Detailed information for compound 434469

Basic information

Technical information
  • TDR Targets ID: 434469
  • Name: methyl N-[6-[4-[[2-fluoro-5-(trifluoromethyl) phenyl]carbamoylamino]phenoxy]-1-methylbenzim idazol-2-yl]carbamate
  • MW: 517.432 | Formula: C24H19F4N5O4
  • H donors: 3 H acceptors: 3 LogP: 4.43 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)Nc1nc2c(n1C)cc(cc2)Oc1ccc(cc1)NC(=O)Nc1cc(ccc1F)C(F)(F)F
  • InChi: 1S/C24H19F4N5O4/c1-33-20-12-16(8-10-18(20)30-21(33)32-23(35)36-2)37-15-6-4-14(5-7-15)29-22(34)31-19-11-13(24(26,27)28)3-9-17(19)25/h3-12H,1-2H3,(H2,29,31,34)(H,30,32,35)
  • InChiKey: PXXIFHQHWGNCHG-UHFFFAOYSA-N  

Network

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Synonyms

  • methyl N-[6-[4-[[2-fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1-methyl-benzimidazol-2-yl]carbamate
  • N-[6-[4-[[[2-fluoro-5-(trifluoromethyl)anilino]-oxomethyl]amino]phenoxy]-1-methyl-2-benzimidazolyl]carbamic acid methyl ester
  • N-[6-[4-[[2-fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1-methyl-benzimidazol-2-yl]carbamic acid methyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TEK tyrosine kinase, endothelial Starlite/ChEMBL References
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni cell adhesion molecule 0.0007 0.0056 0.0056
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0004 0.0012 0.0012
Onchocerca volvulus Tyrosine kinase homolog 0.0172 0.2562 0.2568
Trypanosoma brucei trypanothione reductase 0.0014 0.0159 0.0233
Mycobacterium ulcerans phytoene synthase, CrtB 0.013 0.1929 0.442
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0032 0.0431 0.2156
Loa Loa (eye worm) notch protein 0.0211 0.3162 0.3162
Loa Loa (eye worm) hypothetical protein 0.0654 0.9901 0.9901
Brugia malayi Prion-like- 0.0007 0.0045 0.0045
Schistosoma mansoni hypothetical protein 0.0006 0.0032 0.0032
Schistosoma mansoni Fxna peptidase (M28 family) 0.0008 0.0066 0.0066
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.0067 0.0961 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0011 0.0111 0.0111
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0004 0.0012 0.0012
Brugia malayi MH2 domain containing protein 0.0043 0.0599 0.0599
Giardia lamblia Histone acetyltransferase GCN5 0.0027 0.036 0.1138
Brugia malayi Immunoglobulin domain containing protein 0.0004 0.0002 0.0002
Onchocerca volvulus Slit protein homolog 0.0211 0.3162 0.3172
Plasmodium vivax SET domain protein, putative 0.0022 0.0277 0.2737
Echinococcus granulosus cathepsin l cysteine peptidase 0.0007 0.0046 0.0046
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0006 0.0032 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0046 0.0076
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.013 0.1929 0.193
Brugia malayi Fibronectin type III domain containing protein 0.0004 0.0012 0.0012
Brugia malayi Fibronectin type III domain containing protein 0.0004 0.0012 0.0012
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0056 0.0056
Schistosoma mansoni glutathione synthetase 0.0017 0.0202 0.0203
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0004 0.0012 0.0012
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0011 0.0117 0.0117
Echinococcus granulosus nephrin 0.0007 0.0056 0.0056
Trypanosoma brucei unspecified product 0.0005 0.0021 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0054 0.0067
Echinococcus granulosus titin 0.0007 0.0056 0.0056
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0148 0.1368
Schistosoma mansoni cell adhesion molecule 0.0004 0.0002 0.0002
Echinococcus multilocularis Immunoglobulin 0.0004 0.0002 0.0002
Echinococcus granulosus Netrin receptor DCC 0.0004 0.0012 0.0012
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0005 0.002 0.0012
Schistosoma mansoni hypothetical protein 0.0211 0.3162 0.3176
Schistosoma mansoni netrin receptor unc5 0.0004 0.0002 0.0002
Leishmania major importin beta-1 subunit, putative 0.0009 0.0085 0.0116
Loa Loa (eye worm) hypothetical protein 0.0018 0.0219 0.0219
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0007 0.0045 0.0045
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0005 0.002 0.0012
Loa Loa (eye worm) beta-lactamase 0.0013 0.0148 0.0148
Echinococcus multilocularis thioredoxin glutathione reductase 0.0014 0.0161 0.0161
Echinococcus multilocularis transfer RNA-Phe 0.0007 0.0056 0.0056
Schistosoma mansoni basigin related 0.0004 0.0002 0.0002
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0008 0.0072 0.0182
Echinococcus multilocularis GPCR, family 2 0.0006 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0211 0.3162 0.3162
Loa Loa (eye worm) hypothetical protein 0.0004 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0111 0.1629 0.1629
Schistosoma mansoni nephrin 0.0018 0.0227 0.0228
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0264 0.3965 1
Onchocerca volvulus 0.0022 0.0277 0.0267
Loa Loa (eye worm) hypothetical protein 0.0654 0.9901 0.9901
Loa Loa (eye worm) hypothetical protein 0.0211 0.3162 0.3162
Leishmania major cathepsin L-like protease 0.0007 0.0046 0.0053
Loa Loa (eye worm) hypothetical protein 0.0004 0.0012 0.0012
Leishmania major solanesyl-diphosphate synthase, putative 0.0017 0.0202 0.0302
Schistosoma mansoni basigin related 0.0004 0.0002 0.0002
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0014 0.0154 0.0387
Brugia malayi Calcium binding EGF domain containing protein 0.0211 0.3162 0.3162
Echinococcus multilocularis cell adhesion molecule 0.0004 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0022 0.0277 0.0277
Schistosoma mansoni nicalin (M28 family) 0.0008 0.0066 0.0066
Loa Loa (eye worm) immunoglobulin domain-containing protein 0.0004 0.0002 0.0002
Echinococcus multilocularis cathepsin L cysteine protease 0.0007 0.0046 0.0046
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0007 0.0052 0.0063
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0056 0.0056
Giardia lamblia High cysteine protein 0.0211 0.3162 1
Loa Loa (eye worm) hypothetical protein 0.0004 0.0002 0.0002
Entamoeba histolytica recQ family helicase, putative 0.0005 0.0016 0.0098
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0014 0.0154 0.0225
Echinococcus multilocularis protein jagged 1 0.0211 0.3162 0.3162
Leishmania major squalene synthase, putative 0.0418 0.6309 1
Loa Loa (eye worm) thioredoxin reductase 0.0014 0.0159 0.0159
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0018 0.0219 0.0219
Trichomonas vaginalis D-aminoacylase, putative 0.0013 0.0148 0.0314
Brugia malayi basement membrane proteoglycan precursor 0.0004 0.0002 0.0002
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0007 0.0046 0.0474
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0017 0.0202 0.0202
Echinococcus multilocularis anosmin 1 0.0004 0.0012 0.0012
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0202 0.0302
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0007 0.0045 0.0045
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0004 0.0012 0.0012
Brugia malayi Blistered cuticle protein 3 0.0654 0.9901 0.9901
Loa Loa (eye worm) hypothetical protein 0.0004 0.0002 0.0002
Leishmania major cathepsin L-like protease 0.0007 0.0046 0.0053
Onchocerca volvulus Neurogenic locus notch homolog 0.0211 0.3162 0.3172
Echinococcus granulosus protein jagged 2 0.0211 0.3162 0.3162
Loa Loa (eye worm) polyprenyl synthetase 0.0017 0.0202 0.0202
Brugia malayi hypothetical protein 0.0654 0.9901 0.9901
Trypanosoma cruzi polyprenyl synthase, putative 0.0017 0.0202 0.0302
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0005 0.002 0.002
Onchocerca volvulus Cathepsin F homolog 0.0007 0.0046 0.0034
Echinococcus multilocularis snurportin 1 0.012 0.178 0.178
Trypanosoma cruzi cysteine peptidase, putative 0.0025 0.0326 0.0499
Entamoeba histolytica cysteine proteinase, putative 0.0007 0.0046 0.095
Echinococcus granulosus usherin 0.0004 0.0012 0.0012
Brugia malayi acetyltransferase, GNAT family protein 0.0101 0.1482 0.1482
Trichomonas vaginalis ap endonuclease, putative 0.0007 0.0052 0.009
Echinococcus multilocularis titin 0.0007 0.0056 0.0056
Loa Loa (eye worm) RecQ helicase 0.0009 0.0077 0.0077
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0017 0.0202 0.0955
