Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kinesin family member 11 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | beta tubulin | 0.0028 | 0.0065 | 1 |
Leishmania major | beta tubulin | 0.0028 | 0.0065 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0028 | 0.0065 | 0.0717 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0032 | 0.0081 | 1 |
Leishmania major | beta tubulin | 0.0028 | 0.0065 | 1 |
Loa Loa (eye worm) | tubulin beta chain | 0.0028 | 0.0065 | 0.7949 |
Schistosoma mansoni | tubulin subunit beta | 0.0028 | 0.0065 | 0.083 |
Entamoeba histolytica | kinesin, putative | 0.0032 | 0.0081 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0028 | 0.0065 | 0.0717 |
Leishmania major | beta tubulin | 0.0028 | 0.0065 | 1 |
Leishmania major | beta tubulin | 0.0028 | 0.0065 | 1 |
Giardia lamblia | Beta tubulin | 0.0028 | 0.0065 | 0.7949 |
Toxoplasma gondii | beta tubulin | 0.0028 | 0.0065 | 0.7949 |
Echinococcus multilocularis | beta tubulin | 0.0028 | 0.0065 | 0.0717 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0028 | 0.0065 | 0.7949 |
Echinococcus multilocularis | kinesin family 1 | 0.0247 | 0.0901 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0028 | 0.0065 | 0.7949 |
Entamoeba histolytica | tubulin family protein | 0.0028 | 0.0065 | 0.7949 |
Leishmania major | beta tubulin | 0.0028 | 0.0065 | 1 |
Leishmania major | beta tubulin | 0.0028 | 0.0065 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0028 | 0.0065 | 0.0717 |
Loa Loa (eye worm) | BEN-1 protein | 0.0028 | 0.0065 | 0.7949 |
Giardia lamblia | Beta tubulin | 0.0028 | 0.0065 | 0.7949 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0028 | 0.0065 | 0.0717 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0028 | 0.0065 | 0.7949 |
Plasmodium falciparum | tubulin beta chain | 0.0028 | 0.0065 | 0.7949 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0028 | 0.0065 | 0.0717 |
Leishmania major | beta tubulin | 0.0028 | 0.0065 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0028 | 0.0065 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0215 | 0.0778 | 1 |
Plasmodium falciparum | kinesin-5 | 0.0032 | 0.0081 | 1 |
Mycobacterium tuberculosis | 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) | 0.2639 | 1 | 0.5 |
Trichomonas vaginalis | tubulin, putative | 0.0028 | 0.0065 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0028 | 0.0065 | 0.083 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0028 | 0.0065 | 0.0717 |
Echinococcus multilocularis | beta tubulin | 0.0028 | 0.0065 | 0.0717 |
Leishmania major | beta tubulin | 0.0028 | 0.0065 | 1 |
Trypanosoma brucei | beta tubulin | 0.0028 | 0.0065 | 1 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0028 | 0.0065 | 0.7949 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0028 | 0.0065 | 0.0717 |
Schistosoma mansoni | kinesin eg-5 | 0.0032 | 0.0081 | 0.1044 |
Echinococcus multilocularis | tubulin subunit beta | 0.0028 | 0.0065 | 0.0717 |
Leishmania major | beta tubulin | 0.0028 | 0.0065 | 1 |
Brugia malayi | beta-tubulin, identical | 0.0028 | 0.0065 | 0.7949 |
Trypanosoma brucei | beta tubulin | 0.0028 | 0.0065 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0028 | 0.0065 | 0.083 |
Entamoeba histolytica | tubulin family protein | 0.0028 | 0.0065 | 0.7949 |
Echinococcus granulosus | tubulin subunit beta | 0.0028 | 0.0065 | 0.0717 |
Leishmania major | beta tubulin | 0.0028 | 0.0065 | 1 |
Toxoplasma gondii | beta-tubulin, putative | 0.0028 | 0.0065 | 0.7949 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0028 | 0.0065 | 0.0717 |
Schistosoma mansoni | tubulin subunit beta | 0.0028 | 0.0065 | 0.083 |
Brugia malayi | Tubulin beta-1 chain | 0.0028 | 0.0065 | 0.7949 |
Loa Loa (eye worm) | beta-tubulin | 0.0028 | 0.0065 | 0.7949 |
Leishmania major | beta tubulin | 0.0028 | 0.0065 | 1 |
Leishmania major | beta tubulin | 0.0028 | 0.0065 | 1 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0032 | 0.0081 | 1 |
Leishmania major | beta tubulin | 0.0028 | 0.0065 | 1 |
Mycobacterium ulcerans | 3-dehydroquinate dehydratase | 0.2639 | 1 | 0.5 |
Leishmania major | beta tubulin | 0.0028 | 0.0065 | 1 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0028 | 0.0065 | 1 |
Leishmania major | beta tubulin | 0.0028 | 0.0065 | 1 |
Echinococcus granulosus | beta tubulin | 0.0028 | 0.0065 | 0.0717 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0028 | 0.0065 | 1 |
Plasmodium vivax | kinesin-5 | 0.0032 | 0.0081 | 1 |
Trypanosoma cruzi | beta tubulin, putative | 0.0028 | 0.0065 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0028 | 0.0065 | 0.0717 |
Echinococcus granulosus | beta tubulin | 0.0028 | 0.0065 | 0.0717 |
Schistosoma mansoni | tubulin subunit beta | 0.0028 | 0.0065 | 0.083 |
Leishmania major | beta tubulin | 0.0028 | 0.0065 | 1 |
Giardia lamblia | Beta tubulin | 0.0028 | 0.0065 | 0.7949 |
Leishmania major | beta tubulin | 0.0028 | 0.0065 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0028 | 0.0065 | 0.0717 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0028 | 0.0065 | 0.7949 |
Schistosoma mansoni | tubulin subunit beta | 0.0028 | 0.0065 | 0.083 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0028 | 0.0065 | 1 |
Giardia lamblia | Kinesin-5 | 0.0032 | 0.0081 | 1 |
Leishmania major | beta tubulin | 0.0028 | 0.0065 | 1 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0028 | 0.0065 | 1 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0028 | 0.0065 | 0.0717 |
Trypanosoma brucei | beta tubulin | 0.0028 | 0.0065 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0028 | 0.0065 | 0.0717 |
Brugia malayi | Kinesin motor domain containing protein | 0.0032 | 0.0081 | 1 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0028 | 0.0065 | 0.0717 |
Plasmodium vivax | tubulin beta chain, putative | 0.0028 | 0.0065 | 0.7949 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0028 | 0.0065 | 0.0717 |
Echinococcus granulosus | kinesin family 1 | 0.0247 | 0.0901 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7200 nM | Inhibition of human KSP motor domain by ATPase assay | ChEMBL. | 17725339 |
IC50 (binding) | = 7200 nM | Inhibition of human KSP motor domain by ATPase assay | ChEMBL. | 17725339 |
IC50 (functional) | > 20000 nM | Antiproliferative activity against human SKOV3 cells after 72 hrs | ChEMBL. | 17725339 |
IC50 (functional) | > 20000 nM | Antiproliferative activity against human SKOV3 cells after 72 hrs | ChEMBL. | 17725339 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.