TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 573.185 | Formula: C29H51ClN3O6-
H donors: 4 H acceptors: 3 LogP: 4.43 Rotable bonds: 20
Rule of 5 violations (Lipinski): 2
SMILES: COCCCOc1cc(ccc1OC)C[C@H](C(C)C)C[C@H]([C@H](C[C@H](C(=O)N[C@H](C(=O)N)CC)C(C)C)O)N.[Cl-]
InChi: 1S/C29H51N3O6.ClH/c1-8-24(28(31)34)32-29(35)22(19(4)5)17-25(33)23(30)16-21(18(2)3)14-20-10-11-26(37-7)27(15-20)38-13-9-12-36-6;/h10-11,15,18-19,21-25,33H,8-9,12-14,16-17,30H2,1-7H3,(H2,31,34)(H,32,35);1H/p-1/t21-,22-,23-,24-,25-;/m0./s1
InChiKey: ZMASIJMHDUTSBZ-LLXHTMMXSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	beta tubulin	0.0028	0.0098	0.2062
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0118	0.0444	0.3299
Schistosoma mansoni	polycystin 1-related	0.002	0.0065	0.0448
Plasmodium falciparum	alpha tubulin 1	0.0011	0.003	0.0554
Echinococcus granulosus	tubulin alpha 3 chain	0.0011	0.003	0.0415
Schistosoma mansoni	tyrosine kinase	0.0006	0.0009	0.0027
Trypanosoma brucei	beta tubulin	0.0011	0.003	0.0546
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0118	0.0444	1
Brugia malayi	tubulin alpha-2 chain	0.0011	0.003	0.0415
Schistosoma mansoni	hypothetical protein	0.002	0.0065	0.0448
Leishmania major	beta tubulin	0.0028	0.0098	0.2062
Schistosoma mansoni	memapsin-2 (A01 family)	0.0028	0.0095	0.0673
Echinococcus granulosus	tubulin alpha chain	0.0011	0.003	0.0415
Plasmodium vivax	aspartyl protease, putative	0.0028	0.0095	0.204
Brugia malayi	Tubulin alpha-2 chain	0.0011	0.003	0.0415
Loa Loa (eye worm)	tubulin beta-1 chain	0.0028	0.0098	0.1567
Schistosoma mansoni	rab6-interacting	0.002	0.0065	0.0448
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0006	0.0009	0.0011
Brugia malayi	Tubulin gamma chain	0.0011	0.003	0.0415
Echinococcus multilocularis	tubulin alpha 3 chain	0.0011	0.003	0.0076
Plasmodium vivax	tubulin gamma chain, putative	0.0011	0.003	0.0554
Echinococcus multilocularis	c src tyrosine kinase	0.0006	0.0009	0.0011
Brugia malayi	hypothetical protein	0.0028	0.0095	0.1528
Plasmodium falciparum	plasmepsin I	0.0118	0.0444	1
Plasmodium falciparum	plasmepsin IX	0.0028	0.0095	0.204
Echinococcus granulosus	beta tubulin	0.0028	0.0098	0.1567
Echinococcus multilocularis	mitogen activated protein kinase 11	0.012	0.045	0.139
Leishmania major	alpha tubulin	0.0011	0.003	0.0546
Schistosoma mansoni	tubulin subunit alpha	0.0011	0.003	0.0183
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0006	0.0012	0.0129
Trypanosoma cruzi	epsilon tubulin, putative	0.0011	0.003	0.0546
Mycobacterium ulcerans	3-dehydroquinate dehydratase	0.2588	1	1
Leishmania major	alpha tubulin	0.0011	0.003	0.0546
Brugia malayi	aspartic protease BmAsp-1, identical	0.0028	0.0095	0.1528
Trichomonas vaginalis	tubulin alpha chain, putative	0.0011	0.003	0.0554
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0006	0.0009	0.0061
Echinococcus granulosus	tubulin alpha	0.0011	0.003	0.0415
Echinococcus multilocularis	mitogen activated protein kinase 14	0.012	0.045	0.139
Toxoplasma gondii	alpha-tubulin I, putative	0.0011	0.003	0.0554
Trypanosoma brucei	beta tubulin	0.0028	0.0098	0.2062
Loa Loa (eye worm)	beta-tubulin	0.0028	0.0098	0.1567
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0006	0.0009	0.0011
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0011	0.003	0.0076
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0011	0.003	0.0554
Brugia malayi	Tubulin alpha chain	0.0011	0.003	0.0415
Leishmania major	beta tubulin	0.0028	0.0098	0.2062
Loa Loa (eye worm)	tubulin gamma chain	0.0011	0.003	0.0415
Schistosoma mansoni	tyrosine kinase	0.0006	0.0009	0.0027
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0006	0.0009	0.0061
Echinococcus granulosus	mitogen activated protein kinase 14	0.012	0.045	0.7601
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0028	0.0095	0.0673
Plasmodium falciparum	tubulin gamma chain	0.0011	0.003	0.0554
Schistosoma mansoni	serine/threonine protein kinase	0.0156	0.059	0.4404
Echinococcus multilocularis	Tubulin beta 2C chain	0.0028	0.0098	0.0287
Plasmodium falciparum	tubulin epsilon chain, putative	0.0011	0.003	0.0554
Leishmania major	beta tubulin	0.0028	0.0098	0.2062
Leishmania major	alpha tubulin	0.0011	0.003	0.0546
Plasmodium vivax	plasmepsin IV, putative	0.0118	0.0444	1
Echinococcus granulosus	RUN	0.002	0.0065	0.1018
Echinococcus multilocularis	tubulin gamma 1 chain	0.0011	0.003	0.0076
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0118	0.0444	0.7491
Brugia malayi	P38 map kinase family protein 2	0.012	0.045	0.7601
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.0065	0.1018
Schistosoma mansoni	tubulin subunit beta	0.0028	0.0098	0.069
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0011	0.003	0.0554
Toxoplasma gondii	eukaryotic aspartyl protease superfamily protein	0.0028	0.0095	0.204
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.0065	0.1018
Brugia malayi	alpha-tubulin	0.0011	0.003	0.0415
Echinococcus granulosus	c src tyrosine kinase	0.0006	0.0009	0.0061
Echinococcus granulosus	tubulin beta 4A class IVa	0.0028	0.0098	0.1567
Echinococcus granulosus	Tubulin beta 2C chain	0.0028	0.0098	0.1567
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0095	0.1528
Giardia lamblia	Alpha-tubulin	0.0011	0.003	0.2648
Giardia lamblia	Beta tubulin	0.0028	0.0098	1
Plasmodium vivax	aspartyl protease, putative	0.0028	0.0095	0.204
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0011	0.003	0.0554
Giardia lamblia	Beta tubulin	0.0028	0.0098	1
Trypanosoma brucei	beta tubulin	0.0028	0.0098	0.2062
Echinococcus granulosus	tubulin alpha chain	0.0011	0.003	0.0415
Trypanosoma brucei	beta tubulin	0.0028	0.0098	0.2062
Leishmania major	beta tubulin	0.0028	0.0098	0.2062
Echinococcus granulosus	growth factor receptor bound protein 2	0.0005	0.0007	0.0013
Loa Loa (eye worm)	tubulin alpha 2	0.0006	0.0012	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0444	0.7491
Echinococcus granulosus	Tubulin beta 2C chain	0.0028	0.0098	0.1567
Echinococcus multilocularis	tubulin alpha chain	0.0011	0.003	0.0076
Echinococcus multilocularis	hypothetical protein	0.0011	0.003	0.0076
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0118	0.0444	0.137
Brugia malayi	beta-tubulin, identical	0.0028	0.0098	0.1567
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0118	0.0444	0.7491
Plasmodium vivax	tubulin alpha chain, putative	0.0011	0.003	0.0554
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0005	0.0007	0.0006
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0006	0.0009	0.0011
Loa Loa (eye worm)	aspartyl protease 6	0.0028	0.0095	0.1528
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0028	0.0095	0.1528
Trichomonas vaginalis	tubulin beta chain, putative	0.0006	0.0012	0.0129
Brugia malayi	Tubulin beta-1 chain	0.0028	0.0098	0.1567
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0831	0.3201	1
Schistosoma mansoni	loxhd1	0.002	0.0065	0.0448
Plasmodium vivax	multidomain scavenger receptor, putative	0.002	0.0065	0.136
Plasmodium vivax	aspartyl protease, putative	0.0028	0.0095	0.204
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.0065	0.0186
Loa Loa (eye worm)	tubulin alpha chain	0.0011	0.003	0.0415
Schistosoma mansoni	lipoxygenase	0.002	0.0065	0.0448
Leishmania major	alpha tubulin	0.0011	0.003	0.0546
Onchocerca volvulus		0.002	0.0065	0.6441
Loa Loa (eye worm)	hypothetical protein	0.002	0.0065	0.1018
Echinococcus multilocularis	tubulin alpha chain	0.0011	0.003	0.0076
Trichomonas vaginalis	tubulin beta chain, putative	0.0028	0.0098	0.2093
Schistosoma mansoni	tyrosine kinase	0.0006	0.0009	0.0027
Trypanosoma brucei	alpha tubulin	0.0011	0.003	0.0546
Schistosoma mansoni	cathepsin D (A01 family)	0.0348	0.1333	1
Brugia malayi	tubulin alpha chain - mouse	0.0011	0.003	0.0415
Trichomonas vaginalis	tubulin alpha chain, putative	0.0028	0.0098	0.2093
Entamoeba histolytica	hypothetical protein	0.0037	0.013	1
Echinococcus multilocularis	tubulin beta 1 chain	0.0028	0.0098	0.0287
Entamoeba histolytica	tubulin family protein	0.0028	0.0098	0.7509
Echinococcus granulosus	tubulin alpha 3 chain	0.0011	0.003	0.0415
Schistosoma mansoni	tubulin subunit alpha	0.0011	0.003	0.0183
Trypanosoma cruzi	beta tubulin, putative	0.0028	0.0098	0.2062
Plasmodium falciparum	plasmepsin IV	0.0118	0.0444	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0006	0.0012	0.0129
Schistosoma mansoni	tubulin subunit beta	0.0028	0.0098	0.069
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0006	0.0009	0.0061
Giardia lamblia	Gamma tubulin	0.0011	0.003	0.2648
Schistosoma mansoni	alpha tubulin	0.0011	0.003	0.0183
Leishmania major	epsilon tubulin, putative	0.0011	0.003	0.0546
Loa Loa (eye worm)	doublecortin family protein	0.002	0.0065	0.1018
Brugia malayi	hypothetical protein	0.002	0.0065	0.1018
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0006	0.0012	0.011
Plasmodium vivax	plasmepsin V, putative	0.0028	0.0095	0.204
Onchocerca volvulus		0.002	0.0065	0.6441
Schistosoma mansoni	tubulin subunit beta	0.0028	0.0098	0.069
Toxoplasma gondii	beta-tubulin, putative	0.0028	0.0098	0.2093
Trichomonas vaginalis	tubulin, putative	0.0006	0.0012	0.0129
Loa Loa (eye worm)	BEN-1 protein	0.0028	0.0098	0.1567
Trichomonas vaginalis	tubulin gamma chain, putative	0.0028	0.0098	0.2093
Leishmania major	beta tubulin	0.0028	0.0098	0.2062
Trichomonas vaginalis	tubulin beta chain, putative	0.0011	0.003	0.0554
Echinococcus granulosus	Tubulin alpha 1 chain	0.0011	0.003	0.0415
Toxoplasma gondii	aspartyl protease ASP3	0.0028	0.0095	0.204
Echinococcus granulosus	tubulin epsilon chain	0.0011	0.003	0.0415
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.013	0.2121
Plasmodium falciparum	plasmepsin VI	0.0118	0.0444	1
Loa Loa (eye worm)	alpha-tubulin	0.0011	0.003	0.0415
Loa Loa (eye worm)	tubulin beta-4 chain	0.0028	0.0098	0.1567
Schistosoma mansoni	tubulin subunit epsilon	0.0011	0.003	0.0183
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0011	0.003	0.0415
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0006	0.0009	0.0011
Loa Loa (eye worm)	hypothetical protein	0.002	0.0065	0.1018
Trichomonas vaginalis	tubulin beta chain, putative	0.0011	0.003	0.0554
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0028	0.0095	0.0673
Leishmania major	beta tubulin	0.0028	0.0098	0.2062
Echinococcus multilocularis	Tubulin beta 2C chain	0.0028	0.0098	0.0287
Echinococcus granulosus	tubulin alpha chain	0.0011	0.003	0.0415
Echinococcus multilocularis	mitogen activated protein kinase 14	0.012	0.045	0.139
Echinococcus granulosus	c-Jun N-terminal kinases	0.0156	0.059	1
Echinococcus multilocularis	Polycystic kidney disease protein	0.002	0.0065	0.0186
Echinococcus multilocularis	peroxisome assembly protein 26	0.0011	0.003	0.0076
Loa Loa (eye worm)	tubulin beta chain	0.0028	0.0098	0.1567
Plasmodium vivax	tubulin alpha chain, putative	0.0011	0.003	0.0554
Echinococcus granulosus	Tubulin alpha 1 chain	0.0011	0.003	0.0415
Leishmania major	beta tubulin	0.0028	0.0098	0.2062
Plasmodium falciparum	plasmepsin VII	0.0028	0.0095	0.204
Entamoeba histolytica	tubulin family protein	0.0028	0.0098	0.7509
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.0065	0.0186
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.012	0.045	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0005	0.0007	0.0013
Schistosoma mansoni	tubulin subunit beta	0.0028	0.0098	0.069
Trypanosoma brucei	epsilon tubulin	0.0011	0.003	0.0546
Trypanosoma brucei	epsilon tubulin	0.0011	0.003	0.0546
Schistosoma mansoni	tubulin subunit gamma	0.0011	0.003	0.0183
Treponema pallidum	cell division protein FtsZ	0.0005	0.0006	0.5
Entamoeba histolytica	hypothetical protein	0.0037	0.013	1
Leishmania major	beta tubulin	0.0028	0.0098	0.2062
Echinococcus granulosus	Polycystic kidney disease protein	0.002	0.0065	0.1018
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0006	0.0009	0.0061
Plasmodium vivax	aspartyl proteinase, putative	0.0118	0.0444	1
Toxoplasma gondii	alpha tubulin TUBA1	0.0011	0.003	0.0554
Brugia malayi	Variant SH3 domain containing protein	0.0005	0.0007	0.0013
Echinococcus multilocularis	tubulin alpha 1C chain	0.0011	0.003	0.0076
Echinococcus multilocularis	Tubulin beta 2C chain	0.0028	0.0098	0.0287
Echinococcus multilocularis	beta tubulin	0.0028	0.0098	0.0287
Loa Loa (eye worm)	CMGC/MAPK/JNK protein kinase	0.0156	0.059	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0011	0.003	0.0554
Trichomonas vaginalis	tubulin alpha chain, putative	0.0006	0.0012	0.0129
Schistosoma mansoni	tubulin subunit alpha	0.0011	0.003	0.0183
Giardia lamblia	Beta tubulin	0.0028	0.0098	1
Leishmania major	beta tubulin	0.0028	0.0098	0.2062
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0006	0.0009	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0007	0.0013
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0006	0.0009	0.0027
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0006	0.0009	0.0011
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0028	0.0095	0.0673
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0028	0.0098	0.2093
Brugia malayi	Tubulin beta chain	0.0006	0.0012	0.0097
Schistosoma mansoni	alpha tubulin	0.0011	0.003	0.0183
Echinococcus granulosus	Tubulin beta 2C chain	0.0028	0.0098	0.1567
Leishmania major	alpha tubulin	0.0011	0.003	0.0546
Brugia malayi	Pepsin A precursor	0.0028	0.0095	0.1528
Echinococcus granulosus	tubulin subunit TubB	0.0011	0.003	0.0415
Leishmania major	beta tubulin	0.0028	0.0098	0.2062
Schistosoma mansoni	tubulin subunit beta	0.0028	0.0098	0.069
Echinococcus multilocularis	tubulin epsilon chain	0.0011	0.003	0.0076
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0005	0.0007	0.0002
Plasmodium falciparum	alpha tubulin 2	0.0011	0.003	0.0554
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0006	0.0012	0.0097
Leishmania major	beta tubulin	0.0028	0.0098	0.2062
Plasmodium vivax	aspartyl proteinase, putative	0.0028	0.0095	0.204
Trichomonas vaginalis	tubulin gamma chain, putative	0.0011	0.003	0.0554
Trypanosoma cruzi	epsilon tubulin, putative	0.0011	0.003	0.0546
Loa Loa (eye worm)	tubulin alpha 2	0.0006	0.0012	0.0097
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0028	0.0095	0.1528
Plasmodium falciparum	LCCL domain-containing protein	0.002	0.0065	0.136
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0057	0.0206	0.0626
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0011	0.003	0.0076
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0006	0.0009	0.0061
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0006	0.0009	0.0011
Leishmania major	beta tubulin	0.0028	0.0098	0.2062
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0057	0.0206	0.3425
Echinococcus multilocularis	tubulin alpha chain	0.0011	0.003	0.0076
Echinococcus multilocularis	NCK adaptor protein	0.0005	0.0007	0.0002
Plasmodium falciparum	plasmepsin VIII, putative	0.0028	0.0095	0.204
Schistosoma mansoni	hypothetical protein	0.0037	0.013	0.0934
Leishmania major	alpha tubulin	0.0011	0.003	0.0546
Loa Loa (eye worm)	tubulin beta-2A chain	0.0028	0.0098	0.1567
Loa Loa (eye worm)	SRC-1	0.0006	0.0009	0.0061
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0006	0.0009	0.0011
Toxoplasma gondii	beta-1 tubulin, putative	0.0028	0.0098	0.2093
Brugia malayi	Sex muscle abnormal protein 5	0.0005	0.0007	0.0013
Trypanosoma brucei	alpha tubulin	0.0011	0.003	0.0546
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0028	0.0095	0.0673
Trichomonas vaginalis	tubulin, putative	0.0028	0.0098	0.2093
Echinococcus granulosus	alpha tubulin	0.0011	0.003	0.0415
Echinococcus granulosus	NCK adaptor protein	0.0005	0.0007	0.0013
Trichomonas vaginalis	tubulin beta chain, putative	0.0011	0.003	0.0554
Toxoplasma gondii	aspartyl protease ASP1	0.0118	0.0444	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0005	0.0007	0.0006
Echinococcus granulosus	tubulin beta 1 chain	0.0028	0.0098	0.1567
Trypanosoma brucei	tubulin gamma chain	0.0011	0.003	0.0546
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0006	0.0012	0.0129
Trichomonas vaginalis	tubulin beta chain, putative	0.0011	0.003	0.0554
Leishmania major	alpha tubulin	0.0011	0.003	0.0546
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0005	0.0007	0.0013
Plasmodium falciparum	plasmepsin II	0.0118	0.0444	1
Trypanosoma cruzi	tubulin gamma chain	0.0011	0.003	0.0546
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0006	0.0009	0.0061
Echinococcus granulosus	Tubulin alpha 1 chain	0.0011	0.003	0.0415
Echinococcus granulosus	tubulin alpha chain	0.0011	0.003	0.0415
Schistosoma mansoni	rab6-interacting	0.002	0.0065	0.0448
Trypanosoma cruzi	alpha tubulin, putative	0.0011	0.003	0.0546
Echinococcus multilocularis	beta tubulin	0.0028	0.0098	0.0287
Plasmodium falciparum	plasmepsin X	0.0028	0.0095	0.204
Trypanosoma brucei	beta tubulin	0.0028	0.0098	0.2062
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0011	0.003	0.0554
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.012	0.045	1
Schistosoma mansoni	cathepsin D (A01 family)	0.0348	0.1333	1
Entamoeba histolytica	hypothetical protein	0.0037	0.013	1
Brugia malayi	Doublecortin family protein	0.002	0.0065	0.1018
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.012	0.045	0.7601
Leishmania major	alpha tubulin	0.0011	0.003	0.0546
Trypanosoma brucei	alpha tubulin	0.0011	0.003	0.0546
Schistosoma mansoni	tyrosine kinase	0.0006	0.0009	0.0027
Schistosoma mansoni	nck2/grb4	0.0005	0.0007	0.0006
Echinococcus granulosus	Tubulin beta 2C chain	0.0028	0.0098	0.1567
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0028	0.0095	0.0673
Echinococcus multilocularis	Tubulin beta 2C chain	0.0028	0.0098	0.0287
Toxoplasma gondii	beta tubulin	0.0028	0.0098	0.2093
Echinococcus granulosus	tubulin alpha 1C chain	0.0011	0.003	0.0415
Echinococcus granulosus	peroxisome assembly protein 26	0.0011	0.003	0.0415
Entamoeba histolytica	hypothetical protein	0.0037	0.013	1
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.012	0.045	1
Brugia malayi	hypothetical protein	0.002	0.0065	0.1018
Entamoeba histolytica	tubulin gamma chain	0.0011	0.003	0.2323
Entamoeba histolytica	tubulin alpha chain, putative	0.0011	0.003	0.2323
Leishmania major	alpha tubulin	0.0011	0.003	0.0546
Echinococcus granulosus	tubulin alpha 1C chain	0.0011	0.003	0.0415
Brugia malayi	Stress-activated protein kinase jnk-1	0.0156	0.059	1
Brugia malayi	hypothetical protein	0.0037	0.013	0.2121
Loa Loa (eye worm)	hypothetical protein	0.0011	0.003	0.0415
Plasmodium vivax	tubulin beta chain, putative	0.0028	0.0098	0.2093
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.013	0.0934
Echinococcus granulosus	tubulin subunit beta	0.0028	0.0098	0.1567
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0028	0.0095	0.0673
Loa Loa (eye worm)	alpha-tubulin	0.0011	0.003	0.0415
Brugia malayi	Tubulin alpha-2 chain	0.0011	0.003	0.0415
Echinococcus granulosus	tubulin gamma 1 chain	0.0011	0.003	0.0415
Trichomonas vaginalis	tubulin gamma chain, putative	0.0011	0.003	0.0554
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0006	0.0009	0.0011
Leishmania major	beta tubulin	0.0028	0.0098	0.2062
Giardia lamblia	Alpha-tubulin	0.0011	0.003	0.2648
Echinococcus multilocularis	tubulin alpha 1C chain	0.0011	0.003	0.0076
Toxoplasma gondii	aspartyl protease	0.0028	0.0095	0.204
Leishmania major	beta tubulin	0.0028	0.0098	0.2062
Trichomonas vaginalis	tubulin alpha chain, putative	0.0006	0.0012	0.0129
Onchocerca volvulus		0.0028	0.0095	1
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0005	0.0006	0.5
Echinococcus multilocularis	c Jun NH2 terminal kinase	0.0156	0.059	0.1829
Trichomonas vaginalis	tubulin, putative	0.0006	0.0012	0.0129
Echinococcus multilocularis	tubulin alpha	0.0011	0.003	0.0076
Echinococcus granulosus	tubulin alpha chain	0.0011	0.003	0.0415
Brugia malayi	aspartic protease BmAsp-2, identical	0.0028	0.0095	0.1528
Loa Loa (eye worm)	BEN-1 protein	0.0028	0.0098	0.1567
Schistosoma mansoni	growth factor receptor-bound protein	0.0005	0.0007	0.0006
Leishmania major	alpha tubulin	0.0011	0.003	0.0546
Echinococcus multilocularis	tubulin subunit TubB	0.0011	0.003	0.0076
Echinococcus granulosus	Tubulin beta 2C chain	0.0028	0.0098	0.1567
Leishmania major	beta tubulin	0.0028	0.0098	0.2062
Trypanosoma brucei	alpha tubulin, putative	0.0006	0.0012	0.0127
Echinococcus multilocularis	tubulin subunit beta	0.0028	0.0098	0.0287
Echinococcus multilocularis	tubulin alpha 3 chain	0.0011	0.003	0.0076
Plasmodium falciparum	tubulin beta chain	0.0028	0.0098	0.2093
Echinococcus multilocularis	Tubulin beta 2C chain	0.0028	0.0098	0.0287
Echinococcus multilocularis	RUN	0.002	0.0065	0.0186
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0028	0.0095	0.0673
Onchocerca volvulus		0.0028	0.0095	1
Entamoeba histolytica	tubulin alpha-1 chain	0.0011	0.003	0.2323
Leishmania major	beta tubulin	0.0028	0.0098	0.2062
Trypanosoma brucei	alpha tubulin	0.0011	0.003	0.0546
Schistosoma mansoni	tubulin subunit beta	0.0028	0.0098	0.069
Mycobacterium tuberculosis	3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase)	0.2588	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0028	0.0098	0.2093
Leishmania major	gamma-tubulin	0.0011	0.003	0.0546
Echinococcus granulosus	mitogen activated protein kinase 11	0.012	0.045	0.7601
Trypanosoma brucei	epsilon tubulin	0.0011	0.003	0.0546
Schistosoma mansoni	adapter molecule crk	0.0005	0.0007	0.0006
Echinococcus granulosus	beta tubulin	0.0028	0.0098	0.1567
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0006	0.0009	0.0011
Echinococcus multilocularis	tubulin alpha chain	0.0011	0.003	0.0076
Leishmania major	beta tubulin	0.0028	0.0098	0.2062
Trichomonas vaginalis	tubulin beta chain, putative	0.0011	0.003	0.0554
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.013	0.0388
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0028	0.0098	0.0287
Plasmodium vivax	tubulin epsilon chain, putative	0.0011	0.003	0.0554
Plasmodium falciparum	plasmepsin V	0.0028	0.0095	0.204
Schistosoma mansoni	alpha tubulin	0.0011	0.003	0.0183
Echinococcus multilocularis	tubulin alpha chain	0.0011	0.003	0.0076
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0006	0.0009	0.0061
Brugia malayi	SRC-1	0.0006	0.0009	0.0061
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0011	0.003	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0012	0.0097
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0118	0.0444	1
Brugia malayi	Variant SH3 domain containing protein	0.0005	0.0007	0.0013
Loa Loa (eye worm)	tubulin alpha chain	0.0011	0.003	0.0415
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0028	0.0095	0.0673
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0006	0.0009	0.0061
Schistosoma mansoni	lipoxygenase	0.0057	0.0206	0.1508
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0006	0.0009	0.0011
Brugia malayi	Tyrosine-protein kinase abl-1	0.0006	0.0009	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0095	0.1528
Echinococcus multilocularis	mitogen activated protein kinase 11	0.012	0.045	0.139
Plasmodium falciparum	plasmepsin III	0.0028	0.0095	0.204
Leishmania major	alpha tubulin	0.0011	0.003	0.0546
Leishmania major	alpha tubulin	0.0011	0.003	0.0546
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.012	0.045	1
Brugia malayi	hypothetical protein	0.0028	0.0095	0.1528

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.6 nM	Inhibition of renin in human plasma	ChEMBL.	17824680
IC50 (binding)	= 0.8 nM	Inhibition of human renin	ChEMBL.	17824680
IC50 (binding)	= 1 nM	Inhibition of renin in marmoset plasma	ChEMBL.	17824680

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 489037

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 434129