Detailed information for compound 433302

Basic information

Technical information
  • TDR Targets ID: 433302
  • Name: 6-(3-bromopropyl)-9-fluoro-3-nitroindeno[1,2- c]isoquinoline-5,11-dione
  • MW: 431.212 | Formula: C19H12BrFN2O4
  • H donors: 0 H acceptors: 4 LogP: 3.43 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: BrCCCn1c2c3ccc(cc3C(=O)c2c2c(c1=O)cc(cc2)[N+](=O)[O-])F
  • InChi: 1S/C19H12BrFN2O4/c20-6-1-7-22-17-13-4-2-10(21)8-14(13)18(24)16(17)12-5-3-11(23(26)27)9-15(12)19(22)25/h2-5,8-9H,1,6-7H2
  • InChiKey: ZWWTYVZYDXXIBG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-(3-bromopropyl)-9-fluoro-3-nitro-indeno[1,2-c]isoquinoline-5,11-dione
  • 6-(3-bromopropyl)-9-fluoro-3-nitro-indeno[1,2-c]isoquinoline-5,11-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica calpain large subunit domain III containing protein 0.0086 0.0157 0.1033
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0265 0.0964 0.0905
Leishmania major cysteine peptidase A (CPA) 0.0265 0.0964 0.9698
Schistosoma mansoni calpain-7 (C02 family) 0.0123 0.0325 0.0262
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0265 0.0964 0.9728
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0265 0.0964 0.9728
Echinococcus granulosus calpain 0.0123 0.0325 0.0262
Echinococcus granulosus cysteine protease 0.0146 0.0429 0.0367
Entamoeba histolytica cysteine protease, putative 0.0146 0.0429 0.4054
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0077 0.0117 0.0052
Loa Loa (eye worm) hypothetical protein 0.024 0.0854 0.1493
Onchocerca volvulus 0.0265 0.0964 0.1591
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.2265 1 1
Entamoeba histolytica cysteine protease, putative 0.0146 0.0429 0.4054
Loa Loa (eye worm) hypothetical protein 0.1317 0.5719 1
Entamoeba histolytica cysteine protease, putative 0.0146 0.0429 0.4054
Loa Loa (eye worm) hypothetical protein 0.0081 0.0133 0.0233
Onchocerca volvulus Cathepsin L homolog 0.0265 0.0964 0.1591
Loa Loa (eye worm) fibroinase 0.0265 0.0964 0.1685
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0265 0.0964 0.9728
Onchocerca volvulus Peroxidase homolog 0.1317 0.5719 1
Echinococcus granulosus calpain A 0.0123 0.0325 0.0262
Loa Loa (eye worm) animal heme peroxidase 0.1317 0.5719 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0265 0.0964 0.9698
Entamoeba histolytica cysteine protease, putative 0.0146 0.0429 0.4054
Brugia malayi Cathepsin L-like precursor 0.0184 0.0599 0.1048
Echinococcus granulosus calpain 7 C02 family 0.0123 0.0325 0.0262
Brugia malayi cathepsin Z-like cysteine proteinase 0.0066 0.0065 0.0113
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0265 0.0964 0.1685
Entamoeba histolytica cysteine protease, putative 0.0146 0.0429 0.4054
Plasmodium falciparum cysteine proteinase falcipain 3 0.0265 0.0964 0.6358
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0122 0.032 0.0559
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0265 0.0964 0.9728
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0123 0.0325 0.087
Echinococcus granulosus Polycystic kidney disease protein 0.0379 0.1479 0.1424
Echinococcus multilocularis lipoxygenase domain containing protein 0.0379 0.1479 0.1424
Brugia malayi calpain 5 0.0086 0.0157 0.0275
Schistosoma mansoni cathepsin F (C01 family) 0.0184 0.0599 0.0538
Echinococcus multilocularis calpain 0.0123 0.0325 0.0262
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0265 0.0964 0.6358
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0146 0.0429 0.0367
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0265 0.0964 0.9698
Loa Loa (eye worm) hypothetical protein 0.1317 0.5719 1
Onchocerca volvulus 0.0265 0.0964 0.1591
Onchocerca volvulus 0.1317 0.5719 1
Leishmania major cathepsin L-like protease 0.0265 0.0964 0.9698
Trypanosoma cruzi cruzipain precursor, putative 0.0265 0.0964 0.3009
Trypanosoma cruzi cysteine peptidase, putative 0.0265 0.0964 0.3009
Brugia malayi Cathepsin L-like precursor 0.0265 0.0964 0.1685
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0123 0.0325 0.201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0265 0.0964 0.9698