Treponema pallidum exodeoxyribonuclease (exoA) 0.0007 0.0052 0.0135
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0202 0.0302
Mycobacterium ulcerans 3-dehydroquinate synthase 0.0103 0.151 0.345
Onchocerca volvulus Peroxidasin homolog 0.0657 0.9944 1
Onchocerca volvulus 0.0007 0.0046 0.0034
Mycobacterium ulcerans hypothetical protein 0.0008 0.0066 0.0107
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0148 0.0217
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0007 0.0046 0.0076
Loa Loa (eye worm) hypothetical protein 0.0211 0.3162 0.3162
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0007 0.0046 0.0076
Echinococcus granulosus neurogenic locus notch protein 4 0.0211 0.3162 0.3162
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0046 0.0076
Schistosoma mansoni ap endonuclease 0.0007 0.0052 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0054 0.0067
Onchocerca volvulus 0.0007 0.0046 0.0034
Leishmania major hypothetical protein, conserved 0.0008 0.0066 0.0086
Loa Loa (eye worm) UNCoordinated family member 0.0004 0.0012 0.0012
Brugia malayi Immunoglobulin I-set domain containing protein 0.0008 0.0068 0.0068
Echinococcus granulosus roundabout 2 0.0022 0.0282 0.0282
Echinococcus granulosus neuroglian 0.0014 0.0161 0.0161
Echinococcus multilocularis anosmin 1 0.0004 0.0012 0.0012
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0018 0.0219 0.0219
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0056 0.0056
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0017 0.0202 0.0422
Loa Loa (eye worm) glutathione reductase 0.0014 0.0159 0.0159
Entamoeba histolytica deoxycytidyl transferase, putative 0.0007 0.0054 0.1203
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0017 0.0202 0.0202
Brugia malayi myotactin form A 0.0004 0.0012 0.0012
Trypanosoma brucei farnesyl pyrophosphate synthase 0.0067 0.0961 0.1507
Brugia malayi Cathepsin L-like precursor 0.0007 0.0046 0.0046
Echinococcus multilocularis Immunoglobulin subtype 0.0004 0.0002 0.0002
Echinococcus multilocularis slit 2 protein 0.0211 0.3162 0.3162
Loa Loa (eye worm) animal heme peroxidase 0.0654 0.9901 0.9901
Echinococcus multilocularis protein jagged 2 0.0211 0.3162 0.3162
Echinococcus multilocularis glutaminyl peptide cyclotransferase 0.0008 0.0066 0.0066
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0017 0.0202 0.5452
Schistosoma mansoni NAALADASE L peptidase (M28 family) 0.0078 0.1127 0.1132
Toxoplasma gondii hypothetical protein 0.0008 0.0066 0.0166
Mycobacterium tuberculosis Probable hydrolase 0.0013 0.0148 0.0675
Loa Loa (eye worm) CAMK protein kinase 0.0007 0.0056 0.0056
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0032 0.0431 0.2156
Loa Loa (eye worm) hypothetical protein 0.0211 0.3162 0.3162
Brugia malayi hypothetical protein 0.0004 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0004 0.0012 0.0012
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0035 0.0485 0.244
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0007 0.0045 0.0045
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0017 0.0202 0.0302
Schistosoma mansoni cell polarity protein 0.0211 0.3162 0.3176
Loa Loa (eye worm) hypothetical protein 0.0004 0.0002 0.0002
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0007 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0004 0.0012 0.0012
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0005 0.0024 0.0024
Plasmodium falciparum cysteine proteinase falcipain 3 0.0007 0.0046 0.0474
Trypanosoma cruzi cysteine peptidase, putative 0.0025 0.0326 0.0499
Loa Loa (eye worm) hypothetical protein 0.0043 0.0607 0.0607
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0011 0.0111 0.0112
Brugia malayi Calcitonin receptor-like protein seb-1 0.0018 0.0219 0.0219
Onchocerca volvulus 0.0211 0.3162 0.3172
Loa Loa (eye worm) hypothetical protein 0.0004 0.0002 0.0002
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0004 0.0012 0.0012
Loa Loa (eye worm) projectin 0.0007 0.0056 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0046 0.0076
Toxoplasma gondii ABC1 family protein 0.0013 0.0148 0.0374
Trypanosoma cruzi trypanothione reductase, putative 0.0005 0.002 0.0012
Schistosoma mansoni factor for adipocyte differentiation 0.0004 0.0012 0.0012
Schistosoma mansoni tyrosine kinase 0.0009 0.008 0.0081
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0148 0.0217
Echinococcus multilocularis neuroglian 0.0011 0.0111 0.0111
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0111 0.0111
Schistosoma mansoni septate junction protein 0.0004 0.0002 0.0002
Mycobacterium ulcerans DNA polymerase IV 0.0007 0.0054 0.0081
Brugia malayi EGF-like domain containing protein 0.0211 0.3162 0.3162
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0014 0.0154 0.0326
Loa Loa (eye worm) hypothetical protein 0.066 1 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0005 0.0024 0.0024
Echinococcus granulosus importin subunit beta 1 0.0011 0.0118 0.0118
Schistosoma mansoni hypothetical protein 0.0006 0.0032 0.0032
Loa Loa (eye worm) leucyl aminopeptidase 0.0008 0.0066 0.0066
Echinococcus multilocularis lachesin 0.0007 0.0045 0.0045
Echinococcus multilocularis roundabout 2 0.0011 0.0111 0.0111
Trypanosoma cruzi cruzipain precursor, putative 0.0025 0.0326 0.0499
Trichomonas vaginalis D-aminoacylase, putative 0.0013 0.0148 0.0314
Onchocerca volvulus 0.0007 0.0056 0.0044
Loa Loa (eye worm) LAD-2 short isoform 0.0004 0.0002 0.0002
Echinococcus multilocularis tyrosine protein kinase otk 0.0007 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0654 0.9901 0.9901
Loa Loa (eye worm) hypothetical protein 0.0013 0.0148 0.0148
Brugia malayi SPRY domain containing protein 0.0004 0.0012 0.0012
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0004 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0211 0.3162 0.3162
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0004 0.0012 0.0012
Brugia malayi Cathepsin L-like precursor 0.0007 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0004 0.0013 0.0013
Echinococcus granulosus neural cadherin 0.0211 0.3162 0.3162
Giardia lamblia NADH oxidase lateral transfer candidate 0.0005 0.002 0.0062
Loa Loa (eye worm) hypothetical protein 0.0211 0.3162 0.3162
Mycobacterium tuberculosis Conserved hypothetical protein 0.0007 0.0054 0.0182
Echinococcus granulosus hemicentin 1 0.0007 0.0045 0.0045
Echinococcus multilocularis fibronectin type III domain-containing protein 0.0004 0.0012 0.0012
Echinococcus multilocularis hemicentin 1 0.0007 0.0045 0.0045
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0005 0.002 0.002
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0022 0.0277 0.0278
Mycobacterium tuberculosis Probable lipase LipD 0.0013 0.0148 0.0675
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0184 0.2746 0.2746
Schistosoma mansoni hypothetical protein 0.0004 0.0002 0.0002
Onchocerca volvulus 0.0007 0.0046 0.0034
Schistosoma mansoni hemicentin 0.0007 0.0056 0.0056
Trichomonas vaginalis esterase, putative 0.0013 0.0148 0.0314
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0017 0.0202 0.0766
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.0067 0.0961 0.1507
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0211 0.3162 0.3162
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0004 0.0012 0.0012
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0007 0.0054 0.0054
Trypanosoma cruzi polyprenyl synthase, putative 0.0017 0.0202 0.0302
Echinococcus granulosus Fibronectin type III domain containing protein 0.0004 0.0012 0.0012
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0007 0.0056 0.0056
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0111 0.0111
Echinococcus granulosus basement membrane specific heparan sulfate 0.0004 0.0002 0.0002
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0011 0.0111 0.0111
Brugia malayi Animal haem peroxidase family protein 0.0654 0.9901 0.9901
Schistosoma mansoni hypothetical protein 0.0004 0.0002 0.0002
Plasmodium falciparum importin beta, putative 0.0011 0.0118 0.1224
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0152 0.2256 0.2256
