Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | AGC family protein kinase | 0.0152 | 0.0058 | 0.6724 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0155 | 0.0095 | 0.0066 |
Brugia malayi | C1-like domain containing protein | 0.0162 | 0.0188 | 0.0188 |
Onchocerca volvulus | 0.03 | 0.1931 | 0.2693 | |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0494 | 0.4392 | 0.7572 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0266 | 0.1504 | 0.2527 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0155 | 0.0095 | 0.0066 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0348 | 0.2546 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0154 | 0.0083 | 1 |
Echinococcus multilocularis | rho associated protein kinase | 0.0304 | 0.1984 | 0.3365 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0154 | 0.0083 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 0.1344 | 0.1344 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0416 | 0.3409 | 0.5854 |
Trichomonas vaginalis | AGC family protein kinase | 0.0154 | 0.0083 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.0095 | 0.0095 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0152 | 0.0058 | 0.0058 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0152 | 0.0058 | 0.0058 |
Echinococcus granulosus | protein kinase C gamma type | 0.0318 | 0.216 | 0.3673 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0418 | 0.3428 | 0.5888 |
Toxoplasma gondii | AGC kinase | 0.0152 | 0.0058 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0154 | 0.0083 | 1 |
Schistosoma mansoni | protein kinase C mu | 0.0162 | 0.0188 | 0.0229 |
Echinococcus granulosus | rho-associated protein kinase 1 | 0.0304 | 0.1984 | 0.3365 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0152 | 0.0058 | 0.0058 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0418 | 0.3428 | 0.3428 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0604 | 0.5782 | 0.5782 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0318 | 0.216 | 0.3673 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0418 | 0.3428 | 0.5888 |
Brugia malayi | protein kinase C II. | 0.0604 | 0.5782 | 0.5782 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0304 | 0.1984 | 0.3365 |
Loa Loa (eye worm) | hypothetical protein | 0.0783 | 0.8051 | 0.8051 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0162 | 0.0188 | 0.0188 |
Trichomonas vaginalis | AGC family protein kinase | 0.0154 | 0.0083 | 1 |
Onchocerca volvulus | 0.016 | 0.0162 | 0.0038 | |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0266 | 0.1504 | 0.2527 |
Brugia malayi | Protein kinase domain containing protein | 0.0152 | 0.0058 | 0.0058 |
Loa Loa (eye worm) | hypothetical protein | 0.0684 | 0.6803 | 0.6803 |
Trichomonas vaginalis | AGC family protein kinase | 0.0154 | 0.0083 | 1 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0162 | 0.0188 | 0.0188 |
Echinococcus multilocularis | protein kinase c iota type | 0.025 | 0.1306 | 0.2181 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0154 | 0.0083 | 0.0083 |
Loa Loa (eye worm) | hypothetical protein | 0.0836 | 0.8726 | 0.8726 |
Brugia malayi | Protein kinase domain containing protein | 0.0154 | 0.0083 | 0.0083 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0162 | 0.0162 |
Trichomonas vaginalis | AGC family protein kinase | 0.0154 | 0.0083 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0152 | 0.0058 | 0.6724 |
Onchocerca volvulus | 0.0304 | 0.1984 | 0.2771 | |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0346 | 0.2521 | 0.4303 |
Brugia malayi | Protein kinase domain containing protein | 0.0152 | 0.0058 | 0.0058 |
Brugia malayi | Hr1 repeat family protein | 0.0418 | 0.3428 | 0.3428 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0416 | 0.3409 | 0.5854 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0152 | 0.0058 | 0.0058 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0418 | 0.3428 | 0.5888 |
Entamoeba histolytica | protein kinase, putative | 0.0154 | 0.0083 | 0.0102 |
Trichomonas vaginalis | AGC family protein kinase | 0.0152 | 0.0058 | 0.6724 |
Loa Loa (eye worm) | AGC/DMPK/ROCK protein kinase | 0.0937 | 1 | 1 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0416 | 0.3409 | 0.5854 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.017 | 0.0289 | 0.0289 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.0136 | 0.0136 |
Echinococcus granulosus | protein kinase c iota type | 0.025 | 0.1306 | 0.2181 |
Brugia malayi | Protein kinase c protein 2 | 0.0269 | 0.1537 | 0.1537 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0152 | 0.0058 | 0.0058 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0604 | 0.5782 | 1 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0155 | 0.0095 | 0.0066 |
Trichomonas vaginalis | AGC family protein kinase | 0.0154 | 0.0083 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0154 | 0.0083 | 0.0102 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0152 | 0.0058 | 0.0058 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0416 | 0.3409 | 0.5854 |
Schistosoma mansoni | atypical protein kinase C | 0.025 | 0.1306 | 0.2181 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0604 | 0.5782 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0684 | 0.6803 | 0.6803 |
Onchocerca volvulus | 0.0684 | 0.6803 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0684 | 0.6803 | 0.6803 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0604 | 0.5782 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0154 | 0.0083 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Diet (functional) | < 30 % | In vivo Triglyceride lowering activity at dose as 0.03 % of the diet | ChEMBL. | 6604818 |
Diet (functional) | < 31 % | In vivo Triglyceride lowering activity at a dose of 0.10 % of the diet | ChEMBL. | 6604818 |
Diet (functional) | < 52 % | In vivo Triglyceride lowering activity at dose as 0.01 % of the diet | ChEMBL. | 6604818 |
Diet (functional) | < 75 % | In vivo sterol lowering activity at dose of 0.10 % of the diet | ChEMBL. | 6604818 |
Diet (functional) | < 84 % | In vivo sterol lowering activity, dosed as 0.03 % of the diet | ChEMBL. | 6604818 |
Diet (functional) | = 86 % | In vivo Sterol lowering activity at dose as 0.01% of the diet | ChEMBL. | 6604818 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.