Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Echinococcus multilocularis | fibropellin Ia | 0.0132 | 0.0362 | 0.0362 |
Brugia malayi | Doublecortin family protein | 0.0196 | 0.0958 | 0.2273 |
Brugia malayi | hypothetical protein | 0.0196 | 0.0958 | 0.2273 |
Schistosoma mansoni | polycystin 1-related | 0.0196 | 0.0958 | 0.0958 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Schistosoma mansoni | hypothetical protein | 0.0196 | 0.0958 | 0.0958 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0132 | 0.0362 | 0.0362 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0132 | 0.0362 | 0.086 |
Brugia malayi | Cadherin domain containing protein | 0.0132 | 0.0362 | 0.086 |
Schistosoma mansoni | hypothetical protein | 0.0132 | 0.0362 | 0.0362 |
Brugia malayi | Animal haem peroxidase family protein | 0.0407 | 0.2917 | 0.6921 |
Onchocerca volvulus | Slit protein homolog | 0.0132 | 0.0362 | 0.1242 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0132 | 0.0362 | 0.086 |
Brugia malayi | Animal haem peroxidase family protein | 0.0407 | 0.2917 | 0.6921 |
Echinococcus granulosus | protein jagged 1 | 0.0132 | 0.0362 | 0.0362 |
Schistosoma mansoni | protein kinase | 0.0274 | 0.1686 | 0.1686 |
Echinococcus granulosus | slit 2 protein | 0.0132 | 0.0362 | 0.0362 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0196 | 0.0958 | 0.0958 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.1171 | 1 | 1 |
Schistosoma mansoni | notch | 0.0132 | 0.0362 | 0.0362 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0274 | 0.1686 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0407 | 0.2917 | 0.6921 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.0274 | 0.1686 | 0.1686 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2917 | 0.6921 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2917 | 0.6921 |
Brugia malayi | Delta serrate ligand family protein | 0.0132 | 0.0362 | 0.086 |
Echinococcus multilocularis | peroxidasin | 0.0407 | 0.2917 | 0.2917 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0092 | 0 | 0.5 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0196 | 0.0958 | 0.0958 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.0958 | 0.2273 |
Echinococcus granulosus | protein jagged 1 | 0.0132 | 0.0362 | 0.0362 |
Schistosoma mansoni | hypothetical protein | 0.0132 | 0.0362 | 0.0362 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0132 | 0.0362 | 0.0362 |
Brugia malayi | EGF-like domain containing protein | 0.0132 | 0.0362 | 0.086 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0132 | 0.0362 | 0.0362 |
Onchocerca volvulus | 0.0196 | 0.0958 | 0.3283 | |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2917 | 0.6921 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Brugia malayi | Animal haem peroxidase family protein | 0.0407 | 0.2917 | 0.6921 |
Echinococcus granulosus | fibropellin Ia | 0.0132 | 0.0362 | 0.0362 |
Echinococcus multilocularis | acetylcholinesterase | 0.0547 | 0.4215 | 0.4215 |
Schistosoma mansoni | slit | 0.0132 | 0.0362 | 0.0362 |
Onchocerca volvulus | 0.0132 | 0.0362 | 0.1242 | |
Brugia malayi | Blistered cuticle protein 3 | 0.0407 | 0.2917 | 0.6921 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Loa Loa (eye worm) | Notch2 | 0.0132 | 0.0362 | 0.086 |
Schistosoma mansoni | notch | 0.0132 | 0.0362 | 0.0362 |
Schistosoma mansoni | notch | 0.0132 | 0.0362 | 0.0362 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0132 | 0.0362 | 0.086 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0132 | 0.0362 | 0.1242 |
Echinococcus granulosus | peroxidasin | 0.0407 | 0.2917 | 0.2917 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0132 | 0.0362 | 0.0362 |
Schistosoma mansoni | notch | 0.0132 | 0.0362 | 0.0362 |
Echinococcus granulosus | notch | 0.0132 | 0.0362 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2917 | 0.6921 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0132 | 0.0362 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2917 | 0.6921 |
Schistosoma mansoni | cell polarity protein | 0.0132 | 0.0362 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2917 | 0.6921 |
Brugia malayi | hypothetical protein | 0.0196 | 0.0958 | 0.2273 |
Brugia malayi | EGF-like domain containing protein | 0.0132 | 0.0362 | 0.086 |
Echinococcus granulosus | protein jagged 2 | 0.0132 | 0.0362 | 0.0362 |
Echinococcus granulosus | neural cadherin | 0.0132 | 0.0362 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Brugia malayi | Muscle positioning protein 4 | 0.0132 | 0.0362 | 0.086 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0366 | 0.2534 | 0.2534 |
Brugia malayi | EGF-like domain containing protein | 0.0132 | 0.0362 | 0.086 |