Giardia lamblia Cathepsin B precursor 0.027 0.0989 1
Loa Loa (eye worm) doublecortin family protein 0.0379 0.1479 0.2586
Trypanosoma cruzi cysteine peptidase, putative 0.0265 0.0964 0.3009
Plasmodium vivax vivapain-2 0.0265 0.0964 0.6358
Brugia malayi cathepsin L-like cysteine proteinase 0.0066 0.0065 0.0113
Toxoplasma gondii cathepsin CPL 0.0265 0.0964 0.9728
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0265 0.0964 0.9728
Schistosoma mansoni lipoxygenase 0.1584 0.6921 0.6901
Onchocerca volvulus 0.1317 0.5719 1
Echinococcus granulosus cathepsin l1 0.0265 0.0964 0.0905
Schistosoma mansoni peroxidasin 0.1317 0.5719 0.5691
Brugia malayi cathepsin L-like precursor 0.0184 0.0599 0.1048
Loa Loa (eye worm) hypothetical protein 0.0265 0.0964 0.1685
Entamoeba histolytica cysteine protease, putative 0.0146 0.0429 0.4054
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0066 0.0065 0.0113
Echinococcus multilocularis calpain A 0.0352 0.1356 0.13
Echinococcus multilocularis calpain 7 (C02 family) 0.0123 0.0325 0.0262
Loa Loa (eye worm) hypothetical protein 0.0066 0.0065 0.0113
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0123 0.0325 0.087
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0265 0.0964 0.1685
Echinococcus granulosus calpain A 0.0352 0.1356 0.13
Echinococcus granulosus RUN 0.0379 0.1479 0.1424
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0123 0.0325 0.087
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0351 0.1353 0.1297
Brugia malayi cathepsin Z-like cysteine proteinase 0.0066 0.0065 0.0113
Loa Loa (eye worm) hypothetical protein 0.1317 0.5719 1
Trypanosoma brucei calpain-like protein, putative 0.0123 0.0325 0.201
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0265 0.0964 0.9728
Onchocerca volvulus 0.0265 0.0964 0.1591
Giardia lamblia Cathepsin B precursor 0.027 0.0989 1
Echinococcus multilocularis cysteine protease 0.0265 0.0964 0.0905
Toxoplasma gondii cathepsin B 0.027 0.0989 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0081 0.0133 0.0233
Echinococcus granulosus calpain 5 0.0123 0.0325 0.0262
Brugia malayi Cathepsin L-like precursor 0.0265 0.0964 0.1685
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0265 0.0964 0.9728
Entamoeba histolytica cysteine protease, putative 0.0146 0.0429 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0265 0.0964 0.9698
Loa Loa (eye worm) animal heme peroxidase 0.1317 0.5719 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0146 0.0429 0.3944
Leishmania major cathepsin L-like protease 0.0265 0.0964 0.9698
Onchocerca volvulus 0.0379 0.1479 0.2502
Leishmania major cathepsin L-like protease 0.0265 0.0964 0.9698
Loa Loa (eye worm) hypothetical protein 0.1317 0.5719 1
Loa Loa (eye worm) hypothetical protein 0.1317 0.5719 1
Loa Loa (eye worm) hypothetical protein 0.1317 0.5719 1
Plasmodium vivax unspecified product 0.0081 0.0133 0.0485
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0265 0.0964 0.9728
Trypanosoma cruzi kinesin, putative 0.0086 0.0157 0.0311
Echinococcus multilocularis RUN 0.0379 0.1479 0.1424
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0429 0.3267
Loa Loa (eye worm) animal heme peroxidase 0.1317 0.5719 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0265 0.0964 0.9728
Schistosoma mansoni cathepsin F (C01 family) 0.0265 0.0964 0.0905
Echinococcus granulosus cathepsin b 0.0727 0.3054 0.3008
Loa Loa (eye worm) calpain family protein 1 0.024 0.0854 0.1493
Brugia malayi Animal haem peroxidase family protein 0.1317 0.5719 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0265 0.0964 0.9728
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0146 0.0429 0.0367
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.027 0.0989 0.093
Plasmodium vivax calpain, putative 0.0123 0.0325 0.1838
Onchocerca volvulus Dual oxidase homolog 0.1317 0.5719 1
Brugia malayi Cathepsin L-like precursor 0.0184 0.0599 0.1048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0265 0.0964 0.9728
Brugia malayi Papain family cysteine protease containing protein 0.0066 0.0065 0.0113
