Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Ovis aries | Ghrelin receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | orexin receptor type 2 | Ghrelin receptor | 366 aa | 358 aa | 21.5 % |
Brugia malayi | ORL1-like opioid receptor | Ghrelin receptor | 366 aa | 302 aa | 24.2 % |
Onchocerca volvulus | E3 ubiquitin-protein ligase rpm-1 homolog | Ghrelin receptor | 366 aa | 306 aa | 22.2 % |
Onchocerca volvulus | Ghrelin receptor | 366 aa | 358 aa | 20.7 % | |
Onchocerca volvulus | Ghrelin receptor | 366 aa | 351 aa | 22.5 % | |
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Ghrelin receptor | 366 aa | 340 aa | 22.1 % |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | Ghrelin receptor | 366 aa | 329 aa | 27.4 % |
Echinococcus granulosus | orexin receptor type 2 | Ghrelin receptor | 366 aa | 360 aa | 23.3 % |
Schistosoma mansoni | rhodopsin-like orphan GPCR | Ghrelin receptor | 366 aa | 313 aa | 20.8 % |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | Ghrelin receptor | 366 aa | 342 aa | 22.8 % |
Onchocerca volvulus | Ghrelin receptor | 366 aa | 361 aa | 20.5 % | |
Onchocerca volvulus | Mitochondrial inner membrane protein homolog | Ghrelin receptor | 366 aa | 327 aa | 20.5 % |
Onchocerca volvulus | Ghrelin receptor | 366 aa | 310 aa | 20.0 % | |
Loa Loa (eye worm) | hypothetical protein | Ghrelin receptor | 366 aa | 297 aa | 24.2 % |
Echinococcus multilocularis | allatostatin A receptor | Ghrelin receptor | 366 aa | 323 aa | 25.1 % |
Echinococcus granulosus | g protein coupled receptor | Ghrelin receptor | 366 aa | 337 aa | 24.3 % |
Echinococcus granulosus | allatostatin A receptor | Ghrelin receptor | 366 aa | 323 aa | 25.1 % |
Echinococcus multilocularis | dro:myosuppressin receptor | Ghrelin receptor | 366 aa | 380 aa | 21.8 % |
Onchocerca volvulus | Ghrelin receptor | 366 aa | 317 aa | 23.3 % | |
Echinococcus granulosus | dro:myosuppressin receptor | Ghrelin receptor | 366 aa | 380 aa | 21.8 % |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Ghrelin receptor | 366 aa | 349 aa | 25.5 % |
Echinococcus multilocularis | g protein coupled receptor | Ghrelin receptor | 366 aa | 339 aa | 23.3 % |
Brugia malayi | GnHR receptor homolog | Ghrelin receptor | 366 aa | 308 aa | 21.4 % |
Onchocerca volvulus | Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog | Ghrelin receptor | 366 aa | 313 aa | 22.4 % |
Loa Loa (eye worm) | hypothetical protein | Ghrelin receptor | 366 aa | 310 aa | 23.5 % |
Echinococcus granulosus | thyrotropin releasing hormone receptor | Ghrelin receptor | 366 aa | 329 aa | 27.4 % |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Ghrelin receptor | 366 aa | 299 aa | 26.1 % |
Schistosoma mansoni | adenoreceptor | Ghrelin receptor | 366 aa | 321 aa | 26.2 % |
Schistosoma mansoni | peptide (allatostatin)-like receptor | Ghrelin receptor | 366 aa | 306 aa | 26.1 % |
Onchocerca volvulus | Ghrelin receptor | 366 aa | 308 aa | 22.1 % | |
Onchocerca volvulus | Ghrelin receptor | 366 aa | 318 aa | 23.9 % | |
Onchocerca volvulus | Phospholipase d-related homolog | Ghrelin receptor | 366 aa | 304 aa | 18.8 % |
Loa Loa (eye worm) | neuropeptide F receptor | Ghrelin receptor | 366 aa | 306 aa | 21.6 % |
Echinococcus multilocularis | fmrfamide receptor | Ghrelin receptor | 366 aa | 295 aa | 20.0 % |
Onchocerca volvulus | Ghrelin receptor | 366 aa | 299 aa | 23.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | 3-dehydroquinate dehydratase | 0.1277 | 1 | 0.5 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0028 | 0.0135 | 1 |
Leishmania major | beta tubulin | 0.0028 | 0.0135 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0028 | 0.0135 | 1 |
Trypanosoma brucei | beta tubulin | 0.0028 | 0.0135 | 1 |
Leishmania major | beta tubulin | 0.0028 | 0.0135 | 1 |
Echinococcus granulosus | beta tubulin | 0.0028 | 0.0135 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0028 | 0.0135 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0028 | 0.0135 | 1 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0028 | 0.0135 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0028 | 0.0135 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0028 | 0.0135 | 1 |
Trypanosoma cruzi | beta tubulin, putative | 0.0028 | 0.0135 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0028 | 0.0135 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0028 | 0.0135 | 1 |
Echinococcus multilocularis | tubulin subunit beta | 0.0028 | 0.0135 | 1 |
Trichomonas vaginalis | tubulin, putative | 0.0028 | 0.0135 | 1 |
Leishmania major | beta tubulin | 0.0028 | 0.0135 | 1 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0028 | 0.0135 | 1 |
Giardia lamblia | Beta tubulin | 0.0028 | 0.0135 | 1 |
Leishmania major | beta tubulin | 0.0028 | 0.0135 | 1 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0028 | 0.0135 | 1 |
