Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor II (thrombin) receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0026 | 0.0134 | 1 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0026 | 0.0134 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0026 | 0.0134 | 1 |
Toxoplasma gondii | beta-tubulin, putative | 0.0026 | 0.0134 | 1 |
Echinococcus multilocularis | tubulin subunit beta | 0.0026 | 0.0134 | 1 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0026 | 0.0134 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0026 | 0.0134 | 1 |
Trypanosoma brucei | beta tubulin | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0026 | 0.0134 | 1 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0026 | 0.0134 | 1 |
Giardia lamblia | Beta tubulin | 0.0026 | 0.0134 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0026 | 0.0134 | 1 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0026 | 0.0134 | 1 |
Loa Loa (eye worm) | beta-tubulin | 0.0026 | 0.0134 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0026 | 0.0134 | 1 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0026 | 0.0134 | 1 |
Giardia lamblia | Beta tubulin | 0.0026 | 0.0134 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0026 | 0.0134 | 1 |
Mycobacterium tuberculosis | 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) | 0.1204 | 1 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Brugia malayi | Tubulin beta-1 chain | 0.0026 | 0.0134 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0026 | 0.0134 | 1 |
Echinococcus multilocularis | beta tubulin | 0.0026 | 0.0134 | 1 |
Loa Loa (eye worm) | tubulin beta chain | 0.0026 | 0.0134 | 1 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0026 | 0.0134 | 1 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0026 | 0.0134 | 1 |
Plasmodium falciparum | tubulin beta chain | 0.0026 | 0.0134 | 1 |
Echinococcus granulosus | tubulin subunit beta | 0.0026 | 0.0134 | 1 |
Trypanosoma brucei | beta tubulin | 0.0026 | 0.0134 | 1 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0026 | 0.0134 | 1 |
Trypanosoma brucei | beta tubulin | 0.0026 | 0.0134 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0026 | 0.0134 | 1 |
Mycobacterium ulcerans | 3-dehydroquinate dehydratase | 0.1204 | 1 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0026 | 0.0134 | 1 |
Plasmodium vivax | tubulin beta chain, putative | 0.0026 | 0.0134 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0026 | 0.0134 | 1 |
Brugia malayi | beta-tubulin, identical | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0026 | 0.0134 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0026 | 0.0134 | 1 |
Echinococcus granulosus | beta tubulin | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Toxoplasma gondii | beta tubulin | 0.0026 | 0.0134 | 1 |
Echinococcus granulosus | beta tubulin | 0.0026 | 0.0134 | 1 |
Trypanosoma cruzi | beta tubulin, putative | 0.0026 | 0.0134 | 1 |
Trichomonas vaginalis | tubulin, putative | 0.0026 | 0.0134 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0026 | 0.0134 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0026 | 0.0134 | 1 |
Echinococcus multilocularis | beta tubulin | 0.0026 | 0.0134 | 1 |
Giardia lamblia | Beta tubulin | 0.0026 | 0.0134 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0026 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0026 | 0.0134 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AUC (ADMET) | = 3780 ng.hr/ml | AUC (0 to 6 hrs) in rat at 10 mg/kg, po | ChEMBL. | 17854166 |
IC50 (binding) | = 8 nM | Displacement of [3H]haTRAP from PAR1 in human platelet membrane | ChEMBL. | 17854166 |
IC50 (binding) | = 8 nM | Displacement of [3H]haTRAP from PAR1 in human platelet membrane | ChEMBL. | 17854166 |
Inhibition (functional) | = 55 % | Ex vivo inhibition of haTRAP-induced platelet aggregation in cynomolgus monkey at 3 mg/kg, po after 6 hrs | ChEMBL. | 17854166 |
Inhibition (functional) | = 55 % | Ex vivo inhibition of haTRAP-induced platelet aggregation in cynomolgus monkey at 3 mg/kg, po 24 hrs | ChEMBL. | 17854166 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.