Loa Loa (eye worm) blistered cuticle protein 3 0.0654 0.9901 0.9901
Chlamydia trachomatis UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0161 0.24 0.6035
Brugia malayi Latrophilin receptor protein 2 0.0006 0.0032 0.0032
Schistosoma mansoni nephrin related 0.0004 0.0002 0.0002
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0004 0.0012 0.0012
Brugia malayi protein unc-22 0.0007 0.0056 0.0056
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0032 0.0431 0.2156
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0004 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0211 0.3162 0.3162
Echinococcus multilocularis neuroglian 0.0014 0.0161 0.0161
Trypanosoma cruzi cysteine peptidase, putative 0.0025 0.0326 0.0499
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.0067 0.0961 0.493
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0264 0.3965 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0007 0.0046 0.0046
Brugia malayi basement membrane proteoglycan 0.0004 0.0002 0.0002
Echinococcus multilocularis Immunoglobulin 0.0004 0.0002 0.0002
Echinococcus multilocularis cell adhesion molecule:down regulated by 0.0004 0.0002 0.0002
Echinococcus multilocularis roundabout 2 0.0022 0.0282 0.0282
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0007 0.0046 0.0076
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0017 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0211 0.3162 0.3162
Trichomonas vaginalis D-aminoacylase, putative 0.0013 0.0148 0.0314
Schistosoma mansoni hypothetical protein 0.0211 0.3162 0.3176
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0006 0.0034 0.0085
Brugia malayi Immunoglobulin I-set domain containing protein 0.0004 0.0002 0.0002
Echinococcus granulosus glutaminyl peptide cyclotransferase 0.0008 0.0066 0.0066
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.0067 0.0961 0.0961
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0008 0.0066 0.0066
Echinococcus multilocularis neural cadherin 0.0211 0.3162 0.3162
Echinococcus granulosus histone acetyltransferase KAT2B 0.003 0.0398 0.0398
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0005 0.002 0.0012
Echinococcus granulosus notch 0.0211 0.3162 0.3162
Brugia malayi beta-lactamase 0.0013 0.0148 0.0148
Loa Loa (eye worm) acetyltransferase 0.0101 0.1482 0.1482
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0007 0.0054 0.0055
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0017 0.0202 0.2101
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0326 0.0499
Entamoeba histolytica cysteine proteinase, putative 0.0007 0.0046 0.095
Brugia malayi cathepsin L-like precursor 0.0004 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0011 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0004 0.0012 0.0012
Onchocerca volvulus 0.0211 0.3162 0.3172
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0007 0.0046 0.0076
Onchocerca volvulus 0.0007 0.0046 0.0034
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0013 0.0148 0.0148
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0004 0.0002 0.0002
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0004 0.0012 0.0012
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0008 0.0066 0.0066
Schistosoma mansoni inositol monophosphatase 0.0014 0.0154 0.0154
Schistosoma mansoni hypothetical protein 0.0007 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0211 0.3162 0.3162
Schistosoma mansoni hypothetical protein 0.0004 0.0012 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0046 0.0076
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0017 0.0202 0.0302
Brugia malayi Fibronectin type III domain containing protein 0.0016 0.0183 0.0183
Brugia malayi Delta serrate ligand family protein 0.0211 0.3162 0.3162
Brugia malayi Immunoglobulin domain containing protein 0.0004 0.0002 0.0002
Echinococcus granulosus beta LACTamase domain containing family member 0.0013 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0007 0.0045 0.0045
Onchocerca volvulus Peroxidasin homolog 0.0657 0.9944 1
Leishmania major glutaminyl cyclase, putative 0.0008 0.0066 0.0086
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0007 0.0052 0.0168
Trypanosoma brucei importin beta-1 subunit, putative 0.0011 0.0118 0.0168
Schistosoma mansoni notch 0.0211 0.3162 0.3176
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0023 0.0293 0.0446
Toxoplasma gondii HEAT repeat-containing protein 0.0011 0.0118 0.0297
Trichomonas vaginalis DNA helicase recq, putative 0.0009 0.0077 0.0149
Schistosoma mansoni notch 0.0211 0.3162 0.3176
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.013 0.1929 1
Mycobacterium leprae 3-dehydroquinate synthase AroB 0.0103 0.151 0.3596
Echinococcus granulosus histone acetyltransferase KAT2B 0.0098 0.1439 0.1439
Brugia malayi hypothetical protein 0.0016 0.0183 0.0183
Schistosoma mansoni titin 0.0007 0.0045 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0326 0.0499
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0005 0.002 0.0012
Schistosoma mansoni inositol monophosphatase 0.0014 0.0154 0.0154
Trypanosoma brucei unspecified product 0.0007 0.0054 0.0067
Plasmodium vivax vivapain-2 0.0007 0.0046 0.0276
Mycobacterium tuberculosis Probable lipase LipE 0.0013 0.0148 0.0675
Schistosoma mansoni septate junction protein 0.0004 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0046 0.0076
Loa Loa (eye worm) inositol-1 0.0014 0.0154 0.0154
Echinococcus multilocularis peroxidasin 0.066 1 1
Schistosoma mansoni cell adhesion molecule 0.0019 0.0239 0.024
Echinococcus granulosus anosmin 1 0.0004 0.0012 0.0012
Mycobacterium tuberculosis 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) 0.0103 0.151 0.7806
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0007 0.0054 0.0067
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0326 0.0499
Brugia malayi Cathepsin L-like cysteine proteinase 0.0004 0.0013 0.0013
Echinococcus granulosus protein jagged 1 0.0211 0.3162 0.3162
Toxoplasma gondii peptidase, M28 family protein 0.0008 0.0066 0.0166
Loa Loa (eye worm) hypothetical protein 0.0004 0.0012 0.0012
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0101 0.1482 0.1482
Onchocerca volvulus Putative cubilin 0.0211 0.3162 0.3172
Echinococcus granulosus GPCR family 2 0.0006 0.0032 0.0032
Echinococcus multilocularis cysteine protease 0.0007 0.0046 0.0046
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0004 0.0012 0.0012
Schistosoma mansoni cell adhesion molecule 0.0004 0.0002 0.0002
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0005 0.0016 0.0007
Echinococcus granulosus netrin receptor unc 5 0.0004 0.0002 0.0002
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0011 0.0111 0.0111
Loa Loa (eye worm) transcription factor SMAD2 0.0043 0.0599 0.0599
Schistosoma mansoni factor for adipocyte differentiation 0.0004 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0211 0.3162 0.3162
Brugia malayi Cathepsin L-like precursor 0.0004 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0006 0.0032 0.0032
Trypanosoma cruzi squalene synthase, putative 0.0418 0.6309 1
Brugia malayi FXNA 0.0008 0.0066 0.0066
Loa Loa (eye worm) lethal protein 805 0.0004 0.0012 0.0012
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0007 0.0046 0.0046
Onchocerca volvulus 0.0007 0.0056 0.0044
Toxoplasma gondii NADPH-glutathione reductase 0.0005 0.002 0.0049
Loa Loa (eye worm) polyprenyl synthetase 0.0067 0.0961 0.0961
Leishmania major DNA polymerase eta, putative 0.0007 0.0054 0.0067
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0007 0.0046 0.0474
Trypanosoma brucei DNA polymerase eta, putative 0.0007 0.0054 0.0067
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0005 0.002 0.0012
Brugia malayi Calcium binding EGF domain containing protein 0.0211 0.3162 0.3162
Echinococcus granulosus cell adhesion molecule 0.0004 0.0012 0.0012
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0008 0.0072 0.0228
Loa Loa (eye worm) hypothetical protein 0.0013 0.0148 0.0148
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0017 0.0202 0.0202
Loa Loa (eye worm) fibroinase 0.0007 0.0046 0.0046
Trichomonas vaginalis glutathione reductase, putative 0.0005 0.002 0.0016
