Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 1, group H, member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0142 | 0.2903 | 0.1706 |
Schistosoma mansoni | hypothetical protein | 0.0122 | 0.2284 | 0.3866 |
Entamoeba histolytica | thymidine kinase, putative | 0.0242 | 0.6094 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0142 | 0.2903 | 0.4913 |
Echinococcus multilocularis | transfer RNA-Ile | 0.0236 | 0.5908 | 1 |
Trypanosoma brucei | thymidine kinase | 0.0242 | 0.6094 | 0.5 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0242 | 0.6094 | 0.5 |
Schistosoma mansoni | thymidine kinase | 0.0236 | 0.5908 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0242 | 0.6094 | 0.5 |
Leishmania major | thymidine kinase, putative | 0.0242 | 0.6094 | 0.5 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0242 | 0.6094 | 0.5 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0242 | 0.6094 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0142 | 0.2903 | 0.4913 |
Echinococcus granulosus | Thymidine kinase 2 mitochondrial | 0.0236 | 0.5908 | 1 |
Echinococcus granulosus | thymidine kinase | 0.0236 | 0.5908 | 1 |
Echinococcus granulosus | thymidine kinase | 0.0236 | 0.5908 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0242 | 0.6094 | 0.5 |
Echinococcus multilocularis | thymidine kinase | 0.0236 | 0.5908 | 1 |
Echinococcus multilocularis | thymidine kinase | 0.0236 | 0.5908 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 13 % | Increase in ABCA1 gene expression in THP1 cells at 1 uM relative to GW3965 | ChEMBL. | 17665897 |
Activity (functional) | = 13 % | Increase in ABCA1 gene expression in THP1 cells at 1 uM relative to GW3965 | ChEMBL. | 17665897 |
Activity (functional) | = 36 % | Increase in ABCA1 gene expression in THP1 cells at 10 uM relative to GW3965 | ChEMBL. | 17665897 |
Activity (functional) | = 36 % | Increase in ABCA1 gene expression in THP1 cells at 10 uM relative to GW3965 | ChEMBL. | 17665897 |
EC50 (functional) | = 0.25 uM | Agonist activity at GAL-linked human LXRbeta expressed in THP1 cells assessed as stimulation of coactivator recruitment by FRET assay | ChEMBL. | 17665897 |
EC50 (functional) | = 0.25 uM | Agonist activity at GAL-linked human LXRbeta expressed in THP1 cells assessed as stimulation of coactivator recruitment by FRET assay | ChEMBL. | 17665897 |
Efficacy (functional) | < 15 % | Agonist activity at GAL-linked human LXRalpha expressed in THP1 cells assessed as stimulation of coactivator recruitment by FRET assay relative to GW3965 | ChEMBL. | 17665897 |
Efficacy (functional) | < 15 % | Agonist activity at GAL-linked human LXRalpha expressed in THP1 cells assessed as stimulation of coactivator recruitment by FRET assay relative to GW3965 | ChEMBL. | 17665897 |
Efficacy (functional) | = 82 % | Agonist activity at GAL-linked human LXRbeta expressed in THP1 cells assessed as stimulation of coactivator recruitment by FRET assay relative to GW3965 | ChEMBL. | 17665897 |
Efficacy (functional) | = 82 % | Agonist activity at GAL-linked human LXRbeta expressed in THP1 cells assessed as stimulation of coactivator recruitment by FRET assay relative to GW3965 | ChEMBL. | 17665897 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.