Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | epoxide hydrolase 2, cytoplasmic | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium ulcerans | epoxide hydrolase EphA | Get druggable targets OG5_129061 | All targets in OG5_129061 |
Mycobacterium tuberculosis | Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) | Get druggable targets OG5_129061 | All targets in OG5_129061 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.4647 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0785 | 0.1358 | 0.1358 |
Loa Loa (eye worm) | hypothetical protein | 0.4647 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.4647 | 1 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0785 | 0.1358 | 0.1358 |
Onchocerca volvulus | 0.0785 | 0.1358 | 0.5 | |
Onchocerca volvulus | 0.0785 | 0.1358 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.4647 | 1 | 1 |
Onchocerca volvulus | 0.0785 | 0.1358 | 0.5 | |
Onchocerca volvulus | 0.0785 | 0.1358 | 0.5 | |
Schistosoma mansoni | gliotactin | 0.0785 | 0.1358 | 0.1358 |
Schistosoma mansoni | acetylcholinesterase | 0.0785 | 0.1358 | 0.1358 |
Echinococcus granulosus | carboxylesterase 5A | 0.4647 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.4647 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0785 | 0.1358 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.4647 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4647 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.4647 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.4647 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0785 | 0.1358 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.4647 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0785 | 0.1358 | 0.1358 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0785 | 0.1358 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.4647 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0785 | 0.1358 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0785 | 0.1358 | 0.1358 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0785 | 0.1358 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0785 | 0.1358 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0785 | 0.1358 | 0.1358 |
Onchocerca volvulus | 0.0785 | 0.1358 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.5 nM | Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay | ChEMBL. | 17894481 |
IC50 (binding) | = 2.5 nM | Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay | ChEMBL. | 17894481 |
Solubility | = 26 ug ml-1 | Solubility in sodium phosphate buffer at pH 7 | ChEMBL. | 17894481 |
Stabilty (ADMET) | 0 | Stability in human liver S9 fraction at 100 uM after 1 hr | ChEMBL. | 17894481 |
Stabilty (ADMET) | = 6.8 % | Stability in human liver microsomes at 100 uM after 1 hr | ChEMBL. | 17894481 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.