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.0067 0.0961 0.1507
Echinococcus granulosus cathepsin L cysteine proteinase 0.0007 0.0046 0.0046
Brugia malayi myotactin form B 0.0004 0.0012 0.0012
Leishmania major cathepsin L-like protease 0.0025 0.0326 0.0499
Brugia malayi nicalin 0.0008 0.0066 0.0066
Loa Loa (eye worm) TK/ROR protein kinase 0.0005 0.0024 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0054 0.0067
Echinococcus multilocularis bloom syndrome protein 0.0009 0.0077 0.0077
Trypanosoma brucei importin beta-1 subunit, putative 0.0011 0.0118 0.0168
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0326 0.0499
Loa Loa (eye worm) hypothetical protein 0.0211 0.3162 0.3162
Onchocerca volvulus 0.0007 0.0056 0.0044
Echinococcus multilocularis dna polymerase kappa 0.0007 0.0054 0.0054
Onchocerca volvulus 0.0008 0.0066 0.0054
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0006 0.0032 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0054 0.0067
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0007 0.0046 0.0046
Brugia malayi Animal haem peroxidase family protein 0.0657 0.9944 0.9944
Leishmania major cysteine peptidase A (CPA) 0.0007 0.0046 0.0053
Loa Loa (eye worm) hypothetical protein 0.0018 0.0216 0.0216
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0017 0.0202 0.5452
Brugia malayi Bloom's syndrome protein homolog 0.0009 0.0077 0.0077
Brugia malayi Fibronectin type III domain containing protein 0.0004 0.0012 0.0012
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0011 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0211 0.3162 0.3162
Leishmania major cathepsin L-like protease 0.0025 0.0326 0.0499
Loa Loa (eye worm) hypothetical protein 0.0013 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0654 0.9901 0.9901
Trichomonas vaginalis penicillin-binding protein, putative 0.0013 0.0148 0.0314
Mycobacterium ulcerans DNA polymerase IV 0.0007 0.0054 0.0081
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0183 0.0183
Trypanosoma brucei squalene synthase, putative 0.0418 0.6309 1
Echinococcus multilocularis Netrin receptor DCC 0.0004 0.0012 0.0012
Schistosoma mansoni netrin receptor unc5 0.0004 0.0002 0.0002
Schistosoma mansoni protein tyrosine phosphatase 0.0004 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0211 0.3162 0.3176
Mycobacterium tuberculosis Conserved protein 0.0013 0.0148 0.0675
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.0067 0.0961 1
Loa Loa (eye worm) hypothetical protein 0.0004 0.0012 0.0012
Echinococcus multilocularis Phosphotidylinositol phosphatase PTPRQ 0.0004 0.0012 0.0012
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0006 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0013 0.0148 0.0148
Brugia malayi EGF-like domain containing protein 0.0211 0.3162 0.3162
Brugia malayi Muscle positioning protein 4 0.0211 0.3162 0.3162
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0004 0.0012 0.0012
Trypanosoma brucei DNA polymerase IV, putative 0.0007 0.0054 0.0067
Loa Loa (eye worm) hypothetical protein 0.0007 0.0045 0.0045
Trypanosoma cruzi DNA polymerase kappa, putative 0.0007 0.0054 0.0067
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.003 0.0398 0.1003
Brugia malayi Lethal protein 805 0.0004 0.0012 0.0012
Trichomonas vaginalis inositol monophosphatase, putative 0.0014 0.0154 0.0326
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.003 0.0398 0.1003
Loa Loa (eye worm) hypothetical protein 0.0007 0.0045 0.0045
Echinococcus granulosus bloom syndrome protein 0.0009 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0211 0.3162 0.3162
Onchocerca volvulus 0.0004 0.0013 0.0001
Loa Loa (eye worm) latrophilin receptor protein 2 0.0006 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0654 0.9901 0.9901
Schistosoma mansoni ephrin receptor 0.0007 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.013 0.1929 0.1929
Loa Loa (eye worm) hypothetical protein 0.0211 0.3162 0.3162
Echinococcus granulosus thioredoxin glutathione reductase 0.0014 0.0161 0.0161
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0004 0.0002 0.0002
Echinococcus granulosus farnesyl pyrophosphate synthase 0.0067 0.0961 0.0961
Echinococcus multilocularis roundabout 2 0.0011 0.0111 0.0111
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0045 0.0045
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0009 0.0085 0.0168
Onchocerca volvulus Peroxidase homolog 0.0654 0.9901 0.9956
Trypanosoma brucei DNA polymerase kappa, putative 0.0005 0.0021 0.0014
Mycobacterium ulcerans lipase LipD 0.0013 0.0148 0.0298
Leishmania major cathepsin L-like protease 0.0007 0.0046 0.0053
Echinococcus granulosus inositol monophosphatase 1 0.0014 0.0154 0.0154
Onchocerca volvulus Dual oxidase homolog 0.0654 0.9901 0.9956
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0006 0.0032 0.0032
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0007 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0004 0.0012 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0054 0.0067
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0007 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0007 0.0046 0.0076
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0005 0.002 0.0012
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0056 0.0056
Schistosoma mansoni glutaminase 0.0289 0.434 0.4359
Echinococcus granulosus lachesin 0.0007 0.0045 0.0045
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0056 0.0056
Mycobacterium tuberculosis Conserved protein 0.0013 0.0148 0.0675
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0007 0.0052 0.0163
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0006 0.0032 0.0032
Mycobacterium tuberculosis Probable reductase 0.0032 0.0431 0.2156
Entamoeba histolytica cysteine protease, putative 0.0007 0.0046 0.095
Schistosoma mansoni hypothetical protein 0.0211 0.3162 0.3176
Loa Loa (eye worm) hypothetical protein 0.0011 0.0117 0.0117
Brugia malayi Cathepsin L-like precursor 0.0007 0.0046 0.0046
Schistosoma mansoni glutaminyl-peptide cyclotransferase-related 0.0008 0.0066 0.0066
Leishmania major DNA polymerase kappa, putative 0.0007 0.0054 0.0067
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0022 0.0277 0.0278
Loa Loa (eye worm) hypothetical protein 0.0008 0.0066 0.0066
Trypanosoma cruzi DNA polymerase kappa, putative 0.0007 0.0054 0.0067
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0007 0.0046 0.0076
Schistosoma mansoni hypothetical protein 0.0012 0.0132 0.0133
Loa Loa (eye worm) hypothetical protein 0.0008 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0007 0.0056 0.0056
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0004 0.0012 0.0012
Brugia malayi Cathepsin L-like precursor 0.0004 0.0013 0.0013
Echinococcus granulosus fibropellin Ia 0.0211 0.3162 0.3162
Schistosoma mansoni ap endonuclease 0.0007 0.0052 0.0052
Schistosoma mansoni terminal deoxycytidyl transferase 0.0007 0.0054 0.0055
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0591 0.8948 0.8948
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0004 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.008 0.1171 0.1171
Echinococcus multilocularis fat cadherin tumor suppressor 0.0211 0.3162 0.3162
Schistosoma mansoni notch 0.0211 0.3162 0.3176
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0022 0.0277 0.0699
Brugia malayi Cathepsin L-like precursor 0.0007 0.0046 0.0046
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0007 0.0052 0.0052
Echinococcus granulosus Immunoglobulin subtype 0.0004 0.0002 0.0002
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0008 0.0072 0.0096
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0007 0.0047 0.0047
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0014 0.0154 0.0563
Trypanosoma cruzi squalene synthase, putative 0.0418 0.6309 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0007 0.0056 0.0056
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0202 0.0202
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0007 0.0046 0.0076
Echinococcus granulosus titin 0.0007 0.0056 0.0056
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0008 0.0061 0.0637
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0067 0.0961 0.2179