Echinococcus multilocularis cysteine protease 0.0265 0.0964 0.0905
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0351 0.1353 0.1297
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0244 0.0871 0.0811
Entamoeba histolytica cysteine proteinase 2 0.0146 0.0429 0.4054
Brugia malayi Cathepsin L-like precursor 0.0265 0.0964 0.1685
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0265 0.0964 0.9728
Schistosoma mansoni loxhd1 0.0379 0.1479 0.1424
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0265 0.0964 0.9698
Echinococcus multilocularis calpain 5 0.0123 0.0325 0.0262
Plasmodium vivax unspecified product 0.0146 0.0429 0.2577
Trypanosoma cruzi cruzipain precursor, putative 0.0081 0.0133 0.023
Plasmodium vivax multidomain scavenger receptor, putative 0.0379 0.1479 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0265 0.0964 0.9698
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0077 0.0117 0.0052
Echinococcus multilocularis cathepsin L cysteine protease 0.0265 0.0964 0.0905
Loa Loa (eye worm) hypothetical protein 0.1317 0.5719 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0123 0.0325 0.087
Echinococcus granulosus cathepsin b 0.0727 0.3054 0.3008
Trypanosoma cruzi cysteine peptidase, putative 0.0081 0.0133 0.023
Entamoeba histolytica cysteine proteinase, putative 0.0146 0.0429 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0146 0.0429 0.3944
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0351 0.1353 0.1297
Giardia lamblia Cathepsin B precursor 0.027 0.0989 1
Entamoeba histolytica cysteine protease, putative 0.0146 0.0429 0.4054
Onchocerca volvulus Peroxidasin homolog 0.1317 0.5719 1
Schistosoma mansoni hypothetical protein 0.0379 0.1479 0.1424
Loa Loa (eye worm) hypothetical protein 0.0184 0.0599 0.1048
Loa Loa (eye worm) hypothetical protein 0.1317 0.5719 1
Entamoeba histolytica cysteine protease, putative 0.0146 0.0429 0.4054
Trypanosoma cruzi kinesin, putative 0.0086 0.0157 0.0311
Loa Loa (eye worm) calpain family protein 1 0.0326 0.1242 0.2173
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0351 0.1353 0.1297
Loa Loa (eye worm) hypothetical protein 0.0066 0.0065 0.0113
Echinococcus granulosus cathepsin L 0.0146 0.0429 0.0367
Leishmania major cathepsin L-like protease 0.0265 0.0964 0.9698
Brugia malayi hypothetical protein 0.0379 0.1479 0.2586
Loa Loa (eye worm) hypothetical protein 0.0184 0.0599 0.1048
Schistosoma mansoni cathepsin F (C01 family) 0.0265 0.0964 0.0905
Loa Loa (eye worm) hypothetical protein 0.0379 0.1479 0.2586
Echinococcus granulosus peroxidasin 0.1317 0.5719 0.5691
Brugia malayi cathepsin L precursor 0.0066 0.0065 0.0113
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0265 0.0964 0.9698
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0123 0.0325 0.201
Loa Loa (eye worm) hypothetical protein 0.1317 0.5719 1
Onchocerca volvulus 0.0184 0.0599 0.0946
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0727 0.3054 0.3008
Brugia malayi cathepsin F-like cysteine proteinase 0.0066 0.0065 0.0113
Brugia malayi Papain family cysteine protease containing protein 0.0146 0.0429 0.075
Onchocerca volvulus Cathepsin L homolog 0.0265 0.0964 0.1591
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0727 0.3054 1
Onchocerca volvulus 0.0203 0.0687 0.11
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0265 0.0964 0.9728
Entamoeba histolytica cysteine protease, putative 0.0146 0.0429 0.4054
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.027 0.0989 0.3093
Loa Loa (eye worm) hypothetical protein 0.1317 0.5719 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0265 0.0964 0.6358
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0265 0.0964 0.9728
Brugia malayi Cathepsin L-like precursor 0.0265 0.0964 0.1685
Entamoeba histolytica cysteine proteinase, putative 0.0184 0.0599 0.5946
Loa Loa (eye worm) hypothetical protein 0.0289 0.1075 0.188
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0123 0.0325 0.201
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0123 0.0325 0.087
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0727 0.3054 0.3008
