Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cation-transporting atpase worm | 0.0008 | 0.0294 | 0.0409 |
Chlamydia trachomatis | metal transport ATPase | 0.0008 | 0.0294 | 0.5 |
Mycobacterium tuberculosis | Probable metal cation transporter ATPase P-type CtpE | 0.0008 | 0.0294 | 0.5 |
Mycobacterium ulcerans | cation-transporter p-type ATPase B CtpB | 0.0008 | 0.0294 | 0.5 |
Loa Loa (eye worm) | RecQ helicase | 0.0024 | 0.1637 | 0.1384 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.5035 | 0.7018 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.001 | 0.042 | 0.0266 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0019 | 0.1201 | 0.1674 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0013 | 0.0671 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.5035 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.042 | 0.4422 |
Entamoeba histolytica | Plasma membrane calcium-transporting ATPase, putative | 0.0008 | 0.0294 | 0.4375 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0024 | 0.1637 | 0.1952 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.5035 | 0.7018 |
Schistosoma mansoni | ATPase | 0.0008 | 0.0294 | 0.0409 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.001 | 0.042 | 0.0266 |
Treponema pallidum | hypothetical protein | 0.0008 | 0.0294 | 1 |
Entamoeba histolytica | recQ family helicase, putative | 0.0013 | 0.0671 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.7174 | 0.7089 |
Toxoplasma gondii | P-type ATPase PMA1 | 0.0008 | 0.0294 | 0.3095 |
Mycobacterium ulcerans | cation transporter p-type ATPase D CtpD | 0.0008 | 0.0294 | 0.5 |
Schistosoma mansoni | cation-transporting atpase worm | 0.0008 | 0.0294 | 0.0409 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0016 | 0.0966 | 1 |
Entamoeba histolytica | plasma membrane calcium-transporting ATPase 1, putative | 0.0008 | 0.0294 | 0.4375 |
Mycobacterium tuberculosis | Cation transporter P-type ATPase a CtpA | 0.0008 | 0.0294 | 0.5 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0016 | 0.0949 | 1 |
Echinococcus granulosus | bloom syndrome protein | 0.0024 | 0.1637 | 0.2833 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.7174 | 0.7089 |
Schistosoma mansoni | atpase class VI type 11c | 0.0008 | 0.0294 | 0.0409 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.5035 | 0.7018 |
Schistosoma mansoni | ATPase | 0.0008 | 0.0294 | 0.0409 |
Toxoplasma gondii | haloacid dehalogenase family hydrolase domain-containing protein | 0.0008 | 0.0294 | 0.3095 |
Brugia malayi | hypothetical protein | 0.0087 | 0.7174 | 1 |
Entamoeba histolytica | calcium-transporting P-type ATPase, putative | 0.0008 | 0.0294 | 0.4375 |
Entamoeba histolytica | cation-transporting P-typeATPase, putative | 0.0008 | 0.0294 | 0.4375 |
Treponema pallidum | cation-transporting ATPase, P-type | 0.0008 | 0.0294 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.5035 | 0.7018 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.5035 | 0.4884 |
Schistosoma mansoni | cation-transporting ATPase | 0.0008 | 0.0294 | 0.0409 |
Schistosoma mansoni | type V p-type atpase isoform | 0.0008 | 0.0294 | 0.0409 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.001 | 0.042 | 0.1153 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.042 | 0.013 |
Schistosoma mansoni | Na+/K+ transporting ATPase subunit alpha | 0.0008 | 0.0294 | 0.0409 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0024 | 0.1637 | 1 |
Mycobacterium ulcerans | metal cation transporter ATPase p-type CtpE | 0.0008 | 0.0294 | 0.5 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.001 | 0.042 | 0.0266 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.042 | 0.0183 |
Schistosoma mansoni | phosphoserine phosphatase | 0.0008 | 0.0294 | 0.0409 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0013 | 0.0671 | 1 |
Toxoplasma gondii | heavy metal translocating P-type ATPase subfamily protein | 0.0008 | 0.0294 | 0.3095 |
Toxoplasma gondii | haloacid dehalogenase family hydrolase domain-containing protein | 0.0008 | 0.0294 | 0.3095 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.042 | 0.0183 |