Echinococcus granulosus Immunoglobulin 0.0004 0.0002 0.0002
Echinococcus granulosus slit 2 protein 0.0211 0.3162 0.3162
Echinococcus granulosus tyrosine protein kinase otk 0.0007 0.0045 0.0045
Echinococcus granulosus anosmin 1 0.0004 0.0012 0.0012
Trypanosoma cruzi importin beta-1 subunit, putative 0.0009 0.0085 0.0116
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.012 0.178 0.178
Loa Loa (eye worm) hypothetical protein 0.0016 0.0183 0.0183
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0011 0.0111 0.0111
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0013 0.0148 0.0149
Schistosoma mansoni myosin-binding protein-related 0.0007 0.0056 0.0056
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0004 0.0002 0.0002
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0007 0.0054 0.0054
Schistosoma mansoni hypothetical protein 0.012 0.178 0.1788
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0004 0.0012 0.0012
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0013 0.0148 0.0148
Echinococcus multilocularis dna polymerase eta 0.0007 0.0054 0.0054
Schistosoma mansoni cathepsin F (C01 family) 0.0007 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0007 0.0046 0.0076
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0014 0.0154 0.0225
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0007 0.0052 0.0135
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0046 0.0076
Echinococcus multilocularis Immunoglobulin 0.0011 0.0117 0.0117
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0007 0.0045 0.0034
Leishmania major cathepsin L-like protease 0.0007 0.0046 0.0053
Echinococcus granulosus neuroglian 0.0011 0.0111 0.0111
Echinococcus granulosus cathepsin l1 0.0007 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0012 0.0132 0.0132
Entamoeba histolytica hypothetical protein 0.0009 0.0085 0.2088
Plasmodium falciparum glutathione reductase 0.0005 0.002 0.0203
Echinococcus multilocularis Fibronectin type III domain containing protein 0.0004 0.0012 0.0012
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0006 0.0035 0.016
Plasmodium vivax thioredoxin reductase, putative 0.0014 0.0159 0.1477
Onchocerca volvulus 0.0654 0.9901 0.9956
Trypanosoma brucei DNA polymerase IV, putative 0.0007 0.0054 0.0067
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0007 0.0052 0.0537
Giardia lamblia DINP protein human, muc B family 0.0007 0.0054 0.0172
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0202 0.0202
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0054 0.0067
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0056 0.0056
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0035 0.0485 0.0923
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0022 0.0277 0.0278
Brugia malayi hypothetical protein 0.0004 0.0002 0.0002
Onchocerca volvulus 0.0211 0.3162 0.3172
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0017 0.0202 0.0509
Mycobacterium ulcerans beta-lactamase 0.0013 0.0148 0.0298
Loa Loa (eye worm) hypothetical protein 0.0011 0.0117 0.0117
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0017 0.0202 0.0955
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0008 0.0072 0.0072
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0005 0.002 0.0049
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0007 0.0047 0.0047
Entamoeba histolytica Ran family GTPase 0.0008 0.0072 0.1718
Echinococcus multilocularis anosmin 1 0.0004 0.0012 0.0012
Brugia malayi Heparan sulfate 0.0004 0.0002 0.0002
Plasmodium falciparum histone acetyltransferase GCN5 0.0027 0.036 0.3745
Leishmania major trypanothione reductase 0.0014 0.0159 0.0233
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0007 0.0046 0.0076
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0017 0.0202 0.0462
Echinococcus multilocularis Immunoglobulin 0.0011 0.0117 0.0117
Trypanosoma cruzi glutaminyl cyclase, putative 0.0008 0.0066 0.0086
Onchocerca volvulus Fxna peptidase homolog 0.0008 0.0066 0.0054
Loa Loa (eye worm) ctsf protein 0.0007 0.0046 0.0046
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0005 0.002 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0046 0.0076
Brugia malayi Lethal protein 805 0.0004 0.0012 0.0012
Echinococcus multilocularis neurogenic locus protein delta 0.0211 0.3162 0.3162
Brugia malayi Immunoglobulin domain containing protein 0.0004 0.0002 0.0002
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0005 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0007 0.0045 0.0045
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0008 0.0072 0.056
Schistosoma mansoni farnesyl pyrophosphate synthase 0.0067 0.0961 0.0965
Echinococcus granulosus G1Y162 protein 0.0004 0.0012 0.0012
Mycobacterium ulcerans glutaminase 0.0289 0.434 1
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0017 0.0202 0.0766
Loa Loa (eye worm) hypothetical protein 0.0004 0.0012 0.0012
Leishmania major GTP-binding protein, putative 0.0008 0.0072 0.0096
Leishmania major cathepsin L-like protease 0.0025 0.0326 0.0499
Schistosoma mansoni trans-prenyltransferase 0.0017 0.0202 0.0203
Echinococcus granulosus cathepsin l1 0.0004 0.0013 0.0013
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0005 0.002 0.0012
Echinococcus granulosus defective proboscis extension response 0.0011 0.0117 0.0117
Echinococcus granulosus anosmin 1 0.0004 0.0012 0.0012
Echinococcus granulosus GTP binding nuclear protein Ran 0.0008 0.0072 0.0072
Brugia malayi glutathione reductase 0.0014 0.0159 0.0159
Schistosoma mansoni DNA polymerase eta 0.0007 0.0054 0.0055
Toxoplasma gondii cathepsin CPL 0.0007 0.0046 0.0115
Brugia malayi Importin beta-1 subunit 0.0011 0.0118 0.0118
Plasmodium vivax glutathione reductase, putative 0.0014 0.0159 0.1477
Onchocerca volvulus 0.0013 0.0148 0.0137
Onchocerca volvulus 0.0211 0.3162 0.3172
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0007 0.0052 0.0341
Loa Loa (eye worm) hypothetical protein 0.0004 0.0012 0.0012
Chlamydia trachomatis dehyroquinate synthase 0.0103 0.151 0.3778
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0007 0.0052 0.0063
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0111 0.0111
Schistosoma mansoni tripartite motif protein trim9 0.0004 0.0012 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0046 0.0076
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0326 0.0499
Mycobacterium tuberculosis 3-dehydroquinate synthase AroB 0.0103 0.151 0.7806
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0005 0.002 0.0012
Brugia malayi Calcium binding EGF domain containing protein 0.0211 0.3162 0.3162
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0013 0.0148 0.0149
Echinococcus granulosus histone lysine methyltransferase setb 0.0022 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.0004 0.0013 0.0013
Trichomonas vaginalis ap endonuclease, putative 0.0007 0.0052 0.009
Plasmodium falciparum thioredoxin reductase 0.0005 0.002 0.0203
Echinococcus granulosus delta-like protein 1 0.0211 0.3162 0.3162
Loa Loa (eye worm) hypothetical protein 0.0654 0.9901 0.9901
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0004 0.0012 0.0012
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0017 0.0202 0.0203
Loa Loa (eye worm) hypothetical protein 0.0654 0.9901 0.9901
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0202 0.051
Onchocerca volvulus Fxna peptidase homolog 0.0008 0.0066 0.0054
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0011 0.0117 0.0117
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0211 0.3162 0.3176
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0014 0.0154 0.406
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0017 0.0202 0.0955
Mycobacterium leprae Probable lipase LipE 0.0013 0.0148 0.0043
Mycobacterium tuberculosis Conserved protein 0.0013 0.0148 0.0675
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0202 0.0202
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0046 0.0076
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0017 0.0202 0.0302
Schistosoma mansoni cell adhesion molecule 0.0011 0.0111 0.0112
Schistosoma mansoni titin 0.0007 0.0056 0.0056
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0045 0.0045
