Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0079 | 0.1689 | 1 | |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0292 | 0.9654 | 1 |
Plasmodium vivax | vivapain-2 | 0.0079 | 0.1689 | 0.1368 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0079 | 0.1689 | 0.1368 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Onchocerca volvulus | 0.0079 | 0.1689 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0301 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0301 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0301 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0301 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0047 | 0.0533 | 0.0115 |
Onchocerca volvulus | Cathepsin L homolog | 0.0079 | 0.1689 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0055 | 0.0829 | 0.047 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0292 | 0.9654 | 0.9638 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0079 | 0.1689 | 0.1319 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0055 | 0.0829 | 0.0435 |
Brugia malayi | Cathepsin L-like precursor | 0.0079 | 0.1689 | 0.1319 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0292 | 0.9654 | 0.964 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.0138 | 0.3897 | 0.376 |
Brugia malayi | Cathepsin L-like precursor | 0.0079 | 0.1689 | 0.1319 |
Mycobacterium ulcerans | proteasome PrcB | 0.0292 | 0.9654 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0079 | 0.1689 | 0.1319 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0047 | 0.0533 | 0.0115 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0292 | 0.9654 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0079 | 0.1689 | 0.1319 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.0142 | 0.4053 | 0.3788 |
Loa Loa (eye worm) | cysteine protease | 0.0079 | 0.1689 | 0.1365 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0047 | 0.0533 | 0.011 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0829 | 0.047 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0079 | 0.1689 | 0.1319 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0113 | 0.2973 | 0.2759 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0108 | 0.2793 | 0.2564 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0079 | 0.1689 | 0.1365 |
Echinococcus granulosus | cathepsin b | 0.0301 | 1 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0047 | 0.0533 | 0.011 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0097 | 0.2396 | 0.2135 |
Echinococcus granulosus | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0092 | 0.2189 | 0.1841 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0142 | 0.4053 | 0.393 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0079 | 0.1689 | 0.1365 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0079 | 0.1689 | 0.1365 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0292 | 0.9654 | 0.964 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0292 | 0.9654 | 1 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0292 | 0.9654 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0055 | 0.0829 | 0.042 |
Entamoeba histolytica | cysteine protease, putative | 0.0079 | 0.1689 | 0.1368 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0142 | 0.4053 | 0.3788 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0292 | 0.9654 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0079 | 0.1689 | 0.1368 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0055 | 0.0829 | 0.0435 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0301 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.1689 | 0.1365 |
Giardia lamblia | Cathepsin B precursor | 0.0108 | 0.2793 | 0.2893 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0292 | 0.9654 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Echinococcus granulosus | cathepsin l1 | 0.0079 | 0.1689 | 0.1319 |
Echinococcus multilocularis | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0092 | 0.2189 | 0.1841 |
Echinococcus granulosus | phosphatidylinositol 45 bisphosphate 3 kinase | 0.0142 | 0.4053 | 0.3788 |
Entamoeba histolytica | hypothetical protein | 0.0113 | 0.2973 | 0.2759 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0292 | 0.9654 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0055 | 0.0829 | 0.0435 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0292 | 0.9654 | 0.9638 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0627 | 0.0261 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.0047 | 0.0533 | 0.0163 |
Onchocerca volvulus | 0.0079 | 0.1689 | 1 | |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0113 | 0.2973 | 0.2698 |
Brugia malayi | cathepsin L-like precursor | 0.0055 | 0.0829 | 0.042 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0047 | 0.0533 | 0.0115 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Giardia lamblia | Cathepsin B precursor | 0.0108 | 0.2793 | 0.2893 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0045 | 0.0427 | 0.0053 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0045 | 0.0427 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0829 | 0.047 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0142 | 0.4053 | 0.3821 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.2189 | 0.1884 |
Trypanosoma cruzi | cysteine protease, putative | 0.0045 | 0.0427 | 0.0053 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0079 | 0.1689 | 0.1365 |
Echinococcus multilocularis | cathepsin b | 0.0301 | 1 | 1 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0047 | 0.0533 | 0.0115 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0079 | 0.1689 | 0.1319 |
Onchocerca volvulus | 0.0079 | 0.1689 | 1 | |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0079 | 0.1689 | 0.1319 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0079 | 0.1689 | 0.1319 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0142 | 0.4053 | 0.393 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0045 | 0.0427 | 0.0053 |
Echinococcus multilocularis | cysteine protease | 0.0079 | 0.1689 | 0.1319 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0068 | 0.1316 | 0.1363 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0097 | 0.2396 | 0.2135 |
Toxoplasma gondii | cathepsin B | 0.0108 | 0.2793 | 0.1386 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Onchocerca volvulus | 0.0079 | 0.1689 | 1 | |
Echinococcus granulosus | proteasome prosome macropain | 0.0292 | 0.9654 | 0.9638 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0047 | 0.0533 | 0.0115 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0292 | 0.9654 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0055 | 0.0829 | 0.042 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0142 | 0.4053 | 0.393 |
Giardia lamblia | Cathepsin B precursor | 0.0108 | 0.2793 | 0.2893 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0301 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0063 | 0.1109 | 0.0739 |
Brugia malayi | Cathepsin L-like precursor | 0.0055 | 0.0829 | 0.042 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0079 | 0.1689 | 0.1319 |
Onchocerca volvulus | Cathepsin L homolog | 0.0079 | 0.1689 | 1 |
Onchocerca volvulus | 0.0079 | 0.1689 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Onchocerca volvulus | Cathepsin F homolog | 0.0079 | 0.1689 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0079 | 0.1689 | 0.1319 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Loa Loa (eye worm) | fibroinase | 0.0079 | 0.1689 | 0.1365 |
Echinococcus multilocularis | cysteine protease | 0.0079 | 0.1689 | 0.1319 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0079 | 0.1689 | 0.1365 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0079 | 0.1689 | 0.1365 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0079 | 0.1689 | 0.1319 |
Brugia malayi | Cathepsin L-like precursor | 0.0079 | 0.1689 | 0.1319 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0108 | 0.2793 | 0.2472 |
Echinococcus multilocularis | cathepsin b | 0.0301 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0079 | 0.1689 | 0.1368 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0079 | 0.1689 | 0.1319 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0292 | 0.9654 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0108 | 0.2793 | 0.1386 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0108 | 0.2793 | 0.2564 |
Loa Loa (eye worm) | ctsf protein | 0.0079 | 0.1689 | 0.1365 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0292 | 0.9654 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0079 | 0.1689 | 0.1365 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0079 | 0.1689 | 0.1368 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0142 | 0.4053 | 0.393 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0108 | 0.2793 | 0.2512 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0092 | 0.2189 | 0.1841 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Plasmodium vivax | vivapain-2 | 0.0079 | 0.1689 | 0.1368 |
Onchocerca volvulus | 0.0079 | 0.1689 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0829 | 0.047 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0079 | 0.1689 | 0.1368 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0292 | 0.9654 | 0.964 |
Echinococcus granulosus | cathepsin l1 | 0.0055 | 0.0829 | 0.042 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0142 | 0.4053 | 0.3821 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0142 | 0.4053 | 0.3788 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Loa Loa (eye worm) | cathepsin B | 0.0108 | 0.2793 | 0.2512 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0045 | 0.0427 | 0.0053 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0292 | 0.9654 | 0.9638 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0055 | 0.0829 | 0.042 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0079 | 0.1689 | 0.1319 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0047 | 0.0533 | 0.0115 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.