Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tubulin subunit beta | 0.0027 | 0.0067 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0027 | 0.0067 | 1 |
Echinococcus granulosus | beta tubulin | 0.0027 | 0.0067 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0067 | 1 |
Echinococcus granulosus | tubulin subunit beta | 0.0027 | 0.0067 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0027 | 0.0067 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0067 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0067 | 1 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0027 | 0.0067 | 1 |
Mycobacterium ulcerans | 3-dehydroquinate dehydratase | 0.2459 | 1 | 0.5 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0027 | 0.0067 | 1 |
Trypanosoma brucei | beta tubulin | 0.0027 | 0.0067 | 1 |
Giardia lamblia | Beta tubulin | 0.0027 | 0.0067 | 1 |
Echinococcus granulosus | beta tubulin | 0.0027 | 0.0067 | 1 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0027 | 0.0067 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0067 | 1 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0027 | 0.0067 | 1 |
Echinococcus multilocularis | tubulin subunit beta | 0.0027 | 0.0067 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0027 | 0.0067 | 1 |
Mycobacterium tuberculosis | 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) | 0.2459 | 1 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0027 | 0.0067 | 1 |
Brugia malayi | Tubulin beta-1 chain | 0.0027 | 0.0067 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0027 | 0.0067 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0027 | 0.0067 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0027 | 0.0067 | 1 |
Trypanosoma brucei | beta tubulin | 0.0027 | 0.0067 | 1 |
Trypanosoma brucei | beta tubulin | 0.0027 | 0.0067 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0027 | 0.0067 | 1 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0027 | 0.0067 | 1 |
Echinococcus multilocularis | beta tubulin | 0.0027 | 0.0067 | 1 |
Echinococcus multilocularis | beta tubulin | 0.0027 | 0.0067 | 1 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0027 | 0.0067 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0027 | 0.0067 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0067 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0067 | 1 |
Toxoplasma gondii | beta-tubulin, putative | 0.0027 | 0.0067 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0027 | 0.0067 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0067 | 1 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0027 | 0.0067 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0027 | 0.0067 | 1 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0027 | 0.0067 | 1 |
Loa Loa (eye worm) | tubulin beta chain | 0.0027 | 0.0067 | 1 |
Toxoplasma gondii | beta tubulin | 0.0027 | 0.0067 | 1 |
Brugia malayi | beta-tubulin, identical | 0.0027 | 0.0067 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0027 | 0.0067 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0067 | 1 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0027 | 0.0067 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0067 | 1 |
Trichomonas vaginalis | tubulin, putative | 0.0027 | 0.0067 | 1 |
Giardia lamblia | Beta tubulin | 0.0027 | 0.0067 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0027 | 0.0067 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0067 | 1 |
Plasmodium falciparum | tubulin beta chain | 0.0027 | 0.0067 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0067 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0067 | 1 |
Loa Loa (eye worm) | beta-tubulin | 0.0027 | 0.0067 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0067 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0027 | 0.0067 | 1 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0027 | 0.0067 | 1 |
Trypanosoma cruzi | beta tubulin, putative | 0.0027 | 0.0067 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0027 | 0.0067 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0027 | 0.0067 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0067 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0027 | 0.0067 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0027 | 0.0067 | 1 |
Plasmodium vivax | tubulin beta chain, putative | 0.0027 | 0.0067 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0027 | 0.0067 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0067 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0067 | 1 |
Giardia lamblia | Beta tubulin | 0.0027 | 0.0067 | 1 |
Trypanosoma brucei | beta tubulin | 0.0027 | 0.0067 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0067 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0027 | 0.0067 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0067 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0027 | 0.0067 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0027 | 0.0067 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Inhibition of human plasma kallikrein at 55 uM | ChEMBL. | 17850059 | |
Activity (binding) | Inhibition of pig kidney aminopeptidase M at 55 uM | ChEMBL. | 17850059 | |
Activity (binding) | Inhibition of human urokinase at 55 uM | ChEMBL. | 17850059 | |
Activity (binding) | Inhibition of human thrombin at 55 uM | ChEMBL. | 17850059 | |
Activity (binding) | Inhibition of human NE at 55 uM | ChEMBL. | 17850059 | |
Activity (binding) | Inhibition of human spleen cathepsin D at 55 uM | ChEMBL. | 17850059 | |
Activity (binding) | 0 | Inhibition of human thrombin at 55 uM | ChEMBL. | 17850059 |
Activity (binding) | 0 | Inhibition of human plasma kallikrein at 55 uM | ChEMBL. | 17850059 |
Activity (binding) | 0 | Inhibition of pig kidney aminopeptidase M at 55 uM | ChEMBL. | 17850059 |
Activity (binding) | 0 | Inhibition of human spleen cathepsin D at 55 uM | ChEMBL. | 17850059 |
Activity (binding) | 0 | Inhibition of human NE at 55 uM | ChEMBL. | 17850059 |
Activity (binding) | 0 | Inhibition of human pancreatic chymotrypsin at 55 uM | ChEMBL. | 17850059 |
Activity (binding) | 0 | Inhibition of human urokinase at 55 uM | ChEMBL. | 17850059 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.