Brugia malayi Cadherin domain containing protein 0.0211 0.3162 0.3162
Brugia malayi Animal haem peroxidase family protein 0.0654 0.9901 0.9901
Loa Loa (eye worm) hypothetical protein 0.0007 0.0045 0.0045
Echinococcus granulosus protein jagged 1 0.0211 0.3162 0.3162
Loa Loa (eye worm) hypothetical protein 0.0654 0.9901 0.9901
Loa Loa (eye worm) hypothetical protein 0.0007 0.0045 0.0045
Brugia malayi Thioredoxin reductase 0.0014 0.0159 0.0159
Treponema pallidum octaprenyl-diphosphate synthase 0.0017 0.0202 0.0766
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0008 0.0066 0.0066
Trypanosoma cruzi DNA polymerase kappa, putative 0.0007 0.0054 0.0067
Echinococcus multilocularis Squalene phytoene synthase 0.013 0.1929 0.1929
Schistosoma mansoni hypothetical protein 0.0004 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0211 0.3162 0.3176
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0005 0.002 0.0012
Schistosoma mansoni hypothetical protein 0.013 0.1929 0.1938
Echinococcus granulosus roundabout 2 0.0011 0.0111 0.0111
Loa Loa (eye worm) animal heme peroxidase 0.0657 0.9944 0.9944
Echinococcus granulosus neurogenic locus protein delta 0.0211 0.3162 0.3162
Schistosoma mansoni septate junction protein 0.0007 0.0045 0.0045
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0032 0.0431 0.2156
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0202 0.2103
Echinococcus multilocularis Netrin receptor DCC 0.0004 0.0012 0.0012
Brugia malayi Pre-SET motif family protein 0.0152 0.2256 0.2256
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0004 0.0002 0.0002
Brugia malayi Cathepsin L-like precursor 0.0007 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0013 0.0148 0.0148
Brugia malayi Papain family cysteine protease containing protein 0.0007 0.0046 0.0046
Plasmodium vivax importin-beta 2, putative 0.0011 0.0118 0.1042
Brugia malayi Polyprenyl synthetase family protein 0.0017 0.0202 0.0202
Mycobacterium tuberculosis Probable esterase LipL 0.0013 0.0148 0.0675
Brugia malayi Protein-tyrosine phosphatase 0.0004 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0066 0.0123
Trichomonas vaginalis DNA polymerase eta, putative 0.0007 0.0054 0.0097
Schistosoma mansoni cathepsin F (C01 family) 0.0004 0.0013 0.0013
Schistosoma mansoni neuroglian 0.0011 0.0111 0.0112
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0012 0.0132 0.0588
Schistosoma mansoni septate junction protein 0.0007 0.0045 0.0045
Echinococcus granulosus low density lipoprotein receptor ldl 0.0004 0.0002 0.0002
Echinococcus granulosus snurportin 1 0.012 0.178 0.178
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0007 0.0046 0.0076
Trichomonas vaginalis set domain proteins, putative 0.0173 0.2575 0.5922
Brugia malayi Inositol-1 0.0014 0.0154 0.0154
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0022 0.0277 0.0277
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0202 0.194
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0021 0.0265 0.0265
Schistosoma mansoni roundabout 0.0007 0.0045 0.0045
Echinococcus granulosus dna polymerase eta 0.0007 0.0054 0.0054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0326 0.0499
Brugia malayi ImpB/MucB/SamB family protein 0.0007 0.0054 0.0054
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0005 0.002 0.0012
Plasmodium vivax vivapain-2 0.0007 0.0046 0.0276
Brugia malayi glutaminase DH11.1 0.0289 0.434 0.434
Trichomonas vaginalis DNA helicase recq1, putative 0.0009 0.0077 0.0149
Schistosoma mansoni notch 0.0211 0.3162 0.3176
Loa Loa (eye worm) myotactin form A 0.0004 0.0012 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0005 0.0021 0.0014
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0007 0.0056 0.0056
Loa Loa (eye worm) cysteine protease 0.0007 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0046 0.0076
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0032 0.0431 0.0781
Schistosoma mansoni basigin related 0.0004 0.0002 0.0002
Brugia malayi Immunoglobulin I-set domain containing protein 0.0004 0.0002 0.0002
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0264 0.3965 1
Schistosoma mansoni hypothetical protein 0.0004 0.0002 0.0002
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0017 0.0202 0.0183
Schistosoma mansoni importin beta-1 0.0011 0.0118 0.0118
Brugia malayi Pre-SET motif family protein 0.0022 0.0277 0.0277
Mycobacterium tuberculosis Probable dehydrogenase 0.0032 0.0431 0.2156
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0011 0.0117 0.0117
Onchocerca volvulus 0.0007 0.0046 0.0034
Onchocerca volvulus 0.0007 0.0046 0.0034
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0007 0.0054 0.0182
Echinococcus granulosus Immunoglobulin 0.0004 0.0002 0.0002
Brugia malayi Animal haem peroxidase family protein 0.0654 0.9901 0.9901
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0017 0.0202 0.0202
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0017 0.0202 0.0302
Echinococcus multilocularis importin subunit beta 1 0.0011 0.0118 0.0118
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0202 0.0202
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0008 0.0072 0.0096
Brugia malayi Peptidase family M28 containing protein 0.0008 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0211 0.3162 0.3162
Schistosoma mansoni nephrin 0.0011 0.0111 0.0112
Schistosoma mansoni titin 0.0007 0.0056 0.0056
Echinococcus granulosus peroxidasin 0.066 1 1
Loa Loa (eye worm) hypothetical protein 0.0004 0.0012 0.0012
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0148 0.0217
Loa Loa (eye worm) hypothetical protein 0.0011 0.0111 0.0111
Loa Loa (eye worm) TK protein kinase 0.0005 0.0024 0.0024
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0045 0.0045
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0022 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.0007 0.0046 0.0046
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0008 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0011 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0654 0.9901 0.9901
Loa Loa (eye worm) MH2 domain-containing protein 0.0043 0.0599 0.0599
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0007 0.0052 0.0052
Onchocerca volvulus 0.0211 0.3162 0.3172
Schistosoma mansoni 3-dehydroquinate synthase 0.0103 0.151 0.1517
Onchocerca volvulus 0.0013 0.0148 0.0137
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0007 0.0046 0.0076
Trypanosoma cruzi DNA polymerase kappa, putative 0.0007 0.0054 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0046 0.0076
Schistosoma mansoni hypothetical protein 0.0004 0.0002 0.0002
Echinococcus multilocularis beta LACTamase domain containing family member 0.0013 0.0148 0.0148
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0005 0.0016 0.0007
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0202 0.0302
Schistosoma mansoni notch 0.0211 0.3162 0.3176
Schistosoma mansoni cell adhesion molecule 0.0007 0.0045 0.0045
Schistosoma mansoni titin 0.0004 0.0012 0.0012
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0008 0.0068 0.0068
Leishmania major hypothetical protein, conserved 0.0013 0.0148 0.0217
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0014 0.0159 0.0728
Echinococcus multilocularis titin 0.0004 0.0012 0.0012
Trypanosoma cruzi cysteine peptidase, putative 0.0007 0.0046 0.0053
Trichomonas vaginalis glutaminase, putative 0.0289 0.434 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0005 0.002 0.0012
Loa Loa (eye worm) Notch2 0.0211 0.3162 0.3162
Loa Loa (eye worm) hypothetical protein 0.0211 0.3162 0.3162
Toxoplasma gondii EGF family domain-containing protein 0.0211 0.3162 0.7975
Brugia malayi EGF-like domain containing protein 0.0211 0.3162 0.3162
Echinococcus multilocularis cysteine protease 0.0007 0.0046 0.0046
Echinococcus multilocularis leucine rich repeat containing protein 4 0.0004 0.0002 0.0002
Echinococcus granulosus neurogenic locus notch protein 0.0211 0.3162 0.3162
Schistosoma mansoni cathepsin F (C01 family) 0.0007 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0121 0.1793 0.1793
Brugia malayi ImpB/MucB/SamB family protein 0.0007 0.0054 0.0054
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0008 0.0068 0.0068