Brugia malayi Animal haem peroxidase family protein 0.1317 0.5719 1
Loa Loa (eye worm) hypothetical protein 0.1317 0.5719 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0065 0.0113
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.023 0.0806 0.141
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0727 0.3054 0.3008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0265 0.0964 0.9728
Trypanosoma cruzi cysteine peptidase, putative 0.0265 0.0964 0.3009
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0123 0.0325 0.087
Loa Loa (eye worm) hypothetical protein 0.0727 0.3054 0.534
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0146 0.0429 0.122
Onchocerca volvulus 0.0265 0.0964 0.1591
Loa Loa (eye worm) hypothetical protein 0.0066 0.0065 0.0113
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0265 0.0964 0.9728
Onchocerca volvulus 0.0265 0.0964 0.1591
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0294 0.0514
Trypanosoma cruzi cysteine proteinase, putative 0.0146 0.0429 0.122
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0062 0.0048 0.0085
Brugia malayi Animal haem peroxidase family protein 0.1317 0.5719 1
Trypanosoma cruzi cysteine peptidase, putative 0.0146 0.0429 0.122
Brugia malayi Cathepsin L-like precursor 0.0081 0.0133 0.0233
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0265 0.0964 0.9698
Trypanosoma cruzi cysteine peptidase, putative 0.0265 0.0964 0.3009
Onchocerca volvulus Chorion peroxidase homolog 0.1317 0.5719 1
Schistosoma mansoni cathepsin s 0.0081 0.0133 0.0069
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0123 0.0325 0.087
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0081 0.0133 0.0233
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0429 0.3267
Schistosoma mansoni microsomal glutathione s-transferase 0.0244 0.0871 0.0811
Onchocerca volvulus Cathepsin F homolog 0.0265 0.0964 0.1591
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0265 0.0964 0.9728
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0265 0.0964 0.9728
Entamoeba histolytica cysteine proteinase, putative 0.0146 0.0429 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0265 0.0964 0.9728
Loa Loa (eye worm) hypothetical protein 0.0203 0.0687 0.12
Plasmodium falciparum LCCL domain-containing protein 0.0379 0.1479 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0065 0.0113
Loa Loa (eye worm) calpain 5 0.0086 0.0157 0.0275
Echinococcus multilocularis lipoxygenase domain containing protein 0.0379 0.1479 0.1424
Brugia malayi calpain family protein 1 0.0326 0.1242 0.2173
Loa Loa (eye worm) cathepsin B 0.027 0.0989 0.1729
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0146 0.0429 0.0367
Schistosoma mansoni Mername-AA248 (C02 family) 0.0123 0.0325 0.0262
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0123 0.0325 0.087
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0066 0.0065 0.0113
Onchocerca volvulus Peroxidasin homolog 0.1317 0.5719 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0123 0.0325 0.087
Loa Loa (eye worm) blistered cuticle protein 3 0.1317 0.5719 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0123 0.0325 0.201
Leishmania major cathepsin L-like protease 0.0265 0.0964 0.9698
Echinococcus granulosus cathepsin l cysteine peptidase 0.0265 0.0964 0.0905
Echinococcus multilocularis cathepsin b 0.0727 0.3054 0.3008
Brugia malayi Papain family cysteine protease containing protein 0.0265 0.0964 0.1685
Brugia malayi calpain 7 0.0123 0.0325 0.0568
Entamoeba histolytica cysteine proteinase, putative 0.0146 0.0429 0.4054
Echinococcus multilocularis Polycystic kidney disease protein 0.0379 0.1479 0.1424
Loa Loa (eye worm) animal heme peroxidase 0.1317 0.5719 1
Brugia malayi Animal haem peroxidase family protein 0.1317 0.5719 1
Echinococcus granulosus microsomal glutathione S transferase 3 0.0244 0.0871 0.0811
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0265 0.0964 0.9698
Brugia malayi Animal haem peroxidase family protein 0.1317 0.5719 1
Onchocerca volvulus Peroxidase homolog 0.1317 0.5719 1