Leishmania major | beta tubulin | 0.0028 | 0.0135 | 1 |
Toxoplasma gondii | beta-tubulin, putative | 0.0028 | 0.0135 | 1 |
Brugia malayi | Tubulin beta-1 chain | 0.0028 | 0.0135 | 1 |
Plasmodium falciparum | tubulin beta chain | 0.0028 | 0.0135 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0028 | 0.0135 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0028 | 0.0135 | 1 |
Leishmania major | beta tubulin | 0.0028 | 0.0135 | 1 |
Trypanosoma brucei | beta tubulin | 0.0028 | 0.0135 | 1 |
Brugia malayi | beta-tubulin, identical | 0.0028 | 0.0135 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0028 | 0.0135 | 1 |
Echinococcus granulosus | tubulin subunit beta | 0.0028 | 0.0135 | 1 |
Giardia lamblia | Beta tubulin | 0.0028 | 0.0135 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0028 | 0.0135 | 1 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0028 | 0.0135 | 1 |
Leishmania major | beta tubulin | 0.0028 | 0.0135 | 1 |
Toxoplasma gondii | beta tubulin | 0.0028 | 0.0135 | 1 |
Leishmania major | beta tubulin | 0.0028 | 0.0135 | 1 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0028 | 0.0135 | 1 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0028 | 0.0135 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0028 | 0.0135 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0028 | 0.0135 | 1 |
Leishmania major | beta tubulin | 0.0028 | 0.0135 | 1 |
Leishmania major | beta tubulin | 0.0028 | 0.0135 | 1 |
Echinococcus multilocularis | beta tubulin | 0.0028 | 0.0135 | 1 |
Leishmania major | beta tubulin | 0.0028 | 0.0135 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0028 | 0.0135 | 1 |
Leishmania major | beta tubulin | 0.0028 | 0.0135 | 1 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0028 | 0.0135 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0028 | 0.0135 | 1 |
Giardia lamblia | Beta tubulin | 0.0028 | 0.0135 | 1 |
Loa Loa (eye worm) | tubulin beta chain | 0.0028 | 0.0135 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0028 | 0.0135 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0028 | 0.0135 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0028 | 0.0135 | 1 |
Loa Loa (eye worm) | beta-tubulin | 0.0028 | 0.0135 | 1 |
Plasmodium vivax | tubulin beta chain, putative | 0.0028 | 0.0135 | 1 |
Leishmania major | beta tubulin | 0.0028 | 0.0135 | 1 |
Echinococcus granulosus | beta tubulin | 0.0028 | 0.0135 | 1 |
Mycobacterium tuberculosis | 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) | 0.1277 | 1 | 0.5 |
Leishmania major | beta tubulin | 0.0028 | 0.0135 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0028 | 0.0135 | 1 |
Trypanosoma brucei | beta tubulin | 0.0028 | 0.0135 | 1 |
Leishmania major | beta tubulin | 0.0028 | 0.0135 | 1 |
Leishmania major | beta tubulin | 0.0028 | 0.0135 | 1 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0028 | 0.0135 | 1 |
Leishmania major | beta tubulin | 0.0028 | 0.0135 | 1 |
Echinococcus multilocularis | beta tubulin | 0.0028 | 0.0135 | 1 |
Trypanosoma brucei | beta tubulin | 0.0028 | 0.0135 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0028 | 0.0135 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0028 | 0.0135 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0028 | 0.0135 | 1 |
Leishmania major | beta tubulin | 0.0028 | 0.0135 | 1 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0028 | 0.0135 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0028 | 0.0135 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cmax (ADMET) | = 0.14 uM | Cmax in Wistar rat at 3 mg/kg, po | ChEMBL. | 17887659 |
E/Emax (functional) | = -20 % | Agonist activity at human recombinant GHSR1a expressed in HEK293F cells assessed as stimulation of [35S]GTPgammaS binding relative to ghrelin | ChEMBL. | 17887659 |
E/Emax (functional) | = -20 % | Agonist activity at human recombinant GHSR1a expressed in HEK293F cells assessed as stimulation of [35S]GTPgammaS binding relative to ghrelin | ChEMBL. | 17887659 |
Kbapp (functional) | = 6.4 nM | Antagonist activity at human recombinant GHSR1a expressed in HEK293F cells by [35S]GTPgammaS binding assay | ChEMBL. | 17887659 |
Kbapp (functional) | = 6.4 nM | Antagonist activity at human recombinant GHSR1a expressed in HEK293F cells by [35S]GTPgammaS binding assay | ChEMBL. | 17887659 |
Ki (binding) | = 4 nM | Displacement of [125I]ghrelin from ovine recombinant GHSR1a expressed in HEK293F cells after 6 hrs by scintillation proximity assay | ChEMBL. | 17887659 |
Ki (binding) | = 4 nM | Displacement of [125I]ghrelin from ovine recombinant GHSR1a expressed in HEK293F cells after 6 hrs by scintillation proximity assay | ChEMBL. | 17887659 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.