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0007 0.0056 0.0056
Leishmania major hypothetical protein, conserved 0.013 0.1929 0.3045
Loa Loa (eye worm) hypothetical protein 0.0654 0.9901 0.9901
Trichomonas vaginalis importin beta-1, putative 0.0009 0.0085 0.0168
Mycobacterium ulcerans lipoprotein aminopeptidase LpqL 0.0011 0.011 0.0209
Brugia malayi Immunoglobulin I-set domain containing protein 0.0004 0.0002 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0054 0.0067
Loa Loa (eye worm) hypothetical protein 0.0654 0.9901 0.9901
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0005 0.002 0.0012
Schistosoma mansoni hypothetical protein 0.0004 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0211 0.3162 0.3162
Loa Loa (eye worm) hypothetical protein 0.0004 0.0013 0.0013
Brugia malayi Cathepsin L-like precursor 0.0007 0.0046 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0066 0.0123
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0004 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0006 0.0032 0.0032
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0005 0.002 0.002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0326 0.0499
Loa Loa (eye worm) hypothetical protein 0.0211 0.3162 0.3162
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0161 0.24 1
Brugia malayi GCC2 and GCC3 family protein 0.0211 0.3162 0.3162
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0005 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0654 0.9901 0.9901
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0326 0.0499
Mycobacterium leprae conserved hypothetical protein 0.0013 0.0148 0.0043
Trichomonas vaginalis bromodomain-containing protein, putative 0.003 0.0398 0.089
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0017 0.0202 0.0202
Plasmodium vivax histone acetyltransferase GCN5, putative 0.003 0.0398 0.4016
Onchocerca volvulus 0.0173 0.2575 0.2581
Brugia malayi beta-lactamase family protein 0.0013 0.0148 0.0148
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0045 0.0045
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0005 0.002 0.0012
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0007 0.0052 0.1124
Echinococcus granulosus EG95 0.0004 0.0012 0.0012
Echinococcus granulosus fibronectin type III domain-containing protein 0.0004 0.0012 0.0012
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0008 0.0068 0.0068
Mycobacterium tuberculosis Conserved protein 0.0008 0.0066 0.0243
Leishmania major cathepsin L-like protease 0.0007 0.0046 0.0053
Onchocerca volvulus Glutaminyl cyclase homolog 0.0008 0.0066 0.0054
Echinococcus granulosus Squalene phytoene synthase 0.013 0.1929 0.1929
Echinococcus multilocularis usherin 0.0004 0.0012 0.0012
Echinococcus granulosus 3'partial|cell adhesion molecule:down regulated by 0.0004 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0654 0.9901 0.9901
Mycobacterium tuberculosis Probable lipoprotein aminopeptidase LpqL 0.0011 0.011 0.0473
Loa Loa (eye worm) hypothetical protein 0.0007 0.0056 0.0056
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0005 0.0016 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0326 0.0499
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0004 0.000000000024706 0.00000000006231
Echinococcus multilocularis notch 0.0211 0.3162 0.3162
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0005 0.002 0.0012
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0007 0.0056 0.0056
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0008 0.0072 0.0072
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0007 0.0052 0.0063
Leishmania major farnesyl pyrophosphate synthase 0.0067 0.0961 0.1507
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0046 0.0076
Brugia malayi exodeoxyribonuclease III family protein 0.0007 0.0052 0.0052
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0004 0.0002 0.0002
Echinococcus multilocularis netrin receptor unc 5 0.0004 0.0002 0.0002
Loa Loa (eye worm) glutaminase 0.0289 0.434 0.434
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0008 0.0072 0.0072
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0004 0.0012 0.0012
Schistosoma mansoni peroxidasin 0.0654 0.9901 0.9944
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0004 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0007 0.0054 0.0054
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0014 0.0154 0.031
Echinococcus granulosus twitchin 0.0014 0.0161 0.0161
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0054 0.0067
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0007 0.0052 0.0074
Trichomonas vaginalis ran, putative 0.0008 0.0072 0.0138
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0007 0.0052 0.0063
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0013 0.0148 0.0298
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0013 0.0148 0.0675
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0211 0.3162 0.3172
Brugia malayi notch-like transmembrane receptor 0.0211 0.3162 0.3162
Mycobacterium tuberculosis Probable oxidoreductase 0.0035 0.0485 0.244
Onchocerca volvulus Cathepsin L homolog 0.0007 0.0046 0.0034
Brugia malayi Animal haem peroxidase family protein 0.0654 0.9901 0.9901
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0017 0.0202 0.0202
Echinococcus granulosus dna polymerase kappa 0.0007 0.0054 0.0054
Brugia malayi EGF-like domain containing protein 0.0211 0.3162 0.3162
Onchocerca volvulus 0.0654 0.9901 0.9956
Onchocerca volvulus 0.0013 0.0148 0.0137
Onchocerca volvulus Fxna peptidase homolog 0.0008 0.0066 0.0054
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0005 0.0024 0.0024
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0264 0.3965 0.9132
Brugia malayi Fibronectin type III domain containing protein 0.0004 0.0012 0.0012
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0085 0.124 0.6391
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0004 0.0012 0.0012
Schistosoma mansoni notch 0.0211 0.3162 0.3176
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0202 0.051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0046 0.0076
Loa Loa (eye worm) hypothetical protein 0.0004 0.0002 0.0002
Echinococcus granulosus neurogenic locus notch protein 0.0211 0.3162 0.3162
Loa Loa (eye worm) animal heme peroxidase 0.0654 0.9901 0.9901
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0011 0.0111 0.0111
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0007 0.0046 0.0046
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0014 0.0154 0.0225
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0011 0.0111 0.0111
Echinococcus granulosus roundabout 2 0.0011 0.0111 0.0111
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0005 0.002 0.0203
Echinococcus granulosus Netrin receptor DCC 0.0004 0.0012 0.0012
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0067 0.0961 0.2192
Schistosoma mansoni cell adhesion molecule 0.0007 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0018 0.0216 0.0216
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0017 0.0202 0.5452
Brugia malayi Fibronectin type III domain containing protein 0.0004 0.0012 0.0012
Mycobacterium ulcerans hypothetical protein 0.0013 0.0148 0.0298
Echinococcus granulosus Fibronectin type III 0.0004 0.0012 0.0012
Echinococcus multilocularis inositol monophosphatase 1 0.0014 0.0154 0.0154
Schistosoma mansoni ran 0.0008 0.0072 0.0073
Brugia malayi Immunoglobulin I-set domain containing protein 0.0184 0.2746 0.2746
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0004 0.0002 0.0002
Echinococcus multilocularis protein jagged 1 0.0211 0.3162 0.3162
Loa Loa (eye worm) animal heme peroxidase 0.0654 0.9901 0.9901
Schistosoma mansoni cell adhesion molecule 0.0011 0.0111 0.0112
Onchocerca volvulus 0.0167 0.2484 0.2489
Loa Loa (eye worm) glutaminase 2 0.0289 0.434 0.434
Toxoplasma gondii thioredoxin reductase 0.0014 0.0159 0.04
Loa Loa (eye worm) hypothetical protein 0.0015 0.0173 0.0173
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0013 0.0148 0.0675
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0161 0.24 1
Echinococcus granulosus Immunoglobulin 0.0011 0.0117 0.0117