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.023 0.0806 0.0747
Schistosoma mansoni dopamine-beta-monooxygenase 0.0122 0.032 0.0257
Loa Loa (eye worm) hypothetical protein 0.0066 0.0065 0.0113
Brugia malayi Cathepsin L-like cysteine proteinase 0.0184 0.0599 0.1048
Entamoeba histolytica cysteine protease, putative 0.0146 0.0429 0.4054
Brugia malayi Doublecortin family protein 0.0379 0.1479 0.2586
Entamoeba histolytica cysteine proteinase, putative 0.0265 0.0964 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0265 0.0964 0.9728
Entamoeba histolytica cysteine proteinase 1, putative 0.0146 0.0429 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.0066 0.0065 0.0113
Plasmodium vivax vivapain-2 0.0265 0.0964 0.6358
Plasmodium vivax vivapain-1 0.0146 0.0429 0.2577
Trypanosoma brucei calpain-like protein, putative 0.0123 0.0325 0.201
Leishmania major cathepsin L-like protease 0.0265 0.0964 0.9698
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0265 0.0964 0.9698
Echinococcus multilocularis peroxidasin 0.1317 0.5719 0.5691
Toxoplasma gondii MAPEG family protein 0.0244 0.0871 0.872
Loa Loa (eye worm) hypothetical protein 0.1317 0.5719 1
Entamoeba histolytica cysteine proteinase, putative 0.0146 0.0429 0.4054
Echinococcus granulosus cathepsin L cysteine proteinase 0.0265 0.0964 0.0905
Brugia malayi cathepsin F-like cysteine proteinase 0.0081 0.0133 0.0233
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0265 0.0964 0.9728
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.006 0.004 0.007
Schistosoma mansoni peptidylglycine monooxygenase 0.0122 0.032 0.0257
Loa Loa (eye worm) hypothetical protein 0.0326 0.1242 0.2173
Echinococcus granulosus cathepsin L cysteine protease 0.0146 0.0429 0.0367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0184 0.0599 0.5784
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0727 0.3054 0.3008
Loa Loa (eye worm) cysteine protease 0.0265 0.0964 0.1685
Onchocerca volvulus 0.0379 0.1479 0.2502
Schistosoma mansoni calpain C (C02 family) 0.0123 0.0325 0.0262
Echinococcus multilocularis cathepsin b 0.0727 0.3054 0.3008
Schistosoma mansoni rab6-interacting 0.0379 0.1479 0.1424
Brugia malayi Cathepsin L-like precursor 0.0265 0.0964 0.1685
Onchocerca volvulus 0.0265 0.0964 0.1591
Echinococcus granulosus cathepsin l1 0.0184 0.0599 0.0538
Echinococcus multilocularis cathepsin L cysteine protease 0.0265 0.0964 0.0905
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0265 0.0964 0.9728
Loa Loa (eye worm) hypothetical protein 0.0081 0.0133 0.0233
Loa Loa (eye worm) hypothetical protein 0.0184 0.0599 0.1048
Trypanosoma brucei cysteine peptidase C (CPC) 0.027 0.0989 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0265 0.0964 0.0905
Entamoeba histolytica cysteine protease, putative 0.0146 0.0429 0.4054
Echinococcus multilocularis hypothetical protein 0.0123 0.0325 0.0262
Brugia malayi calpain family protein 1 0.0326 0.1242 0.2173
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.027 0.0989 1
Loa Loa (eye worm) hypothetical protein 0.1317 0.5719 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0066 0.0065 0.0113
Leishmania major cathepsin L-like protease 0.0265 0.0964 0.9698
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0265 0.0964 0.9728
Brugia malayi fibroinase precursor 0.0066 0.0065 0.0113
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.023 0.0806 0.0747
Entamoeba histolytica protein kinase, putative 0.0086 0.0157 0.1033
Brugia malayi Cathepsin L-like precursor 0.0265 0.0964 0.1685
Brugia malayi MH2 domain containing protein 0.0116 0.0294 0.0514
Schistosoma mansoni calpain-7 (C02 family) 0.0123 0.0325 0.0262
Entamoeba histolytica cysteine proteinase, putative 0.0265 0.0964 1
Loa Loa (eye worm) calpain 0.0123 0.0325 0.0568
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0265 0.0964 0.9698
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.027 0.0989 1
Loa Loa (eye worm) hypothetical protein 0.0379 0.1479 0.2586
Trypanosoma cruzi cysteine protease, putative 0.0146 0.0429 0.122
Brugia malayi hypothetical protein 0.0379 0.1479 0.2586
