Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 1, group H, member 2 | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 1, group H, member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Brugia malayi | ecdysteroid receptor | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Onchocerca volvulus | Bile acid receptor homolog | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | nuclear receptor subfamily 1, group H, member 3 | 387 aa | 321 aa | 28.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | RAR-like nuclear receptor | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0022 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0207 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0022 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 21 % | Increase in ABCA1 gene expression in THP1 cells at 1 uM relative to GW3965 | ChEMBL. | 17665897 |
Activity (functional) | = 21 % | Increase in ABCA1 gene expression in THP1 cells at 1 uM relative to GW3965 | ChEMBL. | 17665897 |
Activity (functional) | = 32 % | Increase in ABCA1 gene expression in THP1 cells at 10 uM relative to GW3965 | ChEMBL. | 17665897 |
Activity (functional) | = 32 % | Increase in ABCA1 gene expression in THP1 cells at 10 uM relative to GW3965 | ChEMBL. | 17665897 |
EC50 (functional) | = 0.14 uM | Agonist activity at GAL-linked human LXRbeta expressed in THP1 cells assessed as stimulation of coactivator recruitment by FRET assay | ChEMBL. | 17665897 |
EC50 (functional) | = 0.14 uM | Agonist activity at GAL-linked human LXRbeta expressed in THP1 cells assessed as stimulation of coactivator recruitment by FRET assay | ChEMBL. | 17665897 |
EC50 (functional) | = 2.4 uM | Agonist activity at GAL-linked human LXRalpha expressed in THP1 cells assessed as stimulation of coactivator recruitment by FRET assay | ChEMBL. | 17665897 |
EC50 (functional) | = 2.4 uM | Agonist activity at GAL-linked human LXRalpha expressed in THP1 cells assessed as stimulation of coactivator recruitment by FRET assay | ChEMBL. | 17665897 |
Efficacy (functional) | = 46 % | Agonist activity at GAL-linked human LXRalpha expressed in THP1 cells assessed as stimulation of coactivator recruitment by FRET assay relative to GW3965 | ChEMBL. | 17665897 |
Efficacy (functional) | = 46 % | Agonist activity at GAL-linked human LXRalpha expressed in THP1 cells assessed as stimulation of coactivator recruitment by FRET assay relative to GW3965 | ChEMBL. | 17665897 |
Efficacy (functional) | = 90 % | Agonist activity at GAL-linked human LXRbeta expressed in THP1 cells assessed as stimulation of coactivator recruitment by FRET assay relative to GW3965 | ChEMBL. | 17665897 |
Efficacy (functional) | = 90 % | Agonist activity at GAL-linked human LXRbeta expressed in THP1 cells assessed as stimulation of coactivator recruitment by FRET assay relative to GW3965 | ChEMBL. | 17665897 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.