Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0132 | 0.0362 | 0.086 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0196 | 0.0958 | 0.0958 |
Schistosoma mansoni | lipoxygenase | 0.1171 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0132 | 0.0362 | 0.086 |
Brugia malayi | Animal haem peroxidase family protein | 0.0407 | 0.2917 | 0.6921 |
Entamoeba histolytica | casein kinase, putative | 0.0274 | 0.1686 | 0.5 |
Echinococcus multilocularis | notch | 0.0132 | 0.0362 | 0.0362 |
Onchocerca volvulus | 0.0132 | 0.0362 | 0.1242 | |
Schistosoma mansoni | rab6-interacting | 0.0196 | 0.0958 | 0.0958 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0274 | 0.1686 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Echinococcus multilocularis | protein jagged 1 | 0.0132 | 0.0362 | 0.0362 |
Echinococcus granulosus | RUN | 0.0196 | 0.0958 | 0.0958 |
Onchocerca volvulus | Peroxidasin homolog | 0.0407 | 0.2917 | 1 |
Schistosoma mansoni | loxhd1 | 0.0196 | 0.0958 | 0.0958 |
Onchocerca volvulus | Peroxidase homolog | 0.0407 | 0.2917 | 1 |
Brugia malayi | Casein kinase II, alpha chain | 0.0274 | 0.1686 | 0.4 |
Schistosoma mansoni | hypothetical protein | 0.0132 | 0.0362 | 0.0362 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0407 | 0.2917 | 0.6921 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0274 | 0.1686 | 1 |
Onchocerca volvulus | 0.0132 | 0.0362 | 0.1242 | |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Echinococcus granulosus | acetylcholinesterase | 0.0547 | 0.4215 | 0.4215 |
Echinococcus granulosus | neural cadherin | 0.0132 | 0.0362 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Brugia malayi | Muscle positioning protein 4 | 0.0132 | 0.0362 | 0.086 |
Brugia malayi | hypothetical protein | 0.0196 | 0.0958 | 0.2273 |
Brugia malayi | EGF-like domain containing protein | 0.0132 | 0.0362 | 0.086 |
Echinococcus granulosus | protein jagged 2 | 0.0132 | 0.0362 | 0.0362 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0366 | 0.2534 | 0.2534 |
Brugia malayi | EGF-like domain containing protein | 0.0132 | 0.0362 | 0.086 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0402 | 0.2864 | 0.2864 |
Onchocerca volvulus | Peroxidasin homolog | 0.0407 | 0.2917 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0407 | 0.2917 | 1 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0196 | 0.0958 | 0.0958 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0407 | 0.2917 | 0.6921 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0132 | 0.0362 | 0.0362 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0092 | 0 | 0.5 |
Schistosoma mansoni | notch | 0.0132 | 0.0362 | 0.0362 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0132 | 0.0362 | 0.0362 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0132 | 0.0362 | 0.1242 |
Echinococcus granulosus | peroxidasin | 0.0407 | 0.2917 | 0.2917 |
Schistosoma mansoni | cell polarity protein | 0.0132 | 0.0362 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2917 | 0.6921 |
Echinococcus granulosus | notch | 0.0132 | 0.0362 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2917 | 0.6921 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2917 | 0.6921 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0132 | 0.0362 | 0.0362 |
Onchocerca volvulus | 0.0132 | 0.0362 | 0.1242 | |
Echinococcus granulosus | fibropellin Ia | 0.0132 | 0.0362 | 0.0362 |
Schistosoma mansoni | slit | 0.0132 | 0.0362 | 0.0362 |
Echinococcus multilocularis | acetylcholinesterase | 0.0547 | 0.4215 | 0.4215 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Brugia malayi | Animal haem peroxidase family protein | 0.0407 | 0.2917 | 0.6921 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0132 | 0.0362 | 0.086 |
Brugia malayi | Blistered cuticle protein 3 | 0.0407 | 0.2917 | 0.6921 |
Schistosoma mansoni | notch | 0.0132 | 0.0362 | 0.0362 |
Schistosoma mansoni | notch | 0.0132 | 0.0362 | 0.0362 |
Loa Loa (eye worm) | Notch2 | 0.0132 | 0.0362 | 0.086 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0092 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.0958 | 0.2273 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0196 | 0.0958 | 0.0958 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2917 | 0.6921 |
Echinococcus multilocularis | peroxidasin | 0.0407 | 0.2917 | 0.2917 |
Brugia malayi | Delta serrate ligand family protein | 0.0132 | 0.0362 | 0.086 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0132 | 0.0362 | 0.0362 |
Schistosoma mansoni | hypothetical protein | 0.0132 | 0.0362 | 0.0362 |
Echinococcus granulosus | protein jagged 1 | 0.0132 | 0.0362 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2917 | 0.6921 |
Onchocerca volvulus | 0.0196 | 0.0958 | 0.3283 | |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0132 | 0.0362 | 0.0362 |