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.1065 0.4578 0.4542
Plasmodium falciparum cysteine proteinase falcipain 1 0.0146 0.0429 0.2577
Brugia malayi Papain family cysteine protease containing protein 0.0146 0.0429 0.075
Trypanosoma brucei calpain-like protein, putative 0.0123 0.0325 0.201
Trypanosoma brucei calpain-like protein, putative 0.0123 0.0325 0.201
Schistosoma mansoni peroxidasin 0.1317 0.5719 0.5691
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.079 0.3337 0.3294
Brugia malayi Blistered cuticle protein 3 0.1317 0.5719 1
Schistosoma mansoni calpain (C02 family) 0.0123 0.0325 0.0262
Onchocerca volvulus 0.0265 0.0964 0.1591
Loa Loa (eye worm) ctsf protein 0.0265 0.0964 0.1685
Echinococcus multilocularis calpain family protein 1, d 0.024 0.0854 0.0794
Loa Loa (eye worm) hypothetical protein 0.1317 0.5719 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0265 0.0964 0.9728
Onchocerca volvulus 0.1317 0.5719 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0379 0.1479 0.1424
Loa Loa (eye worm) hypothetical protein 0.0081 0.0133 0.0233
Trypanosoma brucei antigen, putative 0.0123 0.0325 0.201
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0123 0.0325 0.087
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0066 0.0065 0.0113
Trypanosoma cruzi cysteine proteinase, putative 0.0146 0.0429 0.122
Brugia malayi hypothetical protein 0.1317 0.5719 1
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0123 0.0325 0.201
Plasmodium vivax vivapain-3 0.0146 0.0429 0.2577
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0265 0.0964 0.9728
Brugia malayi Papain family cysteine protease containing protein 0.0066 0.0065 0.0113
Echinococcus multilocularis cathepsin L 0.0146 0.0429 0.0367
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0184 0.0599 0.1789
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0294 0.0514
Brugia malayi cathepsin B-like cysteine proteinase 0.0727 0.3054 0.534
Echinococcus granulosus lipoxygenase domain containing protein 0.0379 0.1479 0.1424
Leishmania major cathepsin L-like protease 0.0265 0.0964 0.9698
Schistosoma mansoni peptidyl-glycine monooxygenase 0.023 0.0806 0.0747
Entamoeba histolytica cysteine protease, putative 0.0265 0.0964 1
Entamoeba histolytica cysteine protease, putative 0.0146 0.0429 0.4054
Brugia malayi Peroxidasin 0.1317 0.5719 1
Loa Loa (eye worm) hypothetical protein 0.0122 0.032 0.0559
Schistosoma mansoni polycystin 1-related 0.0379 0.1479 0.1424
Schistosoma mansoni lipoxygenase 0.2265 1 1
Schistosoma mansoni rab6-interacting 0.0379 0.1479 0.1424
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0184 0.0599 0.5784
Loa Loa (eye worm) hypothetical protein 0.023 0.0806 0.141
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0326 0.1242 0.1186

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) = 2.29 uM Cytotoxicity against human HOP62 cells ChEMBL. 17676830
GI50 (functional) = 2.29 uM Cytotoxicity against human UACC62 cells ChEMBL. 17676830
GI50 (functional) = 2.29 uM Cytotoxicity against human HOP62 cells ChEMBL. 17676830
GI50 (functional) = 2.29 uM Cytotoxicity against human UACC62 cells ChEMBL. 17676830
GI50 (functional) = 3.39 uM Cytotoxicity against human DU145 cells ChEMBL. 17676830
GI50 (functional) = 3.39 uM Cytotoxicity against human DU145 cells ChEMBL. 17676830
GI50 (functional) = 7.24 uM Cytotoxicity against human HCT116 cells ChEMBL. 17676830
GI50 (functional) = 7.24 uM Cytotoxicity against human HCT116 cells ChEMBL. 17676830
GI50 (functional) = 27.5 uM Cytotoxicity against human SN12C cells ChEMBL. 17676830
GI50 (functional) = 27.5 uM Cytotoxicity against human SN12C cells ChEMBL. 17676830
GI50 (functional) = 37.2 uM Cytotoxicity against human MDA-MB-435 cells ChEMBL. 17676830
GI50 (functional) = 37.2 uM Cytotoxicity against human MDA-MB-435 cells ChEMBL. 17676830
GI50 (functional) = 46.8 uM Cytotoxicity against human OVCAR3 cells ChEMBL. 17676830
GI50 (functional) = 46.8 uM Cytotoxicity against human OVCAR3 cells ChEMBL. 17676830

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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