Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 602 aa | 546 aa | 30.2 % |
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1302 | 0.1302 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1437 | 0.5 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0028 | 0.0755 | 0.0755 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0755 | 0.0755 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1302 | 0.1302 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0 | 0.5 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0028 | 0.0755 | 0.0755 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0028 | 0.0755 | 0.0755 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1437 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0028 | 0.0755 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0028 | 0.0755 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.2425 | 0.2425 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.1437 | 0.1437 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0755 | 0.0755 |
Onchocerca volvulus | 0.0028 | 0.0755 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0038 | 0.1437 | 0.1437 |
Brugia malayi | Carboxylesterase family protein | 0.0028 | 0.0755 | 0.0755 |
Brugia malayi | Carboxylesterase family protein | 0.0028 | 0.0755 | 0.0755 |
Schistosoma mansoni | gliotactin | 0.0028 | 0.0755 | 0.0755 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0755 | 0.0755 |
Onchocerca volvulus | 0.0028 | 0.0755 | 0.5 | |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.1437 | 0.1437 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.2425 | 0.2425 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0755 | 0.0755 |
Echinococcus multilocularis | neuroligin | 0.0028 | 0.0755 | 0.0755 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0028 | 0.0755 | 0.0755 |
Brugia malayi | Carboxylesterase family protein | 0.0028 | 0.0755 | 0.0755 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.2425 | 0.2425 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0755 | 0.0755 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0028 | 0.0755 | 0.0755 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0028 | 0.0755 | 0.0755 |
Onchocerca volvulus | 0.0028 | 0.0755 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0028 | 0.0755 | 0.0755 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1437 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.2425 | 0.2425 |
Onchocerca volvulus | 0.0028 | 0.0755 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0028 | 0.0755 | 0.0755 |
Echinococcus granulosus | neuroligin | 0.0028 | 0.0755 | 0.0755 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0028 | 0.0755 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0028 | 0.0755 | 0.0755 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0028 | 0.0755 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.1302 | 0.1302 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 1 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0028 | 0.0755 | 0.0755 |
Schistosoma mansoni | acetylcholinesterase | 0.0028 | 0.0755 | 0.0755 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.1437 | 0.1437 |
Loa Loa (eye worm) | carboxylesterase | 0.0028 | 0.0755 | 0.0755 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0028 | 0.0755 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0017 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 1 | 1 |
Onchocerca volvulus | 0.0028 | 0.0755 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0028 | 0.0755 | 0.0755 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0028 | 0.0755 | 0.0755 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0028 | 0.0755 | 0.0755 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0028 | 0.0755 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0755 | 0.0755 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0017 | 0 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0755 | 0.0755 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1437 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1437 | 0.1437 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0017 | 0 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0028 | 0.0755 | 0.0755 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0017 | 0 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0017 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 51.1 nM | Inhibition of human recombinant acetylcholinesterase | ChEMBL. | 17850125 |
IC50 (binding) | = 51.1 nM | Inhibition of human recombinant acetylcholinesterase | ChEMBL. | 17850125 |
IC50 (binding) | = 2390 nM | Inhibition of human recombinant butyrylcholinesterase | ChEMBL. | 17850125 |
IC50 (binding) | = 2390 nM | Inhibition of human recombinant butyrylcholinesterase | ChEMBL. | 17850125 |
Inhibition (binding) | Inhibition of human AChE-induced amyloid beta (1-40) aggregation at 100 uM | ChEMBL. | 17850125 | |
Inhibition (binding) | 0 | Inhibition of human AChE-induced amyloid beta (1-40) aggregation at 100 uM | ChEMBL. | 17850125 |
Inhibition (binding) | = 68.8 % | Inhibition of self-induced amyloid beta (1-40) aggregation at 10 uM by thioflavin T based fluorometric assay | ChEMBL. | 17850125 |
Inhibition (binding) | = 68.8 % | Inhibition of self-induced amyloid beta (1-40) aggregation at 10 uM by thioflavin T based fluorometric assay | ChEMBL. | 17850125 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.