Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0079 | 0.1689 | 1 | |
Onchocerca volvulus | Cathepsin L homolog | 0.0079 | 0.1689 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0301 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0142 | 0.4053 | 0.393 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0108 | 0.2793 | 0.2564 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0055 | 0.0829 | 0.0435 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0045 | 0.0427 | 0.0053 |
Brugia malayi | cathepsin L-like precursor | 0.0055 | 0.0829 | 0.042 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0045 | 0.0427 | 0.0053 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Onchocerca volvulus | 0.0079 | 0.1689 | 1 | |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0079 | 0.1689 | 0.1319 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0079 | 0.1689 | 0.1319 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0292 | 0.9654 | 0.964 |
Brugia malayi | Cathepsin L-like precursor | 0.0055 | 0.0829 | 0.042 |
Loa Loa (eye worm) | cysteine protease | 0.0079 | 0.1689 | 0.1365 |
Onchocerca volvulus | 0.0079 | 0.1689 | 1 | |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0079 | 0.1689 | 0.1319 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.0047 | 0.0533 | 0.0163 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Echinococcus granulosus | cathepsin b | 0.0301 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0301 | 1 | 1 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0097 | 0.2396 | 0.2135 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0068 | 0.1316 | 0.1363 |
Echinococcus multilocularis | cysteine protease | 0.0079 | 0.1689 | 0.1319 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0047 | 0.0533 | 0.0115 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0047 | 0.0533 | 0.0115 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0108 | 0.2793 | 0.1386 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0142 | 0.4053 | 0.393 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.0138 | 0.3897 | 0.376 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0142 | 0.4053 | 0.393 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0055 | 0.0829 | 0.047 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Echinococcus granulosus | cathepsin b | 0.0301 | 1 | 1 |
Trypanosoma cruzi | cysteine protease, putative | 0.0045 | 0.0427 | 0.0053 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0047 | 0.0533 | 0.0115 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.2189 | 0.1884 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0142 | 0.4053 | 0.3788 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0292 | 0.9654 | 0.9638 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0292 | 0.9654 | 0.964 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0108 | 0.2793 | 0.2564 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0079 | 0.1689 | 0.1319 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0292 | 0.9654 | 0.9638 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0047 | 0.0533 | 0.0115 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0079 | 0.1689 | 0.1365 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0627 | 0.0261 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Entamoeba histolytica | cysteine protease, putative | 0.0079 | 0.1689 | 0.1368 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0055 | 0.0829 | 0.0435 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0079 | 0.1689 | 0.1368 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0292 | 0.9654 | 0.5 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0292 | 0.9654 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0301 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0047 | 0.0533 | 0.0115 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0292 | 0.9654 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0045 | 0.0427 | 0.0053 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0079 | 0.1689 | 0.1319 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0301 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0079 | 0.1689 | 0.1365 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0108 | 0.2793 | 0.2512 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0829 | 0.047 |
Toxoplasma gondii | cathepsin B | 0.0108 | 0.2793 | 0.1386 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0142 | 0.4053 | 0.393 |
Giardia lamblia | Cathepsin B precursor | 0.0108 | 0.2793 | 0.2893 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0301 | 1 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0079 | 0.1689 | 0.1365 |
Brugia malayi | Cathepsin L-like precursor | 0.0055 | 0.0829 | 0.042 |
Brugia malayi | Cathepsin L-like precursor | 0.0079 | 0.1689 | 0.1319 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Giardia lamblia | Cathepsin B precursor | 0.0108 | 0.2793 | 0.2893 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.0142 | 0.4053 | 0.3788 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0079 | 0.1689 | 0.1368 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0292 | 0.9654 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0079 | 0.1689 | 0.1365 |
Echinococcus granulosus | cathepsin l1 | 0.0079 | 0.1689 | 0.1319 |
Echinococcus multilocularis | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0092 | 0.2189 | 0.1841 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0047 | 0.0533 | 0.011 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0829 | 0.047 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0047 | 0.0533 | 0.011 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0292 | 0.9654 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0079 | 0.1689 | 0.1319 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0292 | 0.9654 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0142 | 0.4053 | 0.3821 |
Brugia malayi | Cathepsin L-like precursor | 0.0079 | 0.1689 | 0.1319 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0047 | 0.0533 | 0.0115 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0108 | 0.2793 | 0.2472 |
Plasmodium vivax | vivapain-2 | 0.0079 | 0.1689 | 0.1368 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0292 | 0.9654 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Mycobacterium ulcerans | proteasome PrcB | 0.0292 | 0.9654 | 0.5 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0079 | 0.1689 | 0.1319 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0113 | 0.2973 | 0.2759 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0079 | 0.1689 | 0.1365 |
Entamoeba histolytica | hypothetical protein | 0.0113 | 0.2973 | 0.2759 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0079 | 0.1689 | 0.1368 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0829 | 0.047 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0079 | 0.1689 | 0.1365 |
Plasmodium vivax | vivapain-2 | 0.0079 | 0.1689 | 0.1368 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0301 | 1 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0055 | 0.0829 | 0.042 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0292 | 0.9654 | 0.964 |
Echinococcus granulosus | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0092 | 0.2189 | 0.1841 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Onchocerca volvulus | 0.0079 | 0.1689 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0301 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Brugia malayi | Cathepsin L-like precursor | 0.0079 | 0.1689 | 0.1319 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0079 | 0.1689 | 0.1368 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0292 | 0.9654 | 1 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0045 | 0.0427 | 0.0053 |
Echinococcus granulosus | cathepsin l1 | 0.0055 | 0.0829 | 0.042 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Echinococcus multilocularis | cysteine protease | 0.0079 | 0.1689 | 0.1319 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0055 | 0.0829 | 0.042 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0079 | 0.1689 | 0.1365 |
Onchocerca volvulus | Cathepsin L homolog | 0.0079 | 0.1689 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0108 | 0.2793 | 0.2512 |
Loa Loa (eye worm) | ctsf protein | 0.0079 | 0.1689 | 0.1365 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0079 | 0.1689 | 0.1319 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Brugia malayi | Cathepsin L-like precursor | 0.0079 | 0.1689 | 0.1319 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0055 | 0.0829 | 0.0435 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.1689 | 0.1365 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0142 | 0.4053 | 0.3788 |
Onchocerca volvulus | 0.0079 | 0.1689 | 1 | |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0092 | 0.2189 | 0.1841 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Brugia malayi | Cathepsin L-like precursor | 0.0079 | 0.1689 | 0.1319 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0097 | 0.2396 | 0.2135 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0079 | 0.1689 | 0.1319 |
Giardia lamblia | Cathepsin B precursor | 0.0108 | 0.2793 | 0.2893 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0292 | 0.9654 | 1 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0113 | 0.2973 | 0.2698 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0292 | 0.9654 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0142 | 0.4053 | 0.3821 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0079 | 0.1689 | 0.1365 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0079 | 0.1689 | 0.1319 |
Echinococcus granulosus | proteasome prosome macropain | 0.0292 | 0.9654 | 0.9638 |
Onchocerca volvulus | 0.0079 | 0.1689 | 1 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0079 | 0.1689 | 0.1368 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0063 | 0.1109 | 0.0739 |
Echinococcus granulosus | phosphatidylinositol 45 bisphosphate 3 kinase | 0.0142 | 0.4053 | 0.3788 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Onchocerca volvulus | 0.0079 | 0.1689 | 1 | |
Onchocerca volvulus | Cathepsin F homolog | 0.0079 | 0.1689 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0292 | 0.9654 | 0.9638 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.