Brugia malayi | EGF-like domain containing protein | 0.0132 | 0.0362 | 0.086 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0196 | 0.0958 | 0.0958 |
Echinococcus granulosus | slit 2 protein | 0.0132 | 0.0362 | 0.0362 |
Schistosoma mansoni | protein kinase | 0.0274 | 0.1686 | 0.1686 |
Echinococcus granulosus | protein jagged 1 | 0.0132 | 0.0362 | 0.0362 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.1171 | 1 | 1 |
Onchocerca volvulus | Slit protein homolog | 0.0132 | 0.0362 | 0.1242 |
Brugia malayi | Animal haem peroxidase family protein | 0.0407 | 0.2917 | 0.6921 |
Brugia malayi | Animal haem peroxidase family protein | 0.0407 | 0.2917 | 0.6921 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0132 | 0.0362 | 0.086 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.0274 | 0.1686 | 0.1686 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2917 | 0.6921 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0274 | 0.1686 | 1 |
Schistosoma mansoni | notch | 0.0132 | 0.0362 | 0.0362 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0407 | 0.2917 | 0.6921 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Schistosoma mansoni | hypothetical protein | 0.0196 | 0.0958 | 0.0958 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0132 | 0.0362 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Schistosoma mansoni | polycystin 1-related | 0.0196 | 0.0958 | 0.0958 |
Brugia malayi | Doublecortin family protein | 0.0196 | 0.0958 | 0.2273 |
Echinococcus multilocularis | fibropellin Ia | 0.0132 | 0.0362 | 0.0362 |
Brugia malayi | hypothetical protein | 0.0196 | 0.0958 | 0.2273 |
Brugia malayi | Cadherin domain containing protein | 0.0132 | 0.0362 | 0.086 |
Schistosoma mansoni | hypothetical protein | 0.0132 | 0.0362 | 0.0362 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0132 | 0.0362 | 0.086 |
Onchocerca volvulus | 0.0407 | 0.2917 | 1 | |
Brugia malayi | Peroxidasin | 0.0407 | 0.2917 | 0.6921 |
Onchocerca volvulus | Peroxidase homolog | 0.0407 | 0.2917 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Echinococcus multilocularis | acetylcholinesterase | 0.0547 | 0.4215 | 0.4215 |
Echinococcus multilocularis | slit 2 protein | 0.0132 | 0.0362 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2917 | 0.6921 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0407 | 0.2917 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0547 | 0.4215 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0819 | 0.6733 | 0.6733 |
Schistosoma mansoni | septate junction protein | 0.0132 | 0.0362 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.0958 | 0.2273 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2917 | 0.6921 |
Loa Loa (eye worm) | doublecortin family protein | 0.0196 | 0.0958 | 0.2273 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0407 | 0.2917 | 0.6921 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.0274 | 0.1686 | 0.1686 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0132 | 0.0362 | 0.0362 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0274 | 0.1686 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0547 | 0.4215 | 1 |
Onchocerca volvulus | Putative cubilin | 0.0132 | 0.0362 | 0.1242 |
Echinococcus granulosus | acetylcholinesterase | 0.0547 | 0.4215 | 0.4215 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0547 | 0.4215 | 1 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0132 | 0.0362 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0132 | 0.0362 | 0.086 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.0274 | 0.1686 | 0.4 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Onchocerca volvulus | 0.0407 | 0.2917 | 1 | |
Schistosoma mansoni | peroxidasin | 0.0407 | 0.2917 | 0.2917 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2917 | 0.6921 |
Plasmodium vivax | unspecified product | 0.0274 | 0.1686 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0407 | 0.2917 | 0.6921 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0402 | 0.2864 | 0.2864 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0274 | 0.1686 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2917 | 0.6921 |
Onchocerca volvulus | 0.0196 | 0.0958 | 0.3283 | |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0274 | 0.1686 | 1 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0132 | 0.0362 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2917 | 0.6921 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.0274 | 0.1686 | 1 |
Onchocerca volvulus | 0.0132 | 0.0362 | 0.1242 | |
Echinococcus granulosus | protein jagged 2 | 0.0132 | 0.0362 | 0.0362 |
Schistosoma mansoni | hypothetical protein | 0.0132 | 0.0362 | 0.0362 |