Echinococcus granulosus | acetylcholinesterase | 0.0547 | 0.4215 | 0.4215 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0196 | 0.0958 | 0.0958 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0132 | 0.0362 | 0.0362 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0407 | 0.2917 | 0.6921 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0092 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0402 | 0.2864 | 0.2864 |
Onchocerca volvulus | Peroxidasin homolog | 0.0407 | 0.2917 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0407 | 0.2917 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0407 | 0.2917 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0407 | 0.2917 | 1 |
Schistosoma mansoni | loxhd1 | 0.0196 | 0.0958 | 0.0958 |
Echinococcus granulosus | RUN | 0.0196 | 0.0958 | 0.0958 |
Onchocerca volvulus | 0.0132 | 0.0362 | 0.1242 | |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0274 | 0.1686 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0407 | 0.2917 | 0.6921 |
Schistosoma mansoni | hypothetical protein | 0.0132 | 0.0362 | 0.0362 |
Brugia malayi | Casein kinase II, alpha chain | 0.0274 | 0.1686 | 0.4 |
Brugia malayi | EGF-like domain containing protein | 0.0132 | 0.0362 | 0.086 |
Schistosoma mansoni | lipoxygenase | 0.1171 | 1 | 1 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0196 | 0.0958 | 0.0958 |
Echinococcus multilocularis | notch | 0.0132 | 0.0362 | 0.0362 |
Onchocerca volvulus | 0.0132 | 0.0362 | 0.1242 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0407 | 0.2917 | 0.6921 |
Entamoeba histolytica | casein kinase, putative | 0.0274 | 0.1686 | 0.5 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0132 | 0.0362 | 0.086 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Echinococcus multilocularis | protein jagged 1 | 0.0132 | 0.0362 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0274 | 0.1686 | 1 |
Schistosoma mansoni | rab6-interacting | 0.0196 | 0.0958 | 0.0958 |
Echinococcus granulosus | delta-like protein 1 | 0.0132 | 0.0362 | 0.0362 |
Schistosoma mansoni | hypothetical protein | 0.0132 | 0.0362 | 0.0362 |
Brugia malayi | Cadherin domain containing protein | 0.0132 | 0.0362 | 0.086 |
Trypanosoma cruzi | casein kinase II, putative | 0.0274 | 0.1686 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2917 | 0.6921 |
Brugia malayi | EGF-like domain containing protein | 0.0132 | 0.0362 | 0.086 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2917 | 0.6921 |
Schistosoma mansoni | hypothetical protein | 0.0132 | 0.0362 | 0.0362 |
Schistosoma mansoni | notch | 0.0132 | 0.0362 | 0.0362 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0274 | 0.1686 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2917 | 0.6921 |
Brugia malayi | hypothetical protein | 0.0407 | 0.2917 | 0.6921 |
Echinococcus multilocularis | protein jagged 2 | 0.0132 | 0.0362 | 0.0362 |
Echinococcus multilocularis | protein jagged 1 | 0.0132 | 0.0362 | 0.0362 |
Schistosoma mansoni | notch | 0.0132 | 0.0362 | 0.0362 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0132 | 0.0362 | 0.0362 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0132 | 0.0362 | 0.0362 |
Giardia lamblia | Kinase, CMGC CK2 | 0.0274 | 0.1686 | 1 |
Schistosoma mansoni | peroxidasin | 0.0407 | 0.2917 | 0.2917 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0547 | 0.4215 | 0.4215 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0132 | 0.0362 | 0.0362 |
Brugia malayi | EGF-like domain containing protein | 0.0132 | 0.0362 | 0.086 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0274 | 0.1686 | 0.5 |
Schistosoma mansoni | rab6-interacting | 0.0196 | 0.0958 | 0.0958 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.0274 | 0.1686 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0274 | 0.1686 | 1 |
Leishmania major | casein kinase II, putative | 0.0274 | 0.1686 | 0.5 |
Loa Loa (eye worm) | notch protein | 0.0132 | 0.0362 | 0.086 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Echinococcus multilocularis | RUN | 0.0196 | 0.0958 | 0.0958 |
Brugia malayi | EGF-like domain containing protein | 0.0132 | 0.0362 | 0.086 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0092 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0547 | 0.4215 | 0.4215 |
Brugia malayi | Carboxylesterase family protein | 0.0547 | 0.4215 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0547 | 0.4215 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0547 | 0.4215 | 1 |
Echinococcus multilocularis | neural cadherin | 0.0132 | 0.0362 | 0.0362 |
Brugia malayi | Animal haem peroxidase family protein | 0.0407 | 0.2917 | 0.6921 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0132 | 0.0362 | 0.1242 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Onchocerca volvulus | 0.0132 | 0.0362 | 0.1242 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0092 | 0 | 0.5 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0196 | 0.0958 | 0.0958 |
