Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0495 | 0.2821 | 0.2456 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0495 | 0.2821 | 1 |
Brugia malayi | hypothetical protein | 0.0228 | 0.0943 | 1 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0495 | 0.2821 | 1 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0495 | 0.2821 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 55 mm | Antimicrobial activity against Escherichia coli by agar diffusion technique | ChEMBL. | 17316908 |
IZ (functional) | = 55 mm | Antimicrobial activity against Escherichia coli by agar diffusion technique | ChEMBL. | 17316908 |
IZ (functional) | = 75 mm | Antifungal activity against Aspergilus niger by agar diffusion technique | ChEMBL. | 17316908 |
IZ (functional) | = 84 mm | Antimicrobial activity against Bacillus megaterium by agar diffusion technique | ChEMBL. | 17316908 |
IZ (functional) | = 86 mm | Antifungal activity against Aspergilus oryzae by agar diffusion technique | ChEMBL. | 17316908 |
IZ (functional) | = 90 mm | Antimicrobial activity against Bacillus subtilis by agar diffusion technique | ChEMBL. | 17316908 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.