Entamoeba histolytica | plasma membrane calcium ion-transporting ATPase, putative | 0.0008 | 0.0294 | 0.4375 |
Mycobacterium ulcerans | cation transporter p-type ATPase a CtpA | 0.0008 | 0.0294 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.5035 | 0.689 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.042 | 0.4422 |
Entamoeba histolytica | Plasma membrane calcium-transporting ATPase, putative | 0.0008 | 0.0294 | 0.4375 |
Onchocerca volvulus | 0.0008 | 0.0294 | 0.5 | |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0021 | 0.1385 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.5035 | 0.7018 |
Entamoeba histolytica | phospholipid-transporting P-type ATPase, putative | 0.0008 | 0.0294 | 0.4375 |
Entamoeba histolytica | phospholipid-transporting P-type ATPase, putative | 0.0008 | 0.0294 | 0.4375 |
Schistosoma mansoni | DNA helicase recq1 | 0.001 | 0.042 | 0.0585 |
Mycobacterium ulcerans | metal cation transporter p-type ATPase, CtpV | 0.0008 | 0.0294 | 0.5 |
Mycobacterium tuberculosis | Possible metal cation transporting P-type ATPase CtpH | 0.0008 | 0.0294 | 0.5 |
Entamoeba histolytica | Plasma membrane calcium-transporting ATPase, putative | 0.0008 | 0.0294 | 0.4375 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0013 | 0.0671 | 1 |
Schistosoma mansoni | copper ABC transporter ATPase | 0.0008 | 0.0294 | 0.0409 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.5035 | 1 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.5035 | 0.689 |
Mycobacterium ulcerans | metal cation-transporting p-type ATPase F, CtpF | 0.0008 | 0.0294 | 0.5 |
Mycobacterium leprae | PROBABLE CATION-TRANSPORTER ATPASE I CTPI | 0.0008 | 0.0294 | 0.5 |
Schistosoma mansoni | eyes absent homolog | 0.0087 | 0.7174 | 1 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0024 | 0.1637 | 1 |
Mycobacterium leprae | Probable metal cation-transporting P-type ATPase C CtpC | 0.0008 | 0.0294 | 0.5 |
Mycobacterium leprae | PROBABLE CATION-TRANSPORTER P-TYPE ATPASE B CTPB | 0.0008 | 0.0294 | 0.5 |
Toxoplasma gondii | calcium-translocating P-type ATPase, PMCA-type protein | 0.0008 | 0.0294 | 0.3095 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0013 | 0.0671 | 0.2811 |
Echinococcus multilocularis | bloom syndrome protein | 0.0024 | 0.1637 | 0.2833 |
Mycobacterium tuberculosis | Probable cation transporter P-type ATPase D CtpD | 0.0008 | 0.0294 | 0.5 |
Mycobacterium tuberculosis | Probable metal cation transporter P-type ATPase CtpV | 0.0008 | 0.0294 | 0.5 |
Schistosoma mansoni | DNA helicase recq5 | 0.001 | 0.042 | 0.0585 |
Toxoplasma gondii | cation-transporting atpase family protein | 0.0008 | 0.0294 | 0.3095 |
Toxoplasma gondii | sarco/endoplasmic reticulum Ca2+-ATPase | 0.0008 | 0.0294 | 0.3095 |
Mycobacterium ulcerans | cation-transporter ATPase I CtpI | 0.0008 | 0.0294 | 0.5 |
Entamoeba histolytica | phospholipid-transporting P-type ATPase, putative | 0.0008 | 0.0294 | 0.4375 |
Mycobacterium ulcerans | metal cation transporter p-type ATPase a | 0.0008 | 0.0294 | 0.5 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.001 | 0.042 | 0.0266 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.001 | 0.042 | 1 |
Schistosoma mansoni | cation-transporting atpase 13a1 (G-box binding protein) | 0.0008 | 0.0294 | 0.0409 |
Toxoplasma gondii | P-type ATPase4, putative | 0.0008 | 0.0294 | 0.3095 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.5035 | 0.4884 |
Toxoplasma gondii | phospholipid-translocating P-type ATPase, flippase subfamily protein | 0.0008 | 0.0294 | 0.3095 |
Toxoplasma gondii | phospholipid-translocating P-type ATPase, flippase subfamily protein | 0.0008 | 0.0294 | 0.3095 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.001 | 0.042 | 0.013 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.5035 | 0.4884 |
Brugia malayi | RNA binding protein | 0.0063 | 0.5035 | 0.689 |
Mycobacterium ulcerans | metal cation-transporting p-type ATPase CtpC | 0.0008 | 0.0294 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.