Trypanosoma brucei | Casein kinase II | 0.0274 | 0.1686 | 0.5 |
Brugia malayi | notch-like transmembrane receptor | 0.0132 | 0.0362 | 0.086 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0132 | 0.0362 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2917 | 0.6921 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Echinococcus granulosus | carboxylesterase 5A | 0.0547 | 0.4215 | 0.4215 |
Onchocerca volvulus | 0.0132 | 0.0362 | 0.1242 | |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.0274 | 0.1686 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0132 | 0.0362 | 0.0362 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0196 | 0.0958 | 0.0958 |
Schistosoma mansoni | hypothetical protein | 0.0132 | 0.0362 | 0.0362 |
Onchocerca volvulus | 0.0407 | 0.2917 | 1 | |
Echinococcus granulosus | protein jagged 2 | 0.0132 | 0.0362 | 0.0362 |
Schistosoma mansoni | peroxidasin | 0.0407 | 0.2917 | 0.2917 |
Onchocerca volvulus | 0.0407 | 0.2917 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0132 | 0.0362 | 0.086 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.0274 | 0.1686 | 0.4 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2917 | 0.6921 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0274 | 0.1686 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0274 | 0.1686 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Onchocerca volvulus | 0.0196 | 0.0958 | 0.3283 | |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2917 | 0.6921 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0402 | 0.2864 | 0.2864 |
Plasmodium vivax | unspecified product | 0.0274 | 0.1686 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0407 | 0.2917 | 0.6921 |
Loa Loa (eye worm) | doublecortin family protein | 0.0196 | 0.0958 | 0.2273 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.0274 | 0.1686 | 0.1686 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0407 | 0.2917 | 0.6921 |
Loa Loa (eye worm) | hypothetical protein | 0.0547 | 0.4215 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.0958 | 0.2273 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2917 | 0.6921 |
Schistosoma mansoni | septate junction protein | 0.0132 | 0.0362 | 0.0362 |
Schistosoma mansoni | lipoxygenase | 0.0819 | 0.6733 | 0.6733 |
Echinococcus granulosus | acetylcholinesterase | 0.0547 | 0.4215 | 0.4215 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0132 | 0.0362 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0547 | 0.4215 | 1 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0132 | 0.0362 | 0.0362 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0274 | 0.1686 | 1 |
Onchocerca volvulus | Putative cubilin | 0.0132 | 0.0362 | 0.1242 |
Loa Loa (eye worm) | carboxylesterase | 0.0547 | 0.4215 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0407 | 0.2917 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0362 | 0.086 |
Onchocerca volvulus | 0.0407 | 0.2917 | 1 | |
Brugia malayi | Peroxidasin | 0.0407 | 0.2917 | 0.6921 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2917 | 0.6921 |
Echinococcus multilocularis | slit 2 protein | 0.0132 | 0.0362 | 0.0362 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0407 | 0.2917 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0547 | 0.4215 | 0.4215 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antagonist activity at human recombinant P2X3 receptor expressed in Xenopus oocytes assessed as inhibition of ATP-induced ion current at 10 uM by two electrode voltage clamping technique | ChEMBL. | 17676725 | |
Activity (functional) | 0 | Antagonist activity at human recombinant P2X3 receptor expressed in Xenopus oocytes assessed as inhibition of ATP-induced ion current at 10 uM by two electrode voltage clamping technique | ChEMBL. | 17676725 |
Inhibition (functional) | Antagonist activity at mouse recombinant P2X1 receptor expressed in Xenopus oocytes assessed as inhibition of ATP-induced ion current at 10 uM by two electrode voltage clamping technique | ChEMBL. | 17676725 | |
Inhibition (functional) | Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells assessed as BzATP-induced ethidium accumulation at 10 uM | ChEMBL. | 17676725 | |
Inhibition (functional) | 0 | Antagonist activity at mouse recombinant P2X1 receptor expressed in Xenopus oocytes assessed as inhibition of ATP-induced ion current at 10 uM by two electrode voltage clamping technique | ChEMBL. | 17676725 |
Inhibition (functional) | 0 | Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells assessed as BzATP-induced ethidium accumulation at 10 uM | ChEMBL. | 17676725 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.