No reference
Kd (binding)	= 72.8 uM	Binding affinity to Pseudomonas aeruginosa heme oxygenase	ChEMBL.	17629261

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL230539
PubChem: 1895705

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 432667