Schistosoma mansoni hypothetical protein 0.0211 0.3162 0.3176
Onchocerca volvulus 0.0654 0.9901 0.9956
Brugia malayi latrophilin 2 splice variant baaae 0.0012 0.0132 0.0132
Trypanosoma cruzi major cysteine proteinase, putative 0.002 0.0245 0.0369
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0015 0.0173 0.0173
Schistosoma mansoni laminin gamma-3 chain 0.0211 0.3162 0.3176
Schistosoma mansoni ran 0.0008 0.0072 0.0073
Schistosoma mansoni peroxidasin 0.0657 0.9956 1
Brugia malayi RNA, U transporter 1 0.0032 0.0434 0.0434
Giardia lamblia Farnesyl diphosphate synthase 0.0067 0.0961 0.3039
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0202 0.0203
Loa Loa (eye worm) hypothetical protein 0.0006 0.0032 0.0032
Echinococcus multilocularis neurogenic locus notch protein 0.0211 0.3162 0.3162
Loa Loa (eye worm) hypothetical protein 0.0013 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0016 0.0183 0.0183
Brugia malayi beta-lactamase family protein 0.0013 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0004 0.0012 0.0012
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0161 0.24 0.5511
Loa Loa (eye worm) hypothetical protein 0.0004 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0211 0.3162 0.3162
Brugia malayi Immunoglobulin I-set domain containing protein 0.0004 0.0002 0.0002
Entamoeba histolytica acetyltransferase, GNAT family 0.0027 0.036 1
Trypanosoma brucei unspecified product 0.0005 0.0021 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0326 0.0499
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0101 0.1482 0.1489
Trypanosoma brucei DNA polymerase IV, putative 0.0007 0.0054 0.0067
Brugia malayi EGF-like domain containing protein 0.0211 0.3162 0.3162
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0202 0.0202
Brugia malayi Polyprenyl synthetase family protein 0.0067 0.0961 0.0961
Brugia malayi leucyl aminopeptidase 0.0008 0.0066 0.0066
Leishmania major polyprenyl synthase, putative 0.0017 0.0202 0.0302
Schistosoma mansoni hypothetical protein 0.0211 0.3162 0.3176
Trichomonas vaginalis DNA helicase recq, putative 0.0005 0.0016 0.0008
Schistosoma mansoni vesicular amine transporter 0.0011 0.0117 0.0117
Trichomonas vaginalis penicillin-binding protein, putative 0.0013 0.0148 0.0314
Trypanosoma cruzi glutaminyl cyclase, putative 0.0008 0.0066 0.0086
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0035 0.0485 0.244
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0005 0.002 0.0203
Loa Loa (eye worm) hypothetical protein 0.0004 0.0012 0.0012
Schistosoma mansoni glutaminyl cyclase (M28 family) 0.0008 0.0066 0.0066
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0007 0.0054 0.0097
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0004 0.0012 0.0012
Plasmodium falciparum thioredoxin reductase 0.0014 0.0159 0.165
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0007 0.0052 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0005 0.0021 0.0014
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.003 0.0398 0.089
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0014 0.0154 0.0326
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0202 0.0202
Echinococcus multilocularis neurogenic locus notch protein 4 0.0211 0.3162 0.3162
Toxoplasma gondii exonuclease III APE 0.0007 0.0052 0.013
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0014 0.0154 0.0225
Schistosoma mansoni slit 0.0211 0.3162 0.3176
Trypanosoma brucei glutaminyl cyclase, putative 0.0008 0.0066 0.0086
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0067 0.0961 0.2192
Echinococcus multilocularis hemicentin 1 0.0007 0.0045 0.0045
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0008 0.0072 0.0751
Trypanosoma cruzi DNA polymerase eta, putative 0.0007 0.0054 0.0067
Onchocerca volvulus Chorion peroxidase homolog 0.0654 0.9901 0.9956
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0009 0.0085 0.0168
Brugia malayi Cadherin domain containing protein 0.0211 0.3162 0.3162
Echinococcus multilocularis neurogenic locus protein delta 0.0211 0.3162 0.3162
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0066 0.0123
Echinococcus multilocularis fibropellin Ia 0.0211 0.3162 0.3162
Echinococcus granulosus protein jagged 2 0.0211 0.3162 0.3162
Brugia malayi EGF-like domain containing protein 0.0211 0.3162 0.3162
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0017 0.0202 0.0202
Trichomonas vaginalis mercuric reductase, putative 0.0005 0.002 0.0016
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0017 0.0202 0.0422
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0326 0.0499
Schistosoma mansoni hypothetical protein 0.0004 0.0002 0.0002
Echinococcus multilocularis n acetylated alpha linked acidic dipeptidase 2 0.0118 0.1749 0.1749
Schistosoma mansoni serine/threonine protein kinase 0.0007 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0211 0.3162 0.3162
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0056 0.0056
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0008 0.0072 0.0096
Schistosoma mansoni factor for adipocyte differentiation 0.0004 0.0012 0.0012
Onchocerca volvulus Peroxidase homolog 0.0654 0.9901 0.9956
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0067 0.0961 0.2424
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0202 0.0202
Onchocerca volvulus 0.0007 0.0046 0.0034
Echinococcus multilocularis Fibronectin, type III 0.0004 0.0012 0.0012
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.0067 0.0961 0.2192
Plasmodium falciparum glutathione reductase 0.0014 0.0159 0.165
Mycobacterium ulcerans esterase/lipase LipP 0.0013 0.0148 0.0298
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0054 0.0067
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0067 0.0961 0.2179
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0202 0.0956
Echinococcus multilocularis neurogenic locus notch protein 0.0211 0.3162 0.3162
Onchocerca volvulus Cathepsin L homolog 0.0007 0.0046 0.0034
Trichomonas vaginalis Clan MH, family M28, aminopeptidase S-like metallopeptidase 0.0008 0.0066 0.0123
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0054 0.0067
Trypanosoma cruzi trypanothione reductase, putative 0.0014 0.0159 0.0233
Brugia malayi EGF-like domain containing protein 0.0211 0.3162 0.3162
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0017 0.0202 0.1938
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0022 0.0277 0.0278
Trypanosoma cruzi phytoene synthase, putative 0.013 0.1929 0.3045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0046 0.0076
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0202 0.0302
Schistosoma mansoni blooms syndrome DNA helicase 0.0007 0.005 0.005
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0202 0.0302
Loa Loa (eye worm) hypothetical protein 0.0211 0.3162 0.3162
Brugia malayi isocitrate dehydrogenase 0.0017 0.0202 0.0202
Schistosoma mansoni septate junction protein 0.0211 0.3162 0.3176
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0008 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0211 0.3162 0.3162
Loa Loa (eye worm) hypothetical protein 0.0016 0.0183 0.0183
Echinococcus granulosus contactin 0.0011 0.0111 0.0111
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0013 0.0148 0.0675

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 27 nM Inhibition of GST-tagged human recombinant VEGFR2 expressed in baculovirus ChEMBL. 17676829
IC50 (binding) = 27 nM Inhibition of GST-tagged human recombinant VEGFR2 expressed in baculovirus ChEMBL. 17676829
IC50 (binding) = 41 nM Inhibition of TIE-2/c-fms chimeric protein expressed in mouse 3T3 cells assessed as autophosphorylation level by ELISA ChEMBL. 17676829
IC50 (binding) = 41 nM Inhibition of TIE-2/c-fms chimeric protein expressed in mouse 3T3 cells assessed as autophosphorylation level by ELISA ChEMBL. 17676829
IC50 (binding) = 60 nM Inhibition of GST-tagged human recombinant TIE2 expressed in baculovirus ChEMBL. 17676829
IC50 (binding) = 60 nM Inhibition of GST-tagged human recombinant TIE2 expressed in baculovirus ChEMBL. 17676829

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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