Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | adenosine deaminase | 0.0171 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0141 | 0.7416 | 0.7416 |
Schistosoma mansoni | adenosine deaminase | 0.0171 | 1 | 1 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0141 | 0.7416 | 0.7416 |
Mycobacterium ulcerans | adenosine deaminase | 0.0171 | 1 | 1 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0141 | 0.7416 | 0.7416 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0141 | 0.7416 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0171 | 1 | 1 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0141 | 0.7416 | 0.7416 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0171 | 1 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0141 | 0.7416 | 1 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0141 | 0.7416 | 0.7416 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.5169 | 0.5169 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0171 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0171 | 1 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.0171 | 1 | 1 |
Leishmania major | adenine aminohydrolase | 0.0171 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0171 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0171 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.5169 | 0.5169 |
Echinococcus multilocularis | adenosine deaminase | 0.0171 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0087 | 0.2748 | 0.2748 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0141 | 0.7416 | 0.7416 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0087 | 0.2748 | 0.2748 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.5169 | 0.5169 |
Treponema pallidum | adenosine deaminase | 0.0171 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0171 | 1 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0171 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0087 | 0.2748 | 0.2748 |
Plasmodium falciparum | adenosine deaminase | 0.0171 | 1 | 1 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0141 | 0.7416 | 0.7416 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0141 | 0.7416 | 0.7416 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0141 | 0.7416 | 0.7416 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0141 | 0.7416 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0087 | 0.2748 | 0.2748 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.0171 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.5169 | 0.5169 |
Brugia malayi | Adenosylhomocysteinase | 0.0141 | 0.7416 | 0.7416 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0171 | 1 | 1 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0141 | 0.7416 | 0.7416 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3.7 nM | In vitro inhibitory concentration on chloroquine resistant Plasmodium falciparum FcB1 strain | ChEMBL. | 14998331 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.