Onchocerca volvulus | 0.0407 | 0.2917 | 1 | |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0196 | 0.0958 | 0.0958 |
Schistosoma mansoni | hypothetical protein | 0.0132 | 0.0362 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Echinococcus granulosus | carboxylesterase 5A | 0.0547 | 0.4215 | 0.4215 |
Brugia malayi | Carboxylesterase family protein | 0.0547 | 0.4215 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0547 | 0.4215 | 0.4215 |
Brugia malayi | Carboxylesterase family protein | 0.0547 | 0.4215 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0547 | 0.4215 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0132 | 0.0362 | 0.086 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0092 | 0 | 0.5 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0196 | 0.0958 | 0.0958 |
Brugia malayi | notch-like transmembrane receptor | 0.0132 | 0.0362 | 0.086 |
Trypanosoma brucei | Casein kinase II | 0.0274 | 0.1686 | 0.5 |
Onchocerca volvulus | 0.0132 | 0.0362 | 0.1242 | |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0132 | 0.0362 | 0.1242 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Echinococcus multilocularis | neural cadherin | 0.0132 | 0.0362 | 0.0362 |
Brugia malayi | Animal haem peroxidase family protein | 0.0407 | 0.2917 | 0.6921 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0092 | 0 | 0.5 |
Schistosoma mansoni | rab6-interacting | 0.0196 | 0.0958 | 0.0958 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.0274 | 0.1686 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0274 | 0.1686 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0547 | 0.4215 | 0.4215 |
Brugia malayi | EGF-like domain containing protein | 0.0132 | 0.0362 | 0.086 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0274 | 0.1686 | 0.5 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0132 | 0.0362 | 0.0362 |
Echinococcus multilocularis | RUN | 0.0196 | 0.0958 | 0.0958 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Loa Loa (eye worm) | notch protein | 0.0132 | 0.0362 | 0.086 |
Leishmania major | casein kinase II, putative | 0.0274 | 0.1686 | 0.5 |
Echinococcus multilocularis | protein jagged 1 | 0.0132 | 0.0362 | 0.0362 |
Echinococcus multilocularis | protein jagged 2 | 0.0132 | 0.0362 | 0.0362 |
Brugia malayi | hypothetical protein | 0.0407 | 0.2917 | 0.6921 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2917 | 0.6921 |
Schistosoma mansoni | peroxidasin | 0.0407 | 0.2917 | 0.2917 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0132 | 0.0362 | 0.0362 |
Schistosoma mansoni | notch | 0.0132 | 0.0362 | 0.0362 |
Giardia lamblia | Kinase, CMGC CK2 | 0.0274 | 0.1686 | 1 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0132 | 0.0362 | 0.0362 |
Brugia malayi | Cadherin domain containing protein | 0.0132 | 0.0362 | 0.086 |
Trypanosoma cruzi | casein kinase II, putative | 0.0274 | 0.1686 | 0.5 |
Echinococcus granulosus | delta-like protein 1 | 0.0132 | 0.0362 | 0.0362 |
Schistosoma mansoni | hypothetical protein | 0.0132 | 0.0362 | 0.0362 |
Schistosoma mansoni | notch | 0.0132 | 0.0362 | 0.0362 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0274 | 0.1686 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2917 | 0.6921 |
Schistosoma mansoni | hypothetical protein | 0.0132 | 0.0362 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2917 | 0.6921 |
Brugia malayi | EGF-like domain containing protein | 0.0132 | 0.0362 | 0.086 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells assessed as BzATP-induced ethidium accumulation at 10 uM | ChEMBL. | 17676725 | |
Activity (functional) | Antagonist activity at mouse recombinant P2X1 receptor expressed in Xenopus oocytes assessed as inhibition of ATP-induced ion current at 10 uM by two electrode voltage clamping technique | ChEMBL. | 17676725 | |
Activity (functional) | 0 | Antagonist activity at mouse recombinant P2X1 receptor expressed in Xenopus oocytes assessed as inhibition of ATP-induced ion current at 10 uM by two electrode voltage clamping technique | ChEMBL. | 17676725 |
Activity (functional) | 0 | Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells assessed as BzATP-induced ethidium accumulation at 10 uM | ChEMBL. | 17676725 |
Inhibition (functional) | = 53.4 % | Antagonist activity at human recombinant P2X3 receptor expressed in Xenopus oocytes assessed as inhibition of ATP-induced ion current at 100 uM by two electrode voltage clamping technique | ChEMBL. | 17676725 |
Inhibition (functional) | = 53.4 % | Antagonist activity at human recombinant P2X3 receptor expressed in Xenopus oocytes assessed as inhibition of ATP-induced ion current at 100 uM by two electrode voltage clamping technique | ChEMBL. | 17676725 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.