Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | checkpoint kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Schistosoma japonicum | Serine/threonine-protein kinase Chk1, putative | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | nitric oxide synthase, putative | 0.0299 | 1 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0185 | 0.2291 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0299 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0299 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0299 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0299 | 1 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0299 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0299 | 1 | 0.5 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.0202 | 0.3446 | 0.1498 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0185 | 0.2291 | 0.2291 |
Giardia lamblia | Hypothetical protein | 0.0265 | 0.7709 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0299 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0299 | 1 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0265 | 0.7709 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0299 | 1 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0299 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0299 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0299 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0202 | 0.3446 | 0.3446 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0299 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0299 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0299 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0299 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0299 | 1 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0299 | 1 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0299 | 1 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0202 | 0.3446 | 0.1498 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0299 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.