Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | BEN-1 protein | 0.0027 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0134 | 1 |
Echinococcus granulosus | beta tubulin | 0.0027 | 0.0134 | 1 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0027 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0134 | 1 |
Trypanosoma brucei | beta tubulin | 0.0027 | 0.0134 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0027 | 0.0134 | 1 |
Mycobacterium ulcerans | 3-dehydroquinate dehydratase | 0.1224 | 1 | 0.5 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0027 | 0.0134 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0027 | 0.0134 | 1 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0027 | 0.0134 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0027 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0134 | 1 |
Echinococcus multilocularis | tubulin subunit beta | 0.0027 | 0.0134 | 1 |
Trichomonas vaginalis | tubulin, putative | 0.0027 | 0.0134 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0027 | 0.0134 | 1 |
Trypanosoma cruzi | beta tubulin, putative | 0.0027 | 0.0134 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0027 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0134 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0027 | 0.0134 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0027 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0134 | 1 |
Brugia malayi | Tubulin beta-1 chain | 0.0027 | 0.0134 | 1 |
Toxoplasma gondii | beta-tubulin, putative | 0.0027 | 0.0134 | 1 |
Plasmodium falciparum | tubulin beta chain | 0.0027 | 0.0134 | 1 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0027 | 0.0134 | 1 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0027 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0134 | 1 |
Giardia lamblia | Beta tubulin | 0.0027 | 0.0134 | 1 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0027 | 0.0134 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0027 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0134 | 1 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0027 | 0.0134 | 1 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0027 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0134 | 1 |
Giardia lamblia | Beta tubulin | 0.0027 | 0.0134 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0027 | 0.0134 | 1 |
Toxoplasma gondii | beta tubulin | 0.0027 | 0.0134 | 1 |
Brugia malayi | beta-tubulin, identical | 0.0027 | 0.0134 | 1 |
Trypanosoma brucei | beta tubulin | 0.0027 | 0.0134 | 1 |
Echinococcus granulosus | tubulin subunit beta | 0.0027 | 0.0134 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0027 | 0.0134 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0027 | 0.0134 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0027 | 0.0134 | 1 |
Giardia lamblia | Beta tubulin | 0.0027 | 0.0134 | 1 |
Loa Loa (eye worm) | tubulin beta chain | 0.0027 | 0.0134 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0027 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0134 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0027 | 0.0134 | 1 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0027 | 0.0134 | 1 |
Echinococcus multilocularis | beta tubulin | 0.0027 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0134 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0027 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0134 | 1 |
Echinococcus granulosus | beta tubulin | 0.0027 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0134 | 1 |
Plasmodium vivax | tubulin beta chain, putative | 0.0027 | 0.0134 | 1 |
Loa Loa (eye worm) | beta-tubulin | 0.0027 | 0.0134 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0027 | 0.0134 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0027 | 0.0134 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0027 | 0.0134 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0027 | 0.0134 | 1 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0027 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0134 | 1 |
Echinococcus multilocularis | beta tubulin | 0.0027 | 0.0134 | 1 |
Trypanosoma brucei | beta tubulin | 0.0027 | 0.0134 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0027 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0134 | 1 |
Trypanosoma brucei | beta tubulin | 0.0027 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0134 | 1 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0027 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0134 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0027 | 0.0134 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0134 | 1 |
Mycobacterium tuberculosis | 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) | 0.1224 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Inhibition of human NE at 55 uM | ChEMBL. | 17850059 | |
Activity (binding) | Inhibition of human plasma kallikrein at 55 uM | ChEMBL. | 17850059 | |
Activity (binding) | Inhibition of human thrombin at 55 uM | ChEMBL. | 17850059 | |
Activity (binding) | Inhibition of human urokinase at 55 uM | ChEMBL. | 17850059 | |
Activity (binding) | Inhibition of human spleen cathepsin D at 55 uM | ChEMBL. | 17850059 | |
Activity (binding) | Inhibition of pig kidney aminopeptidase M at 55 uM | ChEMBL. | 17850059 | |
Activity (binding) | 0 | Inhibition of human thrombin at 55 uM | ChEMBL. | 17850059 |
Activity (binding) | 0 | Inhibition of pig kidney aminopeptidase M at 55 uM | ChEMBL. | 17850059 |
Activity (binding) | 0 | Inhibition of human spleen cathepsin D at 55 uM | ChEMBL. | 17850059 |
Activity (binding) | 0 | Inhibition of human NE at 55 uM | ChEMBL. | 17850059 |
Activity (binding) | 0 | Inhibition of human plasma kallikrein at 55 uM | ChEMBL. | 17850059 |
Activity (binding) | 0 | Inhibition of human urokinase at 55 uM | ChEMBL. | 17850059 |
IC50 (binding) | = 11100 nM | Inhibition of human pancreatic chymotrypsin | ChEMBL. | 17850059 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.