Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | epoxide hydrolase 2, cytoplasmic | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium ulcerans | epoxide hydrolase EphA | Get druggable targets OG5_129061 | All targets in OG5_129061 |
Mycobacterium tuberculosis | Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) | Get druggable targets OG5_129061 | All targets in OG5_129061 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0026 | 0.0134 | 1 |
Giardia lamblia | Beta tubulin | 0.0026 | 0.0134 | 1 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0026 | 0.0134 | 1 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0026 | 0.0134 | 1 |
Trichomonas vaginalis | tubulin, putative | 0.0026 | 0.0134 | 1 |
Trypanosoma brucei | beta tubulin | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0026 | 0.0134 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0026 | 0.0134 | 1 |
Trypanosoma cruzi | beta tubulin, putative | 0.0026 | 0.0134 | 1 |
Trypanosoma brucei | beta tubulin | 0.0026 | 0.0134 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0026 | 0.0134 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Loa Loa (eye worm) | beta-tubulin | 0.0026 | 0.0134 | 1 |
Mycobacterium ulcerans | 3-dehydroquinate dehydratase | 0.1204 | 1 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Loa Loa (eye worm) | tubulin beta chain | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0026 | 0.0134 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0026 | 0.0134 | 1 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0026 | 0.0134 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0026 | 0.0134 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0026 | 0.0134 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0026 | 0.0134 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0026 | 0.0134 | 1 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0026 | 0.0134 | 1 |
Toxoplasma gondii | beta tubulin | 0.0026 | 0.0134 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0026 | 0.0134 | 1 |
Echinococcus multilocularis | tubulin subunit beta | 0.0026 | 0.0134 | 1 |
Trypanosoma brucei | beta tubulin | 0.0026 | 0.0134 | 1 |
Echinococcus granulosus | tubulin subunit beta | 0.0026 | 0.0134 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Trypanosoma brucei | beta tubulin | 0.0026 | 0.0134 | 1 |
Mycobacterium tuberculosis | 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) | 0.1204 | 1 | 1 |
Giardia lamblia | Beta tubulin | 0.0026 | 0.0134 | 1 |
Plasmodium vivax | tubulin beta chain, putative | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Giardia lamblia | Beta tubulin | 0.0026 | 0.0134 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0026 | 0.0134 | 1 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0026 | 0.0134 | 1 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0026 | 0.0134 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0026 | 0.0134 | 1 |
Toxoplasma gondii | beta-tubulin, putative | 0.0026 | 0.0134 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0026 | 0.0134 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0026 | 0.0134 | 1 |
Plasmodium falciparum | tubulin beta chain | 0.0026 | 0.0134 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0026 | 0.0134 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0026 | 0.0134 | 1 |
Echinococcus granulosus | beta tubulin | 0.0026 | 0.0134 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0026 | 0.0134 | 1 |
Echinococcus granulosus | beta tubulin | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0026 | 0.0134 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Echinococcus multilocularis | beta tubulin | 0.0026 | 0.0134 | 1 |
Echinococcus multilocularis | beta tubulin | 0.0026 | 0.0134 | 1 |
Brugia malayi | beta-tubulin, identical | 0.0026 | 0.0134 | 1 |
Brugia malayi | Tubulin beta-1 chain | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0026 | 0.0134 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0026 | 0.0134 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0026 | 0.0134 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AUC (ADMET) | = 8400 min.g.nM/mg | AUC in dog at 0.3 mg/kg, po | ChEMBL. | 17894481 |
IC50 (binding) | = 1.3 nM | Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay | ChEMBL. | 17894481 |
IC50 (binding) | = 1.3 nM | Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay | ChEMBL. | 17894481 |
IC50 (binding) | = 1.3 nM | Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay | ChEMBL. | 19520575 |
IC50 (binding) | = 9.4 nM | Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis | ChEMBL. | 22522007 |
LogP | = 2.9 | Partition coefficient, log P of the compound | ChEMBL. | 17894481 |
MIC (functional) | > 17 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis H37Ra | ChEMBL. | 22522007 |
Solubility | = 34 ug ml-1 | Solubility in sodium phosphate buffer at pH 7 | ChEMBL. | 17894481 |
Stabilty (ADMET) | = 93 % | Stability in human liver microsomes at 100 uM after 1 hr | ChEMBL. | 17894481 |
Stabilty (ADMET) | = 97 % | Stability in human liver S9 fraction at 100 uM after 1 hr | ChEMBL. | 17894481 |
t1/2 (ADMET) | = 130 min | Elimination half life in dog at 0.3 mg/kg, po | ChEMBL. | 17894481 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.