Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | beta tubulin | 0.0026 | 0.0063 | 1 |
Echinococcus multilocularis | tubulin subunit beta | 0.0026 | 0.0063 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0026 | 0.0063 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0063 | 1 |
Mycobacterium ulcerans | 3-dehydroquinate dehydratase | 0.2554 | 1 | 0.5 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0026 | 0.0063 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0063 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0026 | 0.0063 | 1 |
Loa Loa (eye worm) | tubulin beta chain | 0.0026 | 0.0063 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0026 | 0.0063 | 1 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0026 | 0.0063 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0026 | 0.0063 | 1 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0026 | 0.0063 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0026 | 0.0063 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0026 | 0.0063 | 1 |
Trypanosoma cruzi | beta tubulin, putative | 0.0026 | 0.0063 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0063 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0026 | 0.0063 | 1 |
Trypanosoma brucei | beta tubulin | 0.0026 | 0.0063 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0026 | 0.0063 | 1 |
Loa Loa (eye worm) | beta-tubulin | 0.0026 | 0.0063 | 1 |
Giardia lamblia | Beta tubulin | 0.0026 | 0.0063 | 1 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0026 | 0.0063 | 1 |
Trichomonas vaginalis | tubulin, putative | 0.0026 | 0.0063 | 1 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0026 | 0.0063 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0026 | 0.0063 | 1 |
Trypanosoma brucei | beta tubulin | 0.0026 | 0.0063 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0063 | 1 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0026 | 0.0063 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0026 | 0.0063 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0026 | 0.0063 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0063 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0063 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0063 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0063 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0026 | 0.0063 | 1 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0026 | 0.0063 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0026 | 0.0063 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0026 | 0.0063 | 1 |
Echinococcus granulosus | beta tubulin | 0.0026 | 0.0063 | 1 |
Echinococcus granulosus | beta tubulin | 0.0026 | 0.0063 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0026 | 0.0063 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0063 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0063 | 1 |
Echinococcus multilocularis | beta tubulin | 0.0026 | 0.0063 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0026 | 0.0063 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0063 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0063 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0026 | 0.0063 | 1 |
Brugia malayi | Tubulin beta-1 chain | 0.0026 | 0.0063 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0063 | 1 |
Brugia malayi | beta-tubulin, identical | 0.0026 | 0.0063 | 1 |
Echinococcus multilocularis | beta tubulin | 0.0026 | 0.0063 | 1 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0026 | 0.0063 | 1 |
Giardia lamblia | Beta tubulin | 0.0026 | 0.0063 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0026 | 0.0063 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0063 | 1 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0026 | 0.0063 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0026 | 0.0063 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0063 | 1 |
Toxoplasma gondii | beta-tubulin, putative | 0.0026 | 0.0063 | 1 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0026 | 0.0063 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0026 | 0.0063 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0026 | 0.0063 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0026 | 0.0063 | 1 |
Plasmodium falciparum | tubulin beta chain | 0.0026 | 0.0063 | 1 |
Echinococcus granulosus | tubulin subunit beta | 0.0026 | 0.0063 | 1 |
Trypanosoma brucei | beta tubulin | 0.0026 | 0.0063 | 1 |
Mycobacterium tuberculosis | 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) | 0.2554 | 1 | 0.5 |
Leishmania major | beta tubulin | 0.0026 | 0.0063 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0026 | 0.0063 | 1 |
Trypanosoma brucei | beta tubulin | 0.0026 | 0.0063 | 1 |
Giardia lamblia | Beta tubulin | 0.0026 | 0.0063 | 1 |
Plasmodium vivax | tubulin beta chain, putative | 0.0026 | 0.0063 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0063 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0063 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Effect on U937 cell morphology assessed as irregular membrane protrusions at 0.39 ug/ml after 24 hrs | ChEMBL. | 17887662 |
IC50 (functional) | = 5.64 | Anticancer activity against human U937 cells by MTS assay | ChEMBL. | 20056518 |
IC50 (functional) | = 0.58 uM | Cytotoxicity against human Jurkat cells by MTS assay after 24 hrs | ChEMBL. | 17887662 |
IC50 (functional) | = 0.58 uM | Cytotoxicity against human Jurkat cells by MTS assay after 24 hrs | ChEMBL. | 17887662 |
IC50 (functional) | = 2.3 uM | Cytotoxicity against human U937 cells by MTS assay after 24 hrs | ChEMBL. | 17887662 |
IC50 (functional) | = 2.3 uM | Cytotoxicity against human U937 cells by MTS assay after 24 hrs | ChEMBL. | 17887662 |
IC50 (functional) | = 2.4 uM | Cytotoxicity against human A375 cells by MTS assay after 24 hrs | ChEMBL. | 17887662 |
IC50 (functional) | = 2.4 uM | Cytotoxicity against human A375 cells by MTS assay after 24 hrs | ChEMBL. | 17887662 |
IC50 (functional) | = 2.92 uM | Cytotoxicity against human MD-MB-231 cells by MTS assay after 24 hrs | ChEMBL. | 17887662 |
IC50 (functional) | = 3.36 uM | Cytotoxicity against human HCT116 cells by MTS assay after 24 hrs | ChEMBL. | 17887662 |
IC50 (functional) | = 3.36 uM | Cytotoxicity against human HCT116 cells by MTS assay after 24 hrs | ChEMBL. | 17887662 |
IC50 (functional) | = 4.22 uM | Cytotoxicity against human MCF7 cells by MTS assay after 24 hrs | ChEMBL. | 17887662 |
IC50 (functional) | = 4.22 uM | Cytotoxicity against human MCF7 cells by MTS assay after 24 hrs | ChEMBL. | 17887662 |
IC50 (functional) | = 10.9 uM | Cytotoxicity against human PC3 cells by MTS assay after 24 hrs | ChEMBL. | 17887662 |
IC50 (functional) | = 10.9 uM | Cytotoxicity against human PC3 cells by MTS assay after 24 hrs | ChEMBL. | 17887662 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 17887662 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.