Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNase H family protein | 0.0088 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0088 | 0 | 0.5 |
Echinococcus granulosus | ribonuclease H1 | 0.0088 | 0 | 0.5 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0247 | 0.6591 | 1 |
Brugia malayi | RNase H family protein | 0.0088 | 0 | 0.5 |
Brugia malayi | RNase H family protein | 0.0088 | 0 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.0329 | 1 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0247 | 0.6591 | 1 |
Entamoeba histolytica | thymidine kinase, putative | 0.0247 | 0.6591 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0095 | 0.0309 | 0.0309 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0247 | 0.6591 | 1 |
Giardia lamblia | Thymidine kinase | 0.0247 | 0.6591 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0247 | 0.6591 | 1 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0088 | 0 | 0.5 |
Trypanosoma brucei | thymidine kinase | 0.0247 | 0.6591 | 0.6591 |
Echinococcus multilocularis | ribonuclease H1 | 0.0088 | 0 | 0.5 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0095 | 0.0309 | 0.0309 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0095 | 0.0309 | 0.0309 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0088 | 0 | 0.5 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0095 | 0.0309 | 0.0309 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0247 | 0.6591 | 1 |
Leishmania major | thymidine kinase, putative | 0.0247 | 0.6591 | 1 |
Toxoplasma gondii | ribonuclease HI protein | 0.0088 | 0 | 0.5 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0095 | 0.0309 | 0.0309 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Log activity (ADMET) | = -1 | Negative log transformed activity | ChEMBL. | 2296013 |
EC50 (functional) | > 10 uM | In vitro macrofilaricidal activity against D. viteae was determined using the leakage of incorporated radiolabeled adenine method. | ChEMBL. | 2296013 |
Worm reduction (functional) | = 39 % | In vivo percent reduction of Brugia pahangi worm in gerbils | ChEMBL